{"id":11725,"date":"2026-10-23T10:33:18","date_gmt":"2026-10-23T03:33:18","guid":{"rendered":"https:\/\/biogroupvietnam.com\/?p=11725"},"modified":"2026-10-23T10:51:54","modified_gmt":"2026-10-23T03:51:54","slug":"giai-phap-tang-sinh-te-bao-t-immunocult-g-rex","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/blog\/giai-phap-tang-sinh-te-bao-t-immunocult-g-rex\/","title":{"rendered":"C\u00c1CH NU\u00d4I T\u0102NG SINH T\u1ebe B\u00c0O T TRONG H\u1ec6 TH\u1ed0NG NU\u00d4I T\u0102NG SINH G-REX\u00ae B\u1eb0NG PH\u01af\u01a0NG PH\u00c1P NU\u00d4I C\u1ea4Y H\u1ea0N CH\u1ebe CAN THI\u1ec6P.\u00a0"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"538\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2-1024x538.jpg\" alt=\"\" class=\"wp-image-11732\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2-1024x538.jpg 1024w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2-300x158.jpg 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2-768x404.jpg 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2-1536x807.jpg 1536w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2-600x315.jpg 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2-90x47.jpg 90w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/f7441d9b-8249-4125-9a7f-404008aa2b67-2.jpg 1730w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>T\u1ebf b\u00e0o T l\u00e0 tr\u1ecdng t\u00e2m c\u1ee7a nhi\u1ec1u chi\u1ebfn l\u01b0\u1ee3c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nu\u00f4i nh\u1eadn. V\u00ec v\u1eady, vi\u1ec7c s\u1edf h\u1eefu c\u00e1c gi\u1ea3i ph\u00e1p k\u00edch ho\u1ea1t v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o m\u1ea1nh m\u1ebd, d\u1ec5 d\u00e0ng m\u1edf r\u1ed9ng quy m\u00f4 l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t trong nghi\u00ean c\u1ee9u, t\u1ed1i \u01b0u quy tr\u00ecnh v\u00e0 s\u1ea3n xu\u1ea5t th\u01b0\u01a1ng m\u1ea1i. <\/p>\n\n\n\n<p>Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y mang \u0111\u1ebfn m\u1ed9t quy tr\u00ecnh tinh g\u1ecdn, h\u1ea1n ch\u1ebf t\u1ed1i \u0111a thao t\u00e1c th\u1ee7 c\u00f4ng (low-intervention) khi t\u0103ng sinh t\u1ebf b\u00e0o T nh\u1edd s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa c\u00e1c thu\u1ed1c th\u1eed ImmunoCult\u2122 \u0111\u1ea1t chu\u1ea9n GMP v\u00e0 h\u1ec7 th\u1ed1ng nu\u00f4i t\u0103ng sinh G-Rex\u00ae. <\/p>\n\n\n\n<p>Vi\u1ec7c gi\u1ea3m thi\u1ec3u s\u1ed1 l\u1ea7n can thi\u1ec7p t\u1ea1o ti\u1ec1n \u0111\u1ec1 thu\u1eadn l\u1ee3i \u0111\u1ec3 b\u1ed5 sung ho\u1ea1t ch\u1ea5t k\u00edch ho\u1ea1t v\u00e0 \u0111i\u1ec1u ch\u1ec9nh m\u1eadt \u0111\u1ed9 t\u1ebf b\u00e0o, gi\u00fap \u0111\u1ea1t hi\u1ec7u su\u1ea5t t\u0103ng sinh t\u1ed1i \u01b0u m\u00e0 v\u1eabn b\u1ea3o t\u1ed3n nguy\u00ean v\u1eb9n \u0111\u1ed9 s\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o, ho\u1ea1t t\u00ednh ch\u1ee9c n\u0103ng c\u00f9ng c\u00e1c ki\u1ec3u h\u00ecnh t\u1ebf b\u00e0o T ghi nh\u1edb. <\/p>\n\n\n\n<p>V\u1edbi kh\u1ea3 n\u0103ng t\u01b0\u01a1ng th\u00edch linh ho\u1ea1t cho c\u1ea3 m\u00f4 h\u00ecnh scale-up v\u00e0 scale-out, ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn n\u00e0y l\u00e0 l\u1ef1a ch\u1ecdn l\u00fd t\u01b0\u1edfng cho c\u00e1c \u0111\u01a1n v\u1ecb \u0111ang ph\u00e1t tri\u1ec3n v\u00e0 s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T (c\u1ea3 d\u00f2ng bi\u1ebfn \u0111\u1ed5i gen nh\u01b0 CAR-T, TCR hay d\u00f2ng kh\u00f4ng bi\u1ebfn \u0111\u1ed5i gen).\u00a0<\/p>\n\n\n\n<p><strong>V\u1eadt li\u1ec7u h\u00f3a ch\u1ea5t:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>T\u1ebf b\u00e0o T ng\u01b0\u1eddi:<\/strong> V\u00ed d\u1ee5 t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb kh\u1ed1i b\u1ea1ch c\u1ea7u t\u01b0\u01a1i (fresh leukopak, M\u00e3 s\u1ed1 s\u1ea3n ph\u1ea9m #70500) b\u1eb1ng B\u1ed9 ph\u00e2n l\u1eadp t\u1ebf b\u00e0o T ng\u01b0\u1eddi EasySep\u2122 (Catalog #17951), s\u1eed d\u1ee5ng \u1edf d\u1ea1ng t\u01b0\u01a1i ho\u1eb7c b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh trong CryoStor\u00ae CS10 (Catalog #07930).