{"id":4209,"date":"2024-02-25T10:07:31","date_gmt":"2024-02-25T10:07:31","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/human-organoids-in-basic-research-and-clinical-applications\/"},"modified":"2025-09-29T14:00:04","modified_gmt":"2025-09-29T07:00:04","slug":"ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/","title":{"rendered":"\u1ee8ng D\u1ee5ng Organoids Ng\u01b0\u1eddi Trong Nghi\u00ean C\u1ee9u C\u01a1 B\u1ea3n &amp; L\u00e2m S\u00e0ng"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">M\u1ee5c l\u1ee5c<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Organoids_la_cac_cau_truc_thu_nho_ba_chieu_3D_duoc_nuoi_cay_trong_ong_nghiem_duoc_tao_ra_tu_te_bao_goc_da_nang_cua_con_nguoi_hPSC_hoac_te_bao_goc_truong_thanh_AdSC_co_nguon_goc_tu_cac_ca_nhan_hoac_benh_nhan_khoe_manh_tai_hap_thu_tinh_khong_dong_nhat_cua_te_bao_cau_truc_va_chuc_nang_cua_cac_co_quan_cua_con_nguoi_Su_ra_doi_cua_cac_he_thong_organoid_3D_cua_nguoi_gio_day_co_the_cho_phep_quan_sat_chi_tiet_dang_ke_cac_hinh_thai_te_bao_goc_duy_tri_va_biet_hoa_giong_nhu_cac_mo_chinh_nang_cao_tiem_nang_nghien_cuu_ca_sinh_ly_con_nguoi_va_giai_doan_phat_trien_Vi_chung_tuong_tu_nhu_cac_co_quan_ban_dau_cua_chung_va_mang_thong_tin_di_truyen_cua_con_nguoi_cac_chat_huu_co_co_nguon_goc_tu_benh_nhan_hua_hen_rat_nhieu_cho_nghien_cuu_y_sinh_va_thu_nghiem_thuoc_tien_lam_sang_va_hien_dang_duoc_su_dung_cho_lieu_phap_ca_nhan_hoa_tai_tao_sua_chua_gen_va_cay_ghep_Trong_nhung_thap_ky_gan_day_cac_nha_nghien_cuu_da_thanh_cong_trong_viec_tao_ra_nhieu_loai_organoids_bat_chuoc_cac_co_quan_trong_co_the_song_O_day_nhom_tac_gia_cung_cap_thong_tin_cap_nhat_ve_cac_cong_nghe_biet_hoa_in_vitro_hien_tai_cua_nao_vong_mac_than_gan_phoi_duong_tieu_hoa_tim_mach_mau_va_da_dong_thao_luan_ve_su_khac_biet_giua_cac_organoid_co_nguon_goc_tu_PSC_va_AdSC_tom_tat_cac_ung_dung_tiem_nang_cua_cac_he_thong_organoid_co_nguon_goc_tu_te_bao_goc_trong_phong_thi_nghiem_va_phong_kham_dong_thoi_phac_thao_nhung_thach_thuc_hien_tai_doi_voi_viec_ap_dung_cac_organoid_dieu_nay_se_giup_hieu_sau_hon_ve_cac_co_che_phat_trien_cua_con_nguoi_va_tang_cuong_ung_dung_cua_organoid_trong_nghien_cuu_co_ban_va_nghien_cuu_lam_sang\" >Organoids l\u00e0 c\u00e1c c\u1ea5u tr\u00fac thu nh\u1ecf ba chi\u1ec1u (3D) \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong \u1ed1ng nghi\u1ec7m \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng c\u1ee7a con ng\u01b0\u1eddi (hPSC) ho\u1eb7c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh (AdSC) c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb c\u00e1c c\u00e1 nh\u00e2n ho\u1eb7c b\u1ec7nh nh\u00e2n kh\u1ecfe m\u1ea1nh t\u00e1i h\u1ea5p thu t\u00ednh kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t c\u1ee7a t\u1ebf b\u00e0o, c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c c\u01a1 quan c\u1ee7a con ng\u01b0\u1eddi. S\u1ef1 ra \u0111\u1eddi c\u1ee7a c\u00e1c h\u1ec7 th\u1ed1ng organoid&nbsp;3D c\u1ee7a&nbsp;ng\u01b0\u1eddi gi\u1edd \u0111\u00e2y c\u00f3 th\u1ec3 cho ph\u00e9p quan s\u00e1t chi ti\u1ebft \u0111\u00e1ng k\u1ec3 c\u00e1c h\u00ecnh th\u00e1i t\u1ebf b\u00e0o g\u1ed1c, duy tr\u00ec v\u00e0 bi\u1ec7t h\u00f3a gi\u1ed1ng nh\u01b0 c\u00e1c m\u00f4 ch\u00ednh, n\u00e2ng cao ti\u1ec1m n\u0103ng nghi\u00ean c\u1ee9u c\u1ea3 sinh l\u00fd con ng\u01b0\u1eddi v\u00e0 giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n. V\u00ec ch\u00fang t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c c\u01a1 quan ban \u0111\u1ea7u c\u1ee7a ch\u00fang v\u00e0 mang th\u00f4ng tin di truy\u1ec1n c\u1ee7a con ng\u01b0\u1eddi, c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n h\u1ee9a h\u1eb9n r\u1ea5t nhi\u1ec1u cho nghi\u00ean c\u1ee9u y sinh v\u00e0 th\u1eed nghi\u1ec7m thu\u1ed1c ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho li\u1ec7u ph\u00e1p c\u00e1 nh\u00e2n h\u00f3a, t\u00e1i t\u1ea1o, s\u1eeda ch\u1eefa gen v\u00e0 c\u1ea5y gh\u00e9p. Trong nh\u1eefng th\u1eadp k\u1ef7 g\u1ea7n \u0111\u00e2y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 th\u00e0nh c\u00f4ng trong vi\u1ec7c t\u1ea1o ra nhi\u1ec1u lo\u1ea1i organoids b\u1eaft ch\u01b0\u1edbc c\u00e1c c\u01a1 quan trong c\u01a1 th\u1ec3 s\u1ed1ng. \u1ede \u0111\u00e2y, nh\u00f3m t\u00e1c gi\u1ea3&nbsp;cung c\u1ea5p th\u00f4ng tin c\u1eadp nh\u1eadt v\u1ec1 c\u00e1c c\u00f4ng ngh\u1ec7 bi\u1ec7t h\u00f3a in vitro hi\u1ec7n t\u1ea1i c\u1ee7a n\u00e3o, v\u00f5ng m\u1ea1c, th\u1eadn, gan, ph\u1ed5i, \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, tim, m\u1ea1ch m\u00e1u v\u00e0 \u0111a d\u00f2ng, th\u1ea3o lu\u1eadn v\u1ec1 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c organoid&nbsp;c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb PSC v\u00e0 AdSC, t\u00f3m t\u1eaft c\u00e1c \u1ee9ng d\u1ee5ng ti\u1ec1m n\u0103ng c\u1ee7a c\u00e1c h\u1ec7 th\u1ed1ng organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 ph\u00f2ng kh\u00e1m, \u0111\u1ed3ng th\u1eddi ph\u00e1c th\u1ea3o nh\u1eefng th\u00e1ch th\u1ee9c hi\u1ec7n t\u1ea1i \u0111\u1ed1i v\u1edbi vi\u1ec7c \u00e1p d\u1ee5ng c\u00e1c organoid, \u0111i\u1ec1u n\u00e0y s\u1ebd gi\u00fap hi\u1ec3u s\u00e2u h\u01a1n v\u1ec1 c\u00e1c c\u01a1 ch\u1ebf ph\u00e1t tri\u1ec3n c\u1ee7a con ng\u01b0\u1eddi v\u00e0 t\u0103ng c\u01b0\u1eddng \u1ee9ng d\u1ee5ng c\u1ee7a organoid trong nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng.