{"id":4177,"date":"2024-02-25T09:48:28","date_gmt":"2024-02-25T09:48:28","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/fplc-in-sars-cov-2-research\/"},"modified":"2025-09-29T13:59:58","modified_gmt":"2025-09-29T06:59:58","slug":"su-dung-he-thong-sac-ky-long-tinh-che-protein-fplc-trong-nghien-cuu-sars-cov-2","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/blog\/su-dung-he-thong-sac-ky-long-tinh-che-protein-fplc-trong-nghien-cuu-sars-cov-2\/","title":{"rendered":"S\u1eed D\u1ee5ng H\u1ec7 Th\u1ed1ng S\u1eafc K\u00fd L\u1ecfng Tinh Ch\u1ebf Protein (FPLC) Trong Nghi\u00ean C\u1ee9u SARS-CoV-2"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">M\u1ee5c l\u1ee5c<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/su-dung-he-thong-sac-ky-long-tinh-che-protein-fplc-trong-nghien-cuu-sars-cov-2\/#Mot_so_protein_SARS-CoV-2_the_hien_cac_muc_tieu_chinh_cho_cac_chien_luoc_phat_trien_vac_xin_chong_lai_virus_SARS-CoV-2_Du_lieu_cau_truc_cua_cac_protein_nay_cung_cap_thong_tin_co_gia_tri_cho_viec_phat_trien_thuoc_va_vac_xin_Mot_trong_nhung_buoc_quan_trong_tren_con_duong_phan_tich_cau_truc_la_tinh_che_protein_trong_dung_dich_Sac_ky_long_tinh_che_protein_FPLC_la_phuong_phap_duoc_lua_chon_de_ho_tro_nhiem_vu_tinh_che_protein_cua_ban\" >M\u1ed9t s\u1ed1 protein SARS-CoV-2 th\u1ec3 hi\u1ec7n c\u00e1c m\u1ee5c ti\u00eau ch\u00ednh cho c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u1eafc xin ch\u1ed1ng l\u1ea1i virus SARS-CoV-2. D\u1eef li\u1ec7u c\u1ea5u tr\u00fac c\u1ee7a c\u00e1c protein n\u00e0y cung c\u1ea5p th\u00f4ng tin c\u00f3 gi\u00e1 tr\u1ecb cho vi\u1ec7c ph\u00e1t tri\u1ec3n thu\u1ed1c v\u00e0 v\u1eafc xin. M\u1ed9t trong nh\u1eefng b\u01b0\u1edbc quan tr\u1ecdng tr\u00ean con \u0111\u01b0\u1eddng ph\u00e2n t\u00edch c\u1ea5u tr\u00fac l\u00e0 tinh ch\u1ebf protein trong dung d\u1ecbch. S\u1eafc k\u00fd l\u1ecfng tinh ch\u1ebf protein (FPLC) l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn \u0111\u1ec3 h\u1ed7 tr\u1ee3 nhi\u1ec7m v\u1ee5 tinh ch\u1ebf protein c\u1ee7a b\u1ea1n.<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/su-dung-he-thong-sac-ky-long-tinh-che-protein-fplc-trong-nghien-cuu-sars-cov-2\/#Ket_noi_FPLC_sac_ky_long_tinh_che_protein_va_phan_tich_cau_truc_trong_nghien_cuu_SARS-CoV-2\" >K\u1ebft n\u1ed1i FPLC (s\u1eafc k\u00fd l\u1ecfng tinh ch\u1ebf protein) v\u00e0 ph\u00e2n t\u00edch c\u1ea5u tr\u00fac trong nghi\u00ean c\u1ee9u SARS-CoV-2<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Mot_so_protein_SARS-CoV-2_the_hien_cac_muc_tieu_chinh_cho_cac_chien_luoc_phat_trien_vac_xin_chong_lai_virus_SARS-CoV-2_Du_lieu_cau_truc_cua_cac_protein_nay_cung_cap_thong_tin_co_gia_tri_cho_viec_phat_trien_thuoc_va_vac_xin_Mot_trong_nhung_buoc_quan_trong_tren_con_duong_phan_tich_cau_truc_la_tinh_che_protein_trong_dung_dich_Sac_ky_long_tinh_che_protein_FPLC_la_phuong_phap_duoc_lua_chon_de_ho_tro_nhiem_vu_tinh_che_protein_cua_ban\"><\/span>M\u1ed9t