\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>M\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF<\/strong> (Catalog #100-0956)\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>T\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2<\/strong> (Catalog #100-0785)\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Interleukin-2 t\u00e1i t\u1ed5 h\u1ee3p \u1edf ng\u01b0\u1eddi, kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt (ACF)<\/strong> (Human Recombinant IL-2, ACF; Catalog #78145)\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Bioreactor:<\/strong> V\u00ed d\u1ee5 \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M (ScaleReady; Catalog #80660M) ho\u1eb7c H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M (ScaleReady; Catalog #80055).\u00a0<\/li>\n<\/ul>\n\n\n\n<p><strong>V\u1eadt t\u01b0 b\u1ed5 sung:<\/strong> \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 24-well (ScaleReady; Catalog #80192M) ho\u1eb7c t\u01b0\u01a1ng \u0111\u01b0\u01a1ng \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a li\u1ec1u l\u01b0\u1ee3ng t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t v\u00e0 m\u1eadt \u0111\u1ed9 t\u1ebf b\u00e0o.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"936\" height=\"273\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-1.png\" alt=\"\" class=\"wp-image-11727\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-1.png 936w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-1-300x88.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-1-768x224.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-1-600x175.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-1-90x26.png 90w\" sizes=\"(max-width: 936px) 100vw, 936px\" \/><\/figure>\n\n\n\n<p><strong>H\u00ecnh 1. Quy tr\u00ecnh nu\u00f4i c\u1ea5y \u0111\u1ec3 k\u00edch ho\u1ea1t v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o T trong \u0111\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M v\u00e0 h\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M<\/strong>&nbsp;<\/p>\n\n\n\n<p>T\u1ebf b\u00e0o T ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb kh\u1ed1i b\u1ea1ch c\u1ea7u t\u01b0\u01a1i (fresh leukopak; M\u00e3 danh m\u1ee5c #70500) c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn kh\u1ecfe m\u1ea1nh b\u1eb1ng B\u1ed9 ph\u00e2n l\u1eadp t\u1ebf b\u00e0o T ng\u01b0\u1eddi EasySep\u2122 (M\u00e3 danh m\u1ee5c #17951), v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngay sau ph\u00e2n l\u1eadp ho\u1eb7c sau khi b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh trong CryoStor\u00ae CS10 (M\u00e3 danh m\u1ee5c #07930).<\/p>\n\n\n\n<p>T\u1ebf b\u00e0o T sau ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c c\u1ea5y v\u1edbi m\u1eadt \u0111\u1ed9 1\u20132 \u00d7 10\u2076 t\u1ebf b\u00e0o\/cm\u00b2 trong t\u1ed5ng th\u1ec3 t\u00edch 10 mL (\u0111\u1ed1i v\u1edbi \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M) ho\u1eb7c 50 mL (\u0111\u1ed1i v\u1edbi H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M) m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF (M\u00e3 danh m\u1ee5c #100-0956), sau \u0111\u00f3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng 6,25 ho\u1eb7c 25 \u03bcL\/mL y\u1ebfu t\u1ed1 k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 (M\u00e3 danh m\u1ee5c #100-0785) c\u00f3 b\u1ed5 sung IL-2 ng\u01b0\u1eddi t\u00e1i t\u1ed5 h\u1ee3p (rh IL-2; M\u00e3 danh m\u1ee5c #78145) \u1edf n\u1ed3ng \u0111\u1ed9 180 IU\/mL.