{"id":11301,"date":"2026-06-21T11:13:56","date_gmt":"2026-06-21T04:13:56","guid":{"rendered":"https:\/\/biogroupvietnam.com\/?p=11301"},"modified":"2026-06-21T11:14:56","modified_gmt":"2026-06-21T04:14:56","slug":"dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/","title":{"rendered":"\u0110\u00e2u l\u00e0 c\u00e1ch b\u1ea3o qu\u1ea3n exosome t\u1ed1i \u01b0u cho quy m\u00f4 s\u1ea3n xu\u1ea5t?"},"content":{"rendered":"\n<p>Sau khi tinh s\u1ea1ch exosome, \u0111i\u1ec1u g\u00ec x\u1ea3y ra ti\u1ebfp theo? \u1ede quy m\u00f4 s\u1ea3n xu\u1ea5t, b\u01b0\u1edbc b\u1ea3o qu\u1ea3n v\u00e0 ho\u00e0n thi\u1ec7n th\u00e0nh ph\u1ea9m s\u1ebd quy\u1ebft \u0111\u1ecbnh l\u1edbn \u0111\u1ebfn t\u00ednh \u1ed5n \u0111\u1ecbnh, v\u1eadn chuy\u1ec3n v\u00e0 kh\u1ea3 n\u0103ng m\u1edf r\u1ed9ng s\u1ea3n xu\u1ea5t.<\/p>\n\n\n\n<p>\u1ede giai \u0111o\u1ea1n R&amp;D, exosome th\u01b0\u1eddng \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u1edf 2\u20138\u00b0C trong th\u1eddi gian ng\u1eafn ho\u1eb7c \u0111\u00f4ng l\u1ea1nh s\u00e2u \u1edf -80\u00b0C. Tuy nhi\u00ean, khi quy tr\u00ecnh m\u1edf r\u1ed9ng sang pilot-scale ho\u1eb7c h\u01b0\u1edbng t\u1edbi s\u1ea3n xu\u1ea5t, c\u00e1c y\u00eau c\u1ea7u v\u1ec1 cold chain, logistics, th\u1eddi gian l\u01b0u tr\u1eef, t\u00ednh nh\u1ea5t qu\u00e1n sau ho\u00e0n nguy\u00ean v\u00e0 ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng sau b\u1ea3o qu\u1ea3n tr\u1edf th\u00e0nh nh\u1eefng r\u00e0o c\u1ea3n quan tr\u1ecdng. C\u00f4ng ngh\u1ec7 \u0111\u00f4ng kh\u00f4 exosome \u0111ang \u0111\u01b0\u1ee3c quan t\u00e2m nh\u01b0 m\u1ed9t h\u01b0\u1edbng ti\u1ebfp c\u1eadn ti\u1ec1m n\u0103ng \u0111\u1ec3 t\u0103ng t\u00ednh \u1ed5n \u0111\u1ecbnh, \u0111\u01a1n gi\u1ea3n h\u00f3a \u0111i\u1ec1u ki\u1ec7n v\u1eadn chuy\u1ec3n v\u00e0 h\u1ed7 tr\u1ee3 qu\u00e1 tr\u00ecnh th\u01b0\u01a1ng m\u1ea1i h\u00f3a s\u1ea3n ph\u1ea9m EVs\/Exosome.<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">M\u1ee5c l\u1ee5c<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/#Nhung_thach_thuc_hien_tai_khi_bao_quan_exosome_o_quy_mo_san_xuat\" >Nh\u1eefng th\u00e1ch th\u1ee9c hi\u1ec7n t\u1ea1i khi b\u1ea3o qu\u1ea3n exosome \u1edf quy m\u00f4 s\u1ea3n xu\u1ea5t<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/#Cold_chain\" >Cold chain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/#Logistics\" >Logistics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/#Storage\" >Storage<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/#Cong_nghe_chiet_rot_va_dong_kho_trong_bao_quan_exosome\" >C\u00f4ng ngh\u1ec7 chi\u1ebft r\u00f3t v\u00e0 \u0111\u00f4ng kh\u00f4 trong b\u1ea3o qu\u1ea3n exosome<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/#Vi_sao_dong_kho_exosome_duoc_quan_tam\" >V\u00ec sao \u0111\u00f4ng kh\u00f4 exosome \u0111\u01b0\u1ee3c quan t\u00e2m?