{"id":11398,"date":"2026-08-04T09:32:00","date_gmt":"2026-08-04T02:32:00","guid":{"rendered":"https:\/\/biogroupvietnam.com\/?p=11398"},"modified":"2026-08-10T13:04:33","modified_gmt":"2026-08-10T06:04:33","slug":"vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/","title":{"rendered":"V\u00ec sao nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh quy\u1ebft \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u?"},"content":{"rendered":"\n<p>M\u1ed9t b\u00ecnh Cryogenic Storage \u0111\u1ea1t -190\u00b0C t\u1ea1i th\u1eddi \u0111i\u1ec3m \u0111o v\u1eabn c\u00f3 th\u1ec3 \u0111ang \u00e2m th\u1ea7m l\u00e0m h\u1ecfng m\u1eabu, n\u1ebfu nhi\u1ec7t \u0111\u1ed9 t\u1ea1i v\u1ecb tr\u00ed l\u01b0u tr\u1eef dao \u0111\u1ed9ng l\u1eb7p l\u1ea1i m\u1ed7i khi m\u1edf n\u1eafp, ki\u1ec3m k\u00ea ho\u1eb7c n\u1ea1p nit\u01a1 l\u1ecfng. B\u00e0i vi\u1ebft ph\u00e2n t\u00edch c\u01a1 ch\u1ebf t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o do dao \u0111\u1ed9ng nhi\u1ec7t trong l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u, d\u1eabn ch\u1ee9ng t\u1eeb hai nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y tr\u00ean hiPSC v\u00e0 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4, \u0111\u1ec1 c\u1eadp \u0111\u1ebfn c\u00e1c sai l\u1ea7m v\u00e0 c\u00e1c bi\u1ec7n ph\u00e1p ki\u1ec3m so\u00e1t th\u1ef1c t\u1ebf cho Cell Therapy, Biobank v\u00e0 IVF.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"538\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-on-dinh-nhiet-do-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau-1200x630-1-1024x538.png\" alt=\"V\u00ec sao nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh quy\u1ebft \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u?\" class=\"wp-image-11403\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-on-dinh-nhiet-do-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau-1200x630-1-1024x538.png 1024w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-on-dinh-nhiet-do-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau-1200x630-1-300x158.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-on-dinh-nhiet-do-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau-1200x630-1-768x403.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-on-dinh-nhiet-do-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau-1200x630-1-600x315.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-on-dinh-nhiet-do-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau-1200x630-1-90x47.png 90w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-on-dinh-nhiet-do-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau-1200x630-1.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>M\u1ed9t h\u1ec7 th\u1ed1ng c\u00f3 th\u1ec3 \u0111\u1ea1t -190\u00b0C t\u1ea1i th\u1eddi \u0111i\u1ec3m \u0111o nh\u01b0ng v\u1eabn kh\u00f4ng \u0111\u00e1ng tin c\u1eady n\u1ebfu m\u1eabu th\u01b0\u1eddng xuy\u00ean tr\u1ea3i qua dao \u0111\u1ed9ng nhi\u1ec7t \u0111\u1ed9 l\u1eb7p l\u1ea1i<\/em><\/figcaption><\/figure><\/div>\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Nhiet_do_thap_bao_ve_mau_bang_cach_nao\" >Nhi\u1ec7t \u0111\u1ed9 th\u1ea5p b\u1ea3o v\u1ec7 m\u1eabu b\u1eb1ng c\u00e1ch n\u00e0o?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#%22Nhiet_do_on_dinh%22_khong_co_nghia_la_khong_dao_dong_du_chi_1%C2%B0C\" >\"Nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh\" kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 kh\u00f4ng dao \u0111\u1ed9ng d\u00f9 ch\u1ec9 1\u00b0C<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Dieu_gi_xay_ra_khi_mau_trai_qua_dao_dong_nhiet\" >\u0110i\u1ec1u g\u00ec x\u1ea3y ra khi m\u1eabu tr\u1ea3i qua dao \u0111\u1ed9ng nhi\u1ec7t?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Tinh_the_bang_co_the_tai_to_chuc_recrystallization\" >Tinh th\u1ec3 b\u0103ng c\u00f3 th\u1ec3 t\u00e1i t\u1ed5 ch\u1ee9c (recrystallization)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Mang_te_bao_co_the_mat_on_dinh\" >M\u00e0ng t\u1ebf b\u00e0o c\u00f3 th\u1ec3 m\u1ea5t \u1ed5n \u0111\u1ecbnh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Chat_luong_chuc_nang_co_the_suy_giam_truoc_khi_viability_giam_ro_ret\" >Ch\u1ea5t l\u01b0\u1ee3ng ch\u1ee9c n\u0103ng c\u00f3 th\u1ec3 suy gi\u1ea3m tr\u01b0\u1edbc khi viability gi\u1ea3m r\u00f5 r\u1ec7t<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Bang_chung_khoa_hoc_ve_tac_dong_cua_chu_ky_nhiet\" >B\u1eb1ng ch\u1ee9ng khoa h\u1ecdc v\u1ec1 t\u00e1c \u0111\u1ed9ng c\u1ee7a chu k\u1ef3 nhi\u1ec7t<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Nhung_nguyen_nhan_pho_bien_lam_nhiet_do_mau_khong_on_dinh\" >Nh\u1eefng nguy\u00ean nh\u00e2n ph\u1ed5 bi\u1ebfn l\u00e0m nhi\u1ec7t \u0111\u1ed9 m\u1eabu kh\u00f4ng \u1ed5n \u0111\u1ecbnh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Vi_sao_monitoring_lien_tuc_quan_trong_hon_kiem_tra_thu_cong\" >V\u00ec sao monitoring li\u00ean t\u1ee5c quan tr\u1ecdng h\u01a1n ki\u1ec3m tra th\u1ee7 c\u00f4ng?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Monitoring_chua_du_neu_thieu_phuong_phap_canh_bao_phu_hop\" >Monitoring ch\u01b0a \u0111\u1ee7 n\u1ebfu thi\u1ebfu ph\u01b0\u01a1ng ph\u00e1p c\u1ea3nh b\u00e1o ph\u00f9 h\u1ee3p<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Bai_hoc_tu_mot_su_co_thuc_te_Ngan_hang_Cordlife_tai_Singapore\" >B\u00e0i h\u1ecdc t\u1eeb m\u1ed9t s\u1ef1 c\u1ed1 th\u1ef1c t\u1ebf: Ng\u00e2n h\u00e0ng Cordlife t\u1ea1i Singapore<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Dien_bien_chinh\" >Di\u1ec5n bi\u1ebfn ch\u00ednh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Bai_hoc_rut_ra_cho_van_hanh_Cryogenic_Storage\" >B\u00e0i h\u1ecdc r\u00fat ra cho v\u1eadn h\u00e0nh Cryogenic Storage<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Danh_gia_mot_su_co_nhiet\" >\u0110\u00e1nh gi\u00e1 m\u1ed9t s\u1ef1 c\u1ed1 nhi\u1ec7t<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Ba_yeu_to_can_xem_xet_dong_thoi\" >Ba y\u1ebfu t\u1ed1 c\u1ea7n xem x\u00e9t \u0111\u1ed3ng th\u1eddi<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Chat_luong_mau_phai_duoc_danh_gia_sau_ra_dong_nhu_the_nao\" >Ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu ph\u1ea3i \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 sau r\u00e3 \u0111\u00f4ng nh\u01b0 th\u1ebf n\u00e0o?<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#10_bien_phap_giup_duy_tri_nhiet_do_on_dinh\" >10 bi\u1ec7n ph\u00e1p gi\u00fap duy tr\u00ec nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Nhiet_do_on_dinh_van_de_ky_thuat_hay_quan_tri_chat_luong\" >Nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh: v\u1ea5n \u0111\u1ec1 k\u1ef9 thu\u1eadt hay qu\u1ea3n tr\u1ecb ch\u1ea5t l\u01b0\u1ee3ng?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Cau_hoi_thuong_gap\" >C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Nhiet_do_dao_dong_bao_nhieu_thi_duoc_xem_la_nguy_hiem_cho_mau\" >Nhi\u1ec7t \u0111\u1ed9 dao \u0111\u1ed9ng bao nhi\u00eau th\u00ec \u0111\u01b0\u1ee3c xem l\u00e0 nguy hi\u1ec3m cho m\u1eabu?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Vapor_Phase_hay_Liquid_Phase_on_dinh_nhiet_hon\" >Vapor Phase hay Liquid Phase \u1ed5n \u0111\u1ecbnh nhi\u1ec7t h\u01a1n?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Chi_do_viability_sau_ra_dong_co_du_de_xac_nhan_chat_luong_mau_khong\" >Ch\u1ec9 \u0111o viability sau r\u00e3 \u0111\u00f4ng c\u00f3 \u0111\u1ee7 \u0111\u1ec3 x\u00e1c nh\u1eadn ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu kh\u00f4ng?