<\/p>\n\n\n\n<p>V\u00e0o ng\u00e0y 3, c\u00e1c m\u1ebb nu\u00f4i c\u1ea5y trong G-Rex\u00ae \u0111\u01b0\u1ee3c b\u1ed5 sung th\u00eam m\u00f4i tr\u01b0\u1eddng m\u1edbi ch\u1ee9a IL-2 \u0111\u1ebfn th\u1ec3 t\u00edch t\u1ed1i \u0111a l\u00e0 100 mL (\u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M) ho\u1eb7c 500 mL (H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M), nh\u01b0 \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y trong B\u1ea3ng 1. Kh\u00f4ng th\u1ef1c hi\u1ec7n th\u00eam b\u1ea5t k\u1ef3 thao t\u00e1c can thi\u1ec7p n\u00e0o cho \u0111\u1ebfn th\u1eddi \u0111i\u1ec3m thu ho\u1ea1ch v\u00e0o ng\u00e0y 7 (n\u1ebfu s\u1eed d\u1ee5ng H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M) ho\u1eb7c ng\u00e0y 10 (\u0111\u1ed1i v\u1edbi \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M).<\/p>\n\n\n\n<p><strong>Quy tr\u00ecnh th\u1ef1c hi\u1ec7n:<\/strong>&nbsp;<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>V\u00e0o ng\u00e0y 0, c\u1ea5y t\u1ebf b\u00e0o T ph\u00e2n l\u1eadp sau r\u00e3 \u0111\u00f4ng v\u00e0o \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M ho\u1eb7c H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M v\u1edbi m\u1eadt \u0111\u1ed9 0,5\u20132 \u00d7 10\u2076 t\u1ebf b\u00e0o\/cm\u00b2. K\u00edch ho\u1ea1t t\u1ebf b\u00e0o T b\u1eb1ng T\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 \u1edf n\u1ed3ng \u0111\u1ed9 6,25\u201325 \u03bcL\/mL trong m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF c\u00f3 b\u1ed5 sung rh IL-2 ng\u01b0\u1eddi t\u00e1i t\u1ed5 h\u1ee3p chu\u1ea9n ACF (180 IU\/mL; t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 10 ng\/mL). S\u1eed d\u1ee5ng th\u1ec3 t\u00edch nu\u00f4i c\u1ea5y kh\u1edfi \u0111\u1ea7u \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb nh\u01b0 tr\u00ecnh b\u00e0y trong B\u1ea3ng 1.<\/li>\n<\/ol>\n\n\n\n<p><strong>L\u01b0u \u00fd:<\/strong> M\u1eadt \u0111\u1ed9 nu\u00f4i c\u1ea5y t\u1ed1i thi\u1ec3u \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb l\u00e0 0,5 \u00d7 10\u2076 t\u1ebf b\u00e0o\/cm\u00b2. Chu\u1ea9n \u0111\u1ed9 (titrate) T\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u01b0u cho quy tr\u00ecnh (H\u00ecnh 2).<\/p>\n\n\n\n<p><strong>B\u1ea3ng 1. C\u00e1c thi\u1ebft l\u1eadp nu\u00f4i c\u1ea5y \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb cho h\u1ec7 th\u1ed1ng nu\u00f4i c\u1ea5y G-Rex\u00ae<\/strong>&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Thi\u1ebft b\u1ecb \/ D\u1ee5ng c\u1ee5<\/strong><\/td><td><strong>Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t<\/strong><\/td><td><strong>Th\u1ec3 t\u00edch \u0111\u1ea7u v\u00e0o ng\u00e0y 0<\/strong><\/td><td><strong>Th\u1ec3 t\u00edch cu\u1ed1i c\u00f9ng v\u00e0o ng\u00e0y 3<\/strong><\/td><\/tr><tr><td>\u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M<\/td><td>10\u00a0cm\u00b2<strong> \/ gi\u1ebfng<\/strong>\u00a0<\/td><td>10&nbsp;mL<strong><\/strong>&nbsp;<\/td><td>100&nbsp;mL<strong><\/strong>&nbsp;<\/td><\/tr><tr><td>H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M<\/td><td>50\u00a0cm\u00b2<\/td><td>50&nbsp;mL<strong><\/strong>&nbsp;<\/td><td>500&nbsp;mL<strong><\/strong>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ol start=\"2\" class=\"wp-block-list\">\n<li>V\u00e0o ng\u00e0y 3, b\u1ed5 sung m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF m\u1edbi c\u00f3 ch\u1ee9a rh IL-2 t\u00e1i t\u1ed5 h\u1ee3p ng\u01b0\u1eddi chu\u1ea9n ACF (180 IU\/mL; t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 10 ng\/mL) \u0111\u1ec3 \u0111\u01b0a m\u1ebb nu\u00f4i c\u1ea5y \u0111\u1ea1t th\u1ec3 t\u00edch l\u00e0m vi\u1ec7c t\u1ed1i \u0111a 100 mL \u0111\u1ed1i v\u1edbi \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M ho\u1eb7c 500 mL \u0111\u1ed1i v\u1edbi H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M (xem B\u1ea3ng 1). Kh\u00f4ng c\u1ea7n b\u1ed5 sung th\u00eam dinh d\u01b0\u1ee1ng ho\u1eb7c th\u1ef1c hi\u1ec7n b\u1ea5t k\u1ef3 thao t\u00e1c can thi\u1ec7p n\u00e0o kh\u00e1c tr\u01b0\u1edbc khi thu nh\u1eadn t\u1ebf b\u00e0o (H\u00ecnh 1).