{"id":11356,"date":"2026-07-20T18:21:17","date_gmt":"2026-07-20T11:21:17","guid":{"rendered":"https:\/\/biogroupvietnam.com\/?p=11356"},"modified":"2026-07-20T18:21:19","modified_gmt":"2026-07-20T11:21:19","slug":"dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/","title":{"rendered":"\u0110i\u1ec1u g\u00ec \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 \u0111\u1ed3ng nh\u1ea5t gi\u1eefa c\u00e1c l\u1ea7n nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o?"},"content":{"rendered":"\n<p>B\u1ea1n c\u00f3 t\u1eebng g\u1eb7p t\u00ecnh hu\u1ed1ng m\u1ed9t d\u00f2ng MSC ph\u00e1t tri\u1ec3n r\u1ea5t t\u1ed1t \u1edf l\u1ea7n nu\u00f4i c\u1ea5y \u0111\u1ea7u ti\u00ean, nh\u01b0ng ch\u1ec9 v\u00e0i tu\u1ea7n sau, d\u00f9 s\u1eed d\u1ee5ng \u0111\u00fang protocol, c\u00f9ng m\u00f4i tr\u01b0\u1eddng v\u00e0 c\u00f9ng ng\u01b0\u1eddi thao t\u00e1c, k\u1ebft qu\u1ea3 l\u1ea1i ho\u00e0n to\u00e0n kh\u00e1c? \u0110\u00e2y l\u00e0 v\u1ea5n \u0111\u1ec1 m\u00e0 h\u1ea7u nh\u01b0 ph\u00f2ng th\u00ed nghi\u1ec7m n\u00e0o c\u0169ng t\u1eebng g\u1eb7p.<\/p>\n\n\n\n<p>Hi\u1ec7n t\u01b0\u1ee3ng thi\u1ebfu \u1ed5n \u0111\u1ecbnh n\u00e0y kh\u00f4ng ch\u1ec9 l\u00e0m ti\u00eau t\u1ed1n th\u1eddi gian v\u00e0 l\u00e3ng ph\u00ed ng\u00e2n s\u00e1ch nghi\u00ean c\u1ee9u m\u00e0 c\u00f2n l\u00e0 t\u00e1c nh\u00e2n ch\u00ednh d\u1eabn \u0111\u1ebfn &#8220;cu\u1ed9c kh\u1ee7ng ho\u1ea3ng \u0111\u1ed9 l\u1eb7p l\u1ea1i &#8211; reproducibility crisis &#8221; trong khoa h\u1ecdc s\u1ef1 s\u1ed1ng, g\u00e2y tr\u1edf ng\u1ea1i l\u1edbn cho qu\u00e1 tr\u00ecnh \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng v\u00e0 s\u1ea3n xu\u1ea5t sinh d\u01b0\u1ee3c ph\u1ea9m. Th\u1ef1c ch\u1ea5t, c\u00e2u tr\u1ea3 l\u1eddi cho s\u1ef1 sai kh\u00e1c n\u00e0y n\u1eb1m \u1edf nh\u1eefng bi\u1ebfn s\u1ed1 c\u1ef1c k\u1ef3 nh\u1ecf nh\u01b0ng mang t\u00ednh quy\u1ebft \u0111\u1ecbnh \u0111\u1ebfn t\u1eeb ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a vi m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y, s\u1ef1 bi\u1ebfn thi\u00ean gi\u1eefa c\u00e1c l\u00f4 s\u1ea3n xu\u1ea5t v\u00e0 c\u00e1c chi ti\u1ebft thao t\u00e1c k\u1ef9 thu\u1eadt th\u01b0\u1eddng b\u1ecb b\u1ecf qua.<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">M\u1ee5c l\u1ee5c<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Protocol_giong_nhau_khong_co_nghia_la_dieu_kien_giong_nhau\" >Protocol gi\u1ed1ng nhau kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 \u0111i\u1ec1u ki\u1ec7n gi\u1ed1ng nhau<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Chat_luong_moi_truong_nuoi_cay_%E2%80%93_Yeu_to_quyet_dinh_tinh_tai_lap\" >Ch\u1ea5t l\u01b0\u1ee3ng m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y \u2013 Y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh t\u00ednh t\u00e1i l\u1eadp<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Moi_truong_co_ban_va_FBS_thanh_phan_gay_bien_dong_lon_nhat\" >M\u00f4i tr\u01b0\u1eddng c\u01a1 b\u1ea3n v\u00e0 FBS th\u00e0nh ph\u1ea7n g\u00e2y bi\u1ebfn \u0111\u1ed9ng l\u1edbn nh\u1ea5t<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Lot-to-Lot_Variation_%E2%80%93_nguyen_nhan_thuong_bi_bo_qua\" >Lot-to-Lot Variation \u2013 nguy\u00ean nh\u00e2n th\u01b0\u1eddng b\u1ecb b\u1ecf qua<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Lot-to-Lot_Variation_anh_huong_nhu_the_nao\" >Lot-to-Lot Variation \u1ea3nh h\u01b0\u1edfng nh\u01b0 th\u1ebf n\u00e0o?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Bao_quan_va_su_dung_hoa_chat_dung_cach\" >B\u1ea3o qu\u1ea3n v\u00e0 s\u1eed d\u1ee5ng h\u00f3a ch\u1ea5t \u0111\u00fang c\u00e1ch<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Nhung_bien_so_ngoai_protocol_anh_huong_den_ket_qua_nuoi_cay\" >Nh\u1eefng bi\u1ebfn s\u1ed1 ngo\u00e0i protocol \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Dieu_kien_moi_truong_nuoi_cay\" >\u0110i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Yeu_to_te_bao_va_thao_tac_cay\" >Y\u1ebfu t\u1ed1 t\u1ebf b\u00e0o v\u00e0 thao t\u00e1c c\u1ea5y<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Thao_tac_va_kiem_soat_nhiem\" >Thao t\u00e1c v\u00e0 ki\u1ec3m so\u00e1t nhi\u1ec5m<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Kiem_soat_chat_luong_te_bao_goc_trong_ung_dung_lam_sang\" >Ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c trong \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Lam_the_nao_de_tang_tinh_tai_lap_cua_ket_qua_nuoi_cay\" >L\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 t\u0103ng t\u00ednh t\u00e1i l\u1eadp c\u1ee7a k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/#Ket_luan_va_khuyen_nghi_hanh_dong\" >K\u1ebft lu\u1eadn v\u00e0 khuy\u1ebfn ngh\u1ecb h\u00e0nh \u0111\u1ed9ng<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Protocol_giong_nhau_khong_co_nghia_la_dieu_kien_giong_nhau\"><\/span><strong>Protocol gi\u1ed1ng nhau kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 \u0111i\u1ec1u ki\u1ec7n gi\u1ed1ng nhau<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>M\u1ed9t protocol ch\u1ec9 quy \u0111\u1ecbnh c\u00e1c b\u01b0\u1edbc th\u1ef1c hi\u1ec7n nh\u01b0 lo\u1ea1i m\u00f4i tr\u01b0\u1eddng, m\u1eadt \u0111\u1ed9 gieo c\u1ea5y hay th\u1eddi gian thay m\u00f4i tr\u01b0\u1eddng. Tuy nhi\u00ean, t\u1ebf b\u00e0o l\u00e0 h\u1ec7 th\u1ed1ng s\u1ed1ng r\u1ea5t nh\u1ea1y c\u1ea3m v\u1edbi nh\u1eefng thay \u0111\u1ed5i nh\u1ecf c\u1ee7a m\u00f4i tr\u01b0\u1eddng.