<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Cac_ung_dung_cua_cong_nghe_organoid\" >C\u00e1c \u1ee9ng d\u1ee5ng c\u1ee7a c\u00f4ng ngh\u1ec7 organoid<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Mo_hinh_hoa_benh_di_truyen\" >M\u00f4 h\u00ecnh h\u00f3a b\u1ec7nh di truy\u1ec1n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Kham_pha_thuoc_va_danh_gia_doc_tinh_cua_thuoc\" >Kh\u00e1m ph\u00e1 thu\u1ed1c v\u00e0 \u0111\u00e1nh gi\u00e1 \u0111\u1ed9c t\u00ednh c\u1ee7a thu\u1ed1c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Ung_Thu\" >Ung Th\u01b0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Y_hoc_ca_nhan\" >Y h\u1ecdc c\u00e1 nh\u00e2n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Lieu_phap_chinh_sua_va_cay_ghep_gen\" >Li\u1ec7u ph\u00e1p ch\u1ec9nh s\u1eeda v\u00e0 c\u1ea5y gh\u00e9p gen<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/#Ket_luan_va_quan_diem_cua_nhom_tac_gia\" >K\u1ebft lu\u1eadn v\u00e0 quan \u0111i\u1ec3m c\u1ee7a nh\u00f3m t\u00e1c gi\u1ea3<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Organoids_la_cac_cau_truc_thu_nho_ba_chieu_3D_duoc_nuoi_cay_trong_ong_nghiem_duoc_tao_ra_tu_te_bao_goc_da_nang_cua_con_nguoi_hPSC_hoac_te_bao_goc_truong_thanh_AdSC_co_nguon_goc_tu_cac_ca_nhan_hoac_benh_nhan_khoe_manh_tai_hap_thu_tinh_khong_dong_nhat_cua_te_bao_cau_truc_va_chuc_nang_cua_cac_co_quan_cua_con_nguoi_Su_ra_doi_cua_cac_he_thong_organoid_3D_cua_nguoi_gio_day_co_the_cho_phep_quan_sat_chi_tiet_dang_ke_cac_hinh_thai_te_bao_goc_duy_tri_va_biet_hoa_giong_nhu_cac_mo_chinh_nang_cao_tiem_nang_nghien_cuu_ca_sinh_ly_con_nguoi_va_giai_doan_phat_trien_Vi_chung_tuong_tu_nhu_cac_co_quan_ban_dau_cua_chung_va_mang_thong_tin_di_truyen_cua_con_nguoi_cac_chat_huu_co_co_nguon_goc_tu_benh_nhan_hua_hen_rat_nhieu_cho_nghien_cuu_y_sinh_va_thu_nghiem_thuoc_tien_lam_sang_va_hien_dang_duoc_su_dung_cho_lieu_phap_ca_nhan_hoa_tai_tao_sua_chua_gen_va_cay_ghep_Trong_nhung_thap_ky_gan_day_cac_nha_nghien_cuu_da_thanh_cong_trong_viec_tao_ra_nhieu_loai_organoids_bat_chuoc_cac_co_quan_trong_co_the_song_O_day_nhom_tac_gia_cung_cap_thong_tin_cap_nhat_ve_cac_cong_nghe_biet_hoa_in_vitro_hien_tai_cua_nao_vong_mac_than_gan_phoi_duong_tieu_hoa_tim_mach_mau_va_da_dong_thao_luan_ve_su_khac_biet_giua_cac_organoid_co_nguon_goc_tu_PSC_va_AdSC_tom_tat_cac_ung_dung_tiem_nang_cua_cac_he_thong_organoid_co_nguon_goc_tu_te_bao_goc_trong_phong_thi_nghiem_va_phong_kham_dong_thoi_phac_thao_nhung_thach_thuc_hien_tai_doi_voi_viec_ap_dung_cac_organoid_dieu_nay_se_giup_hieu_sau_hon_ve_cac_co_che_phat_trien_cua_con_nguoi_va_tang_cuong_ung_dung_cua_organoid_trong_nghien_cuu_co_ban_va_nghien_cuu_lam_sang\"><\/span>Organoids l\u00e0 c\u00e1c c\u1ea5u tr\u00fac thu nh\u1ecf ba chi\u1ec1u (3D) \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong \u1ed1ng nghi\u1ec7m \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng c\u1ee7a con ng\u01b0\u1eddi (hPSC) ho\u1eb7c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh (AdSC) c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb c\u00e1c c\u00e1 nh\u00e2n ho\u1eb7c b\u1ec7nh nh\u00e2n kh\u1ecfe m\u1ea1nh t\u00e1i h\u1ea5p thu t\u00ednh kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t c\u1ee7a t\u1ebf b\u00e0o, c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c c\u01a1 quan c\u1ee7a con ng\u01b0\u1eddi. S\u1ef1 ra \u0111\u1eddi c\u1ee7a c\u00e1c h\u1ec7 th\u1ed1ng organoid&nbsp;3D c\u1ee7a&nbsp;ng\u01b0\u1eddi gi\u1edd \u0111\u00e2y c\u00f3 th\u1ec3 cho ph\u00e9p quan s\u00e1t chi ti\u1ebft \u0111\u00e1ng k\u1ec3 c\u00e1c h\u00ecnh th\u00e1i t\u1ebf b\u00e0o g\u1ed1c, duy tr\u00ec v\u00e0 bi\u1ec7t h\u00f3a gi\u1ed1ng nh\u01b0 c\u00e1c m\u00f4 ch\u00ednh, n\u00e2ng cao ti\u1ec1m n\u0103ng nghi\u00ean c\u1ee9u c\u1ea3 sinh l\u00fd con ng\u01b0\u1eddi v\u00e0 giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n. V\u00ec ch\u00fang t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c c\u01a1 quan ban \u0111\u1ea7u c\u1ee7a ch\u00fang v\u00e0 mang th\u00f4ng tin di truy\u1ec1n c\u1ee7a con ng\u01b0\u1eddi, c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n h\u1ee9a h\u1eb9n r\u1ea5t nhi\u1ec1u cho nghi\u00ean c\u1ee9u y sinh v\u00e0 th\u1eed nghi\u1ec7m thu\u1ed1c ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho li\u1ec7u ph\u00e1p c\u00e1 nh\u00e2n h\u00f3a, t\u00e1i t\u1ea1o, s\u1eeda ch\u1eefa gen v\u00e0 c\u1ea5y gh\u00e9p. Trong nh\u1eefng th\u1eadp k\u1ef7 g\u1ea7n \u0111\u00e2y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 th\u00e0nh c\u00f4ng trong vi\u1ec7c t\u1ea1o ra nhi\u1ec1u lo\u1ea1i organoids b\u1eaft ch\u01b0\u1edbc c\u00e1c c\u01a1 quan trong c\u01a1 th\u1ec3 s\u1ed1ng. \u1ede \u0111\u00e2y, nh\u00f3m t\u00e1c gi\u1ea3&nbsp;cung c\u1ea5p th\u00f4ng tin c\u1eadp nh\u1eadt v\u1ec1 c\u00e1c c\u00f4ng ngh\u1ec7 bi\u1ec7t h\u00f3a in vitro hi\u1ec7n t\u1ea1i c\u1ee7a n\u00e3o, v\u00f5ng m\u1ea1c, th\u1eadn, gan, ph\u1ed5i, \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, tim, m\u1ea1ch m\u00e1u v\u00e0 \u0111a d\u00f2ng, th\u1ea3o lu\u1eadn v\u1ec1 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c organoid&nbsp;c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb PSC v\u00e0 AdSC, t\u00f3m t\u1eaft c\u00e1c \u1ee9ng d\u1ee5ng ti\u1ec1m n\u0103ng c\u1ee7a c\u00e1c h\u1ec7 th\u1ed1ng organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 ph\u00f2ng kh\u00e1m, \u0111\u1ed3ng th\u1eddi ph\u00e1c th\u1ea3o nh\u1eefng th\u00e1ch th\u1ee9c hi\u1ec7n t\u1ea1i \u0111\u1ed1i v\u1edbi vi\u1ec7c \u00e1p d\u1ee5ng c\u00e1c organoid, \u0111i\u1ec1u n\u00e0y s\u1ebd gi\u00fap hi\u1ec3u s\u00e2u h\u01a1n v\u1ec1 c\u00e1c c\u01a1 ch\u1ebf ph\u00e1t tri\u1ec3n c\u1ee7a con ng\u01b0\u1eddi v\u00e0 t\u0103ng c\u01b0\u1eddng \u1ee9ng d\u1ee5ng c\u1ee7a organoid trong nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Cac_ung_dung_cua_cong_nghe_organoid\"><\/span><strong>C\u00e1c \u1ee9ng d\u1ee5ng c\u1ee7a c\u00f4ng ngh\u1ec7 organoid<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>C\u00e1c organoids trong \u1ed1ng nghi\u1ec7m t\u00f3m t\u1eaft l\u1ea1i c\u00e1c nguy\u00ean l\u00fd sinh h\u1ecdc c\u01a1 quan v\u00e0 cung c\u1ea5p c\u00e1c h\u1ec7 th\u1ed1ng m\u00f4 h\u00ecnh t\u1ebf b\u00e0o \u0111\u01a1n gi\u1ea3n h\u00f3a v\u00e0 d\u1ec5 ti\u1ebfp c\u1eadn, m\u00f4 ph\u1ecfng c\u00e1c kh\u00eda c\u1ea1nh c\u1ee5 th\u1ec3 c\u1ee7a ki\u1ebfn tr\u00fac 3D, th\u00e0nh ph\u1ea7n c\u1ee7a c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o v\u00e0 ch\u1ee9c n\u0103ng c\u01a1 quan c\u1ee7a con ng\u01b0\u1eddi. C\u00f4ng ngh\u1ec7 organoid c\u00f3 th\u1ec3 \u0111\u00e1p \u1ee9ng nhu c\u1ea7u trong nghi\u00ean c\u1ee9u y h\u1ecdc v\u00e0 h\u1ee9a h\u1eb9n cho m\u1ed9t lo\u1ea1t c\u00e1c \u1ee9ng d\u1ee5ng t\u1ecbnh ti\u1ebfn (H\u00ecnh 1).