{"id":11423,"date":"2026-08-04T19:09:39","date_gmt":"2026-08-04T12:09:39","guid":{"rendered":"https:\/\/biogroupvietnam.com\/?p=11423"},"modified":"2026-08-14T05:52:19","modified_gmt":"2026-08-13T22:52:19","slug":"vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/","title":{"rendered":"V\u00ec sao c\u1ea7n l\u01b0u tr\u1eef l\u1ea1nh t\u1ebf b\u00e0o \u1edf nhi\u1ec7t \u0111\u1ed9 -150\u00b0C ho\u1eb7c th\u1ea5p h\u01a1n?"},"content":{"rendered":"\n<p>T\u1ee7 \u0111\u00f4ng -80\u00b0C c\u00f3 th\u1ec3 &#8220;\u0111\u1ee7 l\u1ea1nh&#8221; v\u1edbi DNA hay protein, nh\u01b0ng v\u1edbi t\u1ebf b\u00e0o s\u1ed1ng d\u00f9ng trong Cell Therapy, Biobank hay IVF th\u00ec ng\u01b0\u1ee1ng nhi\u1ec7t \u0111\u1ed9 n\u00e0y l\u1ea1i kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 b\u1ea3o to\u00e0n ch\u1ee9c n\u0103ng s\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o v\u1ec1 l\u00e2u d\u00e0i. B\u00e0i vi\u1ebft gi\u1ea3i th\u00edch v\u00ec sao c\u1ea7n l\u01b0u tr\u1eef l\u1ea1nh t\u1ebf b\u00e0o \u1edf \u00e2m 150\u00b0C ho\u1eb7c th\u1ea5p h\u01a1n v\u00e0 l\u00fd do c\u00e1c ng\u00e2n h\u00e0ng m\u00e1u cu\u1ed1ng r\u1ed1n, trung t\u00e2m s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o GMP hay c\u00e1c ng\u00e2n h\u00e0ng sinh h\u1ecdc tr\u00ean th\u1ebf gi\u1edbi \u0111\u1ec1u \u0111\u1ea7u t\u01b0 h\u1ec7 th\u1ed1ng Cryogenic Storage (l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u) b\u1eb1ng nit\u01a1 l\u1ecfng, \u0111\u1ed3ng th\u1eddi chia s\u1ebb nh\u1eefng y\u1ebfu t\u1ed1 v\u1eadn h\u00e0nh quy\u1ebft \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu trong su\u1ed1t v\u00f2ng \u0111\u1eddi l\u01b0u tr\u1eef.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"538\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-te-bao-luu-tru-duoi-am-150-do-c-1200x630-1-1024x538.png\" alt=\"\" class=\"wp-image-11432\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-te-bao-luu-tru-duoi-am-150-do-c-1200x630-1-1024x538.png 1024w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-te-bao-luu-tru-duoi-am-150-do-c-1200x630-1-300x158.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-te-bao-luu-tru-duoi-am-150-do-c-1200x630-1-768x403.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-te-bao-luu-tru-duoi-am-150-do-c-1200x630-1-600x315.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-te-bao-luu-tru-duoi-am-150-do-c-1200x630-1-90x47.png 90w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/vi-sao-te-bao-luu-tru-duoi-am-150-do-c-1200x630-1.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>C\u00e1c h\u1ec7 th\u1ed1ng Cryogenic Storage trong th\u1ef1c t\u1ebf th\u01b0\u1eddng v\u1eadn h\u00e0nh d\u01b0\u1edbi -150\u00b0C l\u00fd do \u0111\u1ebfn t\u1eeb nhi\u1ec1u y\u1ebfu t\u1ed1 v\u1eadn h\u00e0nh th\u1ef1c t\u1ebf.<\/em><\/figcaption><\/figure><\/div>\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_87_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Dieu_gi_xay_ra_ben_trong_te_bao_khi_bi_dong_lanh\" >\u0110i\u1ec1u g\u00ec x\u1ea3y ra b\u00ean trong t\u1ebf b\u00e0o khi b\u1ecb \u0111\u00f4ng l\u1ea1nh?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Lua_chon_nhiet_do_luu_tru_lau_dai_co_y_nghia_quyet_dinh\" >L\u1ef1a ch\u1ecdn nhi\u1ec7t \u0111\u1ed9 l\u01b0u tr\u1eef l\u00e2u d\u00e0i c\u00f3 \u00fd ngh\u0129a quy\u1ebft \u0111\u1ecbnh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Glass_Transition_Temperature_%E2%80%94_%E2%80%9Cranh_gioi%E2%80%9D_quan_trong_cua_Cryogenic_Storage\" >Glass Transition Temperature \u2014 &#8220;ranh gi\u1edbi&#8221; quan tr\u1ecdng c\u1ee7a Cryogenic Storage<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Vi_sao_trong_Cell_Therapy_chon_moc_duoi_-150%C2%B0C\" >V\u00ec sao trong Cell Therapy ch\u1ecdn m\u1ed1c d\u01b0\u1edbi -150\u00b0C?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#1_Tao_khoang_dem_an_toan_Safety_Margin\" >1. T\u1ea1o kho\u1ea3ng \u0111\u1ec7m an to\u00e0n (Safety Margin)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#2_Giam_gan_nhu_hoan_toan_chuyen_dong_phan_tu\" >2. Gi\u1ea3m g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#3_Han_che_hien_tuong_tai_ket_tinh_Recrystallization\" >3. H\u1ea1n ch\u1ebf hi\u1ec7n t\u01b0\u1ee3ng t\u00e1i k\u1ebft tinh (Recrystallization)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Tai_sao_-80%C2%B0C_khong_phu_hop_cho_luu_tru_dai_han\" >T\u1ea1i sao -80\u00b0C kh\u00f4ng ph\u00f9 h\u1ee3p cho l\u01b0u tr\u1eef d\u00e0i h\u1ea1n?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Tai_sao_nito_long_tro_thanh_tieu_chuan_pho_bien_nhat\" >T\u1ea1i sao nit\u01a1 l\u1ecfng tr\u1edf th\u00e0nh ti\u00eau chu\u1ea9n ph\u1ed5 bi\u1ebfn nh\u1ea5t?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Luu_tru_pha_long_hay_pha_hoi\" >L\u01b0u tr\u1eef pha l\u1ecfng hay pha h\u01a1i?