<\/li>\n<\/ol>\n\n\n\n<ol start=\"3\" class=\"wp-block-list\">\n<li>V\u00e0o ng\u00e0y 7 ho\u1eb7c ng\u00e0y 10, thu nh\u1eadn t\u1ebf b\u00e0o \u0111\u1ec3 th\u1ef1c hi\u1ec7n c\u00e1c \u0111\u00e1nh gi\u00e1 chuy\u00ean s\u00e2u ti\u1ebfp theo nh\u01b0 \u0111\u1ebfm s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o, ki\u1ec3m tra \u0111\u1ed9 s\u1ed1ng v\u00e0 nhu\u1ed9m x\u00e1c \u0111\u1ecbnh ki\u1ec3u h\u00ecnh (H\u00ecnh 3 v\u00e0 5). C\u1ee5 th\u1ec3, thu nh\u1eadn v\u00e0o ng\u00e0y 7 \u0111\u1ed1i v\u1edbi H\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae 50M v\u00e0 v\u00e0o ng\u00e0y 10 \u0111\u1ed1i v\u1edbi \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M.<\/li>\n<\/ol>\n\n\n\n<p>Ngu\u1ed3n: <a href=\"https:\/\/www.stemcell.com\/low-intervention-protocol-for-t-cell-expansion-in-g-rex-bioreactors.html\">How to Expand T Cells in G-Rex\u00ae Bioreactors Using a Low-Intervention Protocol<\/a><\/p>\n\n\n\n<p><strong>S\u1ed1 li\u1ec7u th\u1ed1ng k\u00ea<\/strong>&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"936\" height=\"720\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-2.png\" alt=\"\" class=\"wp-image-11728\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-2.png 936w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-2-300x231.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-2-768x591.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-2-600x462.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-2-70x54.png 70w\" sizes=\"(max-width: 936px) 100vw, 936px\" \/><\/figure>\n\n\n\n<p><strong>H\u00ecnh 2. Kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t v\u00e0 ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o T thay \u0111\u1ed5i t\u00f9y thu\u1ed9c v\u00e0o m\u1eadt \u0111\u1ed9 nu\u00f4i c\u1ea5y v\u00e0 n\u1ed3ng \u0111\u1ed9 ch\u1ea5t ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122<\/strong>&nbsp;<\/p>\n\n\n\n<p>M\u1ed9t th\u1eed nghi\u1ec7m s\u00e0ng l\u1ecdc s\u01a1 b\u1ed9 \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean nhi\u1ec1u d\u1ea3i m\u1eadt \u0111\u1ed9 c\u1ea5y v\u00e0 li\u1ec1u l\u01b0\u1ee3ng t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t kh\u00e1c nhau nh\u1eb1m \u0111\u00e1nh gi\u00e1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ch\u00fang l\u00ean t\u1ef7 l\u1ec7 s\u1ed1ng c\u0169ng nh\u01b0 m\u1ee9c \u0111\u1ed9 k\u00edch ho\u1ea1t c\u1ee7a t\u1ebf b\u00e0o T, t\u1eeb \u0111\u00f3 l\u00e0m c\u0103n c\u1ee9 l\u1ef1a ch\u1ecdn c\u00e1c \u0111i\u1ec1u ki\u1ec7n t\u1ed1i \u01b0u cho giai \u0111o\u1ea1n t\u0103ng sinh ti\u1ebfp theo.<\/p>\n\n\n\n<p>T\u1ebf b\u00e0o T ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb c\u00e1c kh\u1ed1i b\u1ea1ch c\u1ea7u t\u01b0\u01a1i (fresh leukopak; M\u00e3 danh m\u1ee5c #70500) c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn kh\u1ecfe m\u1ea1nh b\u1eb1ng B\u1ed9 ph\u00e2n l\u1eadp t\u1ebf b\u00e0o T ng\u01b0\u1eddi EasySep\u2122 (M\u00e3 danh m\u1ee5c #17951) v\u00e0 \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh trong CryoStor\u00ae CS10 (M\u00e3 danh m\u1ee5c #07930). V\u00e0o ng\u00e0y 0, t\u1ebf b\u00e0o T \u0111\u00f4ng l\u1ea1nh sau ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c r\u00e3 \u0111\u00f4ng v\u00e0 c\u1ea5y \u1edf c\u00e1c m\u1eadt \u0111\u1ed9 kh\u00e1c nhau v\u00e0o \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 24 gi\u1ebfng, s\u1eed d\u1ee5ng t\u1ed5ng th\u1ec3 t\u00edch 1 mL m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF (M\u00e3 danh m\u1ee5c #100-0956) c\u00f3 b\u1ed5 sung 180 IU\/mL IL-2 ng\u01b0\u1eddi t\u00e1i t\u1ed5 h\u1ee3p (rh IL-2; M\u00e3 danh m\u1ee5c #78145). T\u1ebf b\u00e0o T \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 (M\u00e3 danh m\u1ee5c #100-0785) \u1edf nhi\u1ec1u m\u1ee9c li\u1ec1u kh\u00e1c nhau.<\/p>\n\n\n\n<p>V\u00e0o ng\u00e0y 3, t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c thu nh\u1eadn \u0111\u1ec3 ph\u00e2n t\u00edch. T\u1ef7 l\u1ec7 s\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng m\u00e1y \u0111\u1ebfm t\u1ebf b\u00e0o t\u1ef1 \u0111\u1ed9ng NucleoCounter\u00ae NC-250\u2122, v\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111o d\u00f2ng t\u1ebf b\u00e0o (flow cytometry) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e2n t\u00edch m\u1ee9c \u0111\u1ed9 bi\u1ec3u hi\u1ec7n d\u1ea5u \u1ea5n b\u1ec1 m\u1eb7t CD25 nh\u1eb1m \u0111\u00e1nh gi\u00e1 tr\u1ea1ng th\u00e1i k\u00edch ho\u1ea1t c\u1ee7a t\u1ebf b\u00e0o T.