<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/eo3r3fg6KVWZAenRVBKJRPDUcjeE5iHWbH00KXNc.png\" alt=\"\" width=\"537\" height=\"456\"><\/p>\n<p><i>H\u00ecnh 1. C\u00e1c \u1ee9ng d\u1ee5ng kh\u00e1c nhau c\u1ee7a c\u00f4ng ngh\u1ec7 organoid. S\u01a1 \u0111\u1ed3 m\u00f4 t\u1ea3 c\u00e1c \u1ee9ng d\u1ee5ng kh\u00e1c nhau c\u1ee7a c\u00f4ng ngh\u1ec7 organoid d\u1ef1a tr\u00ean c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u1ec1 c\u1eadp \u1edf tr\u00ean. C\u00f4ng ngh\u1ec7 Organoid cung c\u1ea5p c\u00e1c m\u00f4 h\u00ecnh l\u00fd t\u01b0\u1edfng b\u1eaft ch\u01b0\u1edbc c\u00e1c b\u1ec7nh di truy\u1ec1n \u1edf ng\u01b0\u1eddi do \u0111\u1ed9t bi\u1ebfn c\u1ea3m \u1ee9ng g\u00e2y ra. B\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen nh\u01b0 CRISPR\/Cas9, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 \u0111i\u1ec1u tra m\u1ed9t s\u1ed1 b\u1ec7nh li\u00ean quan \u0111\u1ebfn khi\u1ebfm khuy\u1ebft di truy\u1ec1n. C\u00f4ng ngh\u1ec7 Organoid c\u0169ng \u0111\u00e3 cung c\u1ea5p m\u1ed9t c\u00f4ng c\u1ee5 ti\u1ec1m n\u0103ng \u0111\u1ec3 kh\u00e1m ph\u00e1 thu\u1ed1c th\u00f4ng l\u01b0\u1ee3ng cao v\u00e0 cho ph\u00e9p th\u1eed nghi\u1ec7m \u0111\u1ed9c t\u00ednh ch\u00ednh x\u00e1c v\u00e0 nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng. Nh\u1eefng ti\u1ebfn b\u1ed9 g\u1ea7n \u0111\u00e2y trong nghi\u00ean c\u1ee9u ung th\u01b0 trong c\u00e1c c\u01a1 quan \u0111ang m\u1edf \u0111\u01b0\u1eddng cho li\u1ec7u ph\u00e1p c\u1ea5y gh\u00e9p c\u01a1 quan \u0111\u1ea7y h\u1ee9a h\u1eb9n trong t\u01b0\u01a1ng lai.<\/i><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Mo_hinh_hoa_benh_di_truyen\"><\/span><strong>M\u00f4 h\u00ecnh h\u00f3a b\u1ec7nh di truy\u1ec1n<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Hai \u1ee9ng d\u1ee5ng ch\u00ednh c\u1ee7a organoid ng\u01b0\u1eddi l\u00e0 m\u00f4 h\u00ecnh h\u00f3a c\u00e1c b\u1ec7nh di truy\u1ec1n \u1edf ng\u01b0\u1eddi v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi. Hans Clevers v\u00e0 c\u1ed9ng s\u1ef1. l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u00e3 thi\u1ebft l\u1eadp \u0111\u01b0\u1ee3c c\u00e1c c\u01a1 quan m\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t v\u1edbi t\u1ebf b\u00e0o g\u1ed1c ru\u1ed9t tr\u01b0\u1edfng th\u00e0nh. Sau \u0111\u00f3, c\u00e1c organoid ru\u1ed9t \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111\u1ec3 nghi\u00ean c\u1ee9u b\u1ec7nh x\u01a1 nang (CF), m\u1ed9t b\u1ec7nh di truy\u1ec1n g\u00e2y ra b\u1edfi \u0111\u1ed9t bi\u1ebfn c\u1ee7a ch\u1ea5t \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ed9 d\u1eabn xuy\u00ean m\u00e0ng CF (CFTR). Do \u0111\u00f3, m\u1ed9t x\u00e9t nghi\u1ec7m nhanh ch\u00f3ng v\u00e0 m\u1ea1nh m\u1ebd \u0111\u1ec3 \u0111\u1ecbnh l\u01b0\u1ee3ng ch\u1ee9c n\u0103ng CFTR \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp \u0111\u1ec3 c\u00f3 th\u1ec3 \u0111\u1ea9y nhanh ch\u1ea9n \u0111o\u00e1n, nghi\u00ean c\u1ee9u ch\u1ee9c n\u0103ng, s\u00e0ng l\u1ecdc thu\u1ed1c v\u00e0 chi\u1ebfn l\u01b0\u1ee3c y h\u1ecdc c\u00e1 nh\u00e2n h\u00f3a trong nghi\u00ean c\u1ee9u CF. Sau khi c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 trong ru\u1ed9t \u0111\u01b0\u1ee3c ch\u1ebf t\u1ea1o th\u00e0nh c\u00f4ng, ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u lo\u1ea1i ch\u1ea5t h\u1eefu c\u01a1 kh\u00e1c nhau \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp v\u00e0 s\u1eed d\u1ee5ng \u0111\u1ec3 m\u00f4 h\u00ecnh h\u00f3a b\u1ec7nh di truy\u1ec1n. Menendez v\u00e0 c\u1ed9ng s\u1ef1. t\u1ea1o ra c\u00e1c organoid th\u1eadn \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb m\u1ed9t b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh th\u1eadn \u0111a nang, t\u1ea1o n\u1ec1n t\u1ea3ng cho vi\u1ec7c nghi\u00ean c\u1ee9u c\u00e1c r\u1ed1i lo\u1ea1n th\u1eadn di truy\u1ec1n kh\u00e1c. G\u1ea7n \u0111\u00e2y, c\u00e1c c\u01a1 quan th\u1eadn c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb hiPSC c\u00f3 \u0111\u1ed9t bi\u1ebfn GLA \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u01a1 ch\u1ebf v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho b\u1ec7nh Fabry. C\u00e1c b\u1ec7nh di truy\u1ec1n v\u00f5ng m\u1ea1c c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 h\u00ecnh h\u00f3a b\u1eb1ng c\u00e1c organoid v\u00f5ng m\u1ea1c. T\u01b0\u01a1ng t\u1ef1, c\u00e1c c\u01a1 quan tim NKX2-5- v\u00e0 HAND1-knockout (KO) \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111\u1ec3 m\u00f4 h\u00ecnh h\u1ed9i ch\u1ee9ng tim tr\u00e1i gi\u1ea3m s\u1ea3n, d\u1ecb t\u1eadt b\u1ea9m sinh nghi\u00eam tr\u1ecdng nh\u1ea5t \u1edf ng\u01b0\u1eddi. \u0110\u1eb7c bi\u1ec7t, c\u00e1c c\u01a1 quan n\u00e3o \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c r\u1ed1i lo\u1ea1n di truy\u1ec1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh kh\u00e1c nhau. V\u00ed d\u1ee5, t\u1eadt \u0111\u1ea7u nh\u1ecf, m\u1ed9t ch\u1ee9ng r\u1ed1i lo\u1ea1n li\u00ean quan \u0111\u1ebfn \u0111\u1ed9t bi\u1ebfn CDK5RAP2 kh\u00f3 t\u00e1i h\u1ea5p thu \u1edf chu\u1ed9t, \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 h\u00ecnh h\u00f3a b\u1eb1ng c\u00e1c organoid n\u00e3o c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb iPSC d\u00e0nh ri\u00eang cho t\u1eebng b\u1ec7nh nh\u00e2n. C\u00e1c r\u1ed1i lo\u1ea1n th\u1ea7n kinh kh\u00e1c, bao g\u1ed3m h\u1ed9i ch\u1ee9ng Down, b\u1ec7nh Alzheimer v\u00e0 PD, c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 h\u00ecnh h\u00f3a b\u1eb1ng c\u00e1c organoid n\u00e3o.