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Nhung_yeu_to_khac_quyet_dinh_thanh_cong_cua_Cryogenic_Storage\" >Nh\u1eefng y\u1ebfu t\u1ed1 kh\u00e1c quy\u1ebft \u0111\u1ecbnh th\u00e0nh c\u00f4ng c\u1ee7a Cryogenic Storage<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Y_nghia_doi_voi_Cell_Therapy_Biobank_va_IVF\" >\u00dd ngh\u0129a \u0111\u1ed1i v\u1edbi Cell Therapy, Biobank v\u00e0 IVF<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Nhung_sai_lam_thuong_gap\" >Nh\u1eefng sai l\u1ea7m th\u01b0\u1eddng g\u1eb7p<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Cau_hoi_thuong_gap\" >C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/vi-sao-can-luu-tru-lanh-te-bao-o-nhiet-do-am-150-do-c-hoac-thap-hon\/#Ket_luan\" >K\u1ebft lu\u1eadn<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dieu_gi_xay_ra_ben_trong_te_bao_khi_bi_dong_lanh\"><\/span>\u0110i\u1ec1u g\u00ec x\u1ea3y ra b\u00ean trong t\u1ebf b\u00e0o khi b\u1ecb \u0111\u00f4ng l\u1ea1nh?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>M\u1ed9t t\u1ebf b\u00e0o s\u1ed1ng kh\u00f4ng ch\u1ec9 g\u1ed3m nh\u00e2n v\u00e0 m\u00e0ng t\u1ebf b\u00e0o. B\u00ean trong ch\u1ee9a kho\u1ea3ng 70-80% n\u01b0\u1edbc, c\u00f9ng protein, enzyme, DNA, RNA, lipid, b\u00e0o quan v\u00e0 h\u1ec7 th\u1ed1ng m\u00e0ng n\u1ed9i b\u00e0o.<\/p>\n\n\n\n<p>N\u1ebfu qu\u00e1 tr\u00ecnh l\u00e0m l\u1ea1nh kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t \u0111\u00fang, n\u01b0\u1edbc trong v\u00e0 ngo\u00e0i t\u1ebf b\u00e0o s\u1ebd h\u00ecnh th\u00e0nh c\u00e1c tinh th\u1ec3 b\u0103ng. C\u00e1c tinh th\u1ec3 n\u00e0y c\u00f3 th\u1ec3:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>L\u00e0m r\u00e1ch m\u00e0ng t\u1ebf b\u00e0o<\/li>\n\n\n\n<li>Ph\u00e1 h\u1ee7y ty th\u1ec3<\/li>\n\n\n\n<li>L\u00e0m bi\u1ebfn d\u1ea1ng c\u1ea5u tr\u00fac protein<\/li>\n\n\n\n<li>G\u00e2y t\u1ed5n th\u01b0\u01a1ng DNA<\/li>\n\n\n\n<li>Gi\u1ea3m kh\u1ea3 n\u0103ng s\u1ed1ng sau r\u00e3 \u0111\u00f4ng<\/li>\n<\/ul>\n\n\n\n<p>V\u00ec v\u1eady, cryopreservation kh\u00f4ng \u0111\u01a1n thu\u1ea7n l\u00e0 &#8220;\u0111\u00f4ng l\u1ea1nh&#8221;, m\u00e0 l\u00e0 ki\u1ec3m so\u00e1t to\u00e0n b\u1ed9 qu\u00e1 tr\u00ecnh l\u00e0m l\u1ea1nh \u0111\u1ec3 b\u1ea3o v\u1ec7 c\u1ea5u tr\u00fac t\u1ebf b\u00e0o.<\/p>\n\n\n\n<p><strong>Xem th\u00eam: <\/strong><a href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/lam-the-nao-de-dong-lanh-va-ra-dong-te-bao-hieu-qua\/\">L\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 \u0111\u00f4ng l\u1ea1nh v\u00e0 r\u00e3 \u0111\u00f4ng t\u1ebf b\u00e0o hi\u1ec7u qu\u1ea3?<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lua_chon_nhiet_do_luu_tru_lau_dai_co_y_nghia_quyet_dinh\"><\/span>L\u1ef1a ch\u1ecdn nhi\u1ec7t \u0111\u1ed9 l\u01b0u tr\u1eef l\u00e2u d\u00e0i c\u00f3 \u00fd ngh\u0129a quy\u1ebft \u0111\u1ecbnh<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nhi\u1ec1u ng\u01b0\u1eddi cho r\u1eb1ng sau khi t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c \u0111\u00f4ng l\u1ea1nh, m\u1ecdi ho\u1ea1t \u0111\u1ed9ng sinh h\u1ecdc \u0111\u1ec1u d\u1eebng l\u1ea1i ho\u00e0n to\u00e0n \u2014 \u0111i\u1ec1u n\u00e0y kh\u00f4ng ho\u00e0n to\u00e0n ch\u00ednh x\u00e1c. N\u1ebfu nhi\u1ec7t \u0111\u1ed9 l\u01b0u tr\u1eef ch\u01b0a \u0111\u1ee7 th\u1ea5p, enzyme v\u1eabn c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng r\u1ea5t ch\u1eadm, ph\u1ea3n \u1ee9ng oxy h\u00f3a v\u1eabn ti\u1ebfp di\u1ec5n, lipid m\u00e0ng v\u1eabn c\u00f3 th\u1ec3 t\u00e1i s\u1eafp x\u1ebfp v\u00e0 protein v\u1eabn c\u00f3 nguy c\u01a1 bi\u1ebfn t\u00ednh theo th\u1eddi gian.<\/p>\n\n\n\n<p>M\u1ed7i ph\u1ea3n \u1ee9ng ri\u00eang l\u1ebb di\u1ec5n ra r\u1ea5t ch\u1eadm, nh\u01b0ng trong th\u1eddi gian l\u01b0u tr\u1eef k\u00e9o d\u00e0i nhi\u1ec1u n\u0103m, t\u00e1c \u0111\u1ed9ng t\u00edch l\u0169y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu. M\u1ed9t nghi\u00ean c\u1ee9u t\u1ed5ng h\u1ee3p v\u1ec1 <em>best practice l\u01b0u tr\u1eef m\u1eabu sinh h\u1ecdc d\u00e0i h\u1ea1n <\/em>ghi nh\u1eadn c\u00e1c t\u1ee7 \u0111\u00f4ng ULT -80\u00b0C c\u00f3 th\u1ec3 g\u00e2y suy gi\u1ea3m kh\u1ea3 n\u0103ng s\u1ed1ng \u0111o \u0111\u01b0\u1ee3c \u1edf t\u1ebf b\u00e0o PBMC ch\u1ec9 trong v\u00f2ng , trong khi l\u01b0u tr\u1eef pha h\u01a1i (vapor-phase) \u1edf kho\u1ea3ng -150\u00b0C \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb cho l\u01b0u tr\u1eef h\u00e0ng th\u1eadp k\u1ef7 (<a href=\"https:\/\/unicornlifescience.com\/bio-storage-lab-methods-equipment-long-term\/\">Unicorn Lif 3-12 tu\u1ea7n escience, t\u1ed5ng h\u1ee3p theo ISBER Best Practices<\/a>). \u0110\u00e2y l\u00e0 l\u00fd do vi\u1ec7c l\u1ef1a ch\u1ecdn nhi\u1ec7t \u0111\u1ed9 l\u01b0u tr\u1eef l\u00e2u d\u00e0i c\u00f3 \u00fd ngh\u0129a quy\u1ebft \u0111\u1ecbnh.