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Bao_lau_nen_thuc_hien_temperature_mapping_mot_lan\" >Bao l\u00e2u n\u00ean th\u1ef1c hi\u1ec7n temperature mapping m\u1ed9t l\u1ea7n?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/#Ket_luan\" >K\u1ebft lu\u1eadn<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhiet_do_thap_bao_ve_mau_bang_cach_nao\"><\/span><strong>Nhi\u1ec7t \u0111\u1ed9 th\u1ea5p b\u1ea3o v\u1ec7 m\u1eabu b\u1eb1ng c\u00e1ch n\u00e0o?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Cryopreservation l\u00e0 qu\u00e1 tr\u00ecnh b\u1ea3o qu\u1ea3n t\u1ebf b\u00e0o ho\u1eb7c m\u00f4 \u1edf nhi\u1ec7t \u0111\u1ed9 r\u1ea5t th\u1ea5p nh\u1eb1m l\u00e0m gi\u1ea3m m\u1ea1nh ho\u1eb7c g\u1ea7n nh\u01b0 d\u1eebng c\u00e1c ho\u1ea1t \u0111\u1ed9ng chuy\u1ec3n h\u00f3a, ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc v\u00e0 qu\u00e1 tr\u00ecnh ph\u00e2n h\u1ee7y sinh h\u1ecdc.<\/p>\n\n\n\n<p>Tuy nhi\u00ean, t\u1ebf b\u00e0o ch\u1ee9a m\u1ed9t l\u01b0\u1ee3ng n\u01b0\u1edbc l\u1edbn. Khi nhi\u1ec7t \u0111\u1ed9 gi\u1ea3m, n\u01b0\u1edbc c\u00f3 xu h\u01b0\u1edbng k\u1ebft tinh th\u00e0nh b\u0103ng. N\u1ebfu qu\u00e1 tr\u00ecnh n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t, s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee7a tinh th\u1ec3 b\u0103ng v\u00e0 s\u1ef1 thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 ch\u1ea5t tan trong v\u00e0 ngo\u00e0i t\u1ebf b\u00e0o c\u00f3 th\u1ec3 l\u00e0m t\u1ed5n th\u01b0\u01a1ng m\u00e0ng t\u1ebf b\u00e0o, ty th\u1ec3, protein, DNA\/RNA, khung x\u01b0\u01a1ng t\u1ebf b\u00e0o v\u00e0 c\u00e1c c\u01a1 ch\u1ebf truy\u1ec1n t\u00edn hi\u1ec7u n\u1ed9i b\u00e0o.<\/p>\n\n\n\n<p>Trong m\u1ed9t b\u00e0i t\u1ed5ng quan kinh \u0111i\u1ec3n v\u1ec1 nguy\u00ean l\u00fd cryopreservation, nh\u00e0 khoa h\u1ecdc David E. Pegg x\u00e1c \u0111\u1ecbnh s\u1ef1 h\u00ecnh th\u00e0nh v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a tinh th\u1ec3 b\u0103ng l\u00e0 m\u1ed9t trong nh\u1eefng c\u01a1 ch\u1ebf trung t\u00e2m g\u00e2y t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o trong qu\u00e1 tr\u00ecnh \u0111\u00f4ng l\u1ea1nh v\u00e0 r\u00e3 \u0111\u00f4ng (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18080461\/\">Pegg, 2007, <em>Methods in Molecular Biology<\/em><\/a>). V\u00ec v\u1eady, m\u1ed9t quy tr\u00ecnh \u0111\u00e1ng tin c\u1eady ph\u1ea3i k\u1ebft h\u1ee3p cryoprotectant ph\u00f9 h\u1ee3p, t\u1ed1c \u0111\u1ed9 l\u00e0m l\u1ea1nh \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t v\u00e0 \u0111i\u1ec1u ki\u1ec7n l\u01b0u tr\u1eef \u0111\u1ee7 th\u1ea5p.<\/p>\n\n\n\n<p>Sau khi \u0111\u00f4ng l\u1ea1nh \u0111\u00fang quy tr\u00ecnh, m\u1eabu \u0111\u01b0\u1ee3c \u0111\u01b0a xu\u1ed1ng v\u00f9ng nhi\u1ec7t \u0111\u1ed9 cryogenic, n\u01a1i kh\u1ea3 n\u0103ng chuy\u1ec3n \u0111\u1ed9ng c\u1ee7a c\u00e1c ph\u00e2n t\u1eed gi\u1ea3m r\u1ea5t m\u1ea1nh, gi\u00fap duy tr\u00ec tr\u1ea1ng th\u00e1i c\u1ee7a m\u1eabu trong th\u1eddi gian d\u00e0i. Nh\u01b0ng tr\u1ea1ng th\u00e1i n\u00e0y ch\u1ec9 b\u1ec1n v\u1eefng khi nhi\u1ec7t \u0111\u1ed9 ti\u1ebfp t\u1ee5c \u0111\u01b0\u1ee3c duy tr\u00ec \u1ed5n \u0111\u1ecbnh.<\/p>\n\n\n\n<p>M\u1ed9t h\u1ec7 th\u1ed1ng c\u00f3 th\u1ec3 \u0111\u1ea1t -190\u00b0C t\u1ea1i th\u1eddi \u0111i\u1ec3m \u0111o nh\u01b0ng v\u1eabn kh\u00f4ng \u0111\u00e1ng tin c\u1eady n\u1ebfu m\u1eabu th\u01b0\u1eddng xuy\u00ean tr\u1ea3i qua c\u00e1c chu k\u1ef3: \u0111\u01b0\u1ee3c n\u00e2ng l\u00ean v\u00f9ng nhi\u1ec7t \u0111\u1ed9 cao h\u01a1n khi l\u1ea5y m\u1eabu, h\u1ea1 xu\u1ed1ng tr\u1edf l\u1ea1i sau khi \u0111\u00f3ng n\u1eafp, r\u1ed3i ti\u1ebfp t\u1ee5c t\u0103ng nhi\u1ec7t trong l\u1ea7n thao t\u00e1c&nbsp; k\u1ebf ti\u1ebfp. C\u00e1c bi\u1ebfn \u0111\u1ed9ng n\u00e0y c\u00f3 th\u1ec3 kh\u00f4ng l\u00e0m m\u1eabu r\u00e3 \u0111\u00f4ng ho\u00e0n to\u00e0n, nh\u01b0ng ch\u00fang v\u1eabn c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m thay \u0111\u1ed5i c\u1ea5u tr\u00fac c\u1ee7a pha \u0111\u00f4ng l\u1ea1nh, g\u00e2y stress cho t\u1ebf b\u00e0o v\u00e0 t\u1ea1o ra t\u1ed5n th\u01b0\u01a1ng t\u00edch l\u0169y m\u00e0 m\u1eaft th\u01b0\u1eddng kh\u00f4ng th\u1ec3 nh\u1eadn bi\u1ebft.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>&#8220;Nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh&#8221; kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 kh\u00f4ng dao \u0111\u1ed9ng d\u00f9 ch\u1ec9 1\u00b0C<\/strong><\/h2>\n\n\n\n<p>Kh\u00f4ng c\u00f3 h\u1ec7 th\u1ed1ng th\u1ef1c t\u1ebf n\u00e0o duy tr\u00ec m\u1ed9t gi\u00e1 tr\u1ecb nhi\u1ec7t \u0111\u1ed9 tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng \u0111\u1ed5i. Trong v\u1eadn h\u00e0nh, nhi\u1ec7t \u0111\u1ed9 c\u00f3 th\u1ec3 thay \u0111\u1ed5i nh\u1eb9 do nit\u01a1 l\u1ecfng bay h\u01a1i, h\u1ec7 th\u1ed1ng t\u1ef1 \u0111\u1ed9ng n\u1ea1p LN\u2082, thao t\u00e1c m\u1edf\/\u0111\u00f3ng n\u1eafp b\u00ecnh, \u0111i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng ph\u00f2ng, ho\u1eb7c v\u1ecb tr\u00ed c\u1ee7a c\u1ea3m bi\u1ebfn v\u00e0 c\u1ee7a m\u1eabu trong rack.<\/p>\n\n\n\n<p>Do \u0111\u00f3, &#8220;\u1ed5n \u0111\u1ecbnh&#8221; kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 \u0111\u01b0\u1eddng nhi\u1ec7t \u0111\u1ed9 ph\u1ea3i ho\u00e0n to\u00e0n ph\u1eb3ng. N\u00f3 n\u00ean \u0111\u01b0\u1ee3c hi\u1ec3u l\u00e0:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nhi\u1ec7t \u0111\u1ed9 m\u1eabu lu\u00f4n n\u1eb1m trong v\u00f9ng \u0111\u00e3 x\u00e1c \u0111\u1ecbnh<\/li>\n\n\n\n<li>Kh\u00f4ng v\u01b0\u1ee3t ng\u01b0\u1ee1ng ki\u1ec3m so\u00e1t trong kho\u1ea3ng th\u1eddi gian \u0111\u00e1ng k\u1ec3<\/li>\n\n\n\n<li>Kh\u00f4ng xu\u1ea5t hi\u1ec7n c\u00e1c chu k\u1ef3 t\u0103ng\u2013gi\u1ea3m b\u1ea5t th\u01b0\u1eddng v\u00e0 l\u1eb7p l\u1ea1i<\/li>\n\n\n\n<li>Nhi\u1ec7t \u0111\u1ed9 ph\u1ee5c h\u1ed3i nhanh sau thao t\u00e1c<\/li>\n\n\n\n<li>Bi\u1ebfn \u0111\u1ed9ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n, ghi nh\u1eadn v\u00e0 x\u1eed l\u00fd, v\u1edbi d\u1eef li\u1ec7u ch\u1ee9ng minh tr\u1ea1ng th\u00e1i ki\u1ec3m so\u00e1t<\/li>\n<\/ul>\n\n\n\n<p>\u0110i\u1ec3m quan tr\u1ecdng l\u00e0 theo d\u00f5i m\u1ee9c \u0111\u1ed9, th\u1eddi gian v\u00e0 t\u1ea7n su\u1ea5t dao \u0111\u1ed9ng \u2014 ch\u1ee9 kh\u00f4ng ch\u1ec9 nh\u00ecn v\u00e0o m\u1ed9t gi\u00e1 tr\u1ecb nhi\u1ec7t \u0111\u1ed9 t\u1ee9c th\u1eddi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dieu_gi_xay_ra_khi_mau_trai_qua_dao_dong_nhiet\"><\/span><strong>\u0110i\u1ec1u g\u00ec x\u1ea3y ra khi m\u1eabu tr\u1ea3i qua dao \u0111\u1ed9ng nhi\u1ec7t?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tinh_the_bang_co_the_tai_to_chuc_recrystallization\"><\/span>Tinh th\u1ec3 b\u0103ng c\u00f3 th\u1ec3 t\u00e1i t\u1ed5 ch\u1ee9c (recrystallization)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Trong m\u1eabu \u0111\u00f4ng l\u1ea1nh, c\u00e1c tinh th\u1ec3 b\u0103ng kh\u00f4ng nh\u1ea5t thi\u1ebft b\u1ea5t bi\u1ebfn trong m\u1ecdi \u0111i\u1ec1u ki\u1ec7n. Khi nhi\u1ec7t \u0111\u1ed9 t\u0103ng l\u00ean, m\u1ed9t ph\u1ea7n c\u1ea5u tr\u00fac \u0111\u00f4ng l\u1ea1nh c\u00f3 th\u1ec3 tr\u1edf n\u00ean linh \u0111\u1ed9ng h\u01a1n: c\u00e1c tinh th\u1ec3 b\u0103ng nh\u1ecf c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n th\u00e0nh tinh th\u1ec3 l\u1edbn h\u01a1n, \u0111\u1eb7c bi\u1ec7t khi m\u1eabu tr\u1ea3i qua nhi\u1ec1u chu k\u1ef3 t\u0103ng v\u00e0 gi\u1ea3m nhi\u1ec7t \u2014 hi\u1ec7n t\u01b0\u1ee3ng th\u01b0\u1eddng g\u1ecdi l\u00e0 <em>recrystallization<\/em>.