<\/p>\n\n\n\n<p>Kh\u00e1c v\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc thu\u1ea7n t\u00fay, t\u1ebf b\u00e0o s\u1ed1ng li\u00ean t\u1ee5c ph\u1ea3n h\u1ed3i v\u00e0 t\u1ef1 \u0111i\u1ec1u ch\u1ec9nh tr\u1ea1ng th\u00e1i sinh l\u00fd tr\u01b0\u1edbc nh\u1eefng thay \u0111\u1ed5i d\u00f9 l\u00e0 nh\u1ecf nh\u1ea5t c\u1ee7a m\u00f4i tr\u01b0\u1eddng xung quanh. Ch\u1ec9 c\u1ea7n nhi\u1ec7t \u0111\u1ed9 dao \u0111\u1ed9ng nh\u1eb9, pH thay \u0111\u1ed5i ho\u1eb7c n\u1ed3ng \u0111\u1ed9 CO\u2082 kh\u00f4ng \u1ed5n \u0111\u1ecbnh, qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a t\u1ebf b\u00e0o \u0111\u00e3 c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng. Theo h\u01b0\u1edbng d\u1eabn c\u1ee7a ATCC, vi\u1ec7c ki\u1ec3m so\u00e1t \u1ed5n \u0111\u1ecbnh c\u00e1c \u0111i\u1ec1u ki\u1ec7n nu\u00f4i c\u1ea5y v\u00e0 th\u01b0\u1eddng xuy\u00ean ki\u1ec3m tra ch\u1ea5t l\u01b0\u1ee3ng m\u00f4i tr\u01b0\u1eddng l\u00e0 y\u1ebfu t\u1ed1 quan tr\u1ecdng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 l\u1eb7p l\u1ea1i.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chat_luong_moi_truong_nuoi_cay_%E2%80%93_Yeu_to_quyet_dinh_tinh_tai_lap\"><\/span><strong>Ch\u1ea5t l\u01b0\u1ee3ng m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y \u2013 Y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh t\u00ednh t\u00e1i l\u1eadp<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Moi_truong_co_ban_va_FBS_thanh_phan_gay_bien_dong_lon_nhat\"><\/span>M\u00f4i tr\u01b0\u1eddng c\u01a1 b\u1ea3n v\u00e0 FBS th\u00e0nh ph\u1ea7n g\u00e2y bi\u1ebfn \u0111\u1ed9ng l\u1edbn nh\u1ea5t<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y c\u01a1 b\u1ea3n \u0111\u00f3ng vai tr\u00f2 cung c\u1ea5p c\u00e1c ch\u1ea5t dinh d\u01b0\u1ee1ng c\u1ea7n thi\u1ebft \u0111\u1ec3 t\u1ebf b\u00e0o ph\u00e1t tri\u1ec3n v\u00e0 duy tr\u00ec ch\u1ee9c n\u0103ng b\u00ecnh th\u01b0\u1eddng. N\u1ebfu th\u00e0nh ph\u1ea7n dinh d\u01b0\u1ee1ng kh\u00f4ng ph\u00f9 h\u1ee3p, \u0111\u1ed9 pH m\u1ea5t \u1ed5n \u0111\u1ecbnh ho\u1eb7c xu\u1ea5t hi\u1ec7n t\u1ea1p ch\u1ea5t trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t, b\u1ea3o qu\u1ea3n ho\u1eb7c s\u1eed d\u1ee5ng, t\u1ebf b\u00e0o c\u00f3 th\u1ec3 b\u1ecb stress, gi\u1ea3m kh\u1ea3 n\u0103ng t\u0103ng tr\u01b0\u1edfng v\u00e0 d\u1eabn \u0111\u1ebfn k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y kh\u00f4ng nh\u1ea5t qu\u00e1n.<\/p>\n\n\n\n<p>Huy\u1ebft thanh b\u00f2 thai (FBS) t\u1eeb l\u00e2u \u0111\u00e3 \u0111\u01b0\u1ee3c b\u1ed5 sung v\u00e0o m\u00f4i tr\u01b0\u1eddng c\u01a1 b\u1ea3n v\u1edbi t\u1ef7 l\u1ec7 t\u1eeb 5% \u0111\u1ebfn 20% \u0111\u1ec3 cung c\u1ea5p c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng, hormone v\u00e0 protein b\u00e1m d\u00ednh c\u1ea7n thi\u1ebft cho h\u1ea7u h\u1ebft c\u00e1c d\u00f2ng t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa. FBS ch\u1ee9a h\u00e0ng ng\u00e0n ph\u00e2n t\u1eed sinh h\u1ecdc v\u1edbi n\u1ed3ng \u0111\u1ed9 bi\u1ebfn \u0111\u1ed9ng t\u00f9y thu\u1ed9c v\u00e0o xu\u1ea5t x\u1ee9 \u0111\u1ecba l\u00fd c\u1ee7a \u0111\u00e0n b\u00f2, \u0111i\u1ec1u ki\u1ec7n kh\u00ed h\u1eadu, d\u1ecbch b\u1ec7nh, ch\u1ebf \u0111\u1ed9 \u0103n c\u1ee7a b\u00f2 m\u1eb9 v\u00e0 quy tr\u00ecnh thu ho\u1ea1ch m\u00e1u t\u1ea1i c\u00e1c c\u01a1 s\u1edf gi\u1ebft m\u1ed5. S\u1ef1 thi\u1ebfu ti\u00eau chu\u1ea9n h\u00f3a n\u00e0y khi\u1ebfn m\u1ed7i l\u00f4 FBS tr\u1edf th\u00e0nh m\u1ed9t th\u00e0nh ph\u1ea7n sinh h\u1ecdc kh\u00f4ng th\u1ec3 ki\u1ec3m so\u00e1t t\u1eeb \u0111\u00f3 l\u00e0 nguy\u00ean nh\u00e2n d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t gi\u1eefa c\u00e1c l\u00f4 (Lot-to-Lot Variation).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lot-to-Lot_Variation_%E2%80%93_nguyen_nhan_thuong_bi_bo_qua\"><\/span>Lot-to-Lot Variation \u2013 nguy\u00ean nh\u00e2n th\u01b0\u1eddng b\u1ecb b\u1ecf qua<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Lot-to-Lot Variation hay c\u00f2n g\u1ecdi l\u00e0 batch-to-batch variability l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng c\u00e1c l\u00f4 (lot) s\u1ea3n xu\u1ea5t kh\u00e1c nhau c\u1ee7a c\u00f9ng m\u1ed9t s\u1ea3n ph\u1ea9m v\u1eabn c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t nh\u1ea5t \u0111\u1ecbnh v\u1ec1 th\u00e0nh ph\u1ea7n ho\u1eb7c hi\u1ec7u su\u1ea5t, d\u00f9 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t theo c\u00f9ng quy tr\u00ecnh. \u0110i\u1ec1u n\u00e0y \u0111\u1eb7c bi\u1ec7t ph\u1ed5 bi\u1ebfn \u0111\u1ed1i v\u1edbi c\u00e1c s\u1ea3n ph\u1ea9m sinh h\u1ecdc nh\u01b0: Fetal Bovine Serum (FBS); Human Platelet Lysate (HPL); Cytokine; Growth Factor; Extracellular Matrix; M\u1ed9t s\u1ed1 m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y b\u1ed5 sung protein.<\/p>\n\n\n\n<p>Trong m\u1ed9t quy tr\u00ecnh nu\u00f4i c\u1ea5y l\u00fd t\u01b0\u1edfng, m\u1ed7i l\u00f4 s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c xu\u1ea5t x\u01b0\u1edfng ph\u1ea3i ho\u00e0n to\u00e0n \u0111\u1ed3ng nh\u1ea5t \u0111\u1ec3 kh\u00f4ng l\u00e0m thay \u0111\u1ed5i t\u00ednh ch\u1ea5t sinh l\u00fd c\u1ee7a t\u1ebf b\u00e0o hay k\u1ebft qu\u1ea3 sau nu\u00f4i c\u1ea5y. Tuy nhi\u00ean, do t\u00ednh ch\u1ea5t ph\u1ee9c t\u1ea1p c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n serum, protein, hormone, lipid hay c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng v\u00e0 c\u00e1c \u0111i\u1ec1u ki\u1ec7n ch\u1ebf bi\u1ebfn v\u00e0 b\u1ea3o qu\u1ea3n, s\u1ef1 bi\u1ebfn \u0111\u1ed9ng n\u00e0y v\u1eabn x\u1ea3y ra m\u1ed9t c\u00e1ch kh\u00f4ng mong mu\u1ed1n.