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Glass_Transition_Temperature_%E2%80%94_%E2%80%9Cranh_gioi%E2%80%9D_quan_trong_cua_Cryogenic_Storage\"><\/span>Glass Transition Temperature \u2014 &#8220;ranh gi\u1edbi&#8221; quan tr\u1ecdng c\u1ee7a Cryogenic Storage<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Glass Transition Temperature (Tg) l\u00e0 m\u1ed9t kh\u00e1i ni\u1ec7m quan tr\u1ecdng nh\u1ea5t trong l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u. Khi m\u00f4i tr\u01b0\u1eddng ch\u1ee9a cryoprotectant (v\u00ed d\u1ee5 DMSO) \u0111\u01b0\u1ee3c l\u00e0m l\u1ea1nh xu\u1ed1ng d\u01b0\u1edbi Tg, dung d\u1ecbch chuy\u1ec3n sang tr\u1ea1ng th\u00e1i gi\u1ed1ng th\u1ee7y tinh (vitrified state). \u1ede tr\u1ea1ng th\u00e1i n\u00e0y, ph\u00e2n t\u1eed n\u01b0\u1edbc g\u1ea7n nh\u01b0 kh\u00f4ng c\u00f2n kh\u1ea3 n\u0103ng d\u1ecbch chuy\u1ec3n, khu\u1ebfch t\u00e1n ph\u00e2n t\u1eed g\u1ea7n nh\u01b0 d\u1eebng l\u1ea1i, ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc gi\u1ea3m xu\u1ed1ng m\u1ee9c c\u1ef1c th\u1ea5p, v\u00e0 c\u1ea5u tr\u00fac t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c &#8220;kh\u00f3a&#8221; t\u1ea1i th\u1eddi \u0111i\u1ec3m \u0111\u00f4ng l\u1ea1nh.<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u c\u00f4ng b\u1ed1 tr\u00ean <em>Scientific Reports<\/em> (2025) v\u1ec1 \u1ee9ng su\u1ea5t nhi\u1ec7t trong dung d\u1ecbch vitrification cho th\u1ea5y Tg ph\u1ee5 thu\u1ed9c m\u1ea1nh v\u00e0o th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc c\u1ee7a dung d\u1ecbch cryoprotectant, v\u1edbi 4 c\u00f4ng th\u1ee9c \u0111\u01b0\u1ee3c kh\u1ea3o s\u00e1t tr\u1ea3i d\u00e0i h\u01a1n 50\u00b0C \u2014 dung d\u1ecbch <a>49% DMSO c\u00f3 Tg kho\u1ea3ng <strong>-131\u00b0C<\/strong><\/a><a href=\"#_msocom_1\">[HN1]<\/a>\u00a0, trong khi glycerol, xylitol v\u00e0 sucrose cho Tg cao h\u01a1n nhi\u1ec1u, t\u1eeb -102\u00b0C \u0111\u1ebfn -82\u00b0C (<a href=\"https:\/\/www.nature.com\/articles\/s41598-025-13295-7\">Scientific Reports, 2025<\/a>). \u0110i\u1ec1u n\u00e0y cho th\u1ea5y Tg kh\u00f4ng ph\u1ea3i m\u1ed9t h\u1eb1ng s\u1ed1 c\u1ed1 \u0111\u1ecbnh m\u00e0 thay \u0111\u1ed5i theo c\u00f4ng th\u1ee9c dung d\u1ecbch \u2014 c\u00e0ng c\u1ee7ng c\u1ed1 l\u00fd do c\u1ea7n m\u1ed9t kho\u1ea3ng \u0111\u1ec7m an to\u00e0n \u0111\u1ee7 l\u1edbn thay v\u00ec l\u01b0u tr\u1eef s\u00e1t m\u1ed9t m\u1ed1c Tg gi\u1ea3 \u0111\u1ecbnh. V\u1edbi dung d\u1ecbch ch\u1ee9a DMSO c\u1ee5 th\u1ec3, m\u1ed9t nghi\u00ean c\u1ee9u \u0111o b\u1eb1ng DSC tr\u00ean t\u1ebf b\u00e0o T ng\u01b0\u1eddi ghi nh\u1eadn \u0111i\u1ec3m gi\u1eefa c\u1ee7a qu\u00e1 tr\u00ecnh chuy\u1ec3n pha th\u1ee7y tinh (glass transition) \u1edf kho\u1ea3ng <strong>-123\u00b0C<\/strong> cho m\u00f4i tr\u01b0\u1eddng ngo\u1ea1i b\u00e0o (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6532914\/\">PMC, nghi\u00ean c\u1ee9u t\u1ebf b\u00e0o T mi\u1ec5n d\u1ecbch ng\u01b0\u1eddi<\/a>).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vi_sao_trong_Cell_Therapy_chon_moc_duoi_-150%C2%B0C\"><\/span>V\u00ec sao trong Cell Therapy ch\u1ecdn m\u1ed1c d\u01b0\u1edbi -150\u00b0C?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>M\u1eb7c d\u00f9 Tg th\u01b0\u1eddng r\u01a1i v\u00e0o kho\u1ea3ng -120\u00b0C \u0111\u1ebfn -130\u00b0C (t\u00f9y th\u00e0nh ph\u1ea7n dung d\u1ecbch v\u00e0 \u0111i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n), c\u00e1c h\u1ec7 th\u1ed1ng Cryogenic Storage trong th\u1ef1c t\u1ebf th\u01b0\u1eddng v\u1eadn h\u00e0nh d\u01b0\u1edbi -150\u00b0C. L\u00fd do \u0111\u1ebfn t\u1eeb nhi\u1ec1u y\u1ebfu t\u1ed1 v\u1eadn h\u00e0nh th\u1ef1c t\u1ebf nh\u01b0 t\u1ea1o kho\u1ea3ng \u0111\u1ec7m an to\u00e0n (safety margin), gi\u1ea3m g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed v\u00e0 h\u1ea1n ch\u1ebf hi\u1ec7n t\u01b0\u1ee3ng t\u00e1i k\u1ebft tinh (recrystallization).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Tao_khoang_dem_an_toan_Safety_Margin\"><\/span><strong>1. T\u1ea1o kho\u1ea3ng \u0111\u1ec7m an to\u00e0n (Safety Margin)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Kh\u00f4ng h\u1ec7 th\u1ed1ng n\u00e0o duy tr\u00ec \u0111\u00fang m\u1ed9t nhi\u1ec7t \u0111\u1ed9 tuy\u1ec7t \u0111\u1ed1i tuy\u1ec7t \u0111\u1ed1i trong su\u1ed1t v\u00f2ng \u0111\u1eddi l\u01b0u tr\u1eef. Tr\u00ean th\u1ef1c t\u1ebf lu\u00f4n t\u1ed3n t\u1ea1i dao \u0111\u1ed9ng nhi\u1ec7t \u0111\u1ed9 do m\u1edf n\u1eafp b\u00ecnh, thao t\u00e1c l\u1ea5y m\u1eabu, b\u1ed5 sung LN\u2082 ho\u1eb7c v\u1eadn chuy\u1ec3n m\u1eabu. N\u1ebfu l\u01b0u tr\u1eef s\u00e1t ng\u01b0\u1ee1ng -130\u00b0C, ch\u1ec9 m\u1ed9t dao \u0111\u1ed9ng nh\u1ecf c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0a m\u1eabu v\u01b0\u1ee3t qua Tg. Ng\u01b0\u1ee3c l\u1ea1i, \u1edf d\u01b0\u1edbi -150\u00b0C v\u1eabn c\u00f2n kho\u1ea3ng \u0111\u1ec7m \u0111\u00e1ng k\u1ec3 tr\u01b0\u1edbc khi ch\u1ea1m ng\u01b0\u1ee1ng chuy\u1ec3n pha.