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Kham_pha_thuoc_va_danh_gia_doc_tinh_cua_thuoc\"><\/span><strong>Kh\u00e1m ph\u00e1 thu\u1ed1c v\u00e0 \u0111\u00e1nh gi\u00e1 \u0111\u1ed9c t\u00ednh c\u1ee7a thu\u1ed1c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Nh\u1eefng kh\u00e1m ph\u00e1 y h\u1ecdc hi\u1ec7n nay v\u1ec1 c\u00e1c b\u1ec7nh \u1edf ng\u01b0\u1eddi th\u01b0\u1eddng g\u1eb7p ph\u1ea3i nh\u1eefng h\u1ea1n ch\u1ebf, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1ef1 \u0111a d\u1ea1ng c\u1ee7a t\u1eebng c\u00e1 nh\u00e2n \u1edf b\u1ec7nh nh\u00e2n, k\u1ebft qu\u1ea3 kh\u00f4ng th\u1ec3 \u0111o\u00e1n tr\u01b0\u1edbc v\u00e0 vi\u1ec7c th\u1eed nghi\u1ec7m thu\u1ed1c t\u1ed1n nhi\u1ec1u th\u1eddi gian. C\u00e1c organoid 3D d\u1ef1a tr\u00ean m\u1ed9t c\u0103n b\u1ec7nh c\u1ee5 th\u1ec3 \u0111\u00e3 cho th\u1ea5y ti\u1ec1m n\u0103ng l\u1edbn trong s\u00e0ng l\u1ecdc thu\u1ed1c. C\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb iPSC c\u1ee7a b\u1ec7nh nh\u00e2n ung th\u01b0 nguy\u00ean ph\u00e1t, b\u1ec7nh truy\u1ec1n nhi\u1ec5m ho\u1eb7c b\u1ec7nh ph\u00e1t tri\u1ec3n cho th\u1ea5y c\u00e1c ki\u1ec3u h\u00ecnh l\u00e2m s\u00e0ng t\u01b0\u01a1ng t\u1ef1 v\u00e0 c\u00f3 th\u1ec3 l\u00e0 n\u1ec1n t\u1ea3ng ti\u1ec1m n\u0103ng cho th\u1eed nghi\u1ec7m thu\u1ed1c m\u1edbi. Brotier et al. \u0111\u00e3 x\u00e1c \u0111\u1ecbnh m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf ERK l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng v\u1edbi c\u00e1c organoid ung th\u01b0 nguy\u00ean ph\u00e1t \u1edf ng\u01b0\u1eddi v\u00e0o n\u0103m 2017. Trong c\u00f9ng n\u0103m \u0111\u00f3, Crespo et al. \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u00e1c organoid \u0111\u1ea1i tr\u00e0ng t\u1eeb nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh \u0111a polyp tuy\u1ebfn gia \u0111\u00ecnh (FAP) k\u1ebft h\u1ee3p c\u00e1c \u0111\u1ed9t bi\u1ebfn trong m\u1ed9t ch\u1ea5t \u0111i\u1ec1u ch\u1ec9nh ti\u00eau c\u1ef1c c\u1ee7a con \u0111\u01b0\u1eddng WNT \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 gen polyposis coli tuy\u1ebfn (APC). H\u1ecd c\u0169ng s\u00e0ng l\u1ecdc hai h\u1ee3p ch\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c gi\u1ea3i c\u1ee9u s\u1ef1 t\u0103ng sinh qu\u00e1 m\u1ee9c c\u1ee7a c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 c\u1ee7a b\u1ec7nh nh\u00e2n, \u0111i\u1ec1u n\u00e0y c\u0169ng c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 lo\u1ea1i hoang d\u00e3. Ngo\u1ea1i tr\u1eeb c\u00e1c organoid ung th\u01b0, c\u00e1c organoid n\u00e3o \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 kh\u00e1m ph\u00e1 thu\u1ed1c. C\u00e1c c\u01a1 quan v\u1ecf n\u00e3o b\u1ecb nhi\u1ec5m ZIKV hi\u1ec3n th\u1ecb c\u00e1c ki\u1ec3u h\u00ecnh t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c ki\u1ec3u h\u00ecnh c\u1ee7a h\u1ed9i ch\u1ee9ng Zika b\u1ea9m sinh, bao g\u1ed3m l\u1edbp t\u1ebf b\u00e0o th\u1ea7n kinh m\u1ecfng h\u01a1n v\u00e0 s\u1ef1 gi\u00e3n n\u1edf c\u1ee7a l\u00f2ng th\u1ea5t. Trong m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u, c\u00e1c c\u01a1 quan n\u00e3o b\u1ecb nhi\u1ec5m vi-r\u00fat \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111\u1ec3 cung c\u1ea5p n\u1ec1n t\u1ea3ng cho vi\u1ec7c x\u00e1c nh\u1eadn c\u00e1c \u1ee9ng c\u1eed vi\u00ean thu\u1ed1c kh\u00e1ng vi-r\u00fat, ch\u1eb3ng h\u1ea1n nh\u01b0 duramycin, ivermectin v\u00e0 azithromycin. S\u00e0ng l\u1ecdc thu\u1ed1c th\u00f4ng l\u01b0\u1ee3ng cao th\u01b0\u1eddng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean c\u00e1c c\u01a1 quan \u0111\u01b0\u1eddng ru\u1ed9t. V\u00ed d\u1ee5, Kenji Kozuka et al. nu\u00f4i c\u1ea5y organoid nh\u1ecf trong ru\u1ed9t k\u1ebft trong c\u00e1c \u0111\u0129a 96 gi\u1ebfng v\u00e0 th\u1ef1c hi\u1ec7n s\u00e0ng l\u1ecdc th\u00e0nh c\u00f4ng kho\u1ea3ng 2000 h\u1ee3p ch\u1ea5t cho c\u00e1c lo\u1ea1i thu\u1ed1c ti\u1ec1m n\u0103ng. M\u1ed9t tr\u01b0\u1eddng h\u1ee3p kh\u00e1c l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn li\u00ean quan \u0111\u1ebfn vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c ch\u1ed1ng ti\u00eau ch\u1ea3y v\u00e0 \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t b\u1edfi nh\u00f3m c\u1ee7a Onur Cil.<\/p>\n<p>\u0110\u00e1nh gi\u00e1 \u0111\u1ed9c t\u00ednh v\u00e0 nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng c\u1ee7a thu\u1ed1c \u1edf giai \u0111o\u1ea1n n\u00e0y c\u00f3 nh\u1eefng h\u1ea1n ch\u1ebf nh\u1ea5t \u0111\u1ecbnh, ph\u1ea3n \u1ee9ng \u0111\u1ed9c t\u00ednh c\u1ee7a nhi\u1ec1u lo\u1ea1i thu\u1ed1c ch\u1ec9 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n d\u1ea7n d\u1ea7n trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng ho\u1eb7c \u1edf giai \u0111o\u1ea1n kh\u1edfi \u0111\u1ed9ng. Organoid c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m tra c\u00e1c ph\u1ea3n \u1ee9ng thu\u1ed1c th\u1eed nghi\u1ec7m v\u00ec ph\u1ea3n \u1ee9ng c\u1ee7a ch\u00fang gi\u1ed1ng v\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng m\u00f4 sinh l\u00fd. Do \u0111\u00f3, h\u1ee9a h\u1eb9n s\u1ebd thi\u1ebft l\u1eadp m\u1ed9t m\u00f4 h\u00ecnh s\u00e0ng l\u1ecdc \u0111\u1ed9c t\u00ednh l\u00e2u d\u00e0i v\u1edbi c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m sinh l\u00fd c\u1ee7a con ng\u01b0\u1eddi b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c organoid.<\/p>\n<p>Organoids c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 \u0111\u1ed9c t\u00ednh c\u1ee7a thu\u1ed1c, ch\u1eb3ng h\u1ea1n nh\u01b0 t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1ed1i v\u1edbi gan, tim v\u00e0 th\u1eadn. Skardal v\u00e0 c\u1ed9ng s\u1ef1. \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t h\u1ec7 th\u1ed1ng organoids bao g\u1ed3m c\u00e1c c\u01a1 quan tim, ph\u1ed5i v\u00e0 gan trong m\u1ed9t h\u1ec7 th\u1ed1ng t\u01b0\u1edbi m\u00e1u tu\u1ea7n ho\u00e0n duy nh\u1ea5t trong m\u1ed9t h\u1ec7 th\u1ed1ng trung b\u00ecnh chung v\u1edbi kh\u1ea3 n\u0103ng c\u1ea3m bi\u1ebfn sinh h\u1ecdc c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd v\u00e0 ph\u1ea3n \u1ee9ng \u0111\u1ed9c h\u1ea1i c\u1ee7a thu\u1ed1c tr\u00ean to\u00e0n b\u1ed9 c\u01a1 quan.