s\u1ed1 protein SARS-CoV-2 th\u1ec3 hi\u1ec7n c\u00e1c m\u1ee5c ti\u00eau ch\u00ednh cho c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u1eafc xin ch\u1ed1ng l\u1ea1i virus SARS-CoV-2. D\u1eef li\u1ec7u c\u1ea5u tr\u00fac c\u1ee7a c\u00e1c protein n\u00e0y cung c\u1ea5p th\u00f4ng tin c\u00f3 gi\u00e1 tr\u1ecb cho vi\u1ec7c ph\u00e1t tri\u1ec3n thu\u1ed1c v\u00e0 v\u1eafc xin. M\u1ed9t trong nh\u1eefng b\u01b0\u1edbc quan tr\u1ecdng tr\u00ean con \u0111\u01b0\u1eddng ph\u00e2n t\u00edch c\u1ea5u tr\u00fac l\u00e0 tinh ch\u1ebf protein trong dung d\u1ecbch. S\u1eafc k\u00fd l\u1ecfng tinh ch\u1ebf protein (<a href=\"https:\/\/biogroupvietnam.com\/vi\/products\/nuoi-cay-te-bao-tinh-che-protein\/tinh-che-protein\/\">FPLC<\/a>) l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn \u0111\u1ec3 h\u1ed7 tr\u1ee3 nhi\u1ec7m v\u1ee5 tinh ch\u1ebf protein c\u1ee7a b\u1ea1n.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Ket_noi_FPLC_sac_ky_long_tinh_che_protein_va_phan_tich_cau_truc_trong_nghien_cuu_SARS-CoV-2\"><\/span><strong>K\u1ebft n\u1ed1i FPLC (s\u1eafc k\u00fd l\u1ecfng tinh ch\u1ebf protein) v\u00e0 ph\u00e2n t\u00edch c\u1ea5u tr\u00fac trong nghi\u00ean c\u1ee9u SARS-CoV-2<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Ph\u00e2n t\u00edch c\u1ea5u tr\u00fac sinh h\u1ecdc c\u1ee7a c\u00e1c ph\u00e2n t\u1eed sinh h\u1ecdc v\u00e0 nh\u1eefng thay \u0111\u1ed5i trong c\u1ea5u tr\u00fac \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng c\u1ee7a ph\u00e2n t\u1eed n\u00e0y nh\u01b0 th\u1ebf n\u00e0o. Hi\u1ec3u \u0111\u01b0\u1ee3c ch\u1ee9c n\u0103ng c\u1ee7a protein \u1edf c\u1ea5p \u0111\u1ed9 ph\u00e2n t\u1eed s\u1ebd cung c\u1ea5p th\u00f4ng tin c\u00f3 gi\u00e1 tr\u1ecb cho vi\u1ec7c ph\u00e1t tri\u1ec3n thu\u1ed1c v\u00e0 v\u1eafc xin.<\/p>\n<p>M\u1ed9t s\u1ed1 k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e2n t\u00edch c\u1ea5u tr\u00fac c\u1ee7a protein. K\u00ednh hi\u1ec3n vi \u0111i\u1ec7n t\u1eed l\u1ea1nh (cryo-EM) x\u00e1c \u0111\u1ecbnh c\u1ea5u tr\u00fac c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao c\u1ee7a c\u00e1c ph\u00e2n t\u1eed sinh h\u1ecdc trong dung d\u1ecbch b\u1eb1ng c\u00e1ch l\u00e0m \u0111\u00f4ng nhanh ch\u00fang v\u00e0 t\u1ea1o ra h\u00ecnh \u1ea3nh k\u00ednh hi\u1ec3n vi c\u1ee7a c\u00e1c ph\u00e2n t\u1eed ri\u00eang l\u1ebb \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u00e1i t\u1ea1o l\u1ea1i c\u1ea5u tr\u00fac 3D c\u1ee7a ph\u00e2n t\u1eed. M\u1eb7t kh\u00e1c, ph\u01b0\u01a1ng ph\u00e1p tinh th\u1ec3 h\u1ecdc tia X (Protein X-ray crystallography) c\u1ee7a protein s\u1eed d\u1ee5ng nhi\u1ec5u x\u1ea1 tia X c\u1ee7a c\u00e1c ph\u00e2n t\u1eed sinh h\u1ecdc \u0111\u00e3 k\u1ebft tinh \u0111\u1ec3 thu \u0111\u01b0\u1ee3c c\u1ea5u tr\u00fac 3D c\u1ee7a m\u1ed9t <a href=\"https:\/\/en.wikibooks.org\/wiki\/Structural_Biochemistry\/Proteins\">protein<\/a> c\u1ee5 th\u1ec3. C\u1ea3 hai k\u1ef9 thu\u1eadt \u0111\u1ec1u c\u00f3 \u0111i\u1ec3m chung l\u00e0 ph\u1ee5 thu\u1ed9c v\u00e0o protein r\u1ea5t tinh khi\u1ebft (c\u00f3 \u0111\u1ed9 tinh s\u1ea1ch cao).