<\/p>\n\n\n\n<p>Tinh th\u1ec3 l\u1edbn t\u1ea1o ra t\u00e1c \u0111\u1ed9ng c\u01a1 h\u1ecdc m\u1ea1nh h\u01a1n l\u00ean m\u00e0ng t\u1ebf b\u00e0o, m\u00e0ng b\u00e0o quan, c\u1ea5u tr\u00fac protein v\u00e0 kh\u00f4ng gian n\u1ed9i b\u00e0o. M\u1eabu kh\u00f4ng c\u1ea7n tan ho\u00e0n to\u00e0n m\u1edbi xu\u1ea5t hi\u1ec7n nguy c\u01a1 n\u00e0y \u2014 ch\u1ec9 c\u1ea7n nhi\u1ec7t \u0111\u1ed9 t\u0103ng \u0111\u1ee7 l\u00e2u v\u00e0o v\u00f9ng l\u00e0m t\u0103ng chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed l\u00e0 c\u1ea5u tr\u00fac pha \u0111\u00f4ng l\u1ea1nh c\u00f3 th\u1ec3 b\u1eaft \u0111\u1ea7u thay \u0111\u1ed5i \u2013 t\u1eeb d\u1ea1ng th\u1ee7y tinh v\u00f4 \u0111\u1ecbnh h\u00ecnh sang b\u1eaft \u0111\u1ea7u h\u00ecnh th\u00e0nh tinh th\u1ec3 b\u0103ng<del>.<\/del><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mang_te_bao_co_the_mat_on_dinh\"><\/span>M\u00e0ng t\u1ebf b\u00e0o c\u00f3 th\u1ec3 m\u1ea5t \u1ed5n \u0111\u1ecbnh<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>M\u00e0ng t\u1ebf b\u00e0o c\u1ea5u t\u1ea1o ch\u1ee7 y\u1ebfu t\u1eeb lipid v\u00e0 protein, chuy\u1ec3n qua nhi\u1ec1u tr\u1ea1ng th\u00e1i v\u1eadt l\u00fd kh\u00e1c nhau trong qu\u00e1 tr\u00ecnh l\u00e0m l\u1ea1nh. Dao \u0111\u1ed9ng nhi\u1ec7t l\u1eb7p l\u1ea1i c\u00f3 th\u1ec3 g\u00e2y t\u00e1i s\u1eafp x\u1ebfp lipid, t\u0103ng t\u00ednh th\u1ea5m c\u1ee7a m\u00e0ng, m\u1ea5t c\u00e2n b\u1eb1ng ion, t\u1ed5n th\u01b0\u01a1ng ty th\u1ec3, v\u00e0 kh\u1edfi ph\u00e1t c\u00e1c con \u0111\u01b0\u1eddng stress ho\u1eb7c ch\u1ebft t\u1ebf b\u00e0o sau r\u00e3 \u0111\u00f4ng.<\/p>\n\n\n\n<p>M\u1ed9t m\u1eabu v\u1eabn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 &#8220;c\u00f2n s\u1ed1ng&#8221; ngay sau r\u00e3 \u0111\u00f4ng, nh\u01b0ng kh\u1ea3 n\u0103ng ph\u1ee5c h\u1ed3i, b\u00e1m d\u00ednh ho\u1eb7c t\u0103ng sinh sau \u0111\u00f3 l\u1ea1i suy gi\u1ea3m. \u0110\u00e2y l\u00e0 l\u00fd do ch\u1ec9 \u0111o kh\u1ea3 n\u0103ng t\u1ed3n t\u1ea1i (viability) ngay sau r\u00e3 \u0111\u00f4ng (thawing) ch\u01b0a \u0111\u1ee7 \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 to\u00e0n b\u1ed9 ch\u1ea5t l\u01b0\u1ee3ng cryopreservation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chat_luong_chuc_nang_co_the_suy_giam_truoc_khi_viability_giam_ro_ret\"><\/span>Ch\u1ea5t l\u01b0\u1ee3ng ch\u1ee9c n\u0103ng c\u00f3 th\u1ec3 suy gi\u1ea3m tr\u01b0\u1edbc khi viability gi\u1ea3m r\u00f5 r\u1ec7t<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Viability l\u00e0 ch\u1ec9 ti\u00eau quan tr\u1ecdng, nh\u01b0ng kh\u00f4ng ph\u1ea3n \u00e1nh to\u00e0n b\u1ed9 n\u0103ng l\u1ef1c c\u1ee7a t\u1ebf b\u00e0o. Hai m\u1eabu \u0111\u1ec1u c\u00f3 viability 85% sau r\u00e3 \u0111\u00f4ng v\u1eabn c\u00f3 th\u1ec3 kh\u00e1c nhau \u0111\u00e1ng k\u1ec3 v\u1ec1 t\u1ed5ng s\u1ed1 t\u1ebf b\u00e0o thu h\u1ed3i (total cell recovery), kh\u1ea3 n\u0103ng t\u0103ng sinh, kh\u1ea3 n\u0103ng b\u00e1m d\u00ednh, ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch, kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a, hi\u1ec7u l\u1ef1c (potency), ho\u1ea1t t\u00ednh chuy\u1ec3n h\u00f3a v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh ki\u1ec3u h\u00ecnh.<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u tr\u00ean t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSC) ngu\u1ed3n g\u1ed1c nhau thai cho th\u1ea5y dao \u0111\u1ed9ng nhi\u1ec7t l\u1eb7p l\u1ea1i l\u00e0m gi\u1ea3m r\u00f5 r\u1ec7t s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o, viability v\u00e0 c\u00e1c \u0111\u1eb7c t\u00ednh chuy\u1ec3n h\u00f3a sau r\u00e3 \u0111\u00f4ng, \u0111\u1ed3ng th\u1eddi l\u00e0m t\u0103ng t\u1ef7 l\u1ec7 t\u1ebf b\u00e0o th\u1ef1c hi\u1ec7n apoptosis v\u00e0 l\u00e0m suy gi\u1ea3m \u0111\u00e1ng k\u1ec3 kh\u1ea3 n\u0103ng b\u00e1m d\u00ednh \u2014 trong khi dao \u0111\u1ed9ng ng\u1eafn h\u1ea1n, bi\u00ean \u0111\u1ed9 nh\u1ecf (\u0111\u1ebfn kho\u1ea3ng -100\u00b0C, d\u01b0\u1edbi 20 chu k\u1ef3) kh\u00f4ng g\u00e2y kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 so v\u1edbi l\u01b0u tr\u1eef \u1edf nhi\u1ec7t \u0111\u1ed9 c\u1ed1 \u0111\u1ecbnh (<a href=\"https:\/\/doi.org\/10.1186\/s13287-017-0512-7\">Pogozhykh et al., 2017, <em>Stem Cell Research &amp; Therapy<\/em><\/a>).<\/p>\n\n\n\n<p>N\u00f3i c\u00e1ch kh\u00e1c, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng \u1ed5n \u0111\u1ecbnh c\u00f3 th\u1ec3 t\u1ea1o ra m\u1ed9t lo\u1ea1i r\u1ee7i ro \u00e2m th\u1ea7m: m\u1eabu v\u1eabn &#8220;\u0111\u1ea1t viability&#8221;, nh\u01b0ng kh\u00f4ng c\u00f2n \u0111\u00e1p \u1ee9ng \u0111\u1ea7y \u0111\u1ee7 m\u1ee5c \u0111\u00edch nghi\u00ean c\u1ee9u ho\u1eb7c \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bang_chung_khoa_hoc_ve_tac_dong_cua_chu_ky_nhiet\"><\/span>B\u1eb1ng ch\u1ee9ng khoa h\u1ecdc v\u1ec1 t\u00e1c \u0111\u1ed9ng c\u1ee7a chu k\u1ef3 nhi\u1ec7t<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>M\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t kh\u00f4ng gi\u1ed1ng nhau \u1edf m\u1ecdi lo\u1ea1i t\u1ebf b\u00e0o \u2014 n\u00f3 ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i t\u1ebf b\u00e0o, cryoprotectant, ph\u01b0\u01a1ng ph\u00e1p \u0111\u00f4ng l\u1ea1nh, v\u1eadt ch\u1ee9a, bi\u00ean \u0111\u1ed9 nhi\u1ec7t, s\u1ed1 chu k\u1ef3 v\u00e0 th\u1eddi gian m\u1eabu \u1edf v\u00f9ng nhi\u1ec7t \u0111\u1ed9 cao h\u01a1n. Nh\u01b0ng hai nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho th\u1ea5y \u0111\u00e2y l\u00e0 r\u1ee7i ro th\u1ef1c t\u1ebf c\u1ea7n \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t, kh\u00f4ng ph\u1ea3i gi\u1ea3 \u0111\u1ecbnh l\u00fd thuy\u1ebft.<\/p>\n\n\n\n<p><strong>hiPSC \u2014 dao \u0111\u1ed9ng -80\u00b0C \u2194 -150\u00b0C.<\/strong> M\u1ed9t nghi\u00ean c\u1ee9u n\u0103m 2024 t\u1eeb tr\u00ean t\u1ebf b\u00e0o g\u1ed1c v\u1ea1n n\u0103ng c\u1ea3m \u1ee9ng ng\u01b0\u1eddi (hiPSC), s\u1eed d\u1ee5ng k\u00ednh hi\u1ec3n vi Raman l\u1ea1nh, flow cytometry v\u00e0 c\u00e1c ch\u1ec9 s\u1ed1 hi\u1ec7u su\u1ea5t t\u1ebf b\u00e0o, ghi nh\u1eadn r\u1eb1ng c\u00e1c chu k\u1ef3 nhi\u1ec7t gi\u1eefa -80\u00b0C v\u00e0 -150\u00b0C l\u00e0m gi\u1ea3m \u0111i\u1ec7n th\u1ebf m\u00e0ng ty th\u1ec3 v\u00e0 l\u00e0m gi\u1ea3m hi\u1ec7u su\u1ea5t b\u00e1m d\u00ednh sau r\u00e3 \u0111\u00f4ng khi s\u1ed1 chu k\u1ef3 t\u0103ng l\u00ean. Nh\u00f3m nghi\u00ean c\u1ee9u x\u00e1c \u0111\u1ecbnh c\u01a1 ch\u1ebf li\u00ean quan \u0111\u1ebfn s\u1ef1 di chuy\u1ec3n c\u1ee7a DMSO n\u1ed9i b\u00e0o v\u00e0 qu\u00e1 tr\u00ecnh oxy h\u00f3a cytochrome c khi nhi\u1ec7t \u0111\u1ed9 v\u01b0\u1ee3t ng\u01b0\u1ee1ng chuy\u1ec3n pha th\u1ee7y tinh (glass transition) c\u1ee7a cryoprotectant (<a href=\"https:\/\/doi.org\/10.3389\/fbioe.2024.1443795\">Okuda et al., 2024, <em>Frontiers in Bioengineering and Biotechnology<\/em><\/a>).<\/p>\n\n\n\n<p><strong>MSC nhau thai \u2014 dao \u0111\u1ed9ng -196\u00b0C \u2194 -80\u00b0C\/-100\u00b0C\/-150\u00b0C.<\/strong> Nghi\u00ean c\u1ee9u c\u1ee7a Pogozhykh v\u00e0 c\u1ed9ng s\u1ef1 (2017) so s\u00e1nh nhi\u1ec1u bi\u00ean \u0111\u1ed9 dao \u0111\u1ed9ng nhi\u1ec7t tr\u00ean t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 nhau thai. K\u1ebft qu\u1ea3 cho th\u1ea5y dao \u0111\u1ed9ng l\u00ean \u0111\u1ebfn -80\u00b0C, \u0111\u1eb7c bi\u1ec7t khi l\u1eb7p l\u1ea1i nhi\u1ec1u chu k\u1ef3, l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o, viability v\u00e0 ho\u1ea1t t\u00ednh chuy\u1ec3n h\u00f3a so v\u1edbi l\u01b0u tr\u1eef \u1edf nhi\u1ec7t \u0111\u1ed9 c\u1ed1 \u0111\u1ecbnh \u2014 trong khi dao \u0111\u1ed9ng bi\u00ean \u0111\u1ed9 nh\u1ecf h\u01a1n (\u0111\u1ebfn kho\u1ea3ng -100\u00b0C, d\u01b0\u1edbi 20 chu k\u1ef3) c\u00f3 t\u00e1c \u0111\u1ed9ng kh\u00f4ng \u0111\u00e1ng k\u1ec3 (<a href=\"https:\/\/doi.org\/10.1186\/s13287-017-0512-7\">Pogozhykh et al., 2017<\/a>).