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lot-to-Lot_Variation_anh_huong_nhu_the_nao\"><\/span>Lot-to-Lot Variation \u1ea3nh h\u01b0\u1edfng nh\u01b0 th\u1ebf n\u00e0o?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>M\u1eb7c d\u00f9 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c l\u00f4 th\u01b0\u1eddng kh\u00f4ng l\u1edbn, nh\u01b0ng \u0111\u1ed1i v\u1edbi t\u1ebf b\u00e0o, nh\u1eefng thay \u0111\u1ed5i nh\u1ecf n\u00e0y v\u1eabn \u0111\u1ee7 t\u1ea1o ra kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3. C\u00e1c ch\u1ea5t b\u1ed5 sung c\u00f3 ngu\u1ed3n g\u1ed1c t\u1ef1 nhi\u00ean c\u00f3 s\u1ef1 bi\u1ebfn \u0111\u1ed9ng r\u1ea5t l\u1edbn v\u1ec1 n\u1ed3ng \u0111\u1ed9 c\u00e1c hormone, protein b\u00e1m d\u00ednh v\u00e0 y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng gi\u1eefa c\u00e1c m\u1ebb thu ho\u1ea1ch. \u0110i\u1ec1u n\u00e0y tr\u1ef1c ti\u1ebfp l\u00e0m bi\u1ebfn \u0111\u1ed5i t\u1ed1c \u0111\u1ed9 nh\u00e2n \u0111\u00f4i, kh\u1ea3 n\u0103ng b\u00e1m d\u00ednh, h\u00ecnh th\u00e1i t\u1ebf b\u00e0o thay \u0111\u1ed5i v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c marker c\u0169ng nh\u01b0 kh\u1ea3 n\u0103ng bi\u1ec7t ho\u00e1 c\u1ee7a t\u1ebf b\u00e0o\u2026<\/p>\n\n\n\n<p>G\u00e2y th\u1ea5t b\u1ea1i cho vi\u1ec7c m\u1edf r\u1ed9ng quy m\u00f4 (scaling up) v\u00e0 s\u1ea3n xu\u1ea5t c\u00f4ng nghi\u1ec7p: Trong nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n sinh d\u01b0\u1ee3c ph\u1ea9m \u0111\u1eb7c bi\u1ec7t l\u00e0 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o, s\u1ef1 bi\u1ebfn \u0111\u1ed9ng c\u1ee7a c\u00e1c l\u00f4 s\u1ea3n ph\u1ea9m nguy\u00ean li\u1ec7u nu\u00f4i c\u1ea5y c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i hi\u1ec7u su\u1ea5t t\u0103ng sinh v\u00e0 l\u00e0m thay \u0111\u1ed5i c\u00e1c thu\u1ed9c t\u00ednh ch\u1ea5t l\u01b0\u1ee3ng quan tr\u1ecdng c\u1ee7a s\u1ea3n ph\u1ea9m (CQAs &#8211; Critical Quality Attributes) \u1edf s\u1ea3n ph\u1ea9m cu\u1ed1i c\u00f9ng. S\u1ef1 sai l\u1ec7ch n\u00e0y c\u00f3 th\u1ec3 khi\u1ebfn c\u1ea3 m\u1ed9t l\u00f4 s\u1ea3n xu\u1ea5t l\u1edbn b\u1ecb lo\u1ea1i b\u1ecf, g\u00e2y thi\u1ec7t h\u1ea1i nghi\u00eam tr\u1ecdng v\u1ec1 th\u1eddi gian v\u00e0 kinh t\u1ebf.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bao_quan_va_su_dung_hoa_chat_dung_cach\"><\/span>B\u1ea3o qu\u1ea3n v\u00e0 s\u1eed d\u1ee5ng h\u00f3a ch\u1ea5t \u0111\u00fang c\u00e1ch<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Vi\u1ec7c l\u1ef1a ch\u1ecdn m\u00f4i tr\u01b0\u1eddng ph\u00f9 h\u1ee3p v\u1edbi t\u1eebng lo\u1ea1i t\u1ebf b\u00e0o, b\u1ea3o qu\u1ea3n \u0111\u00fang \u0111i\u1ec1u ki\u1ec7n v\u00e0 s\u1eed d\u1ee5ng theo khuy\u1ebfn c\u00e1o c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec t\u00ednh \u1ed5n \u0111\u1ecbnh c\u1ee7a qu\u00e1 tr\u00ecnh nu\u00f4i c\u1ea5y. M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y b\u1eaft bu\u1ed9c ph\u1ea3i \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi -20oC \u0111\u1ec3 gi\u1eef \u0111\u01b0\u1ee3c s\u1ef1 \u1ed5n \u0111\u1ecbnh c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n v\u00e0 ho\u1ea1t t\u00ednh. Khi s\u1eed d\u1ee5ng, quy tr\u00ecnh chu\u1ea9n \u0111\u00f2i h\u1ecfi ph\u1ea3i r\u00e3 \u0111\u00f4ng ch\u1eadm qua \u0111\u00eam trong t\u1ee7 l\u1ea1nh \u1edf nhi\u1ec7t \u0111\u1ed9 t\u1eeb 2 \u2013 8\u00b0C.<\/p>\n\n\n\n<p>Tuy nhi\u00ean m\u1ed9t sai s\u00f3t r\u1ea5t ph\u1ed5 bi\u1ebfn l\u00e0 \u0111\u1eb7t tr\u1ef1c ti\u1ebfp chai huy\u1ebft thanh \u0111\u00f4ng \u0111\u00e1 v\u00e0o b\u1ec3 \u0111i\u1ec1u nhi\u1ec7t \u1edf 37\u00b0C ho\u1eb7c r\u00e3 \u0111\u00f4ng nhanh \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng. S\u1ef1 thay \u0111\u1ed5i nhi\u1ec7t \u0111\u1ed9 \u0111\u1ed9t ng\u1ed9t n\u00e0y l\u00e0m bi\u1ebfn t\u00ednh c\u00e1c protein h\u00f2a tan, k\u00edch ho\u1ea1t hi\u1ec7n t\u01b0\u1ee3ng k\u1ebft t\u1ee7a protein v\u00e0 s\u1ee3i fibrin, l\u00e0m suy gi\u1ea3m nghi\u00eam tr\u1ecdng ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a m\u00f4i tr\u01b0\u1eddng. Ngo\u00e0i ra, vi\u1ec7c l\u1eb7p l\u1ea1i chu k\u1ef3 \u0111\u00f4ng &#8211; r\u00e3 \u0111\u00f4ng nhi\u1ec1u l\u1ea7n c\u0169ng l\u00e0m h\u1ee7y ho\u1ea1i ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m; do \u0111\u00f3, vi\u1ec7c r\u00e3 \u0111\u00f4ng m\u1ed9t l\u1ea7n r\u1ed3i chia nh\u1ecf (aliquot) th\u00e0nh c\u00e1c ph\u1ea7n l\u00e0 b\u01b0\u1edbc b\u1eaft bu\u1ed9c \u0111\u1ec3 duy tr\u00ec t\u00ednh \u0111\u1ed3ng nh\u1ea5t.