<\/p>\n<p>Nhi\u1ec1u b\u00e0i b\u00e1o \u0111\u00e3 \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n g\u1ea7n \u0111\u00e2y, b\u00e1o c\u00e1o nh\u1eefng hi\u1ec3u bi\u1ebft s\u00e2u s\u1eafc v\u1ec1 ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c protein Covid-19, l\u00e0m s\u00e1ng t\u1ecf c\u00e1ch virus x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o v\u00e0 gi\u00fap hi\u1ec3u ho\u1ea1t \u0111\u1ed9ng c\u1ee7a virus. M\u1ed9t trong nh\u1eefng protein quan tr\u1ecdng l\u00e0 glycoprotein &#8211; protein gai c\u1ee7a SARS-CoV-2. Protein gai li\u00ean k\u1ebft v\u1edbi m\u1ed9t th\u1ee5 th\u1ec3 (ACE2, enzyme chuy\u1ec3n \u0111\u1ed5i angiotensin II) tr\u00ean t\u1ebf b\u00e0o ng\u01b0\u1eddi khi\u1ebfn virus x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o v\u00e0 l\u00e2y nhi\u1ec5m. M\u1ed9t s\u1ed1 nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 b\u00e1o c\u00e1o d\u1eef li\u1ec7u c\u1ea5u tr\u00fac b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p tinh th\u1ec3 h\u1ecdc tia X ho\u1eb7c k\u00ednh hi\u1ec3n vi \u0111i\u1ec7n t\u1eed l\u1ea1nh s\u1ebd gi\u00fap hi\u1ec3u \u0111\u01b0\u1ee3c kh\u1ea3 n\u0103ng nh\u1eadn d\u1ea1ng th\u1ee5 th\u1ec3 c\u1ee7a SARS-CoV-2. Vai tr\u00f2 quan tr\u1ecdng c\u1ee7a protein gai \u0111\u1ed1i v\u1edbi s\u1ef1 l\u00e2y nhi\u1ec5m c\u1ee7a t\u1ebf b\u00e0o v\u1eadt ch\u1ee7 khi\u1ebfn n\u00f3 tr\u1edf th\u00e0nh m\u1ed9t trong nh\u1eefng m\u1ee5c ti\u00eau quan tr\u1ecdng \u0111\u1ec3 can thi\u1ec7p y t\u1ebf. D\u1eef li\u1ec7u c\u1ea5u tr\u00fac s\u1ebd h\u1ed7 tr\u1ee3 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb v\u00e0 v\u1eafc xin kh\u00e1ng virus.<\/p>\n<p>M\u1ed9t m\u1ee5c ti\u00eau thu\u1ed1c h\u1ea5p d\u1eabn kh\u00e1c l\u00e0 protease ch\u00ednh (Mpro, 3CLpro) c\u1ee7a SARS-CoV2. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf protease n\u00e0y, s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a virus c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ng\u0103n ch\u1eb7n. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 b\u00e1o c\u00e1o c\u1ea5u tr\u00fac tia X c\u1ee7a protease c\u00f3 v\u00e0 kh\u00f4ng c\u00f3 ch\u1ea5t \u1ee9c ch\u1ebf. D\u1ef1a tr\u00ean c\u1ea5u tr\u00fac c\u1ee7a ch\u00fang, h\u1ecd \u0111\u00e3 ph\u00e1t tri\u1ec3n h\u1ee3p ch\u1ea5t kh\u1edfi ngu\u1ed3n (lead compound) th\u00e0nh m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh, t\u1ea1o c\u01a1 s\u1edf qu\u00fd gi\u00e1 cho vi\u1ec7c ph\u00e1t tri\u1ec3n m\u1ed9t lo\u1ea1i thu\u1ed1c ch\u1ed1ng virus.