<\/p>\n\n\n\n<p>Hai nghi\u00ean c\u1ee9u n\u00e0y kh\u00f4ng c\u00f3 ngh\u0129a m\u1ecdi dao \u0111\u1ed9ng nh\u1ecf s\u1ebd ngay l\u1eadp t\u1ee9c l\u00e0m h\u1ecfng m\u1eabu. Nh\u01b0ng ch\u00fang c\u1ee7ng c\u1ed1 m\u1ed9t nguy\u00ean t\u1eafc qu\u1ea3n l\u00fd quan tr\u1ecdng: t\u1ea7n su\u1ea5t v\u00e0 bi\u00ean \u0111\u1ed9 ti\u1ebfp x\u00fac nhi\u1ec7t c\u1ea7n \u0111\u01b0\u1ee3c gi\u1ea3m \u0111\u1ebfn m\u1ee9c th\u1ea5p nh\u1ea5t c\u00f3 th\u1ec3, thay v\u00ec \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u00e1ng k\u1ec3 ch\u1ec9 v\u00ec m\u1eabu ch\u01b0a r\u00e3 \u0111\u00f4ng ho\u00e0n to\u00e0n.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhung_nguyen_nhan_pho_bien_lam_nhiet_do_mau_khong_on_dinh\"><\/span><strong>Nh\u1eefng nguy\u00ean nh\u00e2n ph\u1ed5 bi\u1ebfn l\u00e0m nhi\u1ec7t \u0111\u1ed9 m\u1eabu kh\u00f4ng \u1ed5n \u0111\u1ecbnh<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>#<\/strong><strong><\/strong><\/td><td><strong>Nguy\u00ean nh\u00e2n<\/strong><strong><\/strong><\/td><td><strong>V\u00ec sao x\u1ea3y ra<\/strong><strong><\/strong><\/td><\/tr><tr><td>1<\/td><td>M\u1edf n\u1eafp b\u00ecnh qu\u00e1 l\u00e2u<\/td><td>Kh\u00f4ng kh\u00ed \u1ea5m \u0111i v\u00e0o trong khi h\u01a1i l\u1ea1nh tho\u00e1t ra, \u1ea3nh h\u01b0\u1edfng l\u1edbn nh\u1ea5t \u1edf c\u1ed5 b\u00ecnh v\u00e0 ph\u00eda tr\u00ean rack<\/td><\/tr><tr><td>2<\/td><td>N\u00e2ng c\u1ea3 rack l\u00ean \u0111\u1ec3 t\u00ecm m\u1ed9t cryovial<\/td><td>L\u1ed7i v\u1eadn h\u00e0nh ph\u1ed5 bi\u1ebfn khi inventory qu\u1ea3n l\u00fd ch\u01b0a t\u1ed1t; m\u1ed7i l\u1ea7n thao t\u00e1c t\u1ea1o th\u00eam m\u1ed9t chu k\u1ef3 nhi\u1ec7t cho nhi\u1ec1u m\u1eabu kh\u00f4ng li\u00ean quan<\/td><\/tr><tr><td>3<\/td><td>B\u1ed1 tr\u00ed m\u1eabu kh\u00f4ng theo t\u1ea7n su\u1ea5t s\u1eed d\u1ee5ng<\/td><td>M\u1eabu truy c\u1eadp th\u01b0\u1eddng xuy\u00ean \u0111\u1eb7t chung rack v\u1edbi m\u1eabu l\u01b0u tr\u1eef d\u00e0i h\u1ea1n l\u00e0m t\u0103ng ph\u01a1i nhi\u1ec5m nhi\u1ec7t cho nh\u00f3m \u00edt s\u1eed d\u1ee5ng<\/td><\/tr><tr><td>4<\/td><td>M\u1ee9c LN\u2082 th\u1ea5p ho\u1eb7c bi\u1ebfn \u0111\u1ed9ng<\/td><td>\u1ea2nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn chi\u1ec1u cao c\u1ed9t h\u01a1i l\u1ea1nh v\u00e0 ph\u00e2n b\u1ed1 nhi\u1ec7t trong Vapor Phase Storage<\/td><\/tr><tr><td>5<\/td><td>H\u1ec7 th\u1ed1ng ch\u00e2n kh\u00f4ng suy gi\u1ea3m<\/td><td>LN\u2082 bay h\u01a1i nhanh h\u01a1n, t\u1ea7n su\u1ea5t n\u1ea1p t\u0103ng; d\u1ea5u hi\u1ec7u ban \u0111\u1ea7u th\u01b0\u1eddng ch\u1ec9 l\u00e0 chi ph\u00ed LN\u2082 t\u0103ng, ch\u01b0a h\u1eb3n l\u00e0 alarm nhi\u1ec7t \u0111\u1ed9<\/td><\/tr><tr><td>6<\/td><td>Chuy\u1ec3n m\u1eabu gi\u1eefa c\u00e1c thi\u1ebft b\u1ecb kh\u00f4ng ki\u1ec3m so\u00e1t<\/td><td>X\u1ea3y ra khi chuy\u1ec3n t\u1eeb controlled-rate freezer sang b\u00ecnh l\u01b0u tr\u1eef, gi\u1eefa hai b\u00ecnh, ho\u1eb7c trong v\u1eadn chuy\u1ec3n li\u00ean c\u01a1 s\u1edf<\/td><\/tr><tr><td>7<\/td><td>C\u1ea3m bi\u1ebfn kh\u00f4ng \u0111\u1ea1i di\u1ec7n cho v\u00f9ng m\u1eabu<\/td><td>V\u1ecb tr\u00ed c\u1ea3m bi\u1ebfn kh\u00e1c v\u1edbi v\u1ecb tr\u00ed x\u00e1c \u0111\u1ecbnh khi temperature mapping, ho\u1eb7c c\u1ea3m bi\u1ebfn l\u1ec7ch\/ch\u01b0a hi\u1ec7u chu\u1ea9n<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u0110i\u1ec3m chung c\u1ee7a c\u1ea3 b\u1ea3y nguy\u00ean nh\u00e2n: c\u1ea7n b\u1ea3o v\u1ec7 nhi\u1ec7t \u0111\u1ed9 t\u1ea1i <strong>v\u00f9ng m\u1eabu th\u1ef1c t\u1ebf<\/strong>, kh\u00f4ng ch\u1ec9 nhi\u1ec7t \u0111\u1ed9 t\u1ea1i m\u1ed9t \u0111i\u1ec3m thu\u1eadn ti\u1ec7n \u0111\u1ec3 \u0111o. Nguy\u00ean nh\u00e2n #2 v\u00e0 #3 th\u01b0\u1eddng \u0111\u01b0\u1ee3c x\u1eed l\u00fd t\u1eadn g\u1ed1c b\u1eb1ng t\u1ed1i \u01b0u h\u00f3a h\u1ec7 th\u1ed1ng inventory v\u00e0 b\u1ed1 tr\u00ed rack, trong khi nguy\u00ean nh\u00e2n #4 v\u00e0 #5 c\u1ea7n ch\u01b0\u01a1ng tr\u00ecnh b\u1ea3o tr\u00ec d\u1ef1 ph\u00f2ng cho b\u00ecnh MVE<\/p>\n\n\n\n<p><strong>Xem th\u00eam:<\/strong> <a href=\"https:\/\/biogroupvietnam.com\/vi\/dich-vu\/goi-dich-vu-bao-tri-binh-nito-long-ivf\/\">D\u1ecbch v\u1ee5 b\u1ea3o tr\u00ec b\u00ecnh nit\u01a1 l\u1ecfng chuy\u00ean bi\u1ec7t cho trung t\u00e2m IVF<\/a><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"328\" height=\"501\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ky-thuat-vien-lay-mau-ra-khoi-binh-cryogenic-storage-mve.jpg\" alt=\"\" class=\"wp-image-11399\" style=\"width:260px;height:auto\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ky-thuat-vien-lay-mau-ra-khoi-binh-cryogenic-storage-mve.jpg 328w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ky-thuat-vien-lay-mau-ra-khoi-binh-cryogenic-storage-mve-196x300.jpg 196w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ky-thuat-vien-lay-mau-ra-khoi-binh-cryogenic-storage-mve-35x54.jpg 35w\" sizes=\"(max-width: 328px) 100vw, 328px\" \/><figcaption class=\"wp-element-caption\"><em>K\u1ef9 thu\u1eadt vi\u00ean thao t\u00e1c l\u1ea5y m\u1eabu ra kh\u1ecfi b\u00ecnh l\u01b0u tr\u1eef Cryogenic, h\u01a1i nit\u01a1 l\u1ea1nh tho\u00e1t ra ngo\u00e0i (Ngu\u1ed3n: <a href=\"https:\/\/mvebio.com\/our-products\/life-science-freezers\/mve-high-efficiency-series\/\">MVE Biological Solutions<\/a>)<\/em><\/figcaption><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vi_sao_monitoring_lien_tuc_quan_trong_hon_kiem_tra_thu_cong\"><\/span><strong>V\u00ec sao monitoring li\u00ean t\u1ee5c quan tr\u1ecdng h\u01a1n ki\u1ec3m tra th\u1ee7 c\u00f4ng?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u0110o nhi\u1ec7t \u0111\u1ed9 m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y ch\u1ec9 cho bi\u1ebft t\u00ecnh tr\u1ea1ng t\u1ea1i th\u1eddi \u0111i\u1ec3m \u0111o. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 th\u1ec3 b\u1ecf s\u00f3t s\u1ef1 c\u1ed1 x\u1ea3y ra ban \u0111\u00eam, dao \u0111\u1ed9ng ng\u1eafn nh\u01b0ng l\u1eb7p l\u1ea1i, Auto Fill ng\u1eebng ho\u1ea1t \u0111\u1ed9ng, m\u1ee9c LN\u2082 gi\u1ea3m nhanh, n\u1eafp b\u1ecb m\u1edf qu\u00e1 l\u00e2u, c\u1ea3m bi\u1ebfn gi\u00e1n \u0111o\u1ea1n, ho\u1eb7c xu h\u01b0\u1edbng h\u1ec7 th\u1ed1ng x\u1ea5u d\u1ea7n theo th\u1eddi gian.<\/p>\n\n\n\n<p>Monitoring li\u00ean t\u1ee5c t\u1ea1o ra chu\u1ed7i d\u1eef li\u1ec7u gi\u00fap x\u00e1c \u0111\u1ecbnh: h\u1ec7 th\u1ed1ng c\u00f3 duy tr\u00ec tr\u1ea1ng th\u00e1i ki\u1ec3m so\u00e1t kh\u00f4ng, dao \u0111\u1ed9ng xu\u1ea5t hi\u1ec7n khi n\u00e0o v\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn thao t\u00e1c hay thi\u1ebft b\u1ecb kh\u00f4ng, th\u1eddi gian ph\u1ee5c h\u1ed3i sau m\u1edf n\u1eafp, t\u1ea7n su\u1ea5t n\u1ea1p LN\u2082, v\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c b\u00ecnh theo th\u1eddi gian. \u0110\u1ed1i v\u1edbi m\u1eabu c\u00f3 gi\u00e1 tr\u1ecb l\u00e2m s\u00e0ng ho\u1eb7c d\u00e0i h\u1ea1n, d\u1eef li\u1ec7u l\u1ecbch s\u1eed n\u00e0y c\u00f2n l\u00e0 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y \u0111i\u1ec1u ki\u1ec7n l\u01b0u tr\u1eef \u0111\u00e3 \u0111\u01b0\u1ee3c duy tr\u00ec ph\u00f9 h\u1ee3p.