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nhung_bien_so_ngoai_protocol_anh_huong_den_ket_qua_nuoi_cay\"><\/span><strong>Nh\u1eefng bi\u1ebfn s\u1ed1 ngo\u00e0i protocol \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dieu_kien_moi_truong_nuoi_cay\"><\/span>\u0110i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>C\u00e1c \u0111i\u1ec1u ki\u1ec7n v\u1eadt l\u00fd trong ph\u00f2ng th\u00ed nghi\u1ec7m c\u0169ng quy\u1ebft \u0111\u1ecbnh s\u1ef1 \u1ed5n \u0111\u1ecbnh c\u1ee7a m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y. T\u1ee7 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o hi\u1ec7n \u0111\u1ea1i kh\u00f4ng ch\u1ec9 c\u1ea7n duy tr\u00ec \u1ed5n \u0111\u1ecbnh nhi\u1ec7t \u0111\u1ed9 (37\u00b0C), CO\u2082 (th\u01b0\u1eddng 5%) v\u00e0 \u0111\u1ed9 \u1ea9m (>90%) m\u00e0 nhi\u1ec1u h\u1ec7 th\u1ed1ng c\u00f2n cho ph\u00e9p ki\u1ec3m so\u00e1t n\u1ed3ng \u0111\u1ed9 O\u2082 (Tri-gas Incubator). Vi\u1ec7c ki\u1ec3m so\u00e1t \u0111\u1ed3ng th\u1eddi CO\u2082 v\u00e0 O\u2082 gi\u00fap m\u00f4 ph\u1ecfng g\u1ea7n h\u01a1n m\u00f4i tr\u01b0\u1eddng sinh l\u00fd c\u1ee7a t\u1ebf b\u00e0o, \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng trong nghi\u00ean c\u1ee9u t\u1ebf b\u00e0o g\u1ed1c, mi\u1ec5n d\u1ecbch, ung th\u01b0 v\u00e0 nu\u00f4i c\u1ea5y 3D.<\/p>\n\n\n\n<p>\u2022 <strong>Ki\u1ec3m so\u00e1t CO\u2082 v\u00e0 pH:<\/strong> Dao \u0111\u1ed9ng CO\u2082 ch\u1ec9 1\u20132% c\u0169ng c\u00f3 th\u1ec3 ph\u00e1 h\u1ecfng c\u1ea3 d\u00f2ng t\u1ebf b\u00e0o, v\u00ec l\u00e0m l\u1ec7ch pH \u0111\u1ec7m bicarbonate trong m\u00f4i tr\u01b0\u1eddng. Phenol \u0111\u1ecf \u0111\u01b0\u1ee3c th\u00eam v\u00e0o h\u1ea7u h\u1ebft c\u00e1c c\u00f4ng th\u1ee9c m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o nh\u01b0 m\u1ed9t ch\u1ea5t ch\u1ec9 th\u1ecb pH tr\u1ef1c quan v\u00f4 c\u00f9ng nh\u1ea1y b\u00e9n. Khi t\u1ebf b\u00e0o sinh tr\u01b0\u1edfng b\u00ecnh th\u01b0\u1eddng, ch\u00fang ti\u00eau th\u1ee5 ch\u1ea5t dinh d\u01b0\u1ee1ng v\u00e0 th\u1ea3i ra c\u00e1c s\u1ea3n ph\u1ea9m ph\u1ee5 c\u00f3 t\u00ednh axit (nh\u01b0 axit lactic), l\u00e0m \u0111\u1ed9 $pH$ c\u1ee7a m\u00f4i tr\u01b0\u1eddng gi\u1ea3m xu\u1ed1ng, chuy\u1ec3n m\u00e0u c\u1ee7a phenol \u0111\u1ecf t\u1eeb \u0111\u1ecf t\u01b0\u01a1i sang m\u00e0u cam nh\u1ea1t ho\u1eb7c v\u00e0ng. \u0110\u00e2y l\u00e0 t\u00edn hi\u1ec7u sinh h\u1ecdc t\u1ef1 nhi\u00ean b\u00e1o hi\u1ec7u t\u1ebf b\u00e0o c\u1ea7n \u0111\u01b0\u1ee3c thay m\u00f4i tr\u01b0\u1eddng ho\u1eb7c c\u1ea5y chuy\u1ec1n sang \u0111\u0129a nu\u00f4i c\u1ea5y m\u1edbi.<\/p>\n\n\n\n<p>\u2022<strong> \u0110i\u1ec1u ki\u1ec7n n\u1ed3ng \u0111\u1ed9 O2: <\/strong>Khi nh\u1eafc \u0111\u1ebfn t\u1ee7 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o, \u0111a s\u1ed1 m\u1ecdi ng\u01b0\u1eddi th\u01b0\u1eddng ngh\u0129 \u0111\u1ebfn 37\u00b0C v\u00e0 5% CO\u2082. Tuy nhi\u00ean, m\u1ed9t y\u1ebfu t\u1ed1 ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c quan t\u00e2m trong c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m hi\u1ec7n \u0111\u1ea1i l\u00e0 n\u1ed3ng \u0111\u1ed9 oxy (O\u2082). \u0110\u1ed1i v\u1edbi c\u00e1c d\u00f2ng t\u1ebf b\u00e0o nh\u01b0 Mesenchymal Stem Cells (MSCs), nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y vi\u1ec7c nu\u00f4i c\u1ea5y \u1edf \u0111i\u1ec1u ki\u1ec7n oxy sinh l\u00fd (kho\u1ea3ng 2\u20135% O\u2082) c\u00f3 th\u1ec3 gi\u00fap duy tr\u00ec \u0111\u1eb7c t\u00ednh t\u1ebf b\u00e0o g\u1ed1c t\u1ed1t h\u01a1n, gi\u1ea3m stress oxy h\u00f3a v\u00e0 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng t\u0103ng sinh so v\u1edbi \u0111i\u1ec1u ki\u1ec7n oxy kh\u00ed quy\u1ec3n truy\u1ec1n th\u1ed1ng. Tuy nhi\u00ean, kh\u00f4ng ph\u1ea3i m\u1ecdi d\u00f2ng t\u1ebf b\u00e0o \u0111\u1ec1u c\u1ea7n nu\u00f4i \u1edf n\u1ed3ng \u0111\u1ed9 O\u2082 th\u1ea5p. N\u1ebfu n\u1ed3ng \u0111\u1ed9 O\u2082 kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t \u1ed5n \u0111\u1ecbnh gi\u1eefa c\u00e1c l\u1ea7n nu\u00f4i c\u1ea5y, t\u1ebf b\u00e0o c\u00f3 th\u1ec3 thay \u0111\u1ed5i t\u1ed1c \u0111\u1ed9 t\u0103ng sinh v\u00e0 bi\u1ec3u hi\u1ec7n gen, d\u1eabn \u0111\u1ebfn k\u1ebft qu\u1ea3 kh\u00e1c nhau d\u00f9 protocol kh\u00f4ng thay \u0111\u1ed5i.<\/p>\n\n\n\n<p><strong>\u2022 Nhi\u1ec7t \u0111\u1ed9 v\u00e0 \u0111\u1ed9 \u1ea9m:<\/strong> T\u1ee7 \u1ea5m c\u1ea7n gi\u1eef nhi\u1ec7t \u0111\u1ed9 37\u00b0C li\u00ean t\u1ee5c, kh\u00f4ng dao \u0111\u1ed9ng qu\u00e1 \u00b10,1\u00b0C, c\u00f9ng \u0111\u1ed9 \u1ea9m ~95% \u0111\u1ec3 tr\u00e1nh m\u00f4i tr\u01b0\u1eddng b\u1ecb kh\u00f4 v\u00e0 t\u1ebf b\u00e0o b\u1ecb stress. M\u1ecdi dao \u0111\u1ed9ng nh\u1ecf v\u1ec1 nhi\u1ec7t \u0111\u1ed9 (v\u00ed d\u1ee5 \u00b11\u00b0C) ho\u1eb7c CO\u2082 \u0111\u1ec1u c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t c\u01a1 ch\u1ebf s\u1ed1c nhi\u1ec7t, thay \u0111\u1ed5i qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t v\u00e0 h\u00e0nh vi c\u1ee7a t\u1ebf b\u00e0o.