<\/p>\n\n\n\n<p><strong>(A)<\/strong> C\u00e1c c\u1ed9t bi\u1ec3u \u0111\u1ed3 bi\u1ec3u th\u1ecb t\u1ef7 l\u1ec7 s\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o v\u00e0o ng\u00e0y 3 t\u1ea1i t\u1eebng m\u1eadt \u0111\u1ed9 c\u1ea5y t\u01b0\u01a1ng \u1ee9ng v\u1edbi c\u00e1c n\u1ed3ng \u0111\u1ed9 t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t kh\u00e1c nhau. T\u1ef7 l\u1ec7 s\u1ed1ng gi\u1ea3m r\u00f5 r\u1ec7t \u1edf nh\u1eefng t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c c\u1ea5y v\u1edbi m\u1eadt \u0111\u1ed9 1,25 \u00d7 10\u2075 t\u1ebf b\u00e0o\/cm\u00b2. D\u1eef li\u1ec7u \u0111\u01b0\u1ee3c bi\u1ec3u di\u1ec5n d\u01b0\u1edbi d\u1ea1ng gi\u00e1 tr\u1ecb trung b\u00ecnh \u00b1 sai s\u1ed1 chu\u1ea9n (mean \u00b1 SEM; n = 1\u20133 ng\u01b0\u1eddi hi\u1ebfn).<\/p>\n\n\n\n<p><strong>(B)<\/strong> C\u00e1c c\u1ed9t bi\u1ec3u \u0111\u1ed3 bi\u1ec3u th\u1ecb t\u1ea7n su\u1ea5t (t\u1ef7 l\u1ec7 ph\u1ea7n tr\u0103m) t\u1ebf b\u00e0o CD25\u207a trong qu\u1ea7n th\u1ec3 CD4\u207a v\u00e0 CD8\u207a. Vi\u1ec7c s\u1eed d\u1ee5ng l\u01b0\u1ee3ng t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t th\u1ea5p h\u01a1n c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u1ea7n su\u1ea5t t\u1ebf b\u00e0o CD25\u207a sau 3 ng\u00e0y k\u00edch th\u00edch (n = 1\u20133 ng\u01b0\u1eddi hi\u1ebfn).<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"936\" height=\"972\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image.png\" alt=\"\" class=\"wp-image-11726\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image.png 936w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-289x300.png 289w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-768x798.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-600x623.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-52x54.png 52w\" sizes=\"(max-width: 936px) 100vw, 936px\" \/><\/figure>\n\n\n\n<p><strong>H\u00ecnh 3. Kh\u1ea3 n\u0103ng ho\u1ea1t h\u00f3a v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o T trong \u0111\u0129a gi\u1ebfng G-Rex\u00ae6M v\u1edbi thu\u1ed1c th\u1eed ImmunoCult\u2122 t\u1ea1o ra m\u1eadt \u0111\u1ed9 t\u1ebf b\u00e0o s\u1ed1ng cao.<\/strong>&nbsp;<\/p>\n\n\n\n<p>T\u1ebf b\u00e0o T ng\u01b0\u1eddi sau ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng T\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 (M\u00e3 danh m\u1ee5c #100-0785) \u1edf n\u1ed3ng \u0111\u1ed9 6,25 ho\u1eb7c 25 \u03bcL\/mL trong m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF (M\u00e3 danh m\u1ee5c #100-0956) c\u00f3 b\u1ed5 sung IL-2 ng\u01b0\u1eddi t\u00e1i t\u1ed5 h\u1ee3p (rh IL-2; M\u00e3 danh m\u1ee5c #78145). T\u1ebf b\u00e0o \u0111\u01b0\u1ee3c nu\u00f4i t\u0103ng sinh trong \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M trong 10 ng\u00e0y theo quy tr\u00ecnh \u1edf H\u00ecnh 1.<\/p>\n\n\n\n<p><strong>(A)<\/strong> \u0110\u1ed3 th\u1ecb bi\u1ec3u th\u1ecb h\u1ec7 s\u1ed1 t\u0103ng sinh t\u00edch l\u0169y (cumulative fold expansion) v\u00e0 t\u1ef7 l\u1ec7 s\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o; trong \u0111\u00f3 c\u00e1c \u0111i\u1ec3m ch\u1ea5m bi\u1ec3u di\u1ec5n t\u1eebng \u0111i\u1ec3m d\u1eef li\u1ec7u ri\u00eang l\u1ebb, c\u00f2n c\u00e1c c\u1ed9t ho\u1eb7c \u0111\u01b0\u1eddng k\u1ebb bi\u1ec3u th\u1ecb gi\u00e1 tr\u1ecb trung b\u00ecnh t\u01b0\u01a1ng \u1ee9ng (n = 2).<\/p>\n\n\n\n<p><strong>(B)<\/strong> M\u1eadt \u0111\u1ed9 t\u1ebf b\u00e0o b\u1ec1 m\u1eb7t \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 v\u00e0o ng\u00e0y 10. Vi\u1ec7c s\u1eed d\u1ee5ng li\u1ec1u t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t th\u1ea5p h\u01a1n mang l\u1ea1i m\u1eadt \u0111\u1ed9 trung b\u00ecnh \u0111\u1ea1t 3,7 \u00d7 10\u2077 t\u1ebf b\u00e0o\/cm\u00b2, \u0111\u1ea1t m\u1ee9c c\u00f4ng su\u1ea5t t\u1ed1i \u0111a c\u1ee7a thi\u1ebft b\u1ecb (n = 2).