{"id":4175,"date":"2024-02-25T09:47:39","date_gmt":"2024-02-25T09:47:39","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/impingement-jets-mixing-skids-for-high-flow-production-of-nanoparticles-lnp-microemulsions-etc\/"},"modified":"2025-09-29T13:59:57","modified_gmt":"2025-09-29T06:59:57","slug":"thiet-bi-tron-xung-luc-phan-luc-ijm-san-xuat-hat-nano-lipid-lnp","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thiet-bi-tron-xung-luc-phan-luc-ijm-san-xuat-hat-nano-lipid-lnp\/","title":{"rendered":"Thi\u1ebft B\u1ecb Tr\u1ed9n Xung L\u1ef1c Ph\u1ea3n L\u1ef1c (IJM) S\u1ea3n Xu\u1ea5t H\u1ea1t Nano Lipid (LNP)"},"content":{"rendered":"

Thi\u1ebft b\u1ecb tr\u1ed9n xung l\u1ef1c ph\u1ea3n l\u1ef1c d\u00f9ng trong s\u1ea3n xu\u1ea5t h\u1ea1t nano \u1edf t\u1ed1c \u0111\u1ed9 d\u00f2ng cao (nh\u01b0 c\u00e1c h\u1ea1t nano lipid – LNP, vi nh\u0169 t\u01b0\u01a1ng, \u2026).<\/h2>\n

<\/span>Xu h\u01b0\u1edbng nghi\u00ean c\u1ee9u & s\u1ea3n xu\u1ea5t thu\u1ed1c sinh h\u1ecdc mRNA-LNPs<\/strong><\/span><\/h3>\n

Ti\u1ebfp n\u1ed1i s\u1ef1 th\u00e0nh c\u00f4ng c\u1ee7a v\u1eafc xin mRNA COVID-19 (v\u1eafc xin mRNA-LNPs – c\u00e1c ti\u1ec3u ph\u00e2n nano lipid \u0111\u1ec3 bao b\u1ecdc l\u1ea5y mRNA) c\u1ee7a 2 c\u00f4ng ty Pfizer-BioNTech v\u00e0 Moderna, s\u1ebd t\u1ea1o ra xu h\u01b0\u1edbng R&D v\u00e0 s\u1ea3n xu\u1ea5t thu\u1ed1c sinh h\u1ecdc mRNA-LNPs. Nh\u01b0 v\u1eady, thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t h\u1ea1t nano lipid (LNP) thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t c\u00e1c h\u1ea1t nano lipid d\u01b0\u1ee3c ph\u1ea9m (production equipment for pharmaceutical lipid nanoparticles) n\u00e0o s\u1ebd ch\u00ednh x\u00e1c & \u0111\u00e1ng tin c\u1eady? Thi\u1ebft b\u1ecb IJM-Skid (Impingement jets mixing technology), m\u00e1y s\u1eafc k\u00fd FPLC & thi\u1ebft b\u1ecb ph\u00e2n t\u00edch ho\u1ea1t ch\u1ea5t nh\u01b0 RNA, mRNA, siRNA, or DNA-based APIs c\u1ee7a h\u00e3ng KNAUER Wissenschaftliche Ger\u00e4te GmbH (\u0110\u1ee9c) \u0111ang h\u1ed5 tr\u1ee3 hi\u1ec7u qu\u1ea3 trong s\u1ea3n xu\u1ea5t v\u1eafc xin mRNA COVID-19.<\/p>\n

<\/span>T\u1ed5ng quan v\u1ec1 quy tr\u00ecnh s\u1ea3n xu\u1ea5t v\u1eafc xin mRNA<\/strong><\/span><\/h3>\n

 <\/p>\n

\"\"<\/p>\n

<\/span>C\u00f4ng ngh\u1ec7 tr\u1ed9n xung l\u1ef1c ph\u1ea3n l\u1ef1c (IJM)<\/strong><\/span><\/h3>\n