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Monitoring_chua_du_neu_thieu_phuong_phap_canh_bao_phu_hop\"><\/span><strong>Monitoring ch\u01b0a \u0111\u1ee7 n\u1ebfu thi\u1ebfu ph\u01b0\u01a1ng ph\u00e1p c\u1ea3nh b\u00e1o ph\u00f9 h\u1ee3p<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>M\u1ed9t h\u1ec7 th\u1ed1ng c\u00f3 c\u1ea3m bi\u1ebfn v\u00e0 ph\u1ea7n m\u1ec1m v\u1eabn c\u00f3 th\u1ec3 th\u1ea5t b\u1ea1i n\u1ebfu kh\u00f4ng ai ph\u1ea3n \u1ee9ng v\u1edbi c\u1ea3nh b\u00e1o. M\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh qu\u1ea3n l\u00fd alarm chuy\u00ean nghi\u1ec7p c\u1ea7n quy \u0111\u1ecbnh r\u00f5: alarm n\u00e0o l\u00e0 c\u1ea3nh b\u00e1o s\u1edbm, alarm n\u00e0o y\u00eau c\u1ea7u ph\u1ea3n \u1ee9ng kh\u1ea9n c\u1ea5p, ai l\u00e0 ng\u01b0\u1eddi nh\u1eadn \u0111\u1ea7u ti\u00ean, th\u1eddi gian ph\u1ea3n h\u1ed3i t\u1ed1i \u0111a, khi n\u00e0o ph\u1ea3i escalation, ai c\u00f3 quy\u1ec1n ra quy\u1ebft \u0111\u1ecbnh chuy\u1ec3n m\u1eabu, v\u00e0 khi n\u00e0o c\u1ea7n m\u1edf deviation ho\u1eb7c CAPA.<\/p>\n\n\n\n<p>M\u1ed9t alarm nhi\u1ec7t \u0111\u1ed9 cao, v\u00ed d\u1ee5, c\u00f3 th\u1ec3 xu\u1ea5t ph\u00e1t t\u1eeb vi\u1ec7c m\u1edf n\u1eafp b\u00ecnh, m\u1ee9c LN\u2082 th\u1ea5p, l\u1ed7i c\u1ea3m bi\u1ebfn, Auto Fill th\u1ea5t b\u1ea1i, ch\u00e2n kh\u00f4ng suy gi\u1ea3m, ho\u1eb7c m\u1ea5t ngu\u1ed3n \u0111i\u1ec7n cho controller. N\u1ebfu nh\u00e2n vi\u00ean ch\u1ec9 t\u1eaft alarm m\u00e0 kh\u00f4ng x\u00e1c \u0111\u1ecbnh nguy\u00ean nh\u00e2n g\u1ed1c, h\u1ec7 th\u1ed1ng v\u1eabn ch\u01b0a th\u1ef1c s\u1ef1 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bai_hoc_tu_mot_su_co_thuc_te_Ngan_hang_Cordlife_tai_Singapore\"><\/span><strong>B\u00e0i h\u1ecdc t\u1eeb m\u1ed9t s\u1ef1 c\u1ed1 th\u1ef1c t\u1ebf: Ng\u00e2n h\u00e0ng Cordlife t\u1ea1i Singapore<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Ng\u00e0nh Cryogenic Storage\/Biobanking \u0111\u00e3 c\u00f3 m\u1ed9t tr\u01b0\u1eddng h\u1ee3p \u0111\u01b0\u1ee3c c\u01a1 quan qu\u1ea3n l\u00fd c\u00f4ng khai gi\u00e1m s\u00e1t trong nhi\u1ec1u n\u0103m li\u00ean ti\u1ebfp, minh h\u1ecda r\u00f5 v\u00ec sao c\u00e1c nguy\u00ean t\u1eafc n\u00eau tr\u00ean kh\u00f4ng ch\u1ec9 l\u00e0 l\u00fd thuy\u1ebft.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dien_bien_chinh\"><\/span>Di\u1ec5n bi\u1ebfn ch\u00ednh<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Th\u00e1ng 11\/2023, B\u1ed9 Y t\u1ebf Singapore (MOH) ph\u00e1t hi\u1ec7n 7 trong s\u1ed1 22 b\u00ecnh l\u01b0u tr\u1eef cord blood (m\u00e1u cu\u1ed1ng r\u1ed1n) c\u1ee7a Cordlife Group \u2014 m\u1ed9t trong nh\u1eefng ng\u00e2n h\u00e0ng l\u01b0u tr\u1eef t\u1ebf b\u00e0o g\u1ed1c t\u01b0 nh\u00e2n l\u1edbn nh\u1ea5t ch\u00e2u \u00c1 \u2014 \u0111\u00e3 b\u1ecb ph\u01a1i nhi\u1ec5m nhi\u1ec7t \u0111\u1ed9 v\u01b0\u1ee3t ng\u01b0\u1ee1ng cho ph\u00e9p (tr\u00ean -150\u00b0C). MOH ra l\u1ec7nh \u0111\u00ecnh ch\u1ec9 thu nh\u1eadn m\u1eabu m\u1edbi trong t\u1ed1i \u0111a 6 th\u00e1ng (<a href=\"https:\/\/www.moh.gov.sg\/newsroom\/investigation-of-cordlife-group-limited-for-suboptimal-storage-temperature-for-cryopreserved-cord-blood\/\">MOH Singapore, 30\/11\/2023<\/a>). \u0110\u1ebfn th\u00e1ng 4\/2024, k\u1ebft qu\u1ea3 ki\u1ec3m tra x\u00e1c nh\u1eadn kho\u1ea3ng 5.300 \u0111\u01a1n v\u1ecb cord blood trong c\u00e1c b\u00ecnh v\u00e0 dry shipper b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0 &#8220;kh\u00f4ng c\u00f2n kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng&#8221; cho m\u1ee5c \u0111\u00edch gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c. Sau khi kh\u1eafc ph\u1ee5c v\u00e0 v\u01b0\u1ee3t qua hai \u0111\u1ee3t ki\u1ec3m tra c\u1ee7a MOH, Cordlife \u0111\u01b0\u1ee3c ph\u00e9p ho\u1ea1t \u0111\u1ed9ng tr\u1edf l\u1ea1i c\u00f3 ki\u1ec3m so\u00e1t t\u1eeb th\u00e1ng 9\/2024. Nh\u01b0ng \u0111\u1ebfn \u0111\u1ee3t ki\u1ec3m tra gi\u1eefa k\u1ef3 v\u00e0o th\u00e1ng 7\/2025, MOH ph\u00e1t hi\u1ec7n <strong>l\u1ed7i l\u1eb7p l\u1ea1i<\/strong>: Cordlife ti\u1ebfp t\u1ee5c l\u01b0u tr\u1eef c\u00e1c \u0111\u01a1n v\u1ecb cord blood m\u1edbi ch\u01b0a \u0111\u1ea1t nhi\u1ec7t \u0111\u1ed9 cryopreservation ph\u00f9 h\u1ee3p, m\u00e0 kh\u00f4ng \u0111i\u1ec1u tra li\u1ec7u sai l\u1ec7ch quy tr\u00ecnh c\u00f3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng m\u1eabu hay kh\u00f4ng. \u0110\u00e1ng ch\u00fa \u00fd h\u01a1n, MOH ghi nh\u1eadn r\u1eb1ng l\u00e3nh \u0111\u1ea1o ph\u1ee5 tr\u00e1ch qu\u1ea3n tr\u1ecb (Clinical Governance Officer (CGO)) \u0111\u00e3 ch\u1ec9 \u0111\u1ea1o nh\u00e2n vi\u00ean r\u1eb1ng \u0111\u00e2y &#8220;kh\u00f4ng ph\u1ea3i v\u1ea5n \u0111\u1ec1 \u0111\u00e1ng lo ng\u1ea1i&#8221; \u2014 khi\u1ebfn c\u00e1c s\u1ef1 c\u1ed1 t\u01b0\u01a1ng t\u1ef1 sau \u0111\u00f3 kh\u00f4ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o hay \u0111i\u1ec1u tra, v\u00e0 kh\u00f4ng c\u00f3 h\u00e0nh \u0111\u1ed9ng kh\u1eafc ph\u1ee5c\/ph\u00f2ng ng\u1eeba (CAPA) n\u00e0o \u0111\u01b0\u1ee3c tri\u1ec3n khai (<a href=\"https:\/\/www.moh.gov.sg\/newsroom\/cordlife-group-limited-served-one-year-suspension-notice-for-cord-blood-banking-services\/\">MOH Singapore, 29\/9\/2025<\/a>).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bai_hoc_rut_ra_cho_van_hanh_Cryogenic_Storage\"><\/span>B\u00e0i h\u1ecdc r\u00fat ra cho v\u1eadn h\u00e0nh Cryogenic Storage<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>M\u1ed9t s\u1ef1 c\u1ed1 nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tra s\u1ebd kh\u00f4ng &#8220;bi\u1ebfn m\u1ea5t&#8221; \u2014 n\u00f3 t\u00e1i di\u1ec5n.<\/strong> V\u1ea5n \u0111\u1ec1 c\u1ed1t l\u00f5i trong l\u1ea7n \u0111\u00ecnh ch\u1ec9 th\u1ee9 hai c\u1ee7a Cordlife kh\u00f4ng ph\u1ea3i l\u00e0 b\u1ea3n th\u00e2n s\u1ef1 dao \u0111\u1ed9ng nhi\u1ec7t, m\u00e0 l\u00e0 vi\u1ec7c sai l\u1ec7ch kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tra v\u00e0 ghi nh\u1eadn theo \u0111\u00fang quy tr\u00ecnh deviation\/CAPA \u0111\u00e3 n\u00eau \u1edf ph\u1ea7n Alarm Management tr\u00ean \u0111\u00e2y.<\/li>\n\n\n\n<li><strong>V\u0103n h\u00f3a qu\u1ea3n tr\u1ecb quy\u1ebft \u0111\u1ecbnh \u0111\u1ed9 tin c\u1eady c\u1ee7a h\u1ec7 th\u1ed1ng k\u1ef9 thu\u1eadt.<\/strong> M\u1ed9t h\u01b0\u1edbng d\u1eabn n\u1ed9i b\u1ed9 xem nh\u1eb9 sai l\u1ec7ch nhi\u1ec7t \u0111\u1ed9 \u0111\u00e3 v\u00f4 hi\u1ec7u h\u00f3a to\u00e0n b\u1ed9 gi\u00e1 tr\u1ecb c\u1ee7a h\u1ec7 th\u1ed1ng monitoring v\u00e0 alarm \u0111ang c\u00f3 \u2014 \u0111\u00fang nh\u01b0 nguy\u00ean t\u1eafc &#8220;nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh l\u00e0 c\u1ea3 v\u1ea5n \u0111\u1ec1 k\u1ef9 thu\u1eadt l\u1eabn qu\u1ea3n tr\u1ecb&#8221; \u0111\u00e3 tr\u00ecnh b\u00e0y \u1edf ph\u1ea7n tr\u00ean.<\/li>\n\n\n\n<li><strong>Kh\u00f4ng c\u00f3 ng\u01b0\u1ee1ng &#8220;ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c&#8221; m\u1eb7c \u0111\u1ecbnh.<\/strong> Vi\u1ec7c l\u01b0u tr\u1eef m\u1eabu ch\u01b0a \u0111\u1ea1t nhi\u1ec7t \u0111\u1ed9 cryopreservation ph\u00f9 h\u1ee3p, d\u00f9 ch\u1ec9 m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng nh\u1ecf, v\u1eabn c\u1ea7n \u0111\u01b0\u1ee3c investigate \u2014 kh\u00f4ng th\u1ec3 t\u1ef1 cho l\u00e0 an to\u00e0n n\u1ebfu ch\u01b0a c\u00f3 d\u1eef li\u1ec7u ch\u1ee9ng minh.<\/li>\n\n\n\n<li><strong>H\u1eadu qu\u1ea3 kh\u00f4ng ch\u1ec9 d\u1eebng \u1edf m\u1eabu.<\/strong> Ngo\u00e0i r\u1ee7i ro v\u1edbi h\u00e0ng ngh\u00ecn kh\u00e1ch h\u00e0ng, s\u1ef1 c\u1ed1 c\u00f2n d\u1eabn \u0111\u1ebfn h\u1eadu qu\u1ea3 ph\u00e1p l\u00fd, t\u00e0i ch\u00ednh (\u00fd ki\u1ebfn ki\u1ec3m to\u00e1n t\u1eeb ch\u1ed1i) v\u00e0 uy t\u00edn k\u00e9o d\u00e0i nhi\u1ec1u n\u0103m \u2014 cho th\u1ea5y chi ph\u00ed c\u1ee7a vi\u1ec7c \u0111\u1ea7u t\u01b0 \u0111\u00fang m\u1ee9c v\u00e0o h\u1ec7 th\u1ed1ng gi\u00e1m s\u00e1t v\u00e0 qu\u1ea3n tr\u1ecb ch\u1ea5t l\u01b0\u1ee3ng ngay t\u1eeb \u0111\u1ea7u lu\u00f4n th\u1ea5p h\u01a1n chi ph\u00ed kh\u1eafc ph\u1ee5c sau s\u1ef1 c\u1ed1.