<\/p>\n\n\n\n<p><strong>(C)<\/strong> T\u1ea7n su\u1ea5t c\u00e1c d\u01b0\u1edbi nh\u00f3m t\u1ebf b\u00e0o T CD4\u207a v\u00e0 CD8\u207a \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch. \u0110\u1ebfn ng\u00e0y 10, qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o T sau t\u0103ng sinh bao g\u1ed3m c\u1ea3 c\u00e1c d\u01b0\u1edbi nh\u00f3m t\u1ebf b\u00e0o nh\u1edb trung t\u00e2m (central memory) v\u00e0 t\u1ebf b\u00e0o nh\u1edb hi\u1ec7u \u1ee9ng (effector memory).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>T\u2099\/SCM:<\/strong> T\u1ebf b\u00e0o T nguy\u00ean v\u1eb9n v\u00e0 t\u1ebf b\u00e0o T nh\u1edb g\u1ed1c (CCR7\u207aCD45RO\u207b)<\/li>\n\n\n\n<li><strong>T_CM:<\/strong> T\u1ebf b\u00e0o T nh\u1edb trung t\u00e2m (CCR7\u207aCD45RO\u207a)<\/li>\n\n\n\n<li><strong>T_EM:<\/strong> T\u1ebf b\u00e0o T nh\u1edb hi\u1ec7u \u1ee9ng (CCR7\u207bCD45RO\u207a)<\/li>\n\n\n\n<li><strong>T_EFF:<\/strong> T\u1ebf b\u00e0o T hi\u1ec7u \u1ee9ng (CCR7\u207bCD45RO\u207b)<\/li>\n<\/ul>\n\n\n\n<p>D\u1eef li\u1ec7u \u0111\u01b0\u1ee3c bi\u1ec3u di\u1ec5n d\u01b0\u1edbi d\u1ea1ng gi\u00e1 tr\u1ecb trung b\u00ecnh \u00b1 sai s\u1ed1 chu\u1ea9n (mean \u00b1 SEM; n = 2).<\/p>\n\n\n\n<p><strong>(D)<\/strong> \u0110\u1ed3 th\u1ecb bi\u1ec3u th\u1ecb m\u1eadt \u0111\u1ed9 b\u1ec1 m\u1eb7t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o T CD8\u207a nh\u1edb trung t\u00e2m (CD45RO\u207aCCR7\u207a). Trong t\u1ea5t c\u1ea3 c\u00e1c \u0111i\u1ec1u ki\u1ec7n th\u1eed nghi\u1ec7m, s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o T nh\u1edb trung t\u00e2m \u0111\u1ec1u v\u01b0\u1ee3t ng\u01b0\u1ee1ng 2 \u00d7 10\u2076 t\u1ebf b\u00e0o\/cm\u00b2, t\u01b0\u01a1ng \u1ee9ng v\u1edbi t\u1ed5ng s\u1ed1 kho\u1ea3ng 2 \u00d7 10\u2077 t\u1ebf b\u00e0o\/gi\u1ebfng (n = 2).<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"936\" height=\"252\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-3.png\" alt=\"\" class=\"wp-image-11729\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-3.png 936w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-3-300x81.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-3-768x207.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-3-600x162.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-3-90x24.png 90w\" sizes=\"(max-width: 936px) 100vw, 936px\" \/><\/figure>\n\n\n\n<p><strong>H\u00ecnh 4. Kh\u1ea3 n\u0103ng ho\u1ea1t h\u00f3a v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o T trong h\u1ec7 th\u1ed1ng m\u1edf G-Rex\u00ae50M v\u1edbi thu\u1ed1c th\u1eed ImmunoCult\u2122 t\u1ea1o ra m\u1eadt \u0111\u1ed9 t\u1ebf b\u00e0o s\u1ed1ng cao.<\/strong>&nbsp;<\/p>\n\n\n\n<p>T\u1ebf b\u00e0o T ng\u01b0\u1eddi sau ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng T\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 (M\u00e3 danh m\u1ee5c #100-0785) \u1edf n\u1ed3ng \u0111\u1ed9 6,25 ho\u1eb7c 25 \u03bcL\/mL trong m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF (M\u00e3 danh m\u1ee5c #100-0956) c\u00f3 b\u1ed5 sung IL-2 ng\u01b0\u1eddi t\u00e1i t\u1ed5 h\u1ee3p (rh IL-2; M\u00e3 danh m\u1ee5c #78145). T\u1ebf b\u00e0o \u0111\u01b0\u1ee3c nu\u00f4i t\u0103ng sinh trong H\u1ec7 th\u1ed1ng G-Rex\u00ae 50M trong 7 ng\u00e0y theo quy tr\u00ecnh \u1edf H\u00ecnh 1.<\/p>\n\n\n\n<p><strong>(A)<\/strong> \u0110\u1ed3 th\u1ecb k\u1ebft h\u1ee3p d\u1ea1ng c\u1ed9t v\u00e0 \u0111i\u1ec3m l\u1ea7n l\u01b0\u1ee3t bi\u1ec3u th\u1ecb h\u1ec7 s\u1ed1 t\u0103ng sinh t\u00edch l\u0169y trung b\u00ecnh v\u00e0 t\u1ef7 l\u1ec7 s\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o. D\u1eef li\u1ec7u \u0111\u01b0\u1ee3c bi\u1ec3u di\u1ec5n d\u01b0\u1edbi d\u1ea1ng gi\u00e1 tr\u1ecb trung b\u00ecnh (n = 2).