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/#Tu_tinh_sach_den_thanh_pham_dong_kho\" >T\u1eeb tinh s\u1ea1ch \u0111\u1ebfn th\u00e0nh ph\u1ea9m \u0111\u00f4ng kh\u00f4<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhung_thach_thuc_hien_tai_khi_bao_quan_exosome_o_quy_mo_san_xuat\"><\/span><strong>Nh\u1eefng th\u00e1ch th\u1ee9c hi\u1ec7n t\u1ea1i khi b\u1ea3o qu\u1ea3n exosome \u1edf quy m\u00f4 s\u1ea3n xu\u1ea5t<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cold_chain\"><\/span>Cold chain<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>B\u1ea3o qu\u1ea3n l\u1ea1nh s\u00e2u, \u0111\u1eb7c bi\u1ec7t \u1edf -80\u00b0C, \u0111\u00f2i h\u1ecfi h\u1ec7 th\u1ed1ng t\u1ee7 \u0111\u00f4ng, thi\u1ebft b\u1ecb gi\u00e1m s\u00e1t nhi\u1ec7t \u0111\u1ed9, quy tr\u00ecnh c\u1ea3nh b\u00e1o v\u00e0 ph\u01b0\u01a1ng \u00e1n d\u1ef1 ph\u00f2ng. V\u1edbi quy m\u00f4 nh\u1ecf, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c. Nh\u01b0ng khi s\u1ed1 l\u01b0\u1ee3ng vial t\u0103ng l\u00ean, cold chain tr\u1edf th\u00e0nh m\u1ed9t ph\u1ea7n chi ph\u00ed v\u00e0 r\u1ee7i ro v\u1eadn h\u00e0nh \u0111\u00e1ng k\u1ec3.<\/p>\n\n\n\n<p>Kh\u00f4ng ch\u1ec9 c\u1ea7n duy tr\u00ec nhi\u1ec7t \u0111\u1ed9 trong kho, \u0111\u01a1n v\u1ecb s\u1ea3n xu\u1ea5t c\u00f2n ph\u1ea3i ki\u1ec3m so\u00e1t nhi\u1ec7t \u0111\u1ed9 trong qu\u00e1 tr\u00ecnh v\u1eadn chuy\u1ec3n, b\u00e0n giao, l\u01b0u kho trung gian v\u00e0 s\u1eed d\u1ee5ng cu\u1ed1i c\u00f9ng. B\u1ea5t k\u1ef3 \u0111i\u1ec3m \u0111\u1ee9t g\u00e3y n\u00e0o trong chu\u1ed7i l\u1ea1nh \u0111\u1ec1u c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u0111\u1ed9 tin c\u1eady c\u1ee7a s\u1ea3n ph\u1ea9m.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Logistics\"><\/span>Logistics<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Khi exosome \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n d\u1ea1ng dung d\u1ecbch ho\u1eb7c \u0111\u00f4ng l\u1ea1nh s\u00e2u, v\u1eadn chuy\u1ec3n kh\u00f4ng c\u00f2n l\u00e0 thao t\u00e1c \u201c\u0111\u00f3ng g\u00f3i v\u00e0 g\u1eedi \u0111i\u201d. Quy tr\u00ecnh c\u1ea7n th\u00f9ng v\u1eadn chuy\u1ec3n chuy\u00ean d\u1ee5ng, \u0111\u00e1 kh\u00f4 ho\u1eb7c v\u1eadt li\u1ec7u l\u00e0m l\u1ea1nh, th\u1eddi gian giao nh\u1eadn ng\u1eafn, theo d\u00f5i nhi\u1ec7t \u0111\u1ed9 v\u00e0 k\u1ebf ho\u1ea1ch x\u1eed l\u00fd khi ph\u00e1t sinh ch\u1eadm tr\u1ec5.