{"id":4178,"date":"2024-02-25T09:48:00","date_gmt":"2024-02-25T09:48:00","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/pcr-machines-laboratory\/"},"modified":"2025-09-29T13:59:58","modified_gmt":"2025-09-29T06:59:58","slug":"may-pcr-phong-thi-nghiem","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/en\/blog\/pcr-machines-laboratory\/","title":{"rendered":"PCR machines &amp; what you need to know before investing in equipment"},"content":{"rendered":"<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">The first commercial PCR (Polymerase Chain Reaction) machine was developed just a few years after Kary Mullis won the Nobel Prize in 1983 for his invention of the polymerase chain reaction. The PCR machine revolutionized the process by automating what was once a labor-intensive procedure for scientists.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Although commonly referred to as a machine for nucleic acid amplification in samples, the controlled heating and cooling in the thermal cycler PCR machine can be used in various applications, such as DNA sequencing, cloning, gene expression studies, etc. When choosing a PCR machine for the laboratory, it is essential to carefully review the device&#8217;s specifications and identify the actual applications that you plan to use. <i>TurboCycler 2 PCR machine \u2013 durable, with 7-inch touchscreen &amp; remote control<\/i><\/span><\/p>\n<figure class=\"image\">\n<p><div id=\"attachment_6369\" style=\"width: 1432px\" class=\"wp-caption alignnone\"><img fetchpriority=\"high\" decoding=\"async\" aria-describedby=\"caption-attachment-6369\" class=\"wp-image-6369 size-full\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/May-PCR-TurboCycler-2-ben-bi-dieu-khien-tu-xa-1.png\" alt=\"\" width=\"1422\" height=\"800\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/May-PCR-TurboCycler-2-ben-bi-dieu-khien-tu-xa-1.png 1422w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/May-PCR-TurboCycler-2-ben-bi-dieu-khien-tu-xa-1-300x169.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/May-PCR-TurboCycler-2-ben-bi-dieu-khien-tu-xa-1-1024x576.png 1024w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/May-PCR-TurboCycler-2-ben-bi-dieu-khien-tu-xa-1-768x432.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/May-PCR-TurboCycler-2-ben-bi-dieu-khien-tu-xa-1-600x338.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/May-PCR-TurboCycler-2-ben-bi-dieu-khien-tu-xa-1-90x51.png 90w\" sizes=\"(max-width: 1422px) 100vw, 1422px\" \/><p id=\"caption-attachment-6369\" class=\"wp-caption-text\">TurboCycler 2 PCR machine \u2013 durable, with 7-inch touchscreen &amp; remote control<\/p><\/div><\/figure>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/pcr-machines-laboratory\/#Laboratory_PCR_machine_functions\" >Laboratory PCR machine functions&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/pcr-machines-laboratory\/#Blue-ray_Biotech_PCR_machine_and_continuous_improvements\" >Blue-ray Biotech PCR machine and continuous improvements&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/pcr-machines-laboratory\/#Applications_of_PCR_machines_in_virus_detection_and_medical_diagnosis\" >Applications of PCR machines in virus detection and medical diagnosis&nbsp;<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Laboratory_PCR_machine_functions\"><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 20pt;\"><strong>Laboratory PCR machine functions<\/strong><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 16pt;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">PCR machines are essential equipment used daily in molecular biology labs. When purchasing a new PCR machine, scientists should prioritize stability and durability. According to Jeffrey Lai, Product Supervisor at Blue-ray Biotech: &#8220;Today&#8217;s PCR machines must serve as workhorses in the molecular biology lab, not just fancy gadgets.&#8221; Therefore, aside from determining the practical application, laboratories should also focus on the machine&#8217;s longevity and reliability when selecting.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">PCR machines are designed to cycle a sample through a range of temperatures within a specified time frame. Users can program the device to switch between multiple incubation temperatures, each maintained for a set period, and then repeat this cycle for the desired number of cycles. As Jeffrey Lai shared, the temperature and time can be complexly configured according to the scientist&#8217;s technical requirements.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">As scientists develop new methods, thermal cycler PCR machines become increasingly involved in more research processes. For example, PCR machines can be used in CRISPR-Cas9 gene editing technology. Jeffrey Lai also points out that PCR machines can be used for reactions that require precise incubation temperatures, such as enzyme kinetics reactions.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Emerging challenges in science and healthcare worldwide are driving scientists to expand the use of thermal cycler PCR machines. New scientific methods and advanced PCR machines are combined to offer new ways to utilize these devices.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Blue-ray_Biotech_PCR_machine_and_continuous_improvements\"><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 20pt;\"><strong>Blue-ray Biotech PCR machine and continuous improvements<\/strong><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 16pt;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">It has been 37 years since the first commercial PCR machine was introduced\u2014an advanced technology. However, PCR machines still require continuous improvements to meet modern research needs better. Jeffrey Lai recounts: &#8220;The first major improvement was how they changed the incubation temperature. Early PCR machines included multiple components to create different temperatures. The sample was moved from one component to another to create the cycling effect. In the 1980s, using compressors and heating elements led to PCR machines that could heat and cool the sample at the same location. Later, thermal cyclers using Peltier technology replaced compressors and heating elements for incubation, reducing the size and power consumption of PCR machines.