<\/li>\n<\/ul>\n\n\n\n<p><em>(Tr\u01b0\u1eddng h\u1ee3p Cordlife \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y d\u1ef1a tr\u00ean c\u00e1c th\u00f4ng b\u00e1o ch\u00ednh th\u1ee9c c\u1ee7a B\u1ed9 Y t\u1ebf Singapore, mang t\u00ednh minh h\u1ecda cho c\u00e1c nguy\u00ean t\u1eafc v\u1eadn h\u00e0nh, kh\u00f4ng nh\u1eb1m \u0111\u00e1nh gi\u00e1 hay so s\u00e1nh v\u1edbi b\u1ea5t k\u1ef3 \u0111\u01a1n v\u1ecb n\u00e0o t\u1ea1i Vi\u1ec7t Nam.)<\/em><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Danh_gia_mot_su_co_nhiet\"><\/span>\u0110\u00e1nh gi\u00e1 m\u1ed9t s\u1ef1 c\u1ed1 nhi\u1ec7t<ins><\/ins><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ba_yeu_to_can_xem_xet_dong_thoi\"><\/span>Ba y\u1ebfu t\u1ed1 c\u1ea7n xem x\u00e9t \u0111\u1ed3ng th\u1eddi<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Khi \u0111\u00e1nh gi\u00e1 m\u1ed9t temperature excursion, c\u00e2u h\u1ecfi &#8220;nhi\u1ec7t \u0111\u1ed9 \u0111\u00e3 l\u00ean \u0111\u1ebfn bao nhi\u00eau?&#8221; l\u00e0 ch\u01b0a \u0111\u1ee7. C\u1ea7n xem x\u00e9t \u0111\u1ed3ng th\u1eddi ba y\u1ebfu t\u1ed1: m\u1ee9c \u0111\u1ed9, th\u1eddi gian v\u00e0 t\u1ea7n su\u1ea5t, c\u00f9ng v\u1edbi lo\u1ea1i t\u1ebf b\u00e0o, lo\u1ea1i cryoprotectant, v\u1ecb tr\u00ed m\u1eabu, d\u1eef li\u1ec7u temperature mapping v\u00e0 k\u1ebft qu\u1ea3 QC sau r\u00e3 \u0111\u00f4ng.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion-1024x576.png\" alt=\"\" class=\"wp-image-11400\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion-1024x576.png 1024w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion-300x169.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion-768x432.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion-1536x864.png 1536w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion-600x338.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion-90x51.png 90w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/ba-yeu-to-danh-gia-su-co-nhiet-temperature-excursion.png 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>\u0110\u00e1nh gi\u00e1 s\u1ef1 c\u1ed1 nhi\u1ec7t (temperature excursion) c\u1ea7n xem x\u00e9t \u0111\u1ed3ng th\u1eddi ba y\u1ebfu t\u1ed1 m\u1ee9c \u0111\u1ed9, th\u1eddi gian v\u00e0 t\u1ea7n su\u1ea5t.<\/em><\/figcaption><\/figure><\/div>\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chat_luong_mau_phai_duoc_danh_gia_sau_ra_dong_nhu_the_nao\"><\/span>Ch<strong>\u1ea5<\/strong><strong>t l\u01b0<\/strong><strong>\u1ee3<\/strong><strong>ng m<\/strong><strong>\u1eab<\/strong><strong>u ph<\/strong><strong>\u1ea3<\/strong><strong>i<\/strong><strong> \u0111\u01b0<\/strong><strong>\u1ee3<\/strong><strong>c \u0111\u00e1nh gi\u00e1 sau r\u00e3 \u0111\u00f4ng nh\u01b0 th<\/strong><strong>\u1ebf<\/strong><strong> n\u00e0o?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh nh\u1eb1m b\u1ea3o v\u1ec7 ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed1i c\u00f9ng c\u1ee7a m\u1eabu \u2014 v\u00ec v\u1eady ch\u01b0\u01a1ng tr\u00ecnh x\u00e1c nh\u1eadn Cryogenic Storage c\u1ea7n li\u00ean k\u1ebft tr\u1ef1c ti\u1ebfp v\u1edbi k\u1ebft qu\u1ea3 sau r\u00e3 \u0111\u00f4ng.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Nh\u00f3m ch\u1ec9 ti\u00eau<\/strong><\/td><td><strong>V\u00ed d\u1ee5<\/strong><\/td><\/tr><tr><td>S\u1ed1 l\u01b0\u1ee3ng<\/td><td>Total cell recovery, viable cell recovery<\/td><\/tr><tr><td>\u0110\u1ed9 s\u1ed1ng<\/td><td>Viability ngay sau thawing v\u00e0 sau th\u1eddi gian ph\u1ee5c h\u1ed3i<\/td><\/tr><tr><td>H\u00ecnh th\u00e1i<\/td><td>K\u00edch th\u01b0\u1edbc, c\u1ea5u tr\u00fac, \u0111\u1eb7c \u0111i\u1ec3m b\u00e1m d\u00ednh<\/td><\/tr><tr><td>T\u0103ng sinh<\/td><td>Doubling time, expansion capacity<\/td><\/tr><tr><td>Ki\u1ec3u h\u00ecnh<\/td><td>Marker \u0111\u1eb7c tr\u01b0ng b\u1eb1ng flow cytometry<\/td><\/tr><tr><td>Ch\u1ee9c n\u0103ng<\/td><td>Potency, cytotoxicity, differentiation<\/td><\/tr><tr><td>Chuy\u1ec3n h\u00f3a<\/td><td>Mitochondrial activity, metabolic recovery<\/td><\/tr><tr><td>Di truy\u1ec1n<\/td><td>Karyotype, genomic stability khi c\u1ea7n<\/td><\/tr><tr><td>An to\u00e0n<\/td><td>Sterility, mycoplasma, endotoxin t\u00f9y \u1ee9ng d\u1ee5ng<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u0110\u1ed1i v\u1edbi Cell Therapy, ti\u00eau ch\u00ed ch\u1ea5t l\u01b0\u1ee3ng ph\u1ea3i g\u1eafn v\u1edbi m\u1ee5c \u0111\u00edch s\u1eed d\u1ee5ng. M\u1ed9t l\u00f4 t\u1ebf b\u00e0o kh\u00f4ng th\u1ec3 ch\u1ec9 \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn v\u00ec &#8220;viability c\u00f2n cao&#8221; n\u1ebfu potency ho\u1eb7c kh\u1ea3 n\u0103ng t\u0103ng sinh kh\u00f4ng \u0111\u00e1p \u1ee9ng y\u00eau c\u1ea7u.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"10_bien_phap_giup_duy_tri_nhiet_do_on_dinh\"><\/span>10 bi\u1ec7n ph\u00e1p gi\u00fap duy tr\u00ec nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>L\u1ef1a ch\u1ecdn thi\u1ebft b\u1ecb ph\u00f9 h\u1ee3p<\/strong> \u2014 kh\u00f4ng ch\u1ec9 xem dung t\u00edch b\u00ecnh, m\u00e0 \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 \u0111\u1ed3ng \u0111\u1ec1u nhi\u1ec7t, th\u1eddi gian duy tr\u00ec nhi\u1ec7t, t\u1ed1c \u0111\u1ed9 bay h\u01a1i LN\u2082, kh\u1ea3 n\u0103ng ph\u1ee5c h\u1ed3i sau m\u1edf n\u1eafp, hi\u1ec7u qu\u1ea3 ch\u00e2n kh\u00f4ng v\u00e0 n\u0103ng l\u1ef1c monitoring\/c\u1ea3nh b\u00e1o.<\/li>\n\n\n\n<li><strong>Th\u1ef1c hi\u1ec7n temperature mapping<\/strong> \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh v\u1ecb tr\u00ed n\u00f3ng nh\u1ea5t, ch\u00eanh l\u1ec7ch \u0111\u1ec9nh\u2013\u0111\u00e1y, \u1ea3nh h\u01b0\u1edfng c\u1ee7a m\u1ee9c LN\u2082 v\u00e0 v\u1ecb tr\u00ed \u0111\u1eb7t c\u1ea3m bi\u1ebfn ph\u00f9 h\u1ee3p \u2014 ph\u00f9 h\u1ee3p v\u1edbi khuy\u1ebfn ngh\u1ecb l\u01b0u tr\u1eef LN\u2082 trong <a href=\"https:\/\/www.isber.org\/page\/bpr\">ISBER Best Practices: Recommendations for Repositories<\/a>, t\u00e0i li\u1ec7u tham chi\u1ebfu ng\u00e0nh cho biobanking to\u00e0n c\u1ea7u.<\/li>\n\n\n\n<li><strong>Gi\u00e1m s\u00e1t nhi\u1ec7t \u0111\u1ed9 v\u00e0 m\u1ee9c LN\u2082 li\u00ean t\u1ee5c<\/strong> \u2014 theo d\u00f5i c\u1ea3 hai th\u00f4ng s\u1ed1, v\u00ec m\u1ee9c LN\u2082 gi\u00fap ph\u00e1t hi\u1ec7n nguy\u00ean nh\u00e2n tr\u01b0\u1edbc khi nhi\u1ec7t \u0111\u1ed9 v\u01b0\u1ee3t ng\u01b0\u1ee1ng.<\/li>\n\n\n\n<li><strong>Thi\u1ebft l\u1eadp alarm h\u1ee3p l\u00fd<\/strong> \u2014 \u0111\u1ee7 s\u1edbm \u0111\u1ec3 nh\u00e2n vi\u00ean ph\u1ea3n \u1ee9ng k\u1ecbp, nh\u01b0ng kh\u00f4ng qu\u00e1 nh\u1ea1y \u0111\u1ebfn m\u1ee9c t\u1ea1o alarm gi\u1ea3.<\/li>\n\n\n\n<li><strong>Chu\u1ea9n h\u00f3a thao t\u00e1c l\u1ea5y m\u1eabu<\/strong> \u2014 x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c tank, rack, canister, box, h\u00e0ng, c\u1ed9t tr\u01b0\u1edbc khi m\u1edf n\u1eafp b\u00ecnh.<\/li>\n\n\n\n<li><strong>T\u00e1ch m\u1eabu truy c\u1eadp th\u01b0\u1eddng xuy\u00ean kh\u1ecfi m\u1eabu l\u01b0u tr\u1eef d\u00e0i h\u1ea1n<\/strong> \u0111\u1ec3 gi\u1ea3m ph\u01a1i nhi\u1ec5m nhi\u1ec7t kh\u00f4ng c\u1ea7n thi\u1ebft cho c\u00e1c m\u1eabu quan tr\u1ecdng.<\/li>\n\n\n\n<li><strong>Theo d\u00f5i xu h\u01b0\u1edbng ti\u00eau hao LN\u2082<\/strong> \u2014 m\u1ee9c ti\u00eau hao t\u0103ng b\u1ea5t th\u01b0\u1eddng c\u00f3 th\u1ec3 b\u00e1o hi\u1ec7u suy gi\u1ea3m ch\u00e2n kh\u00f4ng, r\u00f2 r\u1ec9, ho\u1eb7c t\u1ea7n su\u1ea5t m\u1edf n\u1eafp t\u0103ng.<\/li>\n\n\n\n<li><strong>Hi\u1ec7u chu\u1ea9n v\u00e0 ki\u1ec3m tra c\u1ea3m bi\u1ebfn \u0111\u1ecbnh k\u1ef3<\/strong>, v\u00ec c\u1ea3m bi\u1ebfn sai l\u1ec7ch c\u00f3 th\u1ec3 t\u1ea1o c\u1ea3m gi\u00e1c an to\u00e0n gi\u1ea3 ho\u1eb7c g\u00e2y alarm kh\u00f4ng c\u1ea7n thi\u1ebft.