<\/p>\n\n\n\n<p>\u0110\u1ed1i v\u1edbi c\u00e1c \u0111\u01a1n v\u1ecb \u0111ang ph\u00e1t tri\u1ec3n exosome h\u01b0\u1edbng t\u1edbi \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng, logistics l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a b\u00e0i to\u00e1n scale-up, kh\u00f4ng ch\u1ec9 l\u00e0 v\u1ea5n \u0111\u1ec1 h\u1eadu c\u1ea7n.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage\"><\/span>Storage<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>L\u01b0u tr\u1eef d\u00e0i h\u1ea1n \u0111\u00f2i h\u1ecfi \u1ed5n \u0111\u1ecbnh c\u1ea5u tr\u00fac, duy tr\u00ec n\u1ed3ng \u0111\u1ed9 h\u1ea1t, h\u1ea1n ch\u1ebf k\u1ebft t\u1ee5 v\u00e0 \u0111\u1ea3m b\u1ea3o kh\u1ea3 n\u0103ng ho\u00e0n nguy\u00ean sau b\u1ea3o qu\u1ea3n. M\u1ed9t s\u1ed1 t\u1ed5ng quan cho th\u1ea5y vi\u1ec7c b\u1ea3o qu\u1ea3n EVs ph\u1ee5 thu\u1ed9c nhi\u1ec1u v\u00e0o ngu\u1ed3n m\u1eabu, dung d\u1ecbch n\u1ec1n, ph\u01b0\u01a1ng ph\u00e1p tinh s\u1ea1ch v\u00e0 ch\u1ea5t b\u1ea3o v\u1ec7; v\u00ec v\u1eady kh\u00f4ng c\u00f3 m\u1ed9t \u0111i\u1ec1u ki\u1ec7n l\u01b0u tr\u1eef duy nh\u1ea5t ph\u00f9 h\u1ee3p cho m\u1ecdi lo\u1ea1i exosome.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cong_nghe_chiet_rot_va_dong_kho_trong_bao_quan_exosome\"><\/span><strong>C\u00f4ng ngh\u1ec7 chi\u1ebft r\u00f3t v\u00e0 \u0111\u00f4ng kh\u00f4 trong b\u1ea3o qu\u1ea3n exosome<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Exosome l\u00e0 c\u1ea5u tr\u00fac m\u00e0ng lipid k\u00edch th\u01b0\u1edbc nano, nh\u1ea1y v\u1edbi \u0111i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n, chu k\u1ef3 \u0111\u00f4ng\u2013r\u00e3 \u0111\u00f4ng, bi\u1ebfn \u0111\u1ed9ng nhi\u1ec7t \u0111\u1ed9 v\u00e0 th\u00e0nh ph\u1ea7n dung d\u1ecbch n\u1ec1n. V\u00ec v\u1eady, n\u1ebfu b\u01b0\u1edbc sau tinh s\u1ea1ch kh\u00f4ng \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf t\u1ed1t, ch\u1ea5t l\u01b0\u1ee3ng exosome c\u00f3 th\u1ec3 thay \u0111\u1ed5i tr\u01b0\u1edbc khi \u0111\u1ebfn giai \u0111o\u1ea1n s\u1eed d\u1ee5ng, nghi\u00ean c\u1ee9u ti\u1ebfp theo ho\u1eb7c ph\u00e1t tri\u1ec3n s\u1ea3n ph\u1ea9m.<\/p>\n\n\n\n<p>\u0110\u00e2y l\u00e0 l\u00fd do c\u00f4ng ngh\u1ec7 <strong>chi\u1ebft r\u00f3t v\u00e0 \u0111\u00f3ng n\u1eafp<\/strong> (<strong>filling &amp; capping<\/strong><strong>) <\/strong>c\u00f9ng<strong> \u0111\u00f4ng kh\u00f4 (lyophilization<\/strong><strong>)<\/strong> tr\u1edf th\u00e0nh hai c\u00f4ng \u0111o\u1ea1n then ch\u1ed1t trong qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i t\u1eeb m\u1eabu tinh s\u1ea1ch sang th\u00e0nh ph\u1ea9m exosome c\u00f3 th\u1ec3 l\u01b0u tr\u1eef, v\u1eadn chuy\u1ec3n v\u00e0 ho\u00e0n nguy\u00ean theo quy tr\u00ecnh chu\u1ea9n h\u00f3a.