<\/p>\n\n\n\n<p>Ch\u00fang t\u00f4i c\u0169ng ghi nh\u1eadn nguy\u00ean t\u1eafc t\u01b0\u01a1ng t\u1ef1 trong t\u00e0i li\u1ec7u k\u1ef9 thu\u1eadt v\u1ec1 ti\u00eau chu\u1ea9n l\u01b0u tr\u1eef nit\u01a1 l\u1ecfng c\u1ee7a ISO 20387 v\u00e0 ISBER Best Practices: m\u1eabu sinh h\u1ecdc n\u00ean \u0111\u01b0\u1ee3c gi\u1eef d\u01b0\u1edbi -135\u00b0C \u2014 ng\u01b0\u1ee1ng Tg c\u1ee7a n\u01b0\u1edbc trong t\u1ebf b\u00e0o \u2014 v\u00e0 l\u00fd t\u01b0\u1edfng trong kho\u1ea3ng -150\u00b0C \u0111\u1ebfn -196\u00b0C \u0111\u1ec3 d\u1eebng ho\u00e0n to\u00e0n ho\u1ea1t \u0111\u1ed9ng sinh h\u1ecdc<\/p>\n\n\n\n<p><strong>Xem th\u00eam: <\/strong><a href=\"https:\/\/biogroupvietnam.com\/vi\/tin-tuc\/binh-nito-long-phong-luu-tru-dieu-kien-dat-chuan-quoc-te\/\">B\u00ecnh nit\u01a1 l\u1ecfng &amp; ph\u00f2ng l\u01b0u tr\u1eef \u2013 \u0110i\u1ec1u ki\u1ec7n \u0111\u1ea1t chu\u1ea9n qu\u1ed1c t\u1ebf<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_Giam_gan_nhu_hoan_toan_chuyen_dong_phan_tu\"><\/span><strong>2. Gi\u1ea3m g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Khi xu\u1ed1ng d\u01b0\u1edbi Tg \u0111\u1ee7 s\u00e2u, n\u01b0\u1edbc kh\u00f4ng c\u00f2n khu\u1ebfch t\u00e1n \u0111\u00e1ng k\u1ec3, enzyme g\u1ea7n nh\u01b0 b\u1ea5t ho\u1ea1t, lipid m\u00e0ng \u1ed5n \u0111\u1ecbnh h\u01a1n v\u00e0 c\u1ea5u tr\u00fac protein \u00edt thay \u0111\u1ed5i h\u01a1n. \u0110i\u1ec1u n\u00e0y \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng v\u1edbi c\u00e1c lo\u1ea1i m\u1eabu nh\u1ea1y c\u1ea3m nh\u01b0 t\u1ebf b\u00e0o g\u1ed1c, CAR-T, NK cell, iPSC hay ph\u00f4i IVF<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Han_che_hien_tuong_tai_ket_tinh_Recrystallization\"><\/span><strong>3. H\u1ea1n ch\u1ebf hi\u1ec7n t\u01b0\u1ee3ng t\u00e1i k\u1ebft tinh (Recrystallization)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>M\u1ed9t trong nh\u1eefng r\u1ee7i ro l\u1edbn nh\u1ea5t khi l\u01b0u tr\u1eef kh\u00f4ng \u0111\u1ee7 l\u1ea1nh l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng c\u00e1c tinh th\u1ec3 b\u0103ng nh\u1ecf ph\u00e1t tri\u1ec3n th\u00e0nh tinh th\u1ec3 l\u1edbn h\u01a1n theo th\u1eddi gian ho\u1eb7c qua c\u00e1c chu k\u1ef3 dao \u0111\u1ed9ng nhi\u1ec7t. Tinh th\u1ec3 l\u1edbn c\u00f3 th\u1ec3 l\u00e0m t\u1ed5n th\u01b0\u01a1ng m\u00e0ng t\u1ebf b\u00e0o, ph\u00e1 h\u1ee7y c\u1ea5u tr\u00fac n\u1ed9i b\u00e0o v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 s\u1ed1ng sau r\u00e3 \u0111\u00f4ng. L\u01b0u tr\u1eef d\u01b0\u1edbi -150\u00b0C gi\u00fap gi\u1ea3m \u0111\u00e1ng k\u1ec3 nguy c\u01a1 n\u00e0y.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/08\/image-1.jpg\" alt=\"\" class=\"wp-image-11425\"\/><figcaption class=\"wp-element-caption\"><em>\u1ea2nh h\u01b0\u1edfng c\u1ee7a s\u1ef1 h\u00ecnh th\u00e0nh tinh th\u1ec3 b\u0103ng c\u1ea3 b\u00ean trong v\u00e0 b\u00ean ngo\u00e0i t\u1ebf b\u00e0o l\u00ean t\u1ebf b\u00e0o (Ngu\u1ed3n: <a href=\"https:\/\/juniperpublishers.com\/aibm\/AIBM.MS.ID.555978.php\">Advances in Biotechnology &amp; Microbiology &#8211; A Brief Review of Current Strategies and Advances in Cryopreservation Techniques<\/a>)<\/em><\/figcaption><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tai_sao_-80%C2%B0C_khong_phu_hop_cho_luu_tru_dai_han\"><\/span>T\u1ea1i sao -80\u00b0C kh\u00f4ng ph\u00f9 h\u1ee3p cho l\u01b0u tr\u1eef d\u00e0i h\u1ea1n?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>T\u1ee7 \u0111\u00f4ng -80\u00b0C r\u1ea5t h\u1eefu \u00edch trong nghi\u00ean c\u1ee9u, ph\u00f9 h\u1ee3p \u0111\u1ec3 l\u01b0u tr\u1eef DNA, RNA, protein, enzyme, vi khu\u1ea9n ho\u1eb7c m\u1ed9t s\u1ed1 d\u00f2ng t\u1ebf b\u00e0o trong th\u1eddi gian ng\u1eafn\/trung h\u1ea1n. Tuy nhi\u00ean, \u0111\u1ed1i v\u1edbi t\u1ebf b\u00e0o s\u1ed1ng c\u1ea7n b\u1ea3o t\u1ed3n ch\u1ee9c n\u0103ng l\u00e2u d\u00e0i, -80\u00b0C th\u01b0\u1eddng kh\u00f4ng \u0111\u01b0\u1ee3c xem l\u00e0 nhi\u1ec7t \u0111\u1ed9 t\u1ed1i \u01b0u: v\u1eabn t\u1ed3n t\u1ea1i chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed, ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc ch\u01b0a d\u1eebng ho\u00e0n to\u00e0n, nguy c\u01a1 t\u00e1i k\u1ebft tinh cao h\u01a1n v\u00e0 kh\u1ea3 n\u0103ng suy gi\u1ea3m ch\u1ea5t l\u01b0\u1ee3ng t\u0103ng theo th\u1eddi gian l\u01b0u tr\u1eef.<\/p>\n\n\n\n<p>\u0110\u00f3 l\u00e0 l\u00fd do c\u00e1c ng\u00e2n h\u00e0ng t\u1ebf b\u00e0o, c\u01a1 s\u1edf IVF v\u00e0 trung t\u00e2m Cell Therapy s\u1eed d\u1ee5ng Cryogenic Storage b\u1eb1ng nit\u01a1 l\u1ecfng thay v\u00ec ch\u1ec9 d\u1ef1a v\u00e0o t\u1ee7 \u0111\u00f4ng -80\u00b0C \u2014 ph\u00f9 h\u1ee3p v\u1edbi khuy\u1ebfn ngh\u1ecb chung c\u1ee7a <a href=\"https:\/\/www.isber.org\/page\/BPR\">ISBER Best Practices<\/a>, ti\u00eau chu\u1ea9n <a href=\"https:\/\/www.iso.org\/standard\/67888.html\">ISO 20387<\/a> v\u1ec1 biobanking v\u00e0 c\u00e1c h\u01b0\u1edbng d\u1eabn NIH\/NCI v\u1ec1 l\u01b0u tr\u1eef m\u1eabu sinh h\u1ecdc d\u00e0i h\u1ea1n (thi\u1ebfu Source).