<\/p>\n\n\n\n<p><strong>(B)<\/strong> M\u1eadt \u0111\u1ed9 t\u1ebf b\u00e0o b\u1ec1 m\u1eb7t \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 sau \u0111\u1ee3t t\u0103ng sinh t\u1ebf b\u00e0o T ng\u1eafn h\u1ea1n trong 7 ng\u00e0y. N\u0103ng su\u1ea5t \u0111\u1ea1t h\u01a1n 2 \u00d7 10\u2077 t\u1ebf b\u00e0o\/cm\u00b2 (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng &gt;1 \u00d7 10\u2079 t\u1ebf b\u00e0o\/thi\u1ebft b\u1ecb) khi s\u1eed d\u1ee5ng li\u1ec1u t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t th\u1ea5p h\u01a1n.<\/p>\n\n\n\n<p><strong>(C)<\/strong> \u0110\u1ed3 th\u1ecb bi\u1ec3u th\u1ecb m\u1eadt \u0111\u1ed9 b\u1ec1 m\u1eb7t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o T CD8\u207a nh\u1edb trung t\u00e2m (CD45RO\u207aCCR7\u207a) v\u00e0o ng\u00e0y 7. S\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o T nh\u1edb trung t\u00e2m \u1edf t\u1ea5t c\u1ea3 c\u00e1c \u0111i\u1ec1u ki\u1ec7n dao \u0111\u1ed9ng trong kho\u1ea3ng 1\u20134 \u00d7 10\u2076 t\u1ebf b\u00e0o\/cm\u00b2. C\u00f3 ghi nh\u1eadn s\u1ef1 bi\u1ebfn thi\u00ean gi\u1eefa c\u00e1c ng\u01b0\u1eddi hi\u1ebfn (donor variability).<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"936\" height=\"318\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-4.png\" alt=\"\" class=\"wp-image-11730\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-4.png 936w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-4-300x102.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-4-768x261.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-4-600x204.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2026\/10\/image-4-90x31.png 90w\" sizes=\"(max-width: 936px) 100vw, 936px\" \/><\/figure>\n\n\n\n<p><strong>H\u00ecnh 5. T\u1ebf b\u00e0o T \u0111\u01b0\u1ee3c t\u0103ng sinh b\u1eb1ng thu\u1ed1c th\u1eed GMP ImmunoCult\u2122 c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o \u0111\u00edch.<\/strong>&nbsp;<\/p>\n\n\n\n<p>T\u1ebf b\u00e0o T ng\u01b0\u1eddi sau ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng T\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 (M\u00e3 danh m\u1ee5c #100-0785) \u1edf n\u1ed3ng \u0111\u1ed9 6,25 \u03bcL\/mL trong m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF (M\u00e3 danh m\u1ee5c #100-0956) c\u00f3 b\u1ed5 sung IL-2 ng\u01b0\u1eddi t\u00e1i t\u1ed5 h\u1ee3p (rh IL-2; M\u00e3 danh m\u1ee5c #78145). T\u1ebf b\u00e0o \u0111\u01b0\u1ee3c nu\u00f4i t\u0103ng sinh trong \u0110\u0129a nu\u00f4i c\u1ea5y G-Rex\u00ae 6M trong 10 ng\u00e0y theo quy tr\u00ecnh \u1edf H\u00ecnh 1.<\/p>\n\n\n\n<p>Ho\u1ea1t t\u00ednh g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o (cytotoxic activity) \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 b\u1eb1ng th\u1eed nghi\u1ec7m d\u1ef1a tr\u00ean k\u1ef9 thu\u1eadt \u0111o d\u00f2ng t\u1ebf b\u00e0o (flow cytometry). C\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u \u0111\u00edch NALM-6 \u0111\u01b0\u1ee3c g\u1eafn nh\u00e3n hu\u1ef3nh quang b\u1eb1ng CellTrace\u2122 Violet theo h\u01b0\u1edbng d\u1eabn c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t v\u00e0 \u0111\u1ed3ng nu\u00f4i c\u1ea5y (co-culture) v\u1edbi c\u00e1c t\u1ebf b\u00e0o T sau t\u0103ng sinh trong \u0110\u0129a \u0111\u00e1y tr\u00f2n 96 gi\u1ebfng (M\u00e3 danh m\u1ee5c #38018) \u1edf c\u00e1c t\u1ef7 l\u1ec7 t\u1ebf b\u00e0o hi\u1ec7u \u1ee9ng\u1ebf b\u00e0o \u0111\u00edch (E) l\u1ea7n l\u01b0\u1ee3t l\u00e0 3:1, 1:1 v\u00e0 0,3:1 trong m\u00f4i tr\u01b0\u1eddng ImmunoCult\u2122-XF kh\u00f4ng b\u1ed5 sung cytokine.