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Ung_Thu\"><\/span><strong>Ung Th\u01b0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>C\u00e1c organoid \u0111\u00e3 l\u00e0m s\u00e2u s\u1eafc th\u00eam ki\u1ebfn th\u1ee9c c\u1ee7a ch\u00fang ta v\u1ec1 b\u1ec7nh ung th\u01b0 \u1edf ng\u01b0\u1eddi. M\u1ed9t thu\u1ed9c t\u00ednh ch\u00ednh c\u1ee7a organoid l\u00e0m cho n\u00f3 c\u00f3 \u00fd ngh\u0129a trong nghi\u00ean c\u1ee9u ung th\u01b0 l\u00e0 organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 b\u1eaft ch\u01b0\u1edbc c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a kh\u1ed1i u. Theo truy\u1ec1n th\u1ed1ng, c\u00e1c m\u00f4 h\u00ecnh ung th\u01b0 \u0111\u1ed9ng v\u1eadt, d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 \u1edf ng\u01b0\u1eddi ho\u1eb7c xenograft kh\u1ed1i u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n ch\u00ednh (PDX) \u0111\u00e3 tr\u1edf th\u00e0nh c\u00f4ng c\u1ee5 quan tr\u1ecdng cho nghi\u00ean c\u1ee9u ung th\u01b0. C\u00e1c c\u00f4ng ngh\u1ec7 organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb AdSC \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n g\u1ea7n \u0111\u00e2y h\u1ed7 tr\u1ee3 c\u00e1c m\u00f4 ung th\u01b0 bi\u1ebfn \u0111\u1ed5i \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong \u1ed1ng nghi\u1ec7m d\u01b0\u1edbi d\u1ea1ng c\u00e1c organoid ung th\u01b0. C\u00e1c c\u01a1 quan ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp l\u1ea7n \u0111\u1ea7u ti\u00ean v\u00e0o n\u0103m 2011 v\u00e0 c\u00e1c lo\u1ea1i c\u01a1 quan ung th\u01b0 kh\u00e1c \u0111\u00e3 xu\u1ea5t hi\u1ec7n k\u1ec3 t\u1eeb \u0111\u00f3. Kh\u00f4ng c\u00f3 g\u00ec \u0111\u00e1ng ng\u1ea1c nhi\u00ean, c\u00e1c m\u00f4 h\u00ecnh c\u01a1 quan ung th\u01b0 kh\u00e1c nhau n\u00e0y cho th\u1ea5y kh\u1ea3 n\u0103ng tuy\u1ec7t v\u1eddi \u0111\u1ec3 hi\u1ec7n t\u01b0\u1ee3ng h\u00f3a c\u00e1c kh\u1ed1i u \u1edf ng\u01b0\u1eddi. S\u1eed d\u1ee5ng c\u00e1c m\u00f4 h\u00ecnh n\u00e0y, kh\u00f4ng ch\u1ec9 s\u00e0ng l\u1ecdc thu\u1ed1c m\u00e0 c\u1ea3 nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh. V\u00ed d\u1ee5, m\u1ed9t h\u1ec7 th\u1ed1ng nu\u00f4i c\u1ea5y \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 nghi\u00ean c\u1ee9u m\u1ed1i quan h\u1ec7 c\u1ee7a c\u00e1c t\u00e1c nh\u00e2n l\u00e2y nhi\u1ec5m nh\u01b0 H. pylori v\u1edbi ung th\u01b0 d\u1ea1 d\u00e0y v\u00e0 c\u00e1c c\u01a1 quan d\u1ea1 d\u00e0y b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e3 bi\u1ec3u hi\u1ec7n c\u00e1c hi\u1ec7n t\u01b0\u1ee3ng b\u1ec7nh l\u00fd t\u01b0\u01a1ng t\u1ef1 nh\u01b0 ung th\u01b0. Do \u0111\u00f3, <strong>vi\u1ec7c s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 organoid l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn \u0111\u1ea7y h\u1ee9a h\u1eb9n \u0111\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 b\u1ec7nh ung th\u01b0 v\u00e0 chuy\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c ti\u1ec1n l\u00e2m s\u00e0ng sang \u0111i\u1ec1u tr\u1ecb \u1edf b\u1ec7nh vi\u1ec7n<\/strong>.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Y_hoc_ca_nhan\"><\/span><strong>Y h\u1ecdc c\u00e1 nh\u00e2n<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u0110\u1ed1i v\u1edbi nhi\u1ec1u b\u1ec7nh ung th\u01b0, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o truy\u1ec1n th\u1ed1ng kh\u00f4ng th\u1ec3 m\u00f4 h\u00ecnh h\u00f3a \u0111\u1ea7y \u0111\u1ee7 sinh h\u1ecdc c\u1ee7a c\u00e1c kh\u1ed1i u t\u1ef1 nhi\u00ean, do \u0111\u00f3 g\u00f3p ph\u1ea7n v\u00e0o t\u1ef7 l\u1ec7 th\u1ea5t b\u1ea1i cao c\u1ee7a c\u00e1c h\u1ee3p ch\u1ea5t ti\u1ec1n l\u00e2m s\u00e0ng trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. V\u1edbi t\u00ednh \u01b0u vi\u1ec7t c\u1ee7a <strong>c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n (PDO)<\/strong> trong \u1ed1ng nghi\u1ec7m trong s\u1ef1 ph\u00e1t tri\u1ec3n nhanh ch\u00f3ng v\u00e0 s\u1ef1 bi\u1ec7t h\u00f3a \u1ed5n \u0111\u1ecbnh c\u0169ng nh\u01b0 kh\u1ea3 n\u0103ng c\u1ee7a PDO trong vi\u1ec7c n\u1eafm b\u1eaft s\u1ef1 \u0111a d\u1ea1ng c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 lo\u1ea1i kh\u1ed1i u, c\u00e1c organoid c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 cho m\u1ed9t b\u1ec7nh nh\u00e2n c\u1ee5 th\u1ec3 trong c\u00e1i g\u1ecdi l\u00e0 li\u1ec7u ph\u00e1p c\u00e1 nh\u00e2n h\u00f3a. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, nh\u1eefng n\u1ed7 l\u1ef1c l\u1edbn \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 thi\u1ebft l\u1eadp th\u00e0nh c\u00f4ng biobanks c\u1ee7a c\u00e1c organoid \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb c\u00e1c kh\u1ed1i u kh\u00e1c nhau, bao g\u1ed3m c\u00e1c kh\u1ed1i u tuy\u1ebfn ti\u1ec1n li\u1ec7t, ph\u1ed5i, \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, gan, tuy\u1ebfn t\u1ee5y v\u00e0 d\u1ea1 d\u00e0y. Lo\u1ea1i thu\u1ed1c ph\u00f9 h\u1ee3p nh\u1ea5t cho b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n nhanh ch\u00f3ng th\u00f4ng qua x\u00e9t nghi\u1ec7m \u0111\u1ed9 nh\u1ea1y c\u1ea3m v\u1edbi thu\u1ed1c; do \u0111\u00f3, k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c hi\u1ec7u qu\u1ea3 nh\u1ea5t c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng, c\u00f3 th\u1ec3 gi\u1ea3m thi\u1ec3u t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c v\u00e0 gi\u1ea3m t\u00e1i ph\u00e1t kh\u1ed1i u. Chi\u1ebfn l\u01b0\u1ee3c n\u00e0y c\u00f3 th\u1ec3 cho ph\u00e9p l\u1ef1a ch\u1ecdn c\u00e1c k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb l\u00fd t\u01b0\u1edfng. M\u1ed9t v\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh l\u00e0 \u0111i\u1ec1u tr\u1ecb CF, m\u1ed9t b\u1ec7nh r\u00fat ng\u1eafn tu\u1ed5i th\u1ecd do \u0111\u1ed9t bi\u1ebfn gen CFTR g\u00e2y ra t\u1ed5n th\u01b0\u01a1ng \u0111\u1eb7c bi\u1ec7t nghi\u00eam tr\u1ecdng cho h\u1ec7 th\u1ed1ng ph\u1ed5i, ti\u00eau h\u00f3a v\u00e0 ti\u1ebft ni\u1ec7u. Berker v\u00e0 c\u1ed9ng s\u1ef1. \u0111\u00e3 l\u00e0m r\u00f5 m\u1ed1i t\u01b0\u01a1ng quan gi\u1eefa ph\u1ea3n \u1ee9ng s\u01b0ng do forskolin (FIS) c\u1ee7a m\u00f4 h\u00ecnh c\u01a1 quan tr\u1ef1c tr\u00e0ng c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n CF v\u00e0 ph\u1ea3n \u1ee9ng \u0111i\u1ec1u tr\u1ecb in vivo c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n CF v\u1edbi nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn CFTR \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u bi\u1ebfn CFTR, v\u00e0 \u0111\u00e2y l\u00e0 \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng \u0111\u1ea7u ti\u00ean c\u1ee7a organoid \u0111\u1ec3 h\u01b0\u1edbng d\u1eabn d\u00f9ng thu\u1ed1c cho t\u1eebng c\u00e1 nh\u00e2n. Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 thu h\u00fat s\u1ef1 quan t\u00e2m \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m FIS nh\u01b0 m\u1ed9t d\u1ea5u \u1ea5n sinh h\u1ecdc ti\u1ec1m n\u0103ng \u0111\u1ec3 \u0111\u1ecbnh l\u01b0\u1ee3ng c\u00e1c ph\u1ea3n \u1ee9ng l\u00e2m s\u00e0ng c\u1ee7a b\u1ed9 \u0111i\u1ec1u bi\u1ebfn CFTR ri\u00eang l\u1ebb. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u c\u0169ng \u0111\u00e3 \u0111i\u1ec1u tra r\u1eb1ng c\u00e1c c\u01a1 quan ung th\u01b0 tr\u1ef1c tr\u00e0ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n ph\u1ea3n \u1ee9ng trong x\u1ea1 tr\u1ecb l\u00e2m s\u00e0ng. Yao et al. \u0111\u00e3 thi\u1ebft l\u1eadp m\u1ed9t ng\u00e2n h\u00e0ng sinh h\u1ecdc c\u01a1 quan s\u1ed1ng t\u1eeb nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ung th\u01b0 tr\u1ef1c tr\u00e0ng ti\u1ebfn tri\u1ec3n c\u1ee5c b\u1ed9 (LARC) v\u00e0 cho th\u1ea5y t\u00e1c d\u1ee5ng c\u1ee7a h\u00f3a tr\u1ecb li\u1ec7u t\u00e2n b\u1ed5 tr\u1ee3 (nCRT) \u0111\u1ed1i v\u1edbi c\u00e1c c\u01a1 quan trong \u1ed1ng nghi\u1ec7m t\u01b0\u01a1ng \u1ee9ng \u0111\u00e1ng k\u1ec3 v\u1edbi t\u00e1c \u0111\u1ed9ng l\u00ean kh\u1ed1i u c\u1ee7a b\u1ec7nh nh\u00e2n, cho th\u1ea5y PDO c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n ph\u1ea3n \u1ee9ng h\u00f3a tr\u1ecb c\u1ee7a b\u1ec7nh nh\u00e2n LARC trong ph\u00f2ng kh\u00e1m. T\u01b0\u01a1ng t\u1ef1, Ganesh et al. \u0111\u00e3 quan s\u00e1t th\u1ea5y m\u1ed1i t\u01b0\u01a1ng quan cao gi\u1eefa c\u00e1c ph\u1ea3n \u1ee9ng c\u1ee7a LARC PDO v\u00e0 ph\u1ea3n \u1ee9ng c\u1ee7a c\u00e1c kh\u1ed1i u c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ed1i v\u1edbi x\u1ea1 tr\u1ecb ho\u1eb7c h\u00f3a tr\u1ecb. S\u00e0ng l\u1ecdc c\u00e1c \u1ee9ng c\u1eed vi\u00ean thu\u1ed1c l\u00e0 m\u1ed9t \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng quan tr\u1ecdng kh\u00e1c c\u1ee7a PDO. G\u1ea7n \u0111\u00e2y, m\u1ed9t ng\u00e2n h\u00e0ng sinh h\u1ecdc s\u1ed1ng \u0111\u00e3 \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp t\u1eeb 30 b\u1ec7nh nh\u00e2n m\u1eafc ung th\u01b0 bi\u1ec3u m\u00f4 tuy\u1ebfn t\u1ee5y (PDAC), v\u1edbi m\u1ee5c \u0111\u00edch s\u00e0ng l\u1ecdc thu\u1ed1c th\u00f4ng l\u01b0\u1ee3ng cao cho 76 t\u00e1c nh\u00e2n \u0111i\u1ec1u tr\u1ecb. K\u1ebft qu\u1ea3 cho th\u1ea5y \u0111\u1ed9 nh\u1ea1y in vitro \u0111\u1ed1i v\u1edbi c\u00e1c t\u00e1c nh\u00e2n n\u00e0y hi\u1ec7n ch\u01b0a \u0111\u01b0\u1ee3c khai th\u00e1c trong ph\u00f2ng kh\u00e1m v\u00e0 cho th\u1ea5y ch\u1ea5t \u1ee9c ch\u1ebf PRMT5 EZP015556 c\u00f3 th\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 trong c\u1ea3 PDO \u00e2m t\u00ednh v\u1edbi methylthioadenosine phosphorylase (MTAP) v\u00e0 m\u1ed9t t\u1eadp h\u1ee3p con PDO d\u01b0\u01a1ng t\u00ednh v\u1edbi MTAP, cho th\u1ea5y t\u1ea7m quan tr\u1ecdng c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn c\u00e1 nh\u00e2n h\u00f3a cho \u0111i\u1ec1u tr\u1ecb ung th\u01b0. C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf n\u00e0y hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh (NCT03573310, NCT02783300 v\u00e0 NCT03614728). N\u00f3i chung, nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y cho th\u1ea5y PDO c\u00f3 ti\u1ec1m n\u0103ng tr\u1edf th\u00e0nh c\u00f4ng c\u1ee5 m\u1ea1nh m\u1ebd, h\u1ea5p d\u1eabn \u0111\u1ec3 m\u00f4 h\u00ecnh h\u00f3a b\u1ec7nh t\u1eadt v\u00e0 s\u00e0ng l\u1ecdc thu\u1ed1c c\u00e1 nh\u00e2n h\u00f3a, m\u1edf ra m\u1ed9t con \u0111\u01b0\u1eddng m\u1edbi cho y h\u1ecdc ch\u00ednh x\u00e1c.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Lieu_phap_chinh_sua_va_cay_ghep_gen\"><\/span><strong>Li\u1ec7u ph\u00e1p ch\u1ec9nh s\u1eeda v\u00e0 c\u1ea5y gh\u00e9p gen<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>S\u1eeda ch\u1eefa gen \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau, ch\u1eb3ng h\u1ea1n nh\u01b0 ung th\u01b0, ti\u1ec3u \u0111\u01b0\u1eddng, b\u1ec7nh tim v\u00e0 h\u1ed9i ch\u1ee9ng suy gi\u1ea3m mi\u1ec5n d\u1ecbch m\u1eafc ph\u1ea3i (AIDS), b\u1eb1ng c\u00e1ch thay \u0111\u1ed5i c\u00e1c gen m\u1ee5c ti\u00eau b\u00ean trong t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3. K\u1ec3 t\u1eeb khi c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o g\u1ed1c Lgr5+ bi\u1ebfn \u0111\u1ed5i gen \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ea1o ra v\u00e0 c\u1ea5y gh\u00e9p th\u00e0nh c\u00f4ng v\u00e0o c\u00e1c m\u00f4 b\u1ecb t\u1ed5n th\u01b0\u01a1ng, vi\u1ec7c s\u1eeda ch\u1eefa gen ng\u00e0y c\u00e0ng tr\u1edf n\u00ean h\u1ee9a h\u1eb9n. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, c\u00f4ng ngh\u1ec7 CRISPR\/Cas9 \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111\u1ec3 s\u1eeda ch\u1eefa gen v\u00ec hi\u1ec7u qu\u1ea3 ch\u1ec9nh s\u1eeda gen cao. Schwank v\u00e0 c\u1ed9ng s\u1ef1. nh\u1eadn th\u1ea5y r\u1eb1ng ch\u1ee9c n\u0103ng CFTR \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eeda ch\u1eefa sau khi \u0111\u1ed9t bi\u1ebfn CFTR \u1edf ng\u01b0\u1eddi F508del \u0111\u01b0\u1ee3c s\u1eeda ch\u1eefa b\u1eb1ng h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa ph\u1ee5 thu\u1ed9c t\u01b0\u01a1ng \u0111\u1ed3ng qua trung gian CRISPR\/Cas9 v\u00e0 ch\u1ee9ng minh ch\u1ee9c n\u0103ng s\u1eeda ch\u1eefa gen, cung c\u1ea5p li\u1ec7u ph\u00e1p gen ti\u1ec1m n\u0103ng cho b\u1ec7nh nh\u00e2n CF. \u0110\u00e1ng ch\u00fa \u00fd, li\u1ec7u ph\u00e1p n\u00e0y \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c tr\u01b0\u1eddng h\u1ee3p ch\u1ec9nh s\u1eeda gen CRISPR\/Cas9 th\u00e0nh c\u00f4ng \u0111\u1ea7u ti\u00ean \u1edf c\u00e1c c\u01a1 quan c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb con ng\u01b0\u1eddi. Do h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa ph\u1ee5 thu\u1ed9c v\u00e0o t\u01b0\u01a1ng \u0111\u1ed3ng qua trung gian CRISPR\/Cas9 n\u00e0y c\u00f3 th\u1ec3 l\u00e0m ph\u00e1t sinh c\u00e1c \u0111\u1ee9t g\u00e3y s\u1ee3i \u0111\u00f4i ngo\u00e0i m\u1ee5c ti\u00eau c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i, n\u00ean m\u1ed9t c\u00f4ng ngh\u1ec7 ti\u00ean ti\u1ebfn h\u01a1n c\u00f3 t\u00ean l\u00e0 ch\u1ec9nh s\u1eeda adenine d\u1ef1a tr\u00ean CRISPR (ABE) \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y cho ph\u00e9p ch\u1ec9nh s\u1eeda c\u01a1 s\u1edf \u0111\u00fang m\u1ee5c ti\u00eau, bao g\u1ed3m chuy\u1ec3n \u0111\u1ed5i ch\u00ednh x\u00e1c c\u00e1c c\u1eb7p c\u01a1 s\u1edf A-T th\u00e0nh c\u1eb7p c\u01a1 s\u1edf G-C b\u1eb1ng enzyme, gi\u00fap s\u1eeda ch\u1eefa ch\u1ee9c n\u0103ng b\u1ecb suy gi\u1ea3m do \u0111\u1ed9t bi\u1ebfn CFTR. Xem x\u00e9t ti\u1ebfn tr\u00ecnh n\u00e0y, vi\u1ec7c ch\u1ec9nh s\u1eeda gen ch\u1eafc ch\u1eafn c\u00f3 th\u1ec3 s\u1eeda ch\u1eefa c\u00e1c \u0111\u1ed9t bi\u1ebfn gen trong PDO, nhanh ch\u00f3ng \u0111\u1ea9y vi\u1ec7c s\u1eeda ch\u1eefa gen v\u00e0o giai \u0111o\u1ea1n l\u00e2m s\u00e0ng.