<\/p>\n\n\n\n<p>C\u00e1c thi\u1ebft b\u1ecb l\u01b0u tr\u1eef \u0111\u1ea1t ch\u1ee9ng nh\u1eadn qu\u1ed1c t\u1ebf \u2014 v\u00ed d\u1ee5 d\u00f2ng b\u00ecnh\/t\u1ee7 nit\u01a1 l\u1ecfng MVE Biological Solutions c\u00f3 \u0111\u0103ng k\u00fd FDA \u2014 c\u0169ng l\u00e0 m\u1ed9t ti\u00eau ch\u00ed \u0111\u00e1ng c\u00e2n nh\u1eafc khi l\u1ef1a ch\u1ecdn h\u1ec7 th\u1ed1ng cho \u1ee9ng d\u1ee5ng GMP (<a href=\"https:\/\/biogroupvietnam.com\/en\/blog\/fda-registered-biological-sample-storage-equipment-mve\/\">t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u00fd ngh\u0129a ch\u1ee9ng nh\u1eadn FDA Registered v\u1edbi thi\u1ebft b\u1ecb l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u<\/a>).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tai_sao_nito_long_tro_thanh_tieu_chuan_pho_bien_nhat\"><\/span>T\u1ea1i sao nit\u01a1 l\u1ecfng tr\u1edf th\u00e0nh ti\u00eau chu\u1ea9n ph\u1ed5 bi\u1ebfn nh\u1ea5t?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nit\u01a1 l\u1ecfng c\u00f3 nhi\u1ec7t \u0111\u1ed9 kho\u1ea3ng -196\u00b0C \u1edf \u00e1p su\u1ea5t kh\u00ed quy\u1ec3n \u2014 th\u1ea5p h\u01a1n Tg m\u1ed9t kho\u1ea3ng l\u1edbn, \u1ed5n \u0111\u1ecbnh, cho kh\u1ea3 n\u0103ng l\u00e0m l\u1ea1nh \u0111\u1ed3ng \u0111\u1ec1u v\u00e0 kh\u00f4ng ph\u1ee5 thu\u1ed9c m\u00e1y n\u00e9n l\u1ea1nh. Trong tr\u01b0\u1eddng h\u1ee3p m\u1ea5t \u0111i\u1ec7n, b\u00ecnh nit\u01a1 l\u1ecfng v\u1eabn duy tr\u00ec nhi\u1ec7t \u0111\u1ed9 trong th\u1eddi gian \u0111\u00e1ng k\u1ec3 n\u1ebfu \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u00e0 v\u1eadn h\u00e0nh \u0111\u00fang \u2014 m\u1ed9t \u01b0u \u0111i\u1ec3m quan tr\u1ecdng v\u1edbi c\u00e1c h\u1ec7 th\u1ed1ng l\u01b0u tr\u1eef d\u00e0i h\u1ea1n.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Luu_tru_pha_long_hay_pha_hoi\"><\/span><strong>L\u01b0u tr\u1eef pha l\u1ecfng hay pha h\u01a1i?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Liquid phase<\/strong><\/td><td><strong>Vapor phase<\/strong><\/td><\/tr><tr><td>M\u1eabu ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi nit\u01a1 l\u1ecfng, cho nhi\u1ec7t \u0111\u1ed9 \u0111\u1ed3ng \u0111\u1ec1u v\u00e0 truy\u1ec1n nhi\u1ec7t hi\u1ec7u qu\u1ea3. C\u1ea7n s\u1eed d\u1ee5ng v\u1eadt t\u01b0 \u0111\u1ea1t ti\u00eau chu\u1ea9n (\u1ed1ng, t\u00fai tr\u1eef m\u1eabu chuy\u00ean d\u1ee5ng \u2014 xem th\u00eam d\u00f2ng CryoShippers v\u00e0 v\u1eadt t\u01b0 l\u01b0u tr\u1eef m\u1eabu sinh h\u1ecdc t\u1ea1i Biogroup Vietnam) v\u00e0 quy tr\u00ecnh ph\u00f9 h\u1ee3p \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 nhi\u1ec5m ch\u00e9o.<\/td><td>M\u1eabu \u0111\u01b0\u1ee3c l\u01b0u trong v\u00f9ng h\u01a1i nit\u01a1, th\u01b0\u1eddng d\u01b0\u1edbi -150\u00b0C, gi\u00fap gi\u1ea3m nguy c\u01a1 ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi nit\u01a1 l\u1ecfng v\u00e0 ph\u00f9 h\u1ee3p v\u1edbi nhi\u1ec1u \u1ee9ng d\u1ee5ng GMP\/Cell Therapy. Theo t\u1ed5ng h\u1ee3p v\u1ec1 v\u1eadt t\u01b0 v\u00e0 thi\u1ebft b\u1ecb l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u, c\u1ea5u h\u00ecnh vapor phase k\u1ebft h\u1ee3p gi\u00e1 \u0111\u1ee1 nh\u00f4m v\u00e0 h\u1ec7 th\u1ed1ng gi\u00e1m s\u00e1t t\u1ef1 \u0111\u1ed9ng \u0111ang tr\u1edf th\u00e0nh ti\u00eau chu\u1ea9n hi\u1ec7n \u0111\u1ea1i trong biobanking, c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u00e0 nhi\u1ec5m ch\u00e9o qua LN\u2082 th\u01b0\u1eddng g\u1eb7p \u1edf liquid phase (Unicorn Lifescience, l\u1ef1a ch\u1ecdn b\u00ecnh ch\u1ee9a nit\u01a1 l\u1ecfng). Nhi\u1ec1u c\u01a1 s\u1edf hi\u1ec7n \u0111\u1ea1i l\u1ef1a ch\u1ecdn c\u1ea5u h\u00ecnh n\u00e0y \u0111\u1ec3 c\u00e2n b\u1eb1ng gi\u1eefa hi\u1ec7u qu\u1ea3 b\u1ea3o qu\u1ea3n v\u00e0 qu\u1ea3n l\u00fd r\u1ee7i ro.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Xem th\u00eam: <\/strong>L\u01b0u pha h\u01a1i v\u00e0 l\u01b0u pha l\u1ecfng, l\u1ef1a ch\u1ecdn n\u00e0o ph\u00f9 h\u1ee3p?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhung_yeu_to_khac_quyet_dinh_thanh_cong_cua_Cryogenic_Storage\"><\/span>Nh\u1eefng y\u1ebfu t\u1ed1 kh\u00e1c quy\u1ebft \u0111\u1ecbnh th\u00e0nh c\u00f4ng c\u1ee7a Cryogenic Storage<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nhi\u1ec7t \u0111\u1ed9 ch\u1ec9 l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a h\u1ec7 th\u1ed1ng. M\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh Cryogenic Storage hi\u1ec7u qu\u1ea3 c\u1ea7n \u0111\u1ed3ng th\u1eddi ki\u1ec3m so\u00e1t:<\/p>\n\n\n\n<p><strong>Quy tr\u00ecnh \u0111\u00f4ng l\u1ea1nh c\u00f3 ki\u1ec3m so\u00e1t.