<\/p>\n\n\n\n<p>M\u1ed9t h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u k\u00e9p (bispecific antibody cocktail) nh\u1eafm \u0111\u1ed3ng th\u1eddi v\u00e0o t\u1ebf b\u00e0o T v\u00e0 t\u1ebf b\u00e0o kh\u1ed1i u \u0111\u01b0\u1ee3c b\u1ed5 sung nh\u1eb1m t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho qu\u00e1 tr\u00ecnh ti\u00eau di\u1ec7t t\u1ebf b\u00e0o \u0111\u00edch. Sau 4\u20135 gi\u1edd \u0111\u1ed3ng nu\u00f4i c\u1ea5y, t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c r\u1eeda b\u1eb1ng PBS v\u00e0 nhu\u1ed9m v\u1edbi Annexin V (M\u00e3 danh m\u1ee5c #100-0328) c\u00f9ng DRAQ7\u2122 tr\u01b0\u1edbc khi ti\u1ebfn h\u00e0nh ph\u00e2n t\u00edch. T\u1ef7 l\u1ec7 ph\u1ea7n tr\u0103m t\u1ebf b\u00e0o b\u1ecb ti\u00eau di\u1ec7t (percentage of killing) \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh d\u1ef1a tr\u00ean t\u1ea7n su\u1ea5t c\u00e1c t\u1ebf b\u00e0o \u0111\u00edch mang d\u1ea5u Annexin V\u207a. T\u1ebf b\u00e0o T sau t\u0103ng sinh t\u1eeb hai ng\u01b0\u1eddi hi\u1ebfn \u0111\u1ed9c l\u1eadp (A v\u00e0 B) \u0111\u1ec1u th\u1ec3 hi\u1ec7n ho\u1ea1t t\u00ednh g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o m\u1ea1nh khi \u0111\u1ed3ng nu\u00f4i c\u1ea5y v\u1edbi c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u NALM-6.<\/p>\n\n\n\n<p>Trong ph\u00e1t tri\u1ec3n v\u00e0 s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T, ch\u1eb3ng h\u1ea1n nh\u01b0 CAR-T v\u00e0 TCR-T, s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa h\u1ec7 th\u1ed1ng nu\u00f4i c\u1ea5y G-Rex\u00ae (ScaleReady) v\u00e0 d\u00f2ng h\u00f3a ch\u1ea5t ImmunoCult\u2122 (STEMCELL Technologies) mang \u0111\u1ebfn m\u1ed9t gi\u1ea3i ph\u00e1p t\u0103ng sinh tinh g\u1ecdn, gi\u00fap gi\u1ea3m \u0111\u00e1ng k\u1ec3 s\u1ed1 thao t\u00e1c th\u1ee7 c\u00f4ng trong qu\u00e1 tr\u00ecnh nu\u00f4i c\u1ea5y. Nh\u1edd c\u01a1 ch\u1ebf trao \u0111\u1ed5i kh\u00ed hi\u1ec7u qu\u1ea3 qua m\u00e0ng \u0111\u00e1y silicone, h\u1ec7 th\u1ed1ng cho ph\u00e9p t\u0103ng sinh t\u1ebf b\u00e0o T \u1edf m\u1eadt \u0111\u1ed9 cao v\u1edbi s\u1ed1 l\u1ea7n can thi\u1ec7p t\u1ed1i thi\u1ec3u, qua \u0111\u00f3 g\u00f3p ph\u1ea7n gi\u1ea3m nguy c\u01a1 nhi\u1ec5m ch\u00e9o v\u00e0 h\u1ea1n ch\u1ebf bi\u1ebfn thi\u00ean gi\u1eefa c\u00e1c m\u1ebb nu\u00f4i c\u1ea5y.<\/p>\n\n\n\n<p>D\u1eef li\u1ec7u th\u1ef1c nghi\u1ec7m cho th\u1ea5y vi\u1ec7c s\u1eed d\u1ee5ng T\u00e1c nh\u00e2n k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T ng\u01b0\u1eddi ImmunoCult\u2122 Human CD3\/CD28\/CD2 \u1edf n\u1ed3ng \u0111\u1ed9 6,25 \u03bcL\/mL c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 \u0111\u1ea1t n\u0103ng su\u1ea5t v\u01b0\u1ee3t 10\u2079 t\u1ebf b\u00e0o tr\u00ean H\u1ec7 th\u1ed1ng G-Rex\u00ae 50M, \u0111\u1ed3ng th\u1eddi duy tr\u00ec qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o T nh\u1edb v\u00e0 ho\u1ea1t t\u00ednh g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o m\u1ea1nh. Nh\u1eefng \u0111\u1eb7c \u0111i\u1ec3m n\u00e0y cho th\u1ea5y ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng c\u1ee7a quy tr\u00ecnh trong c\u00e1c chi\u1ebfn l\u01b0\u1ee3c m\u1edf r\u1ed9ng quy m\u00f4 theo c\u1ea3 h\u01b0\u1edbng scale-up v\u00e0 scale-out.<\/p>\n\n\n\n<p>Xem th\u00eam: <a href=\"https:\/\/biogroupvietnam.com\/vi\/giai-phap\/giai-phap-nuoi-cay-tang-sinh-bao-quan-te-bao-cho-lieu-phap-tien-tien\/\">Gi\u1ea3i Ph\u00e1p Nu\u00f4i C\u1ea5y, T\u0103ng Sinh v\u00e0 B\u1ea3o Qu\u1ea3n T\u1ebf B\u00e0o Cho Li\u1ec7u Ph\u00e1p Ti\u00ean Ti\u1ebfn<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u1ebf b\u00e0o T l\u00e0 tr\u1ecdng t\u00e2m c\u1ee7a nhi\u1ec1u chi\u1ebfn l\u01b0\u1ee3c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nu\u00f4i nh\u1eadn. V\u00ec v\u1eady, vi\u1ec7c s\u1edf h\u1eefu c\u00e1c gi\u1ea3i ph\u00e1p k\u00edch ho\u1ea1t v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o m\u1ea1nh m\u1ebd, d\u1ec5 d\u00e0ng m\u1edf r\u1ed9ng quy m\u00f4 l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t trong nghi\u00ean c\u1ee9u, t\u1ed1i \u01b0u quy tr\u00ecnh v\u00e0 s\u1ea3n<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/giai-phap-tang-sinh-te-bao-t-immunocult-g-rex\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":11731,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11725","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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