Why OriGen’s products are critical in CAR-T therapy

In CAR-T therapy, every step – from cell collection, processing, expansion, packaging, to transportation – demands absolute precision. A single error can compromise cell viability and affect treatment outcomes.

That’s why leading medical centers and pharmaceutical companies worldwide trust CryoStore™ and PermaLife® from OriGen Biomedical – GMP-compliant solutions designed to ensure the integrity and viability of CAR-T cells throughout the entire vein-to-vein process.

 

>> See Origen Biomedical’s introduction article

Origen Biomedical trusted by leading CAR-T centers around the world

Client (Organization)	Country	OriGen products	Application in CAR-T therapy	Key highlights
Baylor College of Medicine & Texas Children’s Hospital	USA	CryoStore™ Freezing Bag	Post-manufacturing cold storage and transport of CAR-T infusion products	A 2021 study across three academic CAR-T centers (including Baylor) showed that 100% used OriGen’s CryoStore™ bags for infusion products, citing their sealed design and safety compliance.
Dana-Farber Cancer Institute	USA	CryoStore™ Freezing Bag	Cryopreservation of CAR-T cells after expansion, pre-infusion	Dana-Farber selected CryoStore™ as the standard CAR-T freezing bag, ensuring T cell viability and integrity from manufacturing to infusion.
M Health Fairview / University of Minnesota	USA	CryoStore™ Freezing Bag	On-site freezing and transport of CAR-T cells	Used CryoStore™ for local CAR-T production. Studies report consistent use of CryoStore™ across multiple U.S. centers due to its proven performance.
Kite Pharma (Yescarta®)	USA	CryoStore™ Freezing Bag	Commercial-scale packaging and cryopreservation of CAR-T products	Each Yescarta (axicabtagene ciloleucel) dose is frozen in CryoStore™ for global distribution at ≤ –150°C, preserving cell viability during ultra-cold CAR-T transport.
Novartis (Kymriah®)	Switzerland / Global	CryoStore™ + CryoPur®	Cryopreservation of Kymriah (tisagenlecleucel) post-production and shipping	As the first FDA-approved CAR-T therapy, Kymriah is frozen in CryoStore™ with CryoPur® DMSO-based cryomedia for safe shipment, enabling global delivery while maintaining GMP standards.
Bristol Myers Squibb (Abecma®)	USA / Global	CryoStore™ Freezing Bag	Frozen storage of CAR-T product Abecma (ide-cel) before infusion	Each Abecma dose (260–500×10^6 cells) is shipped in 1–3 EVA CryoStore™ bags. The durable bag design ensures cell viability and thawing safety during commercial delivery.
Guy’s Cancer Centre – King’s College London	UK	PermaLife® PL240, PL325, PL70	Gas-permeable culture bags for T-cell activation and gene transfer	Used for RetroNectin®-coated culture and viral transduction, allowing efficient gene modification without centrifugation. Closed-system GMP setup supports sterility and process consistency.
Telethon Kids Institute	Australia	CryoStore™ Freezing Bag	Cryopreservation of gene-modified T cells in preclinical CAR-T research	500 ml CryoStore™ bags used for vapor-phase liquid nitrogen storage (–160°C), with proven functional retention of CAR-T cells after thaw.

Why do leading CAR-T centers choose OriGen?

Maximized Cell Performance – Viability Preserved to the Final Step

CryoStore™ enables ultra-cold preservation at ≤ –150°C, safeguarding biological activity during shipping. PermaLife® bags enhance gene transfer efficiency without centrifugation, reducing steps and minimizing risks.

Closed-system design – GMP-compliant safety

All bags feature sealed Luer lock ports, which are ideal for aseptic conditions and minimizing contamination, ensuring robust process integrity.

Proven quality – Trusted by the biggest names in CAR-T

OriGen’s products are the standard for global CAR-T packaging in FDA-approved therapies like Yescarta®, Kymriah®, and Abecma®.

Biogroup Vietnam – Your trusted CAR-T partner

As the official distribution partner of OriGen Biomedical in Vietnam, Biogroup Vietnam offers more than just products — we provide end-to-end support:

• Technical consultation to select the proper CAR-T storage and culture solution
• Training, documentation (IFU, COA), and quality certification

• Proper cold-chain delivery for cell preservation

   

Ready to optimize your CAR-T workflow?

Let CryoStore™ and PermaLife® help you boost efficiency, reduce risks, and confidently scale your CAR-T therapy today.

Learn more at: https://biogroupvietnam.com/public/ 

 

Contact our expert team:

• Email: info@biogroupvietnam.com
• Website: https://biogroupvietnam.com/contact-us 

References

1. OriGen Biomedical. (n.d.). CryoStore™ Freezing Bag product information. Retrieved from https://www.origen.com

2. OriGen Biomedical. (n.d.). PermaLife® Cell Culture Bags product guide. Retrieved from https://www.origen.com

3. U.S. National Library of Medicine. (n.d.). PMC – PubMed Central. Retrieved from https://www.ncbi.nlm.nih.gov/pmc

4. Medic Israel. (n.d.). Cryopreservation and transport procedures for Yescarta® (axicabtagene ciloleucel). Retrieved from https://www.medic.co.il

5. BioLife Solutions. (n.d.). Investor updates and cell therapy logistics performance. Retrieved from https://investors.biolifesolutions.com

6. Pink Sheet (Citeline). (2021). Product profile: Abecma® (idecabtagene vicleucel). Retrieved from https://pink.citeline.com

7. University of Western Australia. (n.d.). CAR-T preclinical studies using CryoStore at Telethon Kids Institute. Retrieved from https://research-repository.uwa.edu.au

8. ISCT & ASGCT. (n.d.). Annual conference abstracts and product usage reports. Retrieved from https://www.celltherapysociety.org / https://www.asgct.org