&#8221; Currently, PCR machine manufacturers, including Blue-ray Biotech, continue using Peltier technology.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">However, PCR machines are still being further improved. Some improvements include faster heating and cooling speeds. The rate of temperature increase can reach up to 10\u00b0C\/second, and some models can even reach up to 20\u00b0C\/second by using specialized incubation blocks and reaction tubes. This significantly reduces the time it takes to complete PCR experiments.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Modern thermal cycler PCR machines also offer more precise and consistent temperatures. Temperature control accuracy can be as small as \u00b10.1\u00b0C, and the temperature change on incubation blocks can be as small as \u00b10.2\u00b0C. This ensures that experiments are conducted under well-controlled conditions, reducing the likelihood of errors.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">However, maximizing the fast heating and cooling capabilities of PCR machines is not always necessary. In some applications, slow temperature changes are the most important. For example, with CRISPR-Cas9, results must be confirmed after gene editing. Some detection methods require incubation temperatures to decrease very slowly, from 85\u00b0C to 25\u00b0C, with a cooling rate of \u00b10.1\u00b0C\/second.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Scientists can even control modern PCR machines remotely via a smartphone. This feature can help scientists decide where to place the PCR machine or make it easier to operate the PCR machine around the clock.<\/span> <a href=\"https:\/\/biogroupvietnam.com\/public\/danh-muc-san-pham\/molecular-biology\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\"><i>Learn more about Blue-ray Biotech thermal cycler PCR machine<\/i><\/span><\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Applications_of_PCR_machines_in_virus_detection_and_medical_diagnosis\"><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 20pt;\"><strong>Applications of PCR machines in virus detection and medical diagnosis<\/strong>&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">The benefits of PCR machines continue to grow. Scientists used real-time PCR machines to measure bacterial growth in cultures. According to their reports, real-time data collection &#8220;significantly simplifies and increases cost-effectiveness in generating bacterial growth curves&#8221; and &#8220;can also monitor bacterial susceptibility to antibiotics, opening up another important application of this PCR technique.&#8221;<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Changing scientific challenges are also expanding the use of thermal cycler PCR machines. One example is the detection of SARS-CoV-2, where PCR machines are used. A group of scientists from the University of California, San Francisco (UCSF) and the UCSF-Abbott Virus Detection and Diagnosis Center demonstrated that the type of PCR machine used in SARS-CoV-2 virus detection tests impacts the detection range.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Other scientists have also explored the use of PCR machines to control this virus. One interesting example is scientists in Mexico using the miniPCR thermal cycler and a microplate reader in a SARS-CoV-2 testing system. These scientists reported that this simple method allows for detecting and amplifying SARS-CoV-2 nucleic acids from approximately ~625 to 2\u00d7105 DNA copies. The accuracy and simplicity of this diagnostic strategy offer a practical and cost-efficient alternative for testing the COVID-19 pandemic, especially in underdeveloped areas where RT-qPCR technology deployment may be limited. The portability, ease of use, and high reproducibility of the miniPCR machine have made it a reliable solution for SARS-CoV-2 detection efforts at COVID-19 control and treatment centers.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">After more than 30 years, PCR machines continue to be a cornerstone in molecular biology labs, from research to diagnostic applications in various fields. As scientists expand the use of PCR machines in disease control, PCR machines prove to be indispensable in projects aimed at improving health and even saving lives. A PCR machine is an essential starting point for operating a practical and professional laboratory. If you need support with laboratory equipment solutions, please get in touch with Biogroup Vietnam for free consultation.<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">&nbsp;<\/span> <span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"> &nbsp;<\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 13.999999999999998pt;\"><strong>Contact for detailed PCR machine advice and other lab solutions:&nbsp;<\/strong>&nbsp;<\/span><\/p>\n<ul>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Website:<\/strong><\/span><a href=\"https:\/\/biogroupvietnam.com\/public\/lien-he\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">&nbsp;<\/span><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\">https:\/\/biogroupvietnam.com\/public\/lien-he<\/span><\/a><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Hotline:<\/strong> +84 963 621 421&nbsp;<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Email:<\/strong>&nbsp;<\/span><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\">info@biogroupvietnam.vn<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The first commercial PCR (Polymerase Chain Reaction) machine was developed just a few years after Kary Mullis won the Nobel Prize in 1983 for his invention of the polymerase chain reaction. The PCR machine revolutionized the process by automating what was once a labor-intensive procedure for scientists. Although commonly referred to as a machine for<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/en\/blog\/pcr-machines-laboratory\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":6365,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PCR machines &amp; what you need to know before investing in equipment<\/title>\n<meta name=\"description\" content=\"The first commercial PCR (Polymerase Chain Reaction) machine was developed just a few years after Kary Mullis won the Nobel Prize in 1983 for his invention of the polymerase chain reaction. 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