<\/p>\n<p>C\u00e1c protein n\u00e0y \u0111\u01b0a ra c\u00e1c m\u1ee5c ti\u00eau ch\u00ednh cho c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u1eafc xin ch\u1ed1ng l\u1ea1i virus SARS-CoV-2 nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a d\u1eef li\u1ec7u c\u1ea5u tr\u00fac c\u1ee7a protein tinh khi\u1ebft. M\u1ed9t trong nh\u1eefng kh\u00eda c\u1ea1nh quan tr\u1ecdng \u0111\u1ec3 ph\u00e2n t\u00edch c\u1ea5u tr\u00fac l\u00e0 tinh ch\u1ebf protein trong dung d\u1ecbch. \u0110i\u1ec1u n\u00e0y trong h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi s\u1eafc k\u00fd l\u1ecfng tinh&nbsp;ch\u1ebf protein (FPLC). H\u1ea7u h\u1ebft c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng cho quy tr\u00ecnh tinh s\u1ea1ch c\u1ee7a h\u1ecd s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa s\u1eafc k\u00fd \u00e1i l\u1ef1c v\u00e0 s\u1eafc k\u00fd l\u1ecdc gel. C\u00e1c h\u1ec7 th\u1ed1ng <a href=\"https:\/\/biogroupvietnam.com\/vi\/products\/nuoi-cay-te-bao-tinh-che-protein\/tinh-che-protein\/\">FPLC<\/a> hi\u1ec7n \u0111\u1ea1i cho ph\u00e9p c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ef1 \u0111\u1ed9ng h\u00f3a qu\u00e1 tr\u00ecnh tinh ch\u1ebf l\u1ecdc protein c\u1ee7a h\u1ecd, t\u0103ng \u0111\u1ed9 l\u1eb7p l\u1ea1i v\u00e0 nh\u1edd \u0111\u00f3 ti\u1ebft ki\u1ec7m th\u1eddi gian v\u00e0 ngu\u1ed3n l\u1ef1c, v\u1eadt t\u01b0. <a href=\"https:\/\/www.knauer.net\/en\/Systems-Solutions\/FPLC\">KNAUER<\/a>&nbsp;(\u0110\u1ee9c) cung c\u1ea5p m\u1ed9t lo\u1ea1t c\u00e1c h\u1ec7 th\u1ed1ng FPLC. T\u00ednh linh ho\u1ea1t, t\u00ednh m\u00f4-\u0111un v\u00e0 d\u1ec5 d\u00e0ng m\u1edf r\u1ed9ng quy m\u00f4 l\u00e0 nh\u1eefng l\u1ee3i \u00edch ch\u00ednh c\u1ee7a n\u1ec1n t\u1ea3ng FPLC c\u1ee7a KNAUER. Tham kh\u1ea3o c\u00e1c h\u1ec7 th\u1ed1ng FPLC \u0111\u01b0\u1ee3c c\u1ea5u h\u00ecnh s\u1eb5n c\u1ee7a KNAUER ho\u1eb7c li\u00ean h\u1ec7 v\u1edbi ch\u00fang t\u00f4i \u0111\u1ec3 thi\u1ebft k\u1ebf m\u1ed9t h\u1ec7 th\u1ed1ng FPLC ph\u00f9 h\u1ee3p v\u1edbi nhu c\u1ea7u c\u1ee7a b\u1ea1n.<\/p>\n<p><i>(Ngu\u1ed3n: KNAUER Wissenschaftliche Ger\u00e4te GmbH).<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>M\u1ed9t s\u1ed1 protein SARS-CoV-2 th\u1ec3 hi\u1ec7n c\u00e1c m\u1ee5c ti\u00eau ch\u00ednh cho c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u1eafc xin ch\u1ed1ng l\u1ea1i virus SARS-CoV-2. D\u1eef li\u1ec7u c\u1ea5u tr\u00fac c\u1ee7a c\u00e1c protein n\u00e0y cung c\u1ea5p th\u00f4ng tin c\u00f3 gi\u00e1 tr\u1ecb cho vi\u1ec7c ph\u00e1t tri\u1ec3n thu\u1ed1c v\u00e0 v\u1eafc xin. M\u1ed9t trong nh\u1eefng b\u01b0\u1edbc quan tr\u1ecdng tr\u00ean con \u0111\u01b0\u1eddng ph\u00e2n<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/su-dung-he-thong-sac-ky-long-tinh-che-protein-fplc-trong-nghien-cuu-sars-cov-2\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":5612,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>S\u1eed D\u1ee5ng H\u1ec7 Th\u1ed1ng S\u1eafc K\u00fd L\u1ecfng Tinh Ch\u1ebf Protein (FPLC) Trong Nghi\u00ean C\u1ee9u 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