<\/strong> L\u00e0m l\u1ea1nh qu\u00e1 nhanh ho\u1eb7c qu\u00e1 ch\u1eadm \u0111\u1ec1u c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o. C\u00e1c ch\u01b0\u01a1ng tr\u00ecnh cryopreservation th\u01b0\u1eddng s\u1eed d\u1ee5ng thi\u1ebft b\u1ecb ki\u1ec3m so\u00e1t t\u1ed1c \u0111\u1ed9 l\u00e0m l\u1ea1nh \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a qu\u00e1 tr\u00ecnh.<\/p>\n\n\n\n<p><strong>Cryoprotectant ph\u00f9 h\u1ee3p.<\/strong> C\u00e1c ch\u1ea5t nh\u01b0 DMSO gi\u00fap gi\u1ea3m h\u00ecnh th\u00e0nh tinh th\u1ec3 b\u0103ng, t\u0103ng t\u1ef7 l\u1ec7 s\u1ed1ng sau r\u00e3 \u0111\u00f4ng v\u00e0 h\u1ed7 tr\u1ee3 qu\u00e1 tr\u00ecnh vitrification. Vi\u1ec7c l\u1ef1a ch\u1ecdn n\u1ed3ng \u0111\u1ed9 v\u00e0 quy tr\u00ecnh lo\u1ea1i b\u1ecf cryoprotectant sau r\u00e3 \u0111\u00f4ng c\u0169ng quan tr\u1ecdng kh\u00f4ng k\u00e9m.<\/p>\n\n\n\n<p><strong>H\u1ec7 th\u1ed1ng Cryogenic Storage \u1ed5n \u0111\u1ecbnh.<\/strong> C\u1ea7n \u0111\u1ea3m b\u1ea3o \u0111\u1ed9 ch\u00e2n kh\u00f4ng \u1ed5n \u0111\u1ecbnh, m\u1ee9c ti\u00eau hao LN\u2082 th\u1ea5p, nhi\u1ec7t \u0111\u1ed9 \u0111\u1ed3ng \u0111\u1ec1u, kh\u1ea3 n\u0103ng ph\u1ee5c h\u1ed3i nhanh sau thao t\u00e1c l\u1ea5y m\u1eabu v\u00e0 tu\u1ed5i th\u1ecd v\u1eadn h\u00e0nh d\u00e0i.<\/p>\n\n\n\n<p><strong>Monitoring li\u00ean t\u1ee5c.<\/strong> C\u00e1c th\u00f4ng s\u1ed1 c\u1ea7n theo d\u00f5i g\u1ed3m nhi\u1ec7t \u0111\u1ed9, m\u1ee9c nit\u01a1 l\u1ecfng, tr\u1ea1ng th\u00e1i c\u1ea3nh b\u00e1o, ngu\u1ed3n \u0111i\u1ec7n c\u1ee7a h\u1ec7 th\u1ed1ng gi\u00e1m s\u00e1t, n\u1ed3ng \u0111\u1ed9 oxy trong ph\u00f2ng v\u00e0 l\u1ecbch s\u1eed s\u1ef1 ki\u1ec7n. ISBER Best Pratices khuy\u1ebfn ngh\u1ecb c\u00e1c biobank trang b\u1ecb c\u1ea3m bi\u1ebfn oxy\/c\u1ea3nh b\u00e1o khi l\u01b0u tr\u1eef b\u1eb1ng kh\u00ed n\u00e9n nh\u01b0 nit\u01a1 l\u1ecfng ho\u1eb7c CO\u2082 l\u1ecfng, do r\u1ee7i ro thi\u1ebfu oxy trong kh\u00f4ng gian k\u00edn (<a href=\"https:\/\/www.biobanking.com\/isber-best-practices-for-biobanks\/\">Biobanking.com, t\u1ed5ng h\u1ee3p ISBER Best Practices<\/a>). B\u00ecnh l\u01b0u tr\u1eef MVE HE k\u1ebft h\u1ee3p CryoVerse Connect l\u00e0 gi\u1ea3i ph\u00e1p l\u01b0u tr\u1eef c\u00f3 ki\u1ec3m so\u00e1t li\u00ean t\u1ee5c, ph\u00e1t hi\u1ec7n s\u1edbm b\u1ea5t th\u01b0\u1eddng tr\u01b0\u1edbc khi \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u1eabu. B\u00ecnh l\u01b0u tr\u1eef c\u00f4ng b\u1ed1 nhi\u1ec7t \u0111\u1ed9 pha h\u01a1i \u2212190\u00b0C \u00b15\u00b0C t\u1ea1i top box khi \u0111\u00e3 n\u1ea1p rack, ph\u00f9 h\u1ee3p v\u1edbi \u1ee9ng d\u1ee5ng th\u1ef1c s\u1ef1 y\u00eau c\u1ea7u d\u01b0\u1edbi \u2212150\u00b0C. CryoVerse Connect h\u1ed7 tr\u1ee3 alarm\/setpoint nhi\u1ec7t \u0111\u1ed9, m\u1ee9c LN\u2082, tr\u1ea1ng th\u00e1i ngu\u1ed3n, event logging v\u00e0 ph\u00e2n quy\u1ec1n ng\u01b0\u1eddi d\u00f9ng.<\/p>\n\n\n\n<p>V\u1edbi c\u00e1c c\u01a1 s\u1edf IVF, y\u00eau c\u1ea7u v\u1eadn h\u00e0nh c\u00f2n g\u1eafn th\u00eam ti\u00eau chu\u1ea9n chuy\u00ean ng\u00e0nh nh\u01b0 HFEA \u2014 xem th\u00eam <a href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/binh-nito-long-mve-tieu-chuan-hfea-cho-luu-tru-mau-ivf\/\">ti\u00eau chu\u1ea9n HFEA cho l\u01b0u tr\u1eef m\u1eabu IVF b\u1eb1ng b\u00ecnh nit\u01a1 l\u1ecfng MVE<\/a> \u0111\u1ec3 hi\u1ec3u th\u00eam y\u00eau c\u1ea7u ri\u00eang c\u1ee7a l\u0129nh v\u1ef1c n\u00e0y.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Y_nghia_doi_voi_Cell_Therapy_Biobank_va_IVF\"><\/span>\u00dd ngh\u0129a \u0111\u1ed1i v\u1edbi Cell Therapy, Biobank v\u00e0 IVF<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>M\u1ed9t m\u1eabu \u0111\u01b0\u1ee3c l\u01b0u tr\u1eef h\u00f4m nay c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng sau 5 n\u0103m, 10 n\u0103m, 20 n\u0103m ho\u1eb7c l\u00e2u h\u01a1n. Trong kho\u1ea3ng th\u1eddi gian \u0111\u00f3, \u0111i\u1ec1u quan tr\u1ecdng nh\u1ea5t kh\u00f4ng ph\u1ea3i l\u00e0 &#8220;m\u1eabu c\u00f2n \u0111\u01b0\u1ee3c gi\u1eef trong b\u00ecnh&#8221;, m\u00e0 l\u00e0 t\u1ef7 l\u1ec7 s\u1ed1ng sau r\u00e3 \u0111\u00f4ng, kh\u1ea3 n\u0103ng t\u0103ng sinh, ch\u1ee9c n\u0103ng sinh h\u1ecdc, \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh di truy\u1ec1n v\u00e0 kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng m\u1ee5c \u0111\u00edch nghi\u00ean c\u1ee9u ho\u1eb7c \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n<p>Do \u0111\u00f3, Cryogenic Storage n\u00ean \u0111\u01b0\u1ee3c nh\u00ecn nh\u1eadn nh\u01b0 m\u1ed9t h\u1ec7 th\u1ed1ng qu\u1ea3n l\u00fd ch\u1ea5t l\u01b0\u1ee3ng d\u00e0i h\u1ea1n, kh\u00f4ng ch\u1ec9 l\u00e0 m\u1ed9t thi\u1ebft b\u1ecb b\u1ea3o qu\u1ea3n \u0111\u01a1n thu\u1ea7n.