<\/li>\n\n\n\n<li><strong>X\u00e2y d\u1ef1ng k\u1ebf ho\u1ea1ch chuy\u1ec3n m\u1eabu kh\u1ea9n c\u1ea5p<\/strong> \u2014 x\u00e1c \u0111\u1ecbnh tr\u01b0\u1edbc b\u00ecnh d\u1ef1 ph\u00f2ng, dung l\u01b0\u1ee3ng tr\u1ed1ng, d\u1ee5ng c\u1ee5, nh\u00e2n s\u1ef1 v\u00e0 h\u1ed3 s\u01a1 chain of custody.<\/li>\n\n\n\n<li><strong>\u0110\u00e0o t\u1ea1o v\u00e0 \u0111\u00e1nh gi\u00e1 n\u0103ng l\u1ef1c nh\u00e2n vi\u00ean<\/strong> \u2014 m\u1ed9t b\u00ecnh t\u1ed1t kh\u00f4ng th\u1ec3 b\u00f9 \u0111\u1eafp cho thao t\u00e1c thi\u1ebfu chu\u1ea9n h\u00f3a.<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"661\" height=\"294\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/3-models-MVE-HE-series-freezers-with-cryoverse-connect-controller.png\" alt=\"\" class=\"wp-image-11401\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/3-models-MVE-HE-series-freezers-with-cryoverse-connect-controller.png 661w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/3-models-MVE-HE-series-freezers-with-cryoverse-connect-controller-300x133.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/3-models-MVE-HE-series-freezers-with-cryoverse-connect-controller-600x267.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/3-models-MVE-HE-series-freezers-with-cryoverse-connect-controller-90x40.png 90w\" sizes=\"(max-width: 661px) 100vw, 661px\" \/><figcaption class=\"wp-element-caption\"><em>B\u00ecnh l\u01b0u tr\u1eef Cryogenic MVE v\u1edbi h\u1ec7 th\u1ed1ng gi\u00e1m s\u00e1t nhi\u1ec7t \u0111\u1ed9 v\u00e0 m\u1ee9c nit\u01a1 l\u1ecfng li\u00ean t\u1ee5c (Ngu\u1ed3n: <a href=\"https:\/\/mvebio.com\/our-products\/life-science-freezers\/mve-he-series-cryoverse-connect-controller\/\">MVE Biological Solutions &#8211; MVE HE Series Freezers with CryoVerse\u2122 Connect Controller<\/a>)<\/em><\/figcaption><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhiet_do_on_dinh_van_de_ky_thuat_hay_quan_tri_chat_luong\"><\/span>Nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh: v\u1ea5n \u0111\u1ec1 k\u1ef9 thu\u1eadt hay qu\u1ea3n tr\u1ecb ch\u1ea5t l\u01b0\u1ee3ng?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>C\u1ea3 hai. \u0110\u00e2y l\u00e0 v\u1ea5n \u0111\u1ec1 k\u1ef9 thu\u1eadt v\u00ec ph\u1ee5 thu\u1ed9c v\u00e0o thi\u1ebft k\u1ebf b\u00ecnh, ch\u00e2n kh\u00f4ng, c\u1ea3m bi\u1ebfn, Auto Fill, \u0111\u01b0\u1eddng c\u1ea5p LN\u2082, monitoring v\u00e0 h\u1ec7 th\u1ed1ng alarm. Nh\u01b0ng \u0111\u00e2y c\u0169ng l\u00e0 v\u1ea5n \u0111\u1ec1 qu\u1ea3n tr\u1ecb v\u00ec ph\u1ee5 thu\u1ed9c v\u00e0o SOP, ph\u00e2n c\u00f4ng tr\u00e1ch nhi\u1ec7m, \u0111\u00e0o t\u1ea1o, qu\u1ea3n l\u00fd inventory, preventive maintenance, deviation, CAPA, change control v\u00e0 business continuity.<\/p>\n\n\n\n<p>N\u1ebfu ch\u1ec9 \u0111\u1ea7u t\u01b0 thi\u1ebft b\u1ecb t\u1ed1t m\u00e0 kh\u00f4ng x\u00e2y d\u1ef1ng h\u1ec7 th\u1ed1ng v\u1eadn h\u00e0nh, nhi\u1ec7t \u0111\u1ed9 v\u1eabn c\u00f3 th\u1ec3 m\u1ea5t \u1ed5n \u0111\u1ecbnh do l\u1ed7i con ng\u01b0\u1eddi. Ng\u01b0\u1ee3c l\u1ea1i, SOP t\u1ed1t c\u0169ng kh\u00f4ng th\u1ec3 b\u00f9 \u0111\u1eafp cho m\u1ed9t thi\u1ebft b\u1ecb c\u00f3 hi\u1ec7u su\u1ea5t c\u00e1ch nhi\u1ec7t k\u00e9m ho\u1eb7c kh\u00f4ng \u0111\u1ee7 kh\u1ea3 n\u0103ng duy tr\u00ec nhi\u1ec7t \u0111\u1ed9 t\u1ea1i to\u00e0n b\u1ed9 v\u00f9ng m\u1eabu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cau_hoi_thuong_gap\"><\/span>C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhiet_do_dao_dong_bao_nhieu_thi_duoc_xem_la_nguy_hiem_cho_mau\"><\/span>Nhi\u1ec7t \u0111\u1ed9 dao \u0111\u1ed9ng bao nhi\u00eau th\u00ec \u0111\u01b0\u1ee3c xem l\u00e0 nguy hi\u1ec3m cho m\u1eabu?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Kh\u00f4ng c\u00f3 m\u1ed9t ng\u01b0\u1ee1ng chung cho m\u1ecdi lo\u1ea1i m\u1eabu. M\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i t\u1ebf b\u00e0o, cryoprotectant, bi\u00ean \u0111\u1ed9 v\u00e0 s\u1ed1 l\u1ea7n dao \u0111\u1ed9ng. C\u1ea7n \u0111\u00e1nh gi\u00e1 theo c\u1ea3 ba y\u1ebfu t\u1ed1 m\u1ee9c \u0111\u1ed9, th\u1eddi gian, t\u1ea7n su\u1ea5t, k\u1ebft h\u1ee3p v\u1edbi d\u1eef li\u1ec7u temperature mapping v\u00e0 k\u1ebft qu\u1ea3 QC sau r\u00e3 \u0111\u00f4ng c\u1ee7a t\u1eebng lo\u1ea1i m\u1eabu c\u1ee5 th\u1ec3.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vapor_Phase_hay_Liquid_Phase_on_dinh_nhiet_hon\"><\/span>Vapor Phase hay Liquid Phase \u1ed5n \u0111\u1ecbnh nhi\u1ec7t h\u01a1n?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>C\u1ea3 hai \u0111\u1ec1u c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh cao n\u1ebfu \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf, l\u1eafp \u0111\u1eb7t v\u00e0 v\u1eadn h\u00e0nh \u0111\u00fang. Liquid Phase c\u00f3 l\u1ee3i th\u1ebf \u0111\u1ed3ng \u0111\u1ec1u nhi\u1ec7t nh\u1edd ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi LN\u2082; Vapor Phase tr\u00e1nh \u0111\u01b0\u1ee3c r\u1ee7i ro li\u00ean quan \u0111\u1ebfn to\u00e0n v\u1eb9n v\u1eadt ch\u1ee9a nh\u01b0ng ph\u1ee5 thu\u1ed9c nhi\u1ec1u h\u01a1n v\u00e0o thi\u1ebft k\u1ebf b\u00ecnh v\u00e0 v\u1eadn h\u00e0nh. L\u1ef1a ch\u1ecdn ph\u00f9 h\u1ee3p c\u1ea7n d\u1ef1a tr\u00ean temperature mapping th\u1ef1c t\u1ebf, kh\u00f4ng ch\u1ec9 tr\u00ean nguy\u00ean l\u00fd l\u00fd thuy\u1ebft.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chi_do_viability_sau_ra_dong_co_du_de_xac_nhan_chat_luong_mau_khong\"><\/span>Ch\u1ec9 \u0111o viability sau r\u00e3 \u0111\u00f4ng c\u00f3 \u0111\u1ee7 \u0111\u1ec3 x\u00e1c nh\u1eadn ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu kh\u00f4ng?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Ch\u01b0a \u0111\u1ee7. Viability ph\u1ea3n \u00e1nh t\u1ef7 l\u1ec7 t\u1ebf b\u00e0o s\u1ed1ng nh\u01b0ng kh\u00f4ng ph\u1ea3n \u00e1nh \u0111\u1ea7y \u0111\u1ee7 kh\u1ea3 n\u0103ng t\u0103ng sinh, b\u00e1m d\u00ednh, ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch hay potency \u2014 nh\u1eefng ch\u1ec9 ti\u00eau c\u00f3 th\u1ec3 suy gi\u1ea3m s\u1edbm h\u01a1n viability sau c\u00e1c chu k\u1ef3 dao \u0111\u1ed9ng nhi\u1ec7t.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bao_lau_nen_thuc_hien_temperature_mapping_mot_lan\"><\/span>Bao l\u00e2u n\u00ean th\u1ef1c hi\u1ec7n temperature mapping m\u1ed9t l\u1ea7n?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>T\u1ea7n su\u1ea5t c\u1ee5 th\u1ec3 n\u00ean \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh theo SOP n\u1ed9i b\u1ed9 v\u00e0 y\u00eau c\u1ea7u quy \u0111\u1ecbnh \u00e1p d\u1ee5ng cho t\u1eebng lo\u1ea1i m\u1eabu (GMP, ISO, ho\u1eb7c ti\u00eau chu\u1ea9n ng\u00e0nh li\u00ean quan). N\u00ean th\u1ef1c hi\u1ec7n l\u1ea1i sau khi thay \u0111\u1ed5i thi\u1ebft b\u1ecb, sau b\u1ea3o tr\u00ec l\u1edbn, ho\u1eb7c khi ph\u00e1t hi\u1ec7n xu h\u01b0\u1edbng b\u1ea5t th\u01b0\u1eddng trong d\u1eef li\u1ec7u monitoring.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ket_luan\"><\/span>K\u1ebft lu\u1eadn<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh quy\u1ebft \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu v\u00ec tr\u1ea1ng th\u00e1i \u0111\u00f4ng l\u1ea1nh kh\u00f4ng ho\u00e0n to\u00e0n b\u1ea5t bi\u1ebfn tr\u01b0\u1edbc m\u1ecdi bi\u1ebfn \u0111\u1ed9ng nhi\u1ec7t. C\u00e1c chu k\u1ef3 t\u0103ng\u2013gi\u1ea3m nhi\u1ec7t c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y t\u00e1i k\u1ebft tinh, l\u00e0m m\u1ea5t \u1ed5n \u0111\u1ecbnh m\u00e0ng t\u1ebf b\u00e0o, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ty th\u1ec3 v\u00e0 l\u00e0m suy gi\u1ea3m kh\u1ea3 n\u0103ng ph\u1ee5c h\u1ed3i ho\u1eb7c ch\u1ee9c n\u0103ng sau r\u00e3 \u0111\u00f4ng \u2014 nh\u01b0 c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean hiPSC v\u00e0 MSC nhau thai \u0111\u00e3 ghi nh\u1eadn.