C\u00f4ng ngh\u1ec7 tr\u1ed9n xung l\u1ef1c ph\u1ea3n l\u1ef1c (IJM) (hay c\u00f2n g\u1ecdi l\u00e0 c\u00f4ng ngh\u1ec7 va ch\u1ea1m ph\u1ea3n l\u1ef1c) cho ph\u00e9p t\u1ea1o c\u00f4ng th\u1ee9c v\u00e0 s\u1ea3n xu\u1ea5t c\u00e1c h\u1ea1t nano lipid ch\u1ea5t l\u01b0\u1ee3ng cao mang API (v\u00ed d\u1ee5: \u0111\u1ed1i v\u1edbi v\u1eafc xin mRNA). Qu\u00e1 tr\u00ecnh bao g\u00f3i c\u00e1c th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c ho\u1ea1t t\u00ednh v\u1edbi lipid d\u1ef1a tr\u00ean c\u00f4ng ngh\u1ec7 tr\u1ed9n xung l\u1ef1c ph\u1ea3n l\u1ef1c, trong \u0111\u00f3 hai d\u00f2ng va ch\u1ea1m v\u1edbi t\u1ed1c \u0111\u1ed9 cao trong m\u1ed9t bu\u1ed3ng tr\u1ed9n ph\u1ea3n l\u1ef1c. M\u1ed9t trong nh\u1eefng d\u00f2ng ch\u1ee9a lipid trong dung m\u00f4i h\u1eefu c\u01a1 v\u00e0 d\u00f2ng c\u00f2n l\u1ea1i ch\u1ee9a API trong n\u01b0\u1edbc).<\/p>\n

Vi\u1ec7c tr\u1ed9n \u1edf t\u1ed1c \u0111\u1ed9 cao l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng h\u00f2a tan c\u1ee7a lipid \u0111\u1ec3 c\u00e1c h\u1ea1t nano \u0111\u1ed3ng nh\u1ea5t \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh. Ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a c\u00e1c h\u1ea1t nano ph\u1ee5 thu\u1ed9c v\u00e0o \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a d\u00f2ng ch\u1ea3y, h\u00ecnh d\u1ea1ng m\u00e1y tr\u1ed9n v\u00e0 v\u1eadn t\u1ed1c ch\u1ea5t l\u1ecfng. B\u01b0\u1edbc cu\u1ed1i c\u00f9ng, h\u1ed7n h\u1ee3p \u0111\u01b0\u1ee3c d\u1eadp t\u1eaft \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ea1t.<\/p>\n

 <\/p>\n

\"\"<\/p>\n

<\/span>Thi\u1ebft b\u1ecb tr\u1ed9n xung l\u1ef1c ph\u1ea3n l\u1ef1c \u1ee9ng d\u1ee5ng s\u1ea3n xu\u1ea5t h\u1ea1t nano \u1edf quy m\u00f4 R&D \u0111\u1ebfn s\u1ea3n xu\u1ea5t<\/strong><\/span><\/h3>\n

S\u1ed1 l\u01b0\u1ee3ng c\u00e1c \u0111\u01a1n v\u1ecb tr\u1ed9n song song ph\u1ee5 thu\u1ed9c v\u00e0o \u1ee9ng d\u1ee5ng. Ngo\u00e0i ra, s\u1ed1 l\u01b0\u1ee3ng m\u00e1y b\u01a1m, \u0111\u1ed3ng h\u1ed3 \u0111o l\u01b0u l\u01b0\u1ee3ng, m\u00e1y tr\u1ed9n ph\u1ea3n l\u1ef1c v\u00e0 \u0111\u01b0\u1eddng \u1ed1ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh cho ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n v\u00e0 quy m\u00f4 y\u00eau c\u1ea7u. T\u1ea5t c\u1ea3 c\u00e1c \u0111\u01b0\u1eddng tr\u01b0\u1ee3t \u0111\u01b0\u1ee3c ch\u1ebf t\u1ea1o trong khung th\u00e9p kh\u00f4ng g\u1ec9 tr\u00ean b\u00e1nh xe v\u00e0 ph\u00f9 h\u1ee3p v\u1edbi quy tr\u00ecnh l\u00e0m s\u1ea1ch CIP trong s\u1ea3n xu\u1ea5t d\u01b0\u1ee3c ph\u1ea9m. Thi\u1ebft b\u1ecb IJM Skid quy m\u00f4 s\u1ea3n xu\u1ea5t nh\u1ecf c\u00f3 hai thi\u1ebft b\u1ecb tr\u1ed9n song song. M\u1ed7i \u0111\u01a1n v\u1ecb ch\u1ee9a b\u1ed1n m\u00e1y b\u01a1m<\/strong>.<\/p>\n