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhung_sai_lam_thuong_gap\"><\/span>Nh\u1eefng sai l\u1ea7m th\u01b0\u1eddng g\u1eb7p<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nhi\u1ec1u \u0111\u01a1n v\u1ecb v\u1eabn m\u1eafc ph\u1ea3i c\u00e1c sai l\u1ea7m sau:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cho r\u1eb1ng -80\u00b0C t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi Cryogenic Storage<\/li>\n\n\n\n<li>Ch\u1ec9 quan t\u00e2m gi\u00e1 mua b\u00ecnh m\u00e0 b\u1ecf qua t\u1ed5ng chi ph\u00ed s\u1edf h\u1eefu (TCO)<\/li>\n\n\n\n<li>Kh\u00f4ng theo d\u00f5i m\u1ee9c ti\u00eau hao LN\u2082 \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00ecnh tr\u1ea1ng ch\u00e2n kh\u00f4ng<\/li>\n\n\n\n<li>Thi\u1ebfu h\u1ec7 th\u1ed1ng c\u1ea3nh b\u00e1o v\u00e0 gi\u00e1m s\u00e1t t\u1eeb xa<\/li>\n\n\n\n<li>Kh\u00f4ng x\u00e2y d\u1ef1ng SOP cho vi\u1ec7c l\u1ea5y m\u1eabu, b\u1ed5 sung LN\u2082 v\u00e0 x\u1eed l\u00fd s\u1ef1 c\u1ed1<\/li>\n\n\n\n<li>M\u1edf n\u1eafp b\u00ecnh qu\u00e1 l\u00e2u ho\u1eb7c qu\u00e1 th\u01b0\u1eddng xuy\u00ean, l\u00e0m t\u0103ng dao \u0111\u1ed9ng nhi\u1ec7t<\/li>\n<\/ul>\n\n\n\n<p>Nh\u1eefng y\u1ebfu t\u1ed1 n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng r\u1ee7i ro \u0111\u1ed1i v\u1edbi ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu trong su\u1ed1t v\u00f2ng \u0111\u1eddi l\u01b0u tr\u1eef.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cau_hoi_thuong_gap\"><\/span>C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>&#8211;<strong>80\u00b0C v\u00e0 -150\u00b0C kh\u00e1c nhau nh\u01b0 th\u1ebf n\u00e0o v\u1ec1 m\u1eb7t sinh h\u1ecdc?<\/strong><\/summary>\n<p>\u1ede -80\u00b0C, chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed v\u00e0 m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc v\u1eabn ti\u1ebfp di\u1ec5n \u1edf m\u1ee9c ch\u1eadm, khi\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu suy gi\u1ea3m d\u1ea7n theo th\u1eddi gian l\u01b0u tr\u1eef. D\u01b0\u1edbi -150\u00b0C, m\u1eabu n\u1eb1m s\u00e2u d\u01b0\u1edbi ng\u01b0\u1ee1ng Glass Transition Temperature, n\u01a1i chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed g\u1ea7n nh\u01b0 d\u1eebng l\u1ea1i ho\u00e0n to\u00e0n.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><strong>Tg (Glass Transition Temperature) ch\u00ednh x\u00e1c l\u00e0 bao nhi\u00eau?<\/strong><\/summary>\n<p>Tg ph\u1ee5 thu\u1ed9c v\u00e0o th\u00e0nh ph\u1ea7n dung d\u1ecbch cryoprotectant. V\u1edbi c\u00e1c dung d\u1ecbch ch\u1ee9a DMSO ph\u1ed5 bi\u1ebfn trong cryopreservation, Tg th\u01b0\u1eddng n\u1eb1m trong kho\u1ea3ng -120\u00b0C \u0111\u1ebfn -130\u00b0C, theo nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111o b\u1eb1ng DSC.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><strong>V\u00ec sao kh\u00f4ng l\u01b0u tr\u1eef ngay t\u1ea1i Tg \u0111\u1ec3 ti\u1ebft ki\u1ec7m chi ph\u00ed LN\u2082?<\/strong><\/summary>\n<p>V\u00ec h\u1ec7 th\u1ed1ng th\u1ef1c t\u1ebf lu\u00f4n c\u00f3 dao \u0111\u1ed9ng nhi\u1ec7t (m\u1edf n\u1eafp, l\u1ea5y m\u1eabu, b\u1ed5 sung LN\u2082, v\u1eadn chuy\u1ec3n). L\u01b0u tr\u1eef s\u00e1t Tg khi\u1ebfn m\u1eabu d\u1ec5 v\u01b0\u1ee3t ng\u01b0\u1ee1ng chuy\u1ec3n pha ch\u1ec9 v\u1edbi m\u1ed9t dao \u0111\u1ed9ng nh\u1ecf. Ng\u01b0\u1ee1ng d\u01b0\u1edbi -150\u00b0C t\u1ea1o kho\u1ea3ng \u0111\u1ec7m an to\u00e0n c\u1ea7n thi\u1ebft.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><strong>Vapor phase v\u00e0 liquid phase, ph\u01b0\u01a1ng ph\u00e1p n\u00e0o ph\u00f9 h\u1ee3p h\u01a1n cho GMP?<\/strong><\/summary>\n<p>C\u1ea3 hai \u0111\u1ec1u c\u00f3 th\u1ec3 \u0111\u1ea1t nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi -150\u00b0C. Vapor phase th\u01b0\u1eddng \u0111\u01b0\u1ee3c \u01b0u ti\u00ean trong nhi\u1ec1u \u1ee9ng d\u1ee5ng GMP\/Cell Therapy v\u00ec gi\u1ea3m nguy c\u01a1 ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u00e0 nhi\u1ec5m ch\u00e9o qua nit\u01a1 l\u1ecfng, d\u00f9 c\u1ea7n \u0111\u1ea7u t\u01b0 h\u1ec7 th\u1ed1ng gi\u00e1m s\u00e1t v\u00e0 gi\u00e1 \u0111\u1ee1 ph\u00f9 h\u1ee3p h\u01a1n.<\/p>\n<\/details>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ket_luan\"><\/span>K\u1ebft lu\u1eadn<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Vi\u1ec7c l\u01b0u tr\u1eef t\u1ebf b\u00e0o d\u01b0\u1edbi -150\u00b0C kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn mang t\u00ednh truy\u1ec1n th\u1ed1ng hay quy \u01b0\u1edbc ng\u00e0nh, m\u00e0 d\u1ef1a tr\u00ean c\u00e1c nguy\u00ean l\u00fd khoa h\u1ecdc v\u1ec1 v\u1eadt li\u1ec7u, nhi\u1ec7t \u0111\u1ed9ng h\u1ecdc v\u00e0 sinh h\u1ecdc t\u1ebf b\u00e0o. D\u01b0\u1edbi ng\u01b0\u1ee1ng n\u00e0y, m\u00f4i tr\u01b0\u1eddng cryopreservation \u0111i v\u00e0o tr\u1ea1ng th\u00e1i g\u1ea7n nh\u01b0 &#8220;\u0111\u00f3ng b\u0103ng \u0111\u1ed9ng h\u1ecdc&#8221;, n\u01a1i chuy\u1ec3n \u0111\u1ed9ng ph\u00e2n t\u1eed v\u00e0 ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc b\u1ecb h\u1ea1n ch\u1ebf \u1edf m\u1ee9c r\u1ea5t th\u1ea5p, gi\u00fap b\u1ea3o t\u1ed3n c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o trong th\u1eddi gian d\u00e0i.