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y c\u0169ng xem lyophilization l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p n\u1ed5i b\u1eadt nh\u1eb1m v\u01b0\u1ee3t qua m\u1ed9t s\u1ed1 gi\u1edbi h\u1ea1n c\u1ee7a b\u1ea3o qu\u1ea3n pha l\u1ecfng truy\u1ec1n th\u1ed1ng; khi k\u1ebft h\u1ee3p ch\u1ea5t b\u1ea3o v\u1ec7 ph\u00f9 h\u1ee3p, ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 th\u1ec3 gi\u00fap duy tr\u00ec k\u00edch th\u01b0\u1edbc, h\u00ecnh th\u00e1i, h\u00e0m l\u01b0\u1ee3ng protein v\u00e0 ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a EVs trong m\u1ed9t s\u1ed1 m\u00f4 h\u00ecnh nghi\u00ean c\u1ee9u.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vi_sao_dong_kho_exosome_duoc_quan_tam\"><\/span><strong>V\u00ec sao \u0111\u00f4ng kh\u00f4 exosome \u0111\u01b0\u1ee3c quan t\u00e2m?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>V\u1ec1 b\u1ea3n ch\u1ea5t, \u0111\u00f4ng kh\u00f4 l\u00e0 qu\u00e1 tr\u00ecnh lo\u1ea1i n\u01b0\u1edbc kh\u1ecfi m\u1eabu th\u00f4ng qua \u0111\u00f4ng l\u1ea1nh, th\u0103ng hoa v\u00e0 s\u1ea5y th\u1ee9 c\u1ea5p d\u01b0\u1edbi \u0111i\u1ec1u ki\u1ec7n ch\u00e2n kh\u00f4ng, nh\u1eb1m t\u1ea1o ra s\u1ea3n ph\u1ea9m kh\u00f4 c\u00f3 th\u1ec3 ho\u00e0n nguy\u00ean tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/p>\n\n\n\n<p>V\u1edbi exosome, gi\u00e1 tr\u1ecb c\u1ee7a \u0111\u00f4ng kh\u00f4 n\u1eb1m \u1edf ba \u0111i\u1ec3m ch\u00ednh:<\/p>\n\n\n\n<p>Th\u1ee9 nh\u1ea5t, <strong>t\u0103ng t\u00ednh \u1ed5n \u0111\u1ecbnh<\/strong>. Khi \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u v\u1edbi ch\u1ea5t b\u1ea3o v\u1ec7 ph\u00f9 h\u1ee3p nh\u01b0 trehalose, sucrose ho\u1eb7c c\u00e1c t\u00e1 d\u01b0\u1ee3c kh\u00e1c, \u0111\u00f4ng kh\u00f4 c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m stress m\u1ea5t n\u01b0\u1edbc, h\u1ea1n ch\u1ebf k\u1ebft t\u1ee5 v\u00e0 h\u1ed7 tr\u1ee3 duy tr\u00ec c\u1ea5u tr\u00fac m\u00e0ng phospholipid c\u1ee7a EVs.<\/p>\n\n\n\n<p>Th\u1ee9 hai, <strong>d\u1ec5 v\u1eadn chuy\u1ec3n h\u01a1n so v\u1edbi m\u1eabu ph\u1ee5 thu\u1ed9c ho\u00e0n to\u00e0n v\u00e0o \u0111\u00f4ng l\u1ea1nh s\u00e2u<\/strong>. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u v\u1ec1 EVs ch\u1ec9 ra r\u1eb1ng ph\u1ee5 thu\u1ed9c v\u00e0o cold chain l\u00e0 g\u00e1nh n\u1eb7ng v\u1ec1 logistics v\u00e0 chi ph\u00ed, trong khi c\u00f4ng th\u1ee9c \u0111\u00f4ng kh\u00f4 c\u00f3 ti\u1ec1m n\u0103ng h\u1ed7 tr\u1ee3 l\u01b0u tr\u1eef \u1edf \u0111i\u1ec1u ki\u1ec7n thu\u1eadn ti\u1ec7n h\u01a1n t\u00f9y theo c\u00f4ng th\u1ee9c v\u00e0 d\u1eef li\u1ec7u \u1ed5n \u0111\u1ecbnh c\u1ee5 th\u1ec3.