<\/p>\n\n\n\n<p class=\"has-text-align-center\"><em>B\u1ea3ng 1: \u0110i\u1ec1u ki\u1ec7n nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o<\/em><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>Y\u1ebfu t\u1ed1<\/strong><\/td><td><strong>Gi\u00e1 tr\u1ecb khuy\u1ebfn ngh\u1ecb<\/strong><\/td><td><strong>Vai tr\u00f2<\/strong><\/td><\/tr><\/thead><tbody><tr><td>Nhi\u1ec7t \u0111\u1ed9<\/td><td>37\u00b0C<\/td><td>Duy tr\u00ec ho\u1ea1t \u0111\u1ed9ng enzyme<\/td><\/tr><tr><td>CO\u2082<\/td><td>5%<\/td><td>\u1ed4n \u0111\u1ecbnh pH m\u00f4i tr\u01b0\u1eddng<\/td><\/tr><tr><td>\u0110\u1ed9 \u1ea9m<\/td><td>&gt;90\u201395%<\/td><td>Gi\u1ea3m bay h\u01a1i m\u00f4i tr\u01b0\u1eddng<\/td><\/tr><tr><td>O\u2082<\/td><td>2\u201321% (t\u00f9y lo\u1ea1i t\u1ebf b\u00e0o)<\/td><td>\u0110i\u1ec1u h\u00f2a chuy\u1ec3n h\u00f3a, t\u0103ng sinh v\u00e0 bi\u1ec7t h\u00f3a<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Yeu_to_te_bao_va_thao_tac_cay\"><\/span>Y\u1ebfu t\u1ed1 t\u1ebf b\u00e0o v\u00e0 thao t\u00e1c c\u1ea5y<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>B\u1ea3n th\u00e2n \u0111\u1eb7c t\u00ednh c\u1ee7a t\u1ebf b\u00e0o v\u00e0 c\u00e1ch thao t\u00e1c c\u0169ng \u1ea3nh h\u01b0\u1edfng l\u1edbn. C\u1ee5 th\u1ec3:<br>\u2022 <strong>Passage c\u1ee7a t\u1ebf b\u00e0o: <\/strong>Qua nhi\u1ec1u l\u1ea7n c\u1ea5y chuy\u1ec1n, t\u1ebf b\u00e0o c\u00f3 th\u1ec3 thay \u0111\u1ed5i bi\u1ec3u hi\u1ec7n gen, gi\u1ea3m kh\u1ea3 n\u0103ng t\u0103ng sinh ho\u1eb7c xu\u1ea5t hi\u1ec7n hi\u1ec7n t\u01b0\u1ee3ng l\u00e3o h\u00f3a. V\u00ec v\u1eady, nhi\u1ec1u ph\u00f2ng th\u00ed nghi\u1ec7m quy \u0111\u1ecbnh s\u1ed1 passage t\u1ed1i \u0111a cho t\u1eebng d\u00f2ng t\u1ebf b\u00e0o \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o d\u1eef li\u1ec7u lu\u00f4n nh\u1ea5t qu\u00e1n.<\/p>\n\n\n\n<p>\u2022<strong> M\u1eadt \u0111\u1ed9 gieo c\u1ea5y: <\/strong>S\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o gieo ban \u0111\u1ea7u qu\u00e1 th\u1ea5p ho\u1eb7c qu\u00e1 cao so v\u1edbi y\u00eau c\u1ea7u c\u1ee7a d\u00f2ng t\u1ebf b\u00e0o s\u1ebd l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng b\u00e1m d\u00ednh v\u00e0 t\u01b0\u01a1ng t\u00e1c t\u1ebf b\u00e0o. Vi\u1ec7c n\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c chu\u1ea9n h\u00f3a cho t\u1eebng lo\u1ea1i t\u1ebf b\u00e0o.<\/p>\n\n\n\n<p>\u2022 <strong>K\u1ef9 thu\u1eadt x\u1eed l\u00fd: <\/strong>D\u00f9ng trypsin ho\u1eb7c pipet qu\u00e1 m\u1ea1nh s\u1ebd t\u1ed5n th\u01b0\u01a1ng m\u00e0ng t\u1ebf b\u00e0o, ph\u00e1 h\u1ee7y protein k\u1ebft d\u00ednh. K\u1ebft qu\u1ea3 l\u00e0 t\u1ebf b\u00e0o kh\u00f3 b\u00e1m ho\u1eb7c ch\u1ebft sau khi gieo, l\u00e0m thay \u0111\u1ed5i m\u1eadt \u0111\u1ed9 v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a d\u00f2ng t\u1ebf b\u00e0o. C\u00e1ch pha lo\u00e3ng m\u00f4i tr\u01b0\u1eddng, t\u1ed1c \u0111\u1ed9 thay m\u00f4i tr\u01b0\u1eddng, t\u1ea5t c\u1ea3 c\u00e1c b\u01b0\u1edbc thao t\u00e1c \u0111\u1ec1u c\u1ea7n \u0111\u1ed3ng nh\u1ea5t \u0111\u1ec3 tr\u00e1nh sai kh\u00e1c.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Thao_tac_va_kiem_soat_nhiem\"><\/span>Thao t\u00e1c v\u00e0 ki\u1ec3m so\u00e1t nhi\u1ec5m<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>M\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n l\u1edbn khi\u1ebfn k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y dao \u0111\u1ed9ng l\u00e0 nhi\u1ec5m khu\u1ea9n, n\u1ea5m ho\u1eb7c Mycoplasma trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i. Vi khu\u1ea9n, n\u1ea5m \u0111\u1ec1u g\u00e2y \u0111\u1ee5c m\u00f4i tr\u01b0\u1eddng, thay \u0111\u1ed5i pH nhanh v\u00e0 c\u00f3 th\u1ec3 nh\u00ecn th\u1ea5y c\u00e1c c\u1ea5u tr\u00fac l\u1ea1 d\u01b0\u1edbi k\u00ednh hi\u1ec3n vi. Mycoplasma th\u00ec kh\u00f3 ph\u00e1t hi\u1ec7n v\u00ec kh\u00f4ng l\u00e0m \u0111\u1ee5c m\u00f4i tr\u01b0\u1eddng nh\u01b0ng \u00e2m th\u1ea7m l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ed1c \u0111\u1ed9 sinh tr\u01b0\u1edfng v\u00e0 thay \u0111\u1ed5i \u0111\u1eb7c t\u00ednh t\u1ebf b\u00e0o, khi\u1ebfn k\u1ebft qu\u1ea3 th\u00ed nghi\u1ec7m kh\u00f4ng \u1ed5n \u0111\u1ecbnh.<\/p>\n\n\n\n<p>Qu\u00e1 tr\u00ecnh thao t\u00e1c, s\u1eed d\u1ee5ng pipet, h\u00f3a ch\u1ea5t, d\u1ee5ng c\u1ee5 c\u1ea5y \u0111\u00e3 b\u1ecb nhi\u1ec5m \u0111\u1ec1u t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho vi sinh x\u00e2m nh\u1eadp. N\u01b0\u1edbc \u1ee7 trong t\u1ee7 \u1ea5m n\u1ebfu kh\u00f4ng thay th\u01b0\u1eddng xuy\u00ean ho\u1eb7c kh\u00f4ng th\u00eam ch\u1ea5t kh\u1eed khu\u1ea9n s\u1ebd tr\u1edf th\u00e0nh m\u00f4i tr\u01b0\u1eddng ph\u00e1t tri\u1ec3n n\u1ea5m m\u1ed1c. T\u1ee7 c\u1ea5y kh\u00f4ng \u0111\u01b0\u1ee3c v\u1ec7 sinh k\u1ef9 c\u00e0ng c\u0169ng cho ph\u00e9p b\u00e0o t\u1eed vi sinh t\u00edch t\u1ee5.<\/p>\n\n\n\n<p><em><strong>Xem th\u00eam:<\/strong> <a href=\"https:\/\/biogroupvietnam.com\/vi\/dich-vu\/cac-chat-gay-o-nhiem-pho-bien-trong-phong-sach-va-cach-phong-ngua\/\">C\u00e1c ch\u1ea5t g\u00e2y \u00f4 nhi\u1ec5m ph\u1ed5 bi\u1ebfn trong ph\u00f2ng s\u1ea1ch v\u00e0 c\u00e1ch ph\u00f2ng ng\u1eeba<\/a><\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kiem_soat_chat_luong_te_bao_goc_trong_ung_dung_lam_sang\"><\/span><strong>Ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c trong \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nh\u1eefng bi\u1ebfn s\u1ed1 k\u1ec3 tr\u00ean kh\u00f4ng ch\u1ec9 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y m\u00e0 c\u00f2n t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o. V\u00ec v\u1eady, trong s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o g\u1ed1c theo cGMP, c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t ph\u1ea3i x\u00e2y d\u1ef1ng h\u1ec7 th\u1ed1ng Quality Control d\u1ef1a tr\u00ean CQAs v\u00e0 CPPs<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"736\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc-1024x736.jpeg\" alt=\"\" class=\"wp-image-11357\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc-1024x736.jpeg 