<\/p>\n\n\n\n<p>\u0110\u1ed1i v\u1edbi Cell Therapy, Gene Therapy, Biobank v\u00e0 IVF, ch\u1ea5t l\u01b0\u1ee3ng m\u1eabu sau nhi\u1ec1u n\u0103m l\u01b0u tr\u1eef c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u, s\u1ea3n xu\u1ea5t ho\u1eb7c \u0111i\u1ec1u tr\u1ecb. \u0110\u1ea7u t\u01b0 v\u00e0o m\u1ed9t h\u1ec7 th\u1ed1ng Cryogenic Storage v\u00ec v\u1eady kh\u00f4ng ch\u1ec9 l\u00e0 \u0111\u1ea7u t\u01b0 v\u00e0o thi\u1ebft b\u1ecb, m\u00e0 c\u00f2n l\u00e0 \u0111\u1ea7u t\u01b0 v\u00e0o \u0111\u1ed9 tin c\u1eady c\u1ee7a to\u00e0n b\u1ed9 chu\u1ed7i gi\u00e1 tr\u1ecb sinh h\u1ecdc \u2014 t\u1eeb quy tr\u00ecnh \u0111\u00f4ng l\u1ea1nh, thi\u1ebft b\u1ecb l\u01b0u tr\u1eef, h\u1ec7 th\u1ed1ng gi\u00e1m s\u00e1t, \u0111\u1ebfn v\u1eadn h\u00e0nh v\u00e0 qu\u1ea3n l\u00fd r\u1ee7i ro.<\/p>\n\n\n\n<p><strong>Xem th\u00eam<\/strong>: Ti\u00eau chu\u1ea9n qu\u1ed1c t\u1ebf cho ph\u00f2ng\/b\u00ecnh l\u01b0u tr\u1eef nit\u01a1 l\u1ecfng<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-background\" style=\"background:linear-gradient(135deg,rgb(234,246,252) 0%,rgb(234,246,252) 100%)\">B\u1ea1n \u0111ang x\u00e2y d\u1ef1ng ho\u1eb7c n\u00e2ng c\u1ea5p h\u1ec7 th\u1ed1ng Cryogenic Storage cho Cell Therapy, Biobank ho\u1eb7c IVF<br>Biogroup Vietnam cung c\u1ea5p gi\u1ea3i ph\u00e1p to\u00e0n di\u1ec7n t\u1eeb t\u01b0 v\u1ea5n thi\u1ebft k\u1ebf, l\u1ef1a ch\u1ecdn c\u1ea5u h\u00ecnh l\u01b0u tr\u1eef pha h\u01a1i ho\u1eb7c pha l\u1ecfng, h\u1ec7 th\u1ed1ng gi\u00e1m s\u00e1t v\u00e0 c\u1ea3nh b\u00e1o, \u0111\u00e0o t\u1ea1o v\u1eadn h\u00e0nh, \u0111\u1ebfn d\u1ecbch v\u1ee5 b\u1ea3o tr\u00ec \u0111\u1ecbnh k\u1ef3. Ch\u00fang t\u00f4i \u0111\u1ed3ng h\u00e0nh c\u00f9ng kh\u00e1ch h\u00e0ng trong vi\u1ec7c x\u00e2y d\u1ef1ng h\u1ea1 t\u1ea7ng l\u01b0u tr\u1eef l\u1ea1nh s\u00e2u an to\u00e0n, \u1ed5n \u0111\u1ecbnh v\u00e0 ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c y\u00eau c\u1ea7u c\u1ee7a nghi\u00ean c\u1ee9u, s\u1ea3n xu\u1ea5t v\u00e0 \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng.<br><br><strong>\ud83d\udce9 Li\u00ean h\u1ec7 Biogroup Vietnam \u0111\u1ec3 th\u1ef1c hi\u1ec7n Cryogenic Storage Health Check, \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh nhi\u1ec7t v\u00e0 x\u00e2y d\u1ef1ng h\u1ec7 th\u1ed1ng b\u1ea3o v\u1ec7 m\u1eabu an to\u00e0n trong su\u1ed1t v\u00f2ng \u0111\u1eddi l\u01b0u tr\u1eef.<\/strong><br><br>Website: <a href=\"https:\/\/biogroupvietnam.com\/vi\/lien-he\/\">https:\/\/biogroupvietnam.com\/vi\/lien-he\/<\/a><br>Hotline: +84 963 621 421<br>Email: info@biogroupvietnam.com<\/p>\n\n\n\n<p><br><strong>T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Biobanking.com. (2020). <em>ISBER Best Practices for Biobanks<\/em>. Truy c\u1eadp t\u1eeb <a href=\"https:\/\/www.biobanking.com\/isber-best-practices-for-biobanks\/\">biobanking.com\/isber-best-practices-for-biobanks<\/a><\/li>\n\n\n\n<li>International Organization for Standardization. (2018). <em>ISO 20387:2018 \u2014 Biotechnology \u2014 Biobanking \u2014 General requirements for biobanking<\/em>. Truy c\u1eadp t\u1eeb <a href=\"https:\/\/www.iso.org\/standard\/67888.html\">iso.org\/standard\/67888.html<\/a><\/li>\n\n\n\n<li>International Society for Biological and Environmental Repositories (ISBER). <em>Best Practices for Repositories, 5th Edition<\/em>. Truy c\u1eadp t\u1eeb <a href=\"https:\/\/www.isber.org\/page\/BPR\">isber.org\/page\/BPR<\/a><\/li>\n\n\n\n<li>Nghi\u00ean c\u1ee9u \u0111\u0103ng tr\u00ean <em>Scientific Reports<\/em> (Nature). (2025). <em>Higher glass transition temperatures reduce thermal stress cracking in aqueous solutions relevant to cryopreservation<\/em>. Truy c\u1eadp t\u1eeb <a href=\"https:\/\/www.nature.com\/articles\/s41598-025-13295-7\">nature.com\/articles\/s41598-025-13295-7<\/a><\/li>\n\n\n\n<li>Nghi\u00ean c\u1ee9u \u0111\u0103ng tr\u00ean PMC (PubMed Central). <em>Physical events occurring during the cryopreservation of immortalized human T cells<\/em>. Truy c\u1eadp t\u1eeb <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6532914\/\">pmc.ncbi.nlm.nih.gov\/articles\/PMC6532914<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>T\u1ee7 \u0111\u00f4ng -80\u00b0C c\u00f3 th\u1ec3 &#8220;\u0111\u1ee7 l\u1ea1nh&#8221; v\u1edbi DNA hay protein, nh\u01b0ng v\u1edbi t\u1ebf b\u00e0o s\u1ed1ng d\u00f9ng trong Cell Therapy, Biobank hay IVF th\u00ec ng\u01b0\u1ee1ng nhi\u1ec7t \u0111\u1ed9 n\u00e0y l\u1ea1i kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 b\u1ea3o to\u00e0n ch\u1ee9c n\u0103ng s\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o v\u1ec1 l\u00e2u d\u00e0i. 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