<\/p>\n\n\n\n<p>Th\u1ee9 ba, <strong>h\u1ed7 tr\u1ee3 th\u01b0\u01a1ng m\u1ea1i h\u00f3a v\u00e0 ti\u00eau chu\u1ea9n h\u00f3a s\u1ea3n ph\u1ea9m<\/strong>. D\u1ea1ng vial \u0111\u00f4ng kh\u00f4 gi\u00fap s\u1ea3n ph\u1ea9m d\u1ec5 \u0111\u01b0\u1ee3c qu\u1ea3n l\u00fd theo l\u00f4, d\u1ec5 ki\u1ec3m tra ngo\u1ea1i quan, \u0111\u1ed9 \u1ea9m d\u01b0, th\u1eddi gian ho\u00e0n nguy\u00ean, k\u00edch th\u01b0\u1edbc h\u1ea1t sau ho\u00e0n nguy\u00ean v\u00e0 c\u00e1c ch\u1ec9 ti\u00eau QC kh\u00e1c.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Ti\u00eau ch\u00ed<\/strong><\/td><td><strong>\u0110\u00f4ng kh\u00f4<\/strong><\/td><td><strong>\u0110\u00f4ng l\u1ea1nh -80\u00b0C<\/strong><\/td><\/tr><tr><td>\u0110i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n<\/td><td>2\u20138\u00b0C \/ nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng<\/td><td>-80\u00b0C li\u00ean t\u1ee5c<\/td><\/tr><tr><td>V\u1eadn chuy\u1ec3n<\/td><td>2\u20138\u00b0C, chi ph\u00ed th\u1ea5p<\/td><td>\u0110\u00e1 kh\u00f4: \u0111\u1eaft &amp; ph\u1ee9c t\u1ea1p<\/td><\/tr><tr><td>\u0110\u1ed9 b\u1ec1n<\/td><td>Cao, \u1ed5n \u0111\u1ecbnh<\/td><td>Gi\u1ea3m ho\u1ea1t t\u00ednh sau m\u1ed7i chu k\u00ec tan-\u0111\u00f4ng<\/td><\/tr><tr><td>B\u1ea3o to\u00e0n c\u1ea5u tr\u00fac m\u00e0ng<\/td><td>T\u1ed1t khi l\u1ef1a ch\u1ecdn ch\u1ea5t b\u1ea3o v\u1ec7 ph\u00f9 h\u1ee3p<\/td><td>C\u00f3 nguy c\u01a1 v\u1ee1 m\u00e0ng phospholipid<\/td><\/tr><tr><td>Th\u01b0\u01a1ng m\u1ea1i h\u00f3a &amp; Scale-up<\/td><td>\u0110\u01a1n gi\u1ea3n h\u00f3a, th\u00e0nh ph\u1ea9m ph\u00f9 h\u1ee3p \u201coff-the-shelf\u201d<\/td><td>Kh\u00f3 th\u01b0\u01a1ng m\u1ea1i h\u00f3a quy m\u00f4 l\u1edbn<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Thi\u1ebft b\u1ecb \u0111\u00f4ng kh\u00f4 c\u1ea7n ch\u1ecdn lo\u1ea1i \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf chuy\u00ean bi\u1ec7t nh\u1eb1m \u0111\u00e1p \u1ee9ng nhu c\u1ea7u \u0111\u00f4ng kh\u00f4 cho c\u00e1c m\u1eabu nh\u1ea1y c\u1ea3m v\u1edbi nhi\u1ec7t \u0111\u1ed9 v\u00e0 c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc cao nh\u01b0 exosome, \u0111\u1ea3m b\u1ea3o kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh v\u01b0\u1ee3t tr\u1ed9i. Tr\u00ean th\u1ecb tr\u01b0\u1eddng n\u1ed5i b\u1eadt v\u1edbi TP Gland d\u00e0nh cho EVs, gi\u00fap thu\u1eadn ti\u1ec7n truy xu\u1ea5t d\u1eef li\u1ec7u v\u00e0 ki\u1ec3m so\u00e1t nhi\u1ec7t \u0111\u1ed9 ch\u00ednh x\u00e1c. Qu\u00e1 tr\u00ecnh s\u1ea5y \u0111\u1ed3ng nh\u1ea5t v\u00e0 \u1ed5n \u0111\u1ecbnh; ch\u00eanh l\u1ec7ch nhi\u1ec7t \u0111\u1ed9 trong bu\u1ed3ng s\u1ea5y lu\u00f4n &lt;1\u00b0C.