{"id":4435,"date":"2025-03-04T08:02:09","date_gmt":"2025-03-04T08:02:09","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/service\/understanding-nk-cell-biology-for-harnessing-nk-cell-therapies-targeting-cancer-and-beyond\/"},"modified":"2025-09-29T13:07:45","modified_gmt":"2025-09-29T06:07:45","slug":"hieu-biet-ve-sinh-hoc-te-bao-nk-de-phat-trien-lieu-phap-huong-toi-dieu-tri-ung-thu-va-hon-the-nua","status":"publish","type":"service","link":"https:\/\/biogroupvietnam.com\/en\/service\/understanding-nk-cell-biology-for-harnessing-nk-cell-therapies-targeting-cancer-and-beyond\/","title":{"rendered":"Understanding NK Cell Biology For Harnessing NK Cell Therapies: Targeting Cancer and Beyond"},"content":{"rendered":"

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, there are several limitations that need to be addressed to target more cancer types. <\/p>\n

Natural killer (NK) cells are a type of innate immune cells that represent a unique biology in cancer immune surveillance. In particular, NK cells obtained from heathy donors can serve as a source for genetically engineered immune cell therapies. Therefore, NK-based therapies, including NK cells, CAR-NK cells, and antibodies that induce antibody-dependent cellular cytotoxicity of NK cells, have emerged. <\/p>\n

With recent advances in genetic engineering and cell biology techniques, NK cell-based therapies have become promising approaches for a wide range of cancers, viral infections, and senescence. This review provides a brief overview of NK cell characteristics and summarizes diseases that could benefit from NK-based therapies. In addition, we discuss recent preclinical and clinical investigations on the use of adoptive NK cell transfer and agents that can modulate NK cell activity.<\/p>\n

Source:<\/strong><\/p>\n

[1] Shin, E., Bak, S. H., Park, T., Kim, J. W., Yoon, S. R., Jung, H., & Noh, J. Y. (2023). Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond.\u202fFrontiers in Immunology<\/i>,\u202f14<\/i>, 1192907. <\/p>\n

[2] Chu, J., Gao, F., Yan, M., Zhao, S., Yan, Z., Shi, B., & Liu, Y. (2022). Natural killer cells: a promising immunotherapy for cancer.\u202fJournal of translational medicine<\/i>,\u202f20<\/i>(1), 240. 
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