1024w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc-300x216.jpeg 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc-768x552.jpeg 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc-1536x1104.jpeg 1536w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc-600x431.jpeg 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc-75x54.jpeg 75w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/07\/so-do-quy-trinh-san-xuat-quy-mo-lon-va-kiem-soat-chat-luong-san-pham-te-bao-goc.jpeg 1975w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>S\u01a1 \u0111\u1ed3 quy tr\u00ecnh s\u1ea3n xu\u1ea5t quy m\u00f4 l\u1edbn v\u00e0 ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c (Ngu\u1ed3n: Theo Chen et al. (2026), \u0111\u0103ng tr\u00ean <a href=\"https:\/\/www.nature.com\/articles\/s41392-026-02582-y\" target=\"_blank\" rel=\"noreferrer noopener\">Signal Transduction and Targeted Therapy<\/a>)<\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Theo c\u00e1c h\u01b0\u1edbng d\u1eabn c\u1ee7a FDA, EMA v\u00e0 nhi\u1ec1u c\u01a1 quan qu\u1ea3n l\u00fd tr\u00ean th\u1ebf gi\u1edbi, quy tr\u00ecnh s\u1ea3n xu\u1ea5t c\u1ea7n tu\u00e2n th\u1ee7 cGMP, <strong>x\u00e2y d\u1ef1ng quy tr\u00ecnh thao t\u00e1c chu\u1ea9n (SOP), x\u00e1c \u0111\u1ecbnh Critical Quality Attributes (CQAs) v\u00e0 Critical Process Parameters (CPPs)<\/strong>, \u0111\u1ed3ng th\u1eddi thi\u1ebft l\u1eadp h\u1ec7 th\u1ed1ng ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng to\u00e0n di\u1ec7n. CQAs l\u00e0 nh\u1eefng \u0111\u1eb7c t\u00ednh quy\u1ebft \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a s\u1ea3n ph\u1ea9m, nh\u01b0 kh\u1ea3 n\u0103ng t\u0103ng sinh, bi\u1ec7t h\u00f3a, \u0111\u1ed9 tinh khi\u1ebft, t\u1ef7 l\u1ec7 s\u1ed1ng v\u00e0 ho\u1ea1t t\u00ednh c\u1ee7a t\u1ebf b\u00e0o. Trong khi \u0111\u00f3, CPPs l\u00e0 c\u00e1c th\u00f4ng s\u1ed1 c\u1ee7a qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t c\u00f3 \u1ea3nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn c\u00e1c CQAs, bao g\u1ed3m th\u00e0nh ph\u1ea7n m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y, m\u1eadt \u0111\u1ed9 t\u1ebf b\u00e0o, th\u1eddi gian nu\u00f4i, nhi\u1ec7t \u0111\u1ed9, CO\u2082, O\u2082 v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng nguy\u00ean li\u1ec7u. N\u1ebfu m\u1ed9t CPP thay \u0111\u1ed5i, ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o c\u0169ng c\u00f3 th\u1ec3 thay \u0111\u1ed5i d\u00f9 v\u1eabn s\u1eed d\u1ee5ng c\u00f9ng m\u1ed9t protocol.<\/p>\n\n\n\n<p>N\u1ed9i dung ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng kh\u00f4ng ch\u1ec9 bao g\u1ed3m vi\u1ec7c theo d\u00f5i c\u00e1c CQAs v\u00e0 CPPs m\u00e0 c\u00f2n \u0111\u00e1nh gi\u00e1 v\u00f4 khu\u1ea9n, Mycoplasma, n\u1ed9i \u0111\u1ed9c t\u1ed1 (Endotoxin), \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh di truy\u1ec1n, kh\u1ea3 n\u0103ng t\u0103ng sinh, bi\u1ec7t h\u00f3a v\u00e0 ho\u1ea1t t\u00ednh c\u1ee7a t\u1ebf b\u00e0o. V\u00ed d\u1ee5 \u0111\u1ed1i v\u1edbi t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSCs), c\u00e1c ti\u00eau ch\u00ed quan tr\u1ecdng c\u00f2n bao g\u1ed3m bi\u1ec3u hi\u1ec7n c\u00e1c marker CD73, CD90 v\u00e0 CD105, kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh t\u1ebf b\u00e0o x\u01b0\u01a1ng, s\u1ee5n v\u00e0 m\u1ee1, c\u0169ng nh\u01b0 c\u00e1c th\u1eed nghi\u1ec7m v\u1ec1 \u0111\u1ed9 tinh khi\u1ebft v\u00e0 an to\u00e0n. Vi\u1ec7c ghi nh\u1eadn \u0111\u1ea7y \u0111\u1ee7 h\u1ed3 s\u01a1 ch\u1ea5t l\u01b0\u1ee3ng trong su\u1ed1t qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t c\u0169ng l\u00e0 y\u00eau c\u1ea7u quan tr\u1ecdng nh\u1eb1m \u0111\u1ea3m b\u1ea3o t\u00ednh nh\u1ea5t qu\u00e1n v\u00e0 h\u1ed7 tr\u1ee3 c\u1ea3i ti\u1ebfn li\u00ean t\u1ee5c h\u1ec7 th\u1ed1ng ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lam_the_nao_de_tang_tinh_tai_lap_cua_ket_qua_nuoi_cay\"><\/span><strong>L\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 t\u0103ng t\u00ednh t\u00e1i l\u1eadp c\u1ee7a k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u0110\u1ec3 gi\u1ea3m thi\u1ec3u sai kh\u00e1c, ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ea7n chu\u1ea9n h\u00f3a nghi\u00eam ng\u1eb7t m\u1ecdi kh\u00e2u v\u00e0 l\u1ef1a ch\u1ecdn m\u00f4i tr\u01b0\u1eddng v\u00e0 ho\u00e1 ch\u1ea5t c\u0169ng nh\u01b0 thi\u1ebft b\u1ecb sao cho \u0111\u1ed3ng nh\u1ea5t v\u00e0 ph\u00f9 h\u1ee3p.<\/p>\n\n\n\n<p>\u2022 S\u1eed d\u1ee5ng \u0111\u00fang lo\u1ea1i m\u00f4i tr\u01b0\u1eddng v\u00e0 b\u1ed5 sung (theo khuy\u1ebfn c\u00e1o c\u1ee7a ATCC), ki\u1ec3m tra h\u1ea1n s\u1eed d\u1ee5ng v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng FBS. \u0110\u1ecbnh k\u1ef3 \u0111o pH v\u00e0 thay m\u00f4i tr\u01b0\u1eddng k\u1ecbp th\u1eddi.<\/p>\n\n\n\n<p>\u2022 Chuy\u1ec3n \u0111\u1ed5i sang m\u00f4i tr\u01b0\u1eddng kh\u00f4ng huy\u1ebft thanh v\u00e0 x\u00e1c \u0111\u1ecbnh h\u00f3a h\u1ecdc (Chemically Defined\/Serum-Free Media): \u0110\u00e2y \u0111\u01b0\u1ee3c coi l\u00e0 ti\u00eau chu\u1ea9n v\u00e0ng m\u1edbi trong nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o hi\u1ec7n \u0111\u1ea1i. Do m\u1ecdi th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc v\u00e0 n\u1ed3ng \u0111\u1ed9 c\u1ee7a ch\u00fang \u0111\u1ec1u \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh r\u00f5 r\u00e0ng, lo\u1ea1i m\u00f4i tr\u01b0\u1eddng n\u00e0y gi\u00fap lo\u1ea1i b\u1ecf ho\u00e0n to\u00e0n s\u1ef1 bi\u1ebfn \u0111\u1ed9ng gi\u1eefa c\u00e1c l\u00f4 s\u1ea3n xu\u1ea5t c\u1ee7a FBS, \u0111\u1ed3ng th\u1eddi ng\u0103n ch\u1eb7n tuy\u1ec7t \u0111\u1ed1i nguy c\u01a1 l\u00e2y nhi\u1ec5m c\u00e1c t\u00e1c nh\u00e2n ngo\u1ea1i lai t\u1eeb \u0111\u1ed9ng v\u1eadt.