<\/p>\n\n\n\n<p>Tuy nhi\u00ean, \u0111\u00f4ng kh\u00f4 kh\u00f4ng n\u00ean \u0111\u01b0\u1ee3c xem l\u00e0 gi\u1ea3i ph\u00e1p m\u1eb7c \u0111\u1ecbnh t\u1ed1t h\u01a1n -80\u00b0C trong m\u1ecdi tr\u01b0\u1eddng h\u1ee3p. V\u00ec v\u1eady, c\u00e1ch ti\u1ebfp c\u1eadn \u0111\u00fang l\u00e0 thi\u1ebft k\u1ebf \u2013 t\u1ed1i \u01b0u \u2013 ki\u1ec3m \u0111\u1ecbnh quy tr\u00ecnh \u0111\u00f4ng kh\u00f4 theo t\u1eebng ngu\u1ed3n exosome v\u00e0 m\u1ee5c ti\u00eau \u1ee9ng d\u1ee5ng.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tu_tinh_sach_den_thanh_pham_dong_kho\"><\/span><strong>T\u1eeb tinh s\u1ea1ch \u0111\u1ebfn th\u00e0nh ph\u1ea9m \u0111\u00f4ng kh\u00f4<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Biogroup Vietnam cung c\u1ea5p gi\u1ea3i ph\u00e1p ho\u00e0n ch\u1ec9nh trong <strong>s\u1ea3n xu\u1ea5t v\u00e0 chuy\u1ec3n giao quy tr\u00ecnh EVs<\/strong>. \u0110i\u1ec3m quan tr\u1ecdng c\u1ee7a gi\u1ea3i ph\u00e1p kh\u00f4ng ch\u1ec9 n\u1eb1m \u1edf thi\u1ebft b\u1ecb, m\u00e0 \u1edf n\u0103ng l\u1ef1c chuy\u1ec3n giao quy tr\u00ecnh t\u1eeb tinh s\u1ea1ch \u0111\u1ebfn th\u00e0nh ph\u1ea9m \u0111\u00f4ng kh\u00f4: thi\u1ebft k\u1ebf protocol, s\u00e0ng l\u1ecdc ch\u1ea5t b\u1ea3o v\u1ec7, t\u1ed1i \u01b0u \u0111\u01b0\u1eddng cong \u0111\u00f4ng kh\u00f4, \u0111\u00e1nh gi\u00e1 ch\u1ea5t l\u01b0\u1ee3ng sau ho\u00e0n nguy\u00ean v\u00e0 t\u01b0 v\u1ea5n c\u1ea5u h\u00ecnh thi\u1ebft b\u1ecb ph\u00f9 h\u1ee3p v\u1edbi quy m\u00f4 s\u1ea3n xu\u1ea5t t\u1ea1i Vi\u1ec7t Nam.<\/p>\n\n\n\n<p><strong>Thi\u1ebft k\u1ebf protocol: <\/strong>Tinh ch\u1ec9nh bi\u1ec3u \u0111\u1ed3 nhi\u1ec7t \u0111\u1ed9 ri\u00eang bi\u1ec7t (ti\u1ec1n \u0111\u00f4ng, th\u0103ng hoa s\u01a1 c\u1ea5p, s\u1ea5y th\u1ee9 c\u1ea5p) theo t\u1eebng ngu\u1ed3n exosome v\u00e0 th\u1ec3 t\u00edch l\u1ecd c\u1ee7a kh\u00e1ch h\u00e0ng.<\/p>\n\n\n\n<p><strong>S\u00e0ng l\u1ecdc ch\u1ea5t b\u1ea3o v\u1ec7:<\/strong> L\u1ef1a ch\u1ecdn v\u00e0 t\u1ed1i \u01b0u h\u00f3a ch\u1ea5t b\u1ea3o v\u1ec7, b\u1ea3o v\u1ec7 to\u00e0n v\u1eb9n m\u00e0ng phospholipid k\u00e9p, b\u1ea3o to\u00e0n c\u1ea5u tr\u00fac kh\u1ed1i b\u00e1nh v\u00e0 \u0111\u00e1p \u1ee9ng ti\u00eau chu\u1ea9n an to\u00e0n.<\/p>\n\n\n\n<p><strong>Ki\u1ec3m \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng:<\/strong> \u0110\u00e1nh gi\u00e1 to\u00e0n di\u1ec7n sau t\u00e1i ho\u00e0n nguy\u00ean: k\u00edch th\u01b0\u1edbc h\u1ea1t, TEM c\u1ea5u tr\u00fac m\u00e0ng, marker \u0111\u1eb7c hi\u1ec7u, \u0111\u1ed9 \u1ea9m t\u1ed3n d\u01b0 v\u00e0 ch\u1ec9 s\u1ed1 ho\u1ea1t t\u00ednh sinh h\u1ecdc.