\"\"<\/p>\n

Tr\u01b0\u1edbc ti\u00ean, dung d\u1ecbch th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m ho\u1ea1t t\u00ednh \u0111\u1eadm \u0111\u1eb7c (API) \u0111\u01b0\u1ee3c pha lo\u00e3ng v\u00e0 sau \u0111\u00f3 tr\u1ed9n v\u1edbi dung m\u00f4i h\u1eefu c\u01a1. Cu\u1ed1i c\u00f9ng, h\u1ed7n h\u1ee3p \u0111\u01b0\u1ee3c d\u1eadp t\u1eaft trong m\u00e1y tr\u1ed9n th\u1ee9 ba. C\u1ea3 hai \u0111\u01a1n v\u1ecb \u0111\u1ec1u c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng \u0111\u1ed9c l\u1eadp.<\/p>\n

Quy m\u00f4 s\u1ea3n xu\u1ea5t l\u1edbn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c c\u1ea5u h\u00ecnh v\u1edbi t\u1ed1i \u0111a t\u00e1m \u0111\u01a1n v\u1ecb tr\u1ed9n song song t\u00f9y thu\u1ed9c v\u00e0o y\u00eau c\u1ea7u c\u1ee7a kh\u00e1ch h\u00e0ng. M\u1ed7i thi\u1ebft b\u1ecb bao g\u1ed3m hai m\u00e1y b\u01a1m \u0111\u1ec3 cung c\u1ea5p c\u00e1c d\u00f2ng lipid v\u00e0 API, hai \u0111\u1ed3ng h\u1ed3 \u0111o l\u01b0u l\u01b0\u1ee3ng \u0111\u1ec3 ki\u1ec3m so\u00e1t d\u00f2ng ch\u1ea3y v\u00e0 m\u1ed9t b\u1ed9 tr\u1ed9n ph\u1ea3n l\u1ef1c<\/strong>. T\u00f9y thu\u1ed9c v\u00e0o c\u1ea5u h\u00ecnh, vi\u1ec7c pha lo\u00e3ng tr\u01b0\u1edbc API v\u00e0 d\u1eadp t\u1eaft c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n cho lu\u1ed3ng k\u1ebft h\u1ee3p c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c \u0111\u01a1n v\u1ecb trong m\u1ed9t b\u01b0\u1edbc quy tr\u00ecnh b\u00ean ngo\u00e0i thi\u1ebft b\u1ecb tr\u1ed9n xung l\u1ef1c ph\u1ea3n l\u1ef1c (IJM).<\/p>\n

(Ngu\u1ed3n: KNAUER Wissenschaftliche Ger\u00e4te GmbH).<\/i><\/p>\n

<\/span>\u0110\u1ec3 t\u00ecm hi\u1ec3u th\u00eam th\u00f4ng tin v\u1ec1 s\u1ea3n ph\u1ea9m c\u00f4ng ngh\u1ec7 n\u00e0y, h\u00e3y li\u00ean h\u1ec7 ch\u00fang t\u00f4i<\/a>!<\/span><\/h3>\n","protected":false},"excerpt":{"rendered":"

Thi\u1ebft b\u1ecb tr\u1ed9n xung l\u1ef1c ph\u1ea3n l\u1ef1c d\u00f9ng trong s\u1ea3n xu\u1ea5t h\u1ea1t nano \u1edf t\u1ed1c \u0111\u1ed9 d\u00f2ng cao (nh\u01b0 c\u00e1c h\u1ea1t nano lipid – LNP, vi nh\u0169 t\u01b0\u01a1ng, \u2026). Xu h\u01b0\u1edbng nghi\u00ean c\u1ee9u & s\u1ea3n xu\u1ea5t thu\u1ed1c sinh h\u1ecdc mRNA-LNPs Ti\u1ebfp n\u1ed1i s\u1ef1 th\u00e0nh c\u00f4ng c\u1ee7a v\u1eafc xin mRNA COVID-19 (v\u1eafc xin mRNA-LNPs – c\u00e1c<\/p>\n

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