<\/p>\n\n\n\n<p><em><strong>T\u00ecm hi\u1ec3u th\u00eam:<\/strong> <a href=\"https:\/\/biogroupvietnam.com\/vi\/san-pham\/cellcor-msc-cd-aof\/\">M\u00f4i Tr\u01b0\u1eddng CellCor\u2122 CD MSC AOF \u2013 GMP<\/a><\/em><\/p>\n\n\n\n<p>\u2022 Thi\u1ebft b\u1ecb:<strong> <\/strong>Hi\u1ec7u chu\u1ea9n \u0111\u1ecbnh k\u1ef3 t\u1ee7 \u1ea5m CO\u2082 (\u0111\u1ea3m b\u1ea3o CO\u2082, nhi\u1ec7t \u0111\u1ed9 \u0111\u00fang m\u1ee9c) v\u00e0 thay n\u01b0\u1edbc, b\u1ed9 l\u1ecdc HEPA theo h\u01b0\u1edbng d\u1eabn. Hi\u1ec7n nay vi\u1ec7c l\u1ef1a ch\u1ecdn t\u1ee7 \u1ea5m gia nhi\u1ec7t t\u1ef1 \u0111\u1ed9ng ho\u1eb7c gia nhi\u1ec7t b\u00e0o \u00e1o n\u01b0\u1edbc c\u0169ng \u0111ang \u0111\u01b0\u1ee3c nhi\u1ec1u \u0111\u01a1n v\u1ecb xem x\u00e9t v\u00e0 l\u1ef1a ch\u1ecdn. Hi\u1ec7n nay \u0111i\u1ec1u ki\u1ec7n O2 c\u0169ng l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 cho th\u1ea5y \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 trong k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y. L\u1ef1a ch\u1ecdn thi\u1ebft b\u1ecb c\u00f3 t\u00ednh \u1ed5n \u0111\u1ecbnh cao, gi\u1ea3m dao \u0111\u1ed9ng v\u00ec \u201cthi\u1ebft b\u1ecb t\u1ed1t s\u1ebd l\u00e0m t\u0103ng t\u00ednh t\u00e1i l\u1eadp c\u1ee7a k\u1ebft qu\u1ea3&#8221;<\/p>\n\n\n\n<p><strong><em>Xem th\u00eam: <\/em><\/strong><a href=\"https:\/\/biogroupvietnam.com\/vi\/dao-tao-webinar\/su-khac-biet-giua-tu-am-co2-gia-nhiet-ao-nuoc-va-tu-am-co2-gia-nhiet-truc-tiep\/\"><em>S\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa t\u1ee7 \u1ea5m CO\u2082 gia nhi\u1ec7t \u00e1o n\u01b0\u1edbc v\u00e0 t\u1ee7 \u1ea5m CO\u2082 gia nhi\u1ec7t tr\u1ef1c ti\u1ebfp<\/em><\/a><\/p>\n\n\n\n<p><strong><em>T\u00ecm hi\u1ec3u th\u00eam:<\/em><\/strong><em> <a href=\"https:\/\/biogroupvietnam.com\/vi\/san-pham\/tu-am-co2-nhiet-truc-tiep-in-vitrocell-nu-5731e\/\">T\u1ee7 \u1ea5m CO\u2082 NuAire In-VitroCell\u00ae NU-5731 (C\u00f3 Ki\u1ec3m So\u00e1t <a href=\"https:\/\/biogroupvietnam.com\/vi\/san-pham\/tu-am-co2-nhiet-truc-tiep-in-vitrocell-nu-5731e\/\">O\u2082<\/a><\/a><\/em><\/p>\n\n\n\n<p>\u2022 <strong>Ki\u1ec3m so\u00e1t nhi\u1ec5m t\u1ea1p: <\/strong>Tu\u00e2n th\u1ee7 nghi\u00eam quy tr\u00ecnh v\u00f4 tr\u00f9ng, th\u01b0\u1eddng xuy\u00ean v\u1ec7 sinh t\u1ee7 c\u1ea5y v\u00e0 m\u00f4i tr\u01b0\u1eddng l\u00e0m vi\u1ec7c. X\u00e9t nghi\u1ec7m \u0111\u1ecbnh k\u1ef3 Mycoplasma v\u00e0 thay n\u01b0\u1edbc t\u1ee7 \u1ea5m \u0111\u1ec3 ng\u0103n ng\u1eeba vi sinh ph\u00e1t tri\u1ec3n.<\/p>\n\n\n\n<p>\u2022<strong> \u0110i\u1ec1u ki\u1ec7n thao t\u00e1c: <\/strong>\u0110\u00e0o t\u1ea1o nh\u00e2n vi\u00ean c\u1ea9n th\u1eadn, quy \u0111\u1ecbnh m\u1eadt \u0111\u1ed9 gieo c\u1ea5y v\u00e0 s\u1ed1 passage t\u1ed1i \u0111a cho m\u1ed7i d\u00f2ng. H\u1ea1n ch\u1ebf m\u1edf n\u1eafp h\u1ed9p c\u1ea5y, thao t\u00e1c nhanh g\u1ecdn. Vi\u1ec7c s\u1eafp x\u1ebfp qu\u00e1 nhi\u1ec1u v\u1eadt d\u1ee5ng b\u00ean trong t\u1ee7 an to\u00e0n sinh h\u1ecdc (biosafety cabinet) s\u1ebd l\u00e0m gi\u00e1n \u0111o\u1ea1n d\u00f2ng kh\u00ed laminar flow, d\u1eabn \u0111\u1ebfn nguy c\u01a1 h\u00fat c\u00e1c b\u00e0o t\u1eed n\u1ea5m ho\u1eb7c vi khu\u1ea9n t\u1eeb m\u00f4i tr\u01b0\u1eddng ngo\u00e0i v\u00e0o \u0111\u0129a nu\u00f4i c\u1ea5y.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>Vi\u1ec7c c\u1ea7n th\u1ef1c hi\u1ec7n<\/strong><\/td><td><strong>M\u1ee5c \u0111\u00edch<\/strong><\/td><\/tr><\/thead><tbody><tr><td>S\u1eed d\u1ee5ng c\u00f9ng m\u1ed9t lot FBS trong su\u1ed1t d\u1ef1 \u00e1n<\/td><td>Gi\u1ea3m Lot-to-Lot Variation<\/td><\/tr><tr><td>\u0110\u00e1nh gi\u00e1 l\u00f4 m\u1edbi tr\u01b0\u1edbc khi thay th\u1ebf<\/td><td>H\u1ea1n ch\u1ebf thay \u0111\u1ed5i hi\u1ec7u su\u1ea5t t\u0103ng tr\u01b0\u1edfng<\/td><\/tr><tr><td>Theo d\u00f5i s\u1ed1 lot c\u1ee7a to\u00e0n b\u1ed9 h\u00f3a ch\u1ea5t<\/td><td>D\u1ec5 truy xu\u1ea5t nguy\u00ean nh\u00e2n khi c\u00f3 sai l\u1ec7ch<\/td><\/tr><tr><td>Hi\u1ec7u chu\u1ea9n \u0111\u1ecbnh k\u1ef3 t\u1ee7 \u1ea5m CO\u2082<\/td><td>Duy tr\u00ec nhi\u1ec7t \u0111\u1ed9 v\u00e0 pH \u1ed5n \u0111\u1ecbnh<\/td><\/tr><tr><td>Ki\u1ec3m tra Mycoplasma th\u01b0\u1eddng xuy\u00ean<\/td><td>Ng\u0103n ng\u1eeba nhi\u1ec5m d\u1eabn \u0111\u1ebfn \u1ea3nh h\u01b0\u1edfng l\u00f4<\/td><\/tr><tr><td>Gi\u1edbi h\u1ea1n s\u1ed1 passage<\/td><td>\u0110\u1ea3m b\u1ea3o t\u00ednh \u0111\u1ed3ng nh\u1ea5t c\u1ee7a t\u1ebf b\u00e0o<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Nh\u1eefng bi\u1ec7n ph\u00e1p n\u00e0y tuy \u0111\u01a1n gi\u1ea3n nh\u01b0ng l\u1ea1i c\u00f3 t\u00e1c \u0111\u1ed9ng r\u1ea5t l\u1edbn \u0111\u1ebfn <strong>\u0111\u1ed9 t\u00e1i l\u1eadp <\/strong>c\u1ee7a k\u1ebft qu\u1ea3. C\u00e1c chuy\u00ean gia c\u0169ng nh\u1ea5n m\u1ea1nh r\u1eb1ng kh\u1ea3 n\u0103ng l\u1eb7p l\u1ea1i c\u1ee7a m\u1ed9t th\u00ed nghi\u1ec7m ph\u1ee5 thu\u1ed9c v\u00e0o vi\u1ec7c ki\u1ec3m so\u00e1t to\u00e0n b\u1ed9 \u0111i\u1ec1u ki\u1ec7n th\u1ef1c nghi\u1ec7m ch\u1ee9 kh\u00f4ng ch\u1ec9 d\u1ef1a tr\u00ean protocol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ket_luan_va_khuyen_nghi_hanh_dong\"><\/span><strong>K\u1ebft lu\u1eadn v\u00e0 khuy\u1ebfn ngh\u1ecb h\u00e0nh \u0111\u1ed9ng<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>M\u1ed9t protocol chu\u1ea9n l\u00e0 \u0111i\u1ec1u ki\u1ec7n c\u1ea7n, nh\u01b0ng ch\u01b0a ph\u1ea3i \u0111i\u1ec1u ki\u1ec7n \u0111\u1ee7 \u0111\u1ec3 t\u1ea1o ra k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u1ed5n \u0111\u1ecbnh. Nh\u1eefng y\u1ebfu t\u1ed1 nh\u01b0 <strong>Lot-to-Lot Variation<\/strong>, ch\u1ea5t l\u01b0\u1ee3ng m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y, passage c\u1ee7a t\u1ebf b\u00e0o, \u0111i\u1ec1u ki\u1ec7n t\u1ee7 \u1ea5m v\u00e0 ki\u1ec3m so\u00e1t nhi\u1ec5m t\u1ea1p \u0111\u1ec1u c\u00f3 th\u1ec3 t\u1ea1o ra kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 gi\u1eefa c\u00e1c l\u1ea7n th\u00ed nghi\u1ec7m.<\/p>\n\n\n\n<p>V\u00ec v\u1eady, n\u1ebfu mu\u1ed1n n\u00e2ng cao \u0111\u1ed9 tin c\u1eady c\u1ee7a d\u1eef li\u1ec7u, k\u1ebft qu\u1ea3 nu\u00f4i c\u1ea5y c\u00e1c \u0111\u01a1n v\u1ecb kh\u00f4ng ch\u1ec9 c\u1ea7n chu\u1ea9n h\u00f3a quy tr\u00ecnh thao t\u00e1c m\u00e0 c\u00f2n ph\u1ea3i x\u00e2y d\u1ef1ng h\u1ec7 th\u1ed1ng qu\u1ea3n l\u00fd v\u1eadt t\u01b0, theo d\u00f5i s\u1ed1 lot v\u00e0 l\u1ef1a ch\u1ecdn c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng nghi\u00eam ng\u1eb7t. \u0110\u1ed1i v\u1edbi nh\u1eefng \u1ee9ng d\u1ee5ng \u0111\u00e3 c\u00f3 m\u00f4i tr\u01b0\u1eddng x\u00e1c \u0111\u1ecbnh h\u00f3a h\u1ecdc ph\u00f9 h\u1ee3p, vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i sang serum-free ho\u1eb7c chemically defined media c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m \u0111\u00e1ng k\u1ec3 bi\u1ebfn thi\u00ean gi\u1eefa c\u00e1c l\u00f4 v\u00e0 c\u1ea3i thi\u1ec7n t\u00ednh t\u00e1i l\u1eadp c\u1ee7a k\u1ebft qu\u1ea3.<\/p>\n\n\n\n<p><strong>T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>ATCC \u2013 Animal Cell Culture Guide <a href=\"https:\/\/www.atcc.org\/resources\/culture-guides\/animal-cell-culture-guide\">https:\/\/www.atcc.org\/resources\/culture-guides\/animal-cell-culture-guide<\/a>?<\/li>\n\n\n\n<li>Chen, S., Zhang, L., Ren, Y. et al. Clinical translational research on stem cell products: prospects and challenges. Sig Transduct Target Ther 11, 178 (2026). <a href=\"https:\/\/doi.org\/10.1038\/s41392-026-02582-y\">https:\/\/doi.org\/10.1038\/s41392-026-02582-y<\/a><\/li>\n\n\n\n<li>Lebedev, T., Mikheeva, A., Gasca, V., Spirin, P., &amp; Prassolov, V. (2025). Systematic Comparison of FBS and Medium Variation Effect on Key Cellular Processes Using Morphological Profiling. Cells, 14(5), 336. <a href=\"https:\/\/doi.org\/10.3390\/cells14050336\">https:\/\/doi.org\/10.3390\/cells14050336<\/a><\/li>\n\n\n\n<li>Pavlacky, J., &amp; Polak, J. (2020). Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models. Frontiers in endocrinology, 11, 57. <a href=\"https:\/\/doi.org\/10.3389\/fendo.2020.00057\">https:\/\/doi.org\/10.3389\/fendo.2020.00057<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/nc3rs.org.uk\/3rs-resource-library\/improving-human-relevance-cell-culture-using-animal-free-culture-media\">https:\/\/nc3rs.org.uk\/3rs-resource-library\/improving-human-relevance-cell-culture-using-animal-free-culture-media<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/cellculturecompany.com\/serum-free-cell-culture-media-benefits-challenges-and-how-to-make-the-switch\/\">https:\/\/cellculturecompany.com\/serum-free-cell-culture-media-benefits-challenges-and-how-to-make-the-switch\/<\/a><\/li>\n\n\n\n<li>Weiskirchen, S., Schr\u00f6der, S. K., Buhl, E. M., &amp; Weiskirchen, R. (2023). A Beginner&#8217;s Guide to Cell Culture: Practical Advice for Preventing Needless Problems. Cells, 12(5), 682. <a href=\"https:\/\/doi.org\/10.3390\/cells12050682\">https:\/\/doi.org\/10.3390\/cells12050682<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>B\u1ea1n c\u00f3 t\u1eebng g\u1eb7p t\u00ecnh hu\u1ed1ng m\u1ed9t d\u00f2ng MSC ph\u00e1t tri\u1ec3n r\u1ea5t t\u1ed1t \u1edf l\u1ea7n nu\u00f4i c\u1ea5y \u0111\u1ea7u ti\u00ean, nh\u01b0ng ch\u1ec9 v\u00e0i tu\u1ea7n sau, d\u00f9 s\u1eed d\u1ee5ng \u0111\u00fang protocol, c\u00f9ng m\u00f4i tr\u01b0\u1eddng v\u00e0 c\u00f9ng ng\u01b0\u1eddi thao t\u00e1c, k\u1ebft qu\u1ea3 l\u1ea1i ho\u00e0n to\u00e0n kh\u00e1c? \u0110\u00e2y l\u00e0 v\u1ea5n \u0111\u1ec1 m\u00e0 h\u1ea7u nh\u01b0 ph\u00f2ng th\u00ed nghi\u1ec7m n\u00e0o c\u0169ng<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/dieu-gi-anh-huong-den-su-dong-nhat-giua-cac-lan-nuoi-cay-te-bao\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":11357,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11356","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u0110i\u1ec1u g\u00ec \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 \u0111\u1ed3ng nh\u1ea5t gi\u1eefa c\u00e1c l\u1ea7n nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o?<\/title>\n<meta name=\"description\" content=\"V\u00ec sao c\u00f9ng protocol nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o nh\u01b0ng k\u1ebft qu\u1ea3 kh\u00e1c nhau? 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