<\/p>\n\n\n\n<p>V\u1edbi exosome, b\u1ea3o qu\u1ea3n kh\u00f4ng ph\u1ea3i l\u00e0 b\u01b0\u1edbc ph\u1ee5 sau tinh s\u1ea1ch. \u0110\u00e2y l\u00e0 m\u1ed9t ph\u1ea7n quan tr\u1ecdng quy\u1ebft \u0111\u1ecbnh kh\u1ea3 n\u0103ng m\u1edf r\u1ed9ng quy tr\u00ecnh, t\u00ednh \u1ed5n \u0111\u1ecbnh th\u00e0nh ph\u1ea9m v\u00e0 m\u1ee9c \u0111\u1ed9 s\u1eb5n s\u00e0ng cho s\u1ea3n xu\u1ea5t. \u0110\u00f4ng kh\u00f4 exosome \u0111ang m\u1edf ra m\u1ed9t h\u01b0\u1edbng ti\u1ebfp c\u1eadn \u0111\u00e1ng ch\u00fa \u00fd cho c\u00e1c \u0111\u01a1n v\u1ecb mu\u1ed1n gi\u1ea3m ph\u1ee5 thu\u1ed9c v\u00e0o cold chain, t\u1ed1i \u01b0u v\u1eadn chuy\u1ec3n v\u00e0 ph\u00e1t tri\u1ec3n th\u00e0nh ph\u1ea9m d\u1ea1ng vial d\u1ec5 qu\u1ea3n l\u00fd h\u01a1n. Tuy nhi\u00ean, hi\u1ec7u qu\u1ea3 c\u1ee7a \u0111\u00f4ng kh\u00f4 ph\u1ee5 thu\u1ed9c nhi\u1ec1u v\u00e0o ngu\u1ed3n exosome, c\u00f4ng th\u1ee9c b\u1ea3o v\u1ec7, chu tr\u00ecnh \u0111\u00f4ng kh\u00f4 v\u00e0 b\u1ed9 ti\u00eau ch\u00ed QC sau ho\u00e0n nguy\u00ean. Vi\u1ec7c ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c \u0111\u01a1n v\u1ecb chuy\u00ean m\u00f4n s\u1ebd gi\u00fap b\u1ea1n \u0111i \u0111\u00fang h\u01b0\u1edbng ngay t\u1eeb \u0111\u1ea7u.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sau khi tinh s\u1ea1ch exosome, \u0111i\u1ec1u g\u00ec x\u1ea3y ra ti\u1ebfp theo? \u1ede quy m\u00f4 s\u1ea3n xu\u1ea5t, b\u01b0\u1edbc b\u1ea3o qu\u1ea3n v\u00e0 ho\u00e0n thi\u1ec7n th\u00e0nh ph\u1ea9m s\u1ebd quy\u1ebft \u0111\u1ecbnh l\u1edbn \u0111\u1ebfn t\u00ednh \u1ed5n \u0111\u1ecbnh, v\u1eadn chuy\u1ec3n v\u00e0 kh\u1ea3 n\u0103ng m\u1edf r\u1ed9ng s\u1ea3n xu\u1ea5t. \u1ede giai \u0111o\u1ea1n R&amp;D, exosome th\u01b0\u1eddng \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u1edf 2\u20138\u00b0C trong th\u1eddi gian<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dau-la-cach-bao-quan-exosome-toi-uu-cho-quy-mo-san-xuat\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":11302,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u0110\u00e2u l\u00e0 c\u00e1ch b\u1ea3o qu\u1ea3n exosome t\u1ed1i \u01b0u cho quy m\u00f4 s\u1ea3n xu\u1ea5t?<\/title>\n<meta name=\"description\" content=\"\u0110\u00f4ng kh\u00f4 exosome \u0111ang m\u1edf ra m\u1ed9t h\u01b0\u1edbng ti\u1ebfp c\u1eadn \u0111\u00e1ng ch\u00fa \u00fd cho c\u00e1c \u0111\u01a1n v\u1ecb mu\u1ed1n gi\u1ea3m ph\u1ee5 thu\u1ed9c v\u00e0o cold chain, t\u1ed1i \u01b0u v\u1eadn chuy\u1ec3n v\u00e0 ph\u00e1t tri\u1ec3n 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