{"id":4300,"date":"2025-07-23T13:13:00","date_gmt":"2025-07-23T13:13:00","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/non-animal-research-nih\/"},"modified":"2025-09-29T14:00:19","modified_gmt":"2025-09-29T07:00:19","slug":"nih-dung-tai-tro-nghien-cuu-tren-dong-vat-phuong-phap-thay-the","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/en\/news\/non-animal-research-nih\/","title":{"rendered":"NIH stops funding animal research \u2013 What are new alternative methods?"},"content":{"rendered":"<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">The National Institutes of Health (NIH) has officially announced the cessation of funding for animal testing research. This marks a significant shift in the direction of modern research.<\/span><\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">This is a crucial time for scientists, research organizations, and biotechnology companies to reassess their development strategies. There&#8217;s a stronger focus on investing in non-animal platforms. New research groups can also leverage non-animal testing methods to attract more funding.<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure class=\"image\"><img fetchpriority=\"high\" decoding=\"async\" style=\"aspect-ratio: 2240\/1260;\" src=\"https:\/\/biogroupvietnam.com\/uploads\/NIH-dung-tai-tro-nghien-cuu-tren-dong-vat-7.jpg\" alt=\"NIH stops funding animal research\" width=\"2240\" height=\"1260\" \/><figcaption><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><i>NIH stops funding animal research<\/i><\/span><\/figcaption><\/figure>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/en\/news\/non-animal-research-nih\/#Limitations_of_animal_testing\" >Limitations of animal testing&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/en\/news\/non-animal-research-nih\/#NIH_funding_policy_encouraging_non-animal_testing\" >NIH funding policy encouraging non-animal testing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/en\/news\/non-animal-research-nih\/#Alternative_testing_solution_%E2%80%93_STEMdiff%E2%84%A2\" >Alternative testing solution \u2013 STEMdiff\u2122&nbsp;<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Limitations_of_animal_testing\"><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 20pt;\">Limitations of animal testing&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Animal-based biomedical research has been a longstanding tradition, contributing significantly to the development of treatments and drugs. However, there are still many limitations:&nbsp;<\/span><\/p>\n<ul>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Lack of accuracy:&nbsp;<\/strong>Animal models frequently fail to reflect the impact of drugs on the human body accurately.<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>High cost and time consumption:&nbsp;<\/strong>Animal testing requires extensive preparation and monitoring.<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Ethical concerns:&nbsp;<\/strong>The use of animals in biomedical research is increasingly criticized due to ethical issues related to testing on living beings.&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">These limitations have prompted large organizations, such as the NIH, and researchers to quickly seek alternative methods to optimize research and ensure humane practices.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"NIH_funding_policy_encouraging_non-animal_testing\"><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 20pt;\">NIH funding policy encouraging non-animal testing<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Given the persistent limitations of animal testing, the NIH has decided to stop funding studies that rely solely on animal models and encourages the development of more sustainable alternative solutions.<\/span><\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">According to Drug Discovery &amp; Development (July 2024), this decision reflects a broader trend of promoting modern alternatives, such as 3D models, organoids, organ-on-a-chip technologies, and AI-based simulation platforms. These aim to improve accuracy, reduce costs, and, in particular, minimize reliance on animals in research.<\/span><\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">This also directly responds to the FDA Modernization Act 2.0, passed by the U.S. Congress in 2022, which removed the mandatory requirement for animal testing before clinical trials in humans. Instead, the law encourages the use of more appropriate alternatives with better potential for predicting efficacy and safety.<\/span><\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">The NIH&#8217;s decision to stop funding animal-only research is expected to:&nbsp;&nbsp;<\/span><\/p>\n<ul>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Promote the advancement of biotechnology,&nbsp;<\/strong>particularly in disease modeling and drug development.&nbsp;&nbsp;<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Reduce costs and time<\/strong> in the pharmaceutical research and development process.&nbsp;&nbsp;<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Improve ethics<\/strong> in preclinical research.&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">However, the NIH emphasizes that it is not eliminating animal research but is prioritizing studies that integrate human models or alternative methods to increase the transferability of results to clinical settings. This trend has made non-animal research solutions the focal point for many biotechnology companies.