<\/p>\n\n\n\n<p>R\u1ee7i ro n\u00e0y \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng \u0111\u1ed1i v\u1edbi t\u1ebf b\u00e0o g\u1ed1c, iPSC, CAR-T, NK cell, MSC, ph\u00f4i v\u00e0 no\u00e3n, m\u00e1u cu\u1ed1ng r\u1ed1n, m\u1eabu Biobank, v\u00e0 c\u00e1c l\u00f4 t\u1ebf b\u00e0o c\u00f3 gi\u00e1 tr\u1ecb nghi\u00ean c\u1ee9u ho\u1eb7c l\u00e2m s\u00e0ng cao.<\/p>\n\n\n\n<p>M\u1ed9t h\u1ec7 th\u1ed1ng Cryogenic Storage \u0111\u00e1ng tin c\u1eady kh\u00f4ng th\u1ec3 ch\u1ec9 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 b\u1eb1ng nhi\u1ec7t \u0111\u1ed9 th\u1ea5p nh\u1ea5t ho\u1eb7c l\u01b0\u1ee3ng LN\u2082 c\u00f2n l\u1ea1i trong b\u00ecnh. H\u1ec7 th\u1ed1ng ph\u1ea3i ch\u1ee9ng minh r\u1eb1ng: nhi\u1ec7t \u0111\u1ed9 v\u00f9ng m\u1eabu \u0111\u01b0\u1ee3c duy tr\u00ec \u1ed5n \u0111\u1ecbnh, dao \u0111\u1ed9ng nhi\u1ec7t \u0111\u01b0\u1ee3c gi\u1edbi h\u1ea1n, m\u1ee9c LN\u2082 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t, c\u1ea3m bi\u1ebfn ph\u1ea3n \u00e1nh \u0111\u00fang v\u00f9ng c\u00f3 nguy c\u01a1, alarm \u0111\u01b0\u1ee3c ph\u1ea3n \u1ee9ng k\u1ecbp th\u1eddi, thao t\u00e1c truy xu\u1ea5t \u0111\u01b0\u1ee3c chu\u1ea9n h\u00f3a, thi\u1ebft b\u1ecb \u0111\u01b0\u1ee3c b\u1ea3o tr\u00ec d\u1ef1 ph\u00f2ng, d\u1eef li\u1ec7u \u0111\u01b0\u1ee3c l\u01b0u gi\u1eef v\u00e0 truy xu\u1ea5t, v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng sau r\u00e3 \u0111\u00f4ng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 ph\u00f9 h\u1ee3p.<\/p>\n\n\n\n<p>Trong Cell Therapy, Biobank v\u00e0 IVF, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng ch\u1ec9 l\u00e0 m\u1ed9t th\u00f4ng s\u1ed1 k\u1ef9 thu\u1eadt \u2014 \u0111\u00f3 l\u00e0 m\u1ed9t Critical Quality Parameter \u1ea3nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn t\u00ednh to\u00e0n v\u1eb9n, kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng v\u00e0 gi\u00e1 tr\u1ecb l\u00e2u d\u00e0i c\u1ee7a t\u00e0i s\u1ea3n sinh h\u1ecdc, ph\u00f9 h\u1ee3p v\u1edbi y\u00eau c\u1ea7u v\u1ec1 n\u0103ng l\u1ef1c v\u00e0 t\u00ednh nh\u1ea5t qu\u00e1n v\u1eadn h\u00e0nh trong <a href=\"https:\/\/www.iso.org\/standard\/67888.html\">ti\u00eau chu\u1ea9n ISO 20387:2018 v\u1ec1 Biobanking<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td>B\u1ea1n c\u00f3 ki\u1ec3m so\u00e1t t\u1ed1t vi\u1ec7c l\u01b0u tr\u1eef m\u1eabu hi\u1ec7n t\u1ea1i?<br>&nbsp;<br>Biogroup Vietnam cung c\u1ea5p <strong><u>Gi\u1ea3i ph\u00e1p Cryogenic Storage t\u1ed5ng th\u1ec3 cho Ng\u00e2n h\u00e0ng m\u00e1u cu\u1ed1ng r\u1ed1n<\/u><\/strong>, Cell Therapy, Biobank, IVF, v\u00e0 ph\u00f2ng th\u00ed nghi\u1ec7m nghi\u00ean c\u1ee9u, bao g\u1ed3m:<br>Kh\u1ea3o s\u00e1t hi\u1ec7n tr\u1ea1ng h\u1ec7 th\u1ed1ng, \u0111\u00e1nh gi\u00e1 nguy c\u01a1 dao \u0111\u1ed9ng nhi\u1ec7t<br>T\u01b0 v\u1ea5n l\u1ef1a ch\u1ecdn b\u00ecnh l\u01b0u tr\u1eef MVE, Vapor Phase ho\u1eb7c Liquid Phase, h\u1ec7 th\u1ed1ng Auto Fill v\u00e0 \u0111\u01b0\u1eddng c\u1ea5p LN\u2082, monitoring nhi\u1ec7t \u0111\u1ed9\/m\u1ee9c LN\u2082\/n\u1ed3ng \u0111\u1ed9 O\u2082,<br>Thi\u1ebft k\u1ebf alarm escalation, t\u1ed1i \u01b0u rack v\u00e0 inventory, preventive maintenance<br>\u0110\u00e0o t\u1ea1o thao t\u00e1c truy xu\u1ea5t v\u00e0 x\u00e2y d\u1ef1ng k\u1ebf ho\u1ea1ch chuy\u1ec3n m\u1eabu kh\u1ea9n c\u1ea5p.<br>&nbsp;<br><strong>\ud83d\udce9 Li\u00ean h\u1ec7 Biogroup Vietnam \u0111\u1ec3 th\u1ef1c hi\u1ec7n Cryogenic Storage Health Check, \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh nhi\u1ec7t v\u00e0 x\u00e2y d\u1ef1ng h\u1ec7 th\u1ed1ng b\u1ea3o v\u1ec7 m\u1eabu an to\u00e0n trong su\u1ed1t v\u00f2ng \u0111\u1eddi l\u01b0u tr\u1eef.<\/strong><br><strong>&nbsp;<\/strong><br>Form: <a href=\"https:\/\/biogroupvietnam.com\/vi\/lien-he\/\">https:\/\/biogroupvietnam.com\/vi\/lien-he\/<\/a><br>Hotline: +84 963 621 421<br>Email: info@biogroupvietnam.com<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Okuda, J., Watanabe, N., Nakamura, T., Mizushima, K., Xi, H., Kumamoto, Y., Fujita, K., &amp; Kino-Oka, M. (2024). The impact of repeated temperature cycling on cryopreserved human iPSC viability stems from cytochrome redox state changes. <em>Frontiers in Bioengineering and Biotechnology<\/em>, 12, 1443795. <a href=\"https:\/\/doi.org\/10.3389\/fbioe.2024.1443795\">https:\/\/doi.org\/10.3389\/fbioe.2024.1443795<\/a><\/li>\n\n\n\n<li>Pogozhykh, D., Pogozhykh, O., Prokopyuk, V., Kuleshova, L., Goltsev, A., Blasczyk, R., &amp; M\u00fcller, T. (2017). Influence of temperature fluctuations during cryopreservation on vital parameters, differentiation potential, and transgene expression of placental multipotent stromal cells. <em>Stem Cell Research &amp; Therapy<\/em>, 8, 66. <a href=\"https:\/\/doi.org\/10.1186\/s13287-017-0512-7\">https:\/\/doi.org\/10.1186\/s13287-017-0512-7<\/a><\/li>\n\n\n\n<li>Pegg, D. E. (2007). Principles of cryopreservation. <em>Methods in Molecular Biology<\/em>, 368, 39\u201357. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18080461\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18080461\/<\/a><\/li>\n\n\n\n<li>Ministry of Health, Singapore. (2023, November 30). Investigation of Cordlife Group Limited for suboptimal storage temperature for cryopreserved cord blood. <a href=\"https:\/\/www.moh.gov.sg\/newsroom\/investigation-of-cordlife-group-limited-for-suboptimal-storage-temperature-for-cryopreserved-cord-blood\/\">https:\/\/www.moh.gov.sg\/newsroom\/investigation-of-cordlife-group-limited-for-suboptimal-storage-temperature-for-cryopreserved-cord-blood\/<\/a><\/li>\n\n\n\n<li>Ministry of Health, Singapore. (2025, September 29). Cordlife Group Limited served one-year suspension notice for cord blood banking services. <a href=\"https:\/\/www.moh.gov.sg\/newsroom\/cordlife-group-limited-served-one-year-suspension-notice-for-cord-blood-banking-services\/\">https:\/\/www.moh.gov.sg\/newsroom\/cordlife-group-limited-served-one-year-suspension-notice-for-cord-blood-banking-services\/<\/a><\/li>\n\n\n\n<li>Ministry of Health, Singapore. (2025, November 26). Cordlife Group Limited required to stop collecting, testing, processing, and storing new cord blood. <a href=\"https:\/\/www.moh.gov.sg\/newsroom\/cordlife-group-limited-required-to-stop-collecting--testing--processing--and-storing-new-cord-blood\/\">https:\/\/www.moh.gov.sg\/newsroom\/cordlife-group-limited-required-to-stop-collecting&#8211;testing&#8211;processing&#8211;and-storing-new-cord-blood\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>M\u1ed9t b\u00ecnh Cryogenic Storage \u0111\u1ea1t -190\u00b0C t\u1ea1i th\u1eddi \u0111i\u1ec3m \u0111o v\u1eabn c\u00f3 th\u1ec3 \u0111ang \u00e2m th\u1ea7m l\u00e0m h\u1ecfng m\u1eabu, n\u1ebfu nhi\u1ec7t \u0111\u1ed9 t\u1ea1i v\u1ecb tr\u00ed l\u01b0u tr\u1eef dao \u0111\u1ed9ng l\u1eb7p l\u1ea1i m\u1ed7i khi m\u1edf n\u1eafp, ki\u1ec3m k\u00ea ho\u1eb7c n\u1ea1p nit\u01a1 l\u1ecfng. B\u00e0i vi\u1ebft ph\u00e2n t\u00edch c\u01a1 ch\u1ebf t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o do dao \u0111\u1ed9ng nhi\u1ec7t<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-nhiet-do-on-dinh-quyet-dinh-chat-luong-mau-luu-tru-lanh-sau\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":11405,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>V\u00ec sao nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh quy\u1ebft \u0111\u1ecbnh ch\u1ea5t 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