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Alternative_testing_solution_%E2%80%93_STEMdiff%E2%84%A2\"><\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 20pt;\">Alternative testing solution \u2013 STEMdiff\u2122&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">With the change in NIH funding policy, STEMCELL Technologies offers alternative animal models, notably the STEMdiff\u2122 platform, which differentiates stem cells into specific cell lines and organoid models. This product line enables the creation of organoids derived from iPSC or ESC cells, representing organs such as the brain, intestine, liver, and lungs, thereby simulating the real biological environments found in the human body.<\/span><\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Each STEMdiff\u2122 kit comes with detailed, easy-to-follow instructions to standardize the differentiation process. They are particularly useful when working with gene-edited or patient-derived hPSC cell lines, allowing for the generation of homogeneous cell types with the same genotype. This system is compatible with cell maintenance media, such as TeSR\u2122, and is part of a comprehensive solution for human stem cell culture and differentiation.<\/span><\/p>\n<p><a href=\"https:\/\/www.stemcell.com\/products\/brands\/stemdiff-hpsc-esc-ipsc-differentiation.html\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\"><i>&gt;&gt; See details: STEMdiff\u2122 Pluripotent Stem Cell Differentiation Media<\/i><\/span><\/a><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><i>&nbsp;<\/i><\/span><\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 16pt;\"><strong>Key advantages of STEMdiff\u2122:&nbsp;<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Minimizing errors in experiments:&nbsp;<\/strong>STEMdiff\u2122 culture media are optimized under strict quality control systems, reducing variability between differentiations and across cell lines.<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Compatibility with multiple ES and iPS cell lines:&nbsp;<\/strong>STEMdiff\u2122 efficiently differentiates various ES and iPS cell lines, offering great flexibility in research and preclinical applications.<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Standardized differentiation of cells from three germ layers:&nbsp;<\/strong>With simple kits, differentiating cells into ectoderm, mesoderm, and endoderm-derived lines becomes easier, laying the groundwork for specialized research models, such as organoids.<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"><strong>Creation and storage of progenitor cells:&nbsp;<\/strong>STEMdiff supports the creation and cryopreservation of progenitor cell lines, providing researchers with more control over experimental design. It also saves time and ensures consistent cell sources for subsequent differentiation steps as required by the research.<\/span><\/li>\n<\/ul>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">With the NIH&#8217;s strong shift towards non-animal testing methods, this presents a great opportunity for researchers and organizations to adopt more ethical and effective approaches. Products like STEMdiff\u2122 by STEMCELL Technologies are ideal solutions to replace traditional animal models.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Biogroup Vietnam is a strategic distribution partner of STEMCELL Technologies in Vietnam. If you need advice on non-animal research solutions or further information, we are always ready to assist.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\"> &nbsp;<\/span><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 13.999999999999998pt;\"><strong>Contact our expert:<\/strong>&nbsp;&nbsp;<\/span><\/p>\n<ul>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Website:<\/span><a href=\"https:\/\/biogroupvietnam.com\/public\/lien-he\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">&nbsp;<\/span><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\">https:\/\/biogroupvietnam.com\/public\/lien-he<\/span><\/a><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">&nbsp;&nbsp;<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Hotline: +84 963 621 421&nbsp;<\/span><\/li>\n<li><span style=\"background-color: transparent; color: #000000; font-family: Arial,sans-serif; font-size: 12pt;\">Email:&nbsp;<\/span><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\">infor@biogroupvietnam.com&nbsp;<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/biogroupvietnam.com\/bai-viet\/stemprep-tissue-dissociator\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\"><i>&gt;&gt; Related article: \u201cSTEMprep\u2122 Tissue Dissociator \u2013 Simplifying the tissue processing workflow<\/i><\/span><\/a><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\"><i>\u201d<\/i><\/span><\/p>\n<p><a href=\"https:\/\/biogroupvietnam.com\/public\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"background-color: transparent; color: #1155cc; font-family: Arial,sans-serif; font-size: 12pt;\"><i>&gt;&gt; Explore more about STEMCELL Technologies products<\/i><\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The National Institutes of Health (NIH) has officially announced the cessation of funding for animal testing research. 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