<\/p>\n<p>Gh\u00e9p t\u1ea1ng l\u00e0 ngu\u1ed3n l\u1ef1c thi\u1ebft y\u1ebfu c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n b\u1ecb suy n\u1ed9i t\u1ea1ng. Tuy nhi\u00ean, v\u1eabn c\u00f2n nhi\u1ec1u th\u00e1ch th\u1ee9c, \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u00ecnh tr\u1ea1ng \u0111\u00e0o th\u1ea3i m\u1ea3nh gh\u00e9p nghi\u00eam tr\u1ecdng v\u00e0 t\u00ecnh tr\u1ea1ng thi\u1ebfu ng\u01b0\u1eddi hi\u1ebfn t\u1ea1ng ng\u00e0y c\u00e0ng t\u0103ng. C\u00e1c organoid \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y in vitro c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh nh\u1eefng ngu\u1ed3n m\u00f4 ti\u1ec1m n\u0103ng, cung c\u1ea5p m\u1ed9t n\u1ec1n t\u1ea3ng \u0111\u1ea7y h\u1ee9a h\u1eb9n cho li\u1ec7u ph\u00e1p c\u1ea5y gh\u00e9p t\u1ef1 th\u00e2n.<\/p>\n<p>\u0110\u1ec3 bi\u1ebfn li\u1ec7u ph\u00e1p c\u1ea5y gh\u00e9p t\u1ea1ng th\u00e0nh hi\u1ec7n th\u1ef1c, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 n\u1ed7 l\u1ef1c r\u1ea5t nhi\u1ec1u \u0111\u1ec3 x\u00e1c minh t\u00ednh kh\u1ea3 thi c\u1ee7a n\u00f3. V\u00ed d\u1ee5, Watson v\u00e0 c\u1ed9ng s\u1ef1. \u0111\u00e3 c\u1ea5y gh\u00e9p m\u1ed9t organoid \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb hPSC v\u00e0o chu\u1ed9t ch\u1ee7 v\u00e0 ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u01a1 quan \u0111\u01b0\u1ee3c c\u1ea5y gh\u00e9p cho th\u1ea5y s\u1ef1 m\u1edf r\u1ed9ng v\u00e0 tr\u01b0\u1edfng th\u00e0nh r\u00f5 r\u1ec7t. McLelland v\u00e0 c\u1ed9ng s\u1ef1. \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng c\u00e1c t\u1ea5m organoid v\u00f5ng m\u1ea1c \u0111\u01b0\u1ee3c c\u1ea5y gh\u00e9p c\u00f3 th\u1ec3 h\u00ecnh th\u00e0nh c\u00e1c k\u1ebft n\u1ed1i kh\u1edbp th\u1ea7n kinh v\u00e0 c\u00e1c h\u00ecnh chi\u1ebfu m\u1edf r\u1ed9ng \u1edf chu\u1ed9t ch\u1ee7 b\u1ecb r\u1ed1i lo\u1ea1n v\u00f5ng m\u1ea1c. Chen v\u00e0 c\u1ed9ng s\u1ef1. quan s\u00e1t th\u1ea5y c\u00e1c c\u01a1 quan ch\u1ed3i ph\u1ed5i cho th\u1ea5y h\u00ecnh th\u00e1i ph\u00e2n nh\u00e1nh v\u00e0 \u0111\u1eb7c \u0111i\u1ec3m g\u1ea7n t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c m\u00f4 \u0111\u01b0\u1ee3c quan s\u00e1t tr\u00ean c\u01a1 th\u1ec3 \u1edf th\u1eddi \u0111i\u1ec3m 5 th\u00e1ng sau khi c\u1ea5y gh\u00e9p ngo\u00e0i t\u1eed cung. V\u01b0\u01a1ng v\u00e0 c\u1ed9ng s\u1ef1. \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u00e1c organoid n\u00e3o v\u00e0 sau \u0111\u00f3 c\u1ea5y ch\u00fang v\u00e0o m\u00f4 h\u00ecnh chu\u1ed9t b\u1ecb \u0111\u1ed9t qu\u1ef5. H\u1ecd quan s\u00e1t th\u1ea5y kh\u1ed1i l\u01b0\u1ee3ng nh\u1ed3i m\u00e1u n\u00e3o gi\u1ea3m v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng v\u1eadn \u0111\u1ed9ng th\u1ea7n kinh sau khi c\u1ea5y gh\u00e9p. \u0110\u00e1ng ch\u00fa \u00fd, nh\u00f3m c\u1ee7a ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c nh\u1eadn r\u1eb1ng c\u00e1c organoid n\u00e3o ng\u01b0\u1eddi c\u00f3 th\u1ec3 t\u00edch h\u1ee3p ch\u1ee9c n\u0103ng v\u00e0o c\u00e1c m\u1ea1ch th\u1ea7n kinh v\u00e0 thi\u1ebft l\u1eadp c\u00e1c h\u00ecnh chi\u1ebfu d\u01b0\u1edbi v\u1ecf n\u00e3o \u1edf chu\u1ed9t ch\u1ee7. Nhi\u1ec1u nghi\u00ean c\u1ee9u kh\u00e1c v\u1ec1 c\u1ea5y gh\u00e9p organoid \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, cung c\u1ea5p c\u01a1 s\u1edf l\u00fd thuy\u1ebft quan tr\u1ecdng cho vi\u1ec7c kh\u00e1m ph\u00e1 li\u1ec7u ph\u00e1p c\u1ea5y gh\u00e9p.<\/p>\n<p>M\u1eb7c d\u00f9 c\u00e1c organoid \u0111\u01b0\u1ee3c c\u1ea5y gh\u00e9p t\u01b0\u01a1ng \u0111\u1ed1i non n\u1edbt so v\u1edbi c\u00e1c c\u01a1 quan t\u1ef1 nhi\u00ean c\u1ee7a v\u1eadt ch\u1ee7 do s\u1ef1 tr\u01b0\u1edfng th\u00e0nh ch\u1ee9c n\u0103ng ch\u01b0a ho\u00e0n ch\u1ec9nh v\u00e0 c\u00f3 th\u1ec3 c\u00f3 c\u00e1c t\u01b0\u01a1ng t\u00e1c t\u1ebf b\u00e0o d\u1ecb h\u00ecnh, <strong>vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c organoid trong \u0111i\u1ec1u tr\u1ecb v\u1eabn s\u1ebd l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00f3 \u00fd ngh\u0129a thay th\u1ebf cho vi\u1ec7c gh\u00e9p t\u1ea1ng<\/strong>.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Ket_luan_va_quan_diem_cua_nhom_tac_gia\"><\/span><strong>K\u1ebft lu\u1eadn v\u00e0 quan \u0111i\u1ec3m c\u1ee7a nh\u00f3m t\u00e1c gi\u1ea3<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>C\u00e1c organoid ng\u01b0\u1eddi h\u1ee9a h\u1eb9n r\u1ea5t nhi\u1ec1u cho c\u00e1c \u1ee9ng d\u1ee5ng t\u1eeb nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n \u0111\u1ebfn y sinh. M\u00f4 h\u00ecnh h\u00f3a b\u1ec7nh b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c organoid \u0111\u00e3 \u0111\u01b0\u1ee3c li\u00ean k\u1ebft m\u1ed9t c\u00e1ch t\u1ef1 nhi\u00ean v\u1edbi th\u1eed nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng trong giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n thu\u1ed1c v\u00e0 s\u00e0ng l\u1ecdc thu\u1ed1c th\u00f4ng l\u01b0\u1ee3ng cao b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c organoid \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u ung th\u01b0. Ngo\u00e0i ra, c\u00e1c organoid ung th\u01b0 c\u00f3 th\u1ec3 l\u00e0 c\u00f4ng c\u1ee5 ti\u1ec1m n\u0103ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c lo\u1ea1i thu\u1ed1c hi\u1ec7u qu\u1ea3 \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0. V\u00ed d\u1ee5, b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng v\u1edbi c\u00e1c ki\u1ec3u gen kh\u00e1c nhau \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 \u0111\u1ed9 nh\u1ea1y c\u1ea3m kh\u00e1c nhau v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf EZH2. C\u00e1c h\u1ec7 th\u1ed1ng organoid c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho th\u1eed nghi\u1ec7m \u0111\u1ed9 an to\u00e0n v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a thu\u1ed1c v\u00ec t\u00ednh hi\u1ec7u qu\u1ea3 c\u1ee7a ch\u00fang. H\u01a1n n\u1eefa, c\u00e1c c\u00f4ng ngh\u1ec7 3D organoid \u0111\u00e3 cung c\u1ea5p c\u00e1c n\u1ec1n t\u1ea3ng h\u1ea5p d\u1eabn \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c t\u01b0\u01a1ng t\u00e1c m\u1ea7m b\u1ec7nh c\u1ee7a v\u1eadt ch\u1ee7 trong c\u00e1c b\u1ec7nh truy\u1ec1n nhi\u1ec5m kh\u00e1c nhau \u1edf ng\u01b0\u1eddi, bao g\u1ed3m nhi\u1ec5m k\u00fd sinh tr\u00f9ng \u0111\u01a1n b\u00e0o, vi khu\u1ea9n v\u00e0 vi r\u00fat. V\u00ed d\u1ee5, m\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng c\u00e1c organoid n\u00e3o c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tra c\u00e1c c\u01a1 ch\u1ebf c\u01a1 b\u1ea3n c\u1ee7a ch\u1ee9ng \u0111\u1ea7u nh\u1ecf do ZIKV g\u00e2y ra v\u00e0 c\u00e1c organoid b\u1ecb nhi\u1ec5m ZIKV \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n l\u00e0 nh\u1ecf h\u01a1n so v\u1edbi \u0111\u1ed1i ch\u1ee9ng, ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng quan s\u00e1t th\u1ea5y \u1edf b\u1ec7nh nh\u00e2n. M\u1ed9t v\u00ed d\u1ee5 \u0111\u1ea7y c\u1ea3m h\u1ee9ng kh\u00e1c li\u00ean quan \u0111\u1ebfn s\u1ef1 c\u1ea7n thi\u1ebft g\u1ea7n \u0111\u00e2y \u0111\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c m\u00f4 h\u00ecnh organoid cho \u0111\u1ea1i d\u1ecbch SARS-CoV-2 m\u1edbi n\u1ed5i. \u0110\u1ea1i d\u1ecbch b\u1ec7nh vi-r\u00fat corona 2019 (COVID-19) hi\u1ec7n nay do SARS-CoV-2 g\u00e2y ra l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u1eed vong v\u1edbi t\u1ef7 l\u1ec7 t\u1eed vong \u1edf ng\u01b0\u1eddi cao h\u01a1n so v\u1edbi b\u1ec7nh c\u00fam th\u00f4ng th\u01b0\u1eddng. Ph\u00e1t tri\u1ec3n v\u1eafc-xin v\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng l\u1ea1i COVID-19 l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 c\u1ea5p b\u00e1ch v\u00e0 c\u00e1c organoid ng\u01b0\u1eddi \u0111\u00e3 cung c\u1ea5p c\u00e1c c\u00f4ng c\u1ee5 nghi\u00ean c\u1ee9u c\u00f3 gi\u00e1 tr\u1ecb cho nghi\u00ean c\u1ee9u c\u01a1 ch\u1ebf b\u1ec7nh sinh v\u1ec1 SARS-CoV-2. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y r\u1eb1ng c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb AdSC b\u1ecb nhi\u1ec5m SARS-CoV-2 \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb \u0111\u01b0\u1eddng th\u1edf c\u1ee7a con ng\u01b0\u1eddi v\u00e0 ru\u1ed9t c\u0169ng nh\u01b0 trong c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u1ea1ch m\u00e1u, n\u00e3o v\u00e0 th\u1eadn c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb PSC. Organoid c\u0169ng \u0111ang n\u1ed5i l\u00ean nh\u01b0 l\u00e0 ngu\u1ed3n ti\u1ec1m n\u0103ng c\u1ee7a c\u00e1c m\u00f4 c\u00f3 th\u1ec3 c\u1ea5y gh\u00e9p v\u00e0 c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o ch\u1ee9c n\u0103ng cho c\u00e1c li\u1ec7u ph\u00e1p thay th\u1ebf t\u1ebf b\u00e0o trong y h\u1ecdc t\u00e1i t\u1ea1o. Nhi\u1ec1u n\u1ed7 l\u1ef1c th\u00e0nh c\u00f4ng \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 c\u1ea5y gh\u00e9p c\u00e1c lo\u1ea1i organoid kh\u00e1c nhau v\u00e0o v\u1eadt ch\u1ee7, bao g\u1ed3m c\u00e1c organoid v\u00f5ng m\u1ea1c, \u0111\u1ea1i tr\u00e0ng, ru\u1ed9t, gan v\u00e0 th\u1eadn; c\u00e1c c\u01a1 quan n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 t\u00edch h\u1ee3p hi\u1ec7u qu\u1ea3 v\u1edbi m\u00f4 ch\u1ee7 ho\u1eb7c c\u00f3 th\u1ec3 t\u00e1i t\u1ea1o l\u1ea1i ch\u1ee9c n\u0103ng c\u1ee7a c\u01a1 quan \u1edf m\u1ed9t m\u1ee9c \u0111\u1ed9 nh\u1ea5t \u0111\u1ecbnh. Li\u1ec7u ph\u00e1p thay th\u1ebf t\u1ef1 th\u00e2n c\u0169ng s\u1ebd cho ph\u00e9p s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ch\u1ec9nh s\u1eeda gen \u0111\u1ed1i v\u1edbi c\u00e1c \u0111\u1ed9t bi\u1ebfn li\u00ean quan \u0111\u1ebfn b\u1ec7nh t\u1eadt.<\/p>\n<p>M\u1eb7c d\u00f9 l\u0129nh v\u1ef1c organoid 3D \u0111ang ph\u00e1t tri\u1ec3n v\u00e0 cung c\u1ea5p c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ed5i m\u1edbi cho nghi\u00ean c\u1ee9u y sinh v\u00e0 nghi\u00ean c\u1ee9u t\u1ecbnh ti\u1ebfn l\u00e2m s\u00e0ng, nh\u01b0ng v\u1eabn c\u00f2n m\u1ed9t s\u1ed1 tr\u1edf ng\u1ea1i c\u1ea7n \u0111\u01b0\u1ee3c gi\u1ea3i quy\u1ebft (H\u00ecnh 2).<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/MYJTGDkf0Xf1a4x4SxVLrU01OwzCtoRfFmvgEzC3.png\" alt=\"\" width=\"579\" height=\"535\"><\/p>\n<p><i>H\u00ecnh 2. Nh\u1eefng th\u00e1ch th\u1ee9c v\u00e0 tri\u1ec3n v\u1ecdng c\u1ee7a c\u00f4ng ngh\u1ec7 organoid. Quan \u0111i\u1ec3m v\u1ec1 nh\u1eefng th\u00e1ch th\u1ee9c v\u00e0 tri\u1ec3n v\u1ecdng c\u1ee7a c\u00e1c c\u00f4ng ngh\u1ec7 organoid. C\u1ee5 th\u1ec3, k\u00edch th\u01b0\u1edbc c\u1ee7a c\u00e1c organoid \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n cho \u0111\u1ebfn nay \u0111\u00e3 b\u1ecb h\u1ea1n ch\u1ebf do thi\u1ebfu c\u1ea5u tr\u00fac m\u1ea1ch m\u00e1u, nh\u01b0ng vi\u1ec7c th\u1ef1c hi\u1ec7n t\u1ea1o m\u1ea1ch th\u00f4ng qua nu\u00f4i c\u1ea5y v\u1edbi c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 c\u00f3 th\u1ec3 cung c\u1ea5p m\u1ed9t c\u00e1ch g\u1ea7n nh\u01b0 sinh l\u00fd \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t dinh d\u01b0\u1ee1ng. S\u1ef1 tr\u01b0\u1edfng th\u00e0nh ch\u1eadm l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 quan tr\u1ecdng kh\u00e1c h\u1ea1n ch\u1ebf m\u00f4 h\u00ecnh b\u1ec7nh \u1edf c\u00e1c giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n sau n\u00e0y, nh\u01b0ng vi\u1ec7c x\u1eed l\u00fd tr\u01b0\u1edbc c\u00e1c organoid b\u1eb1ng c\u00e1c h\u1ee3p ch\u1ea5t ph\u00e2n t\u1eed nh\u1ecf c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t gi\u1ea3i ph\u00e1p cho r\u00e0o c\u1ea3n n\u00e0y. H\u01a1n n\u1eefa, vi\u1ec7c thi\u1ebft l\u1eadp c\u00e1c t\u01b0\u01a1ng t\u00e1c m\u00f4 ngo\u00e0i da, trung m\u00f4 v\u00e0 n\u1ed9i b\u00ec trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn \u0111\u1ea7y h\u1ee9a h\u1eb9n \u0111\u1ec3 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng t\u00e1i h\u1ea5p thu c\u00e1c t\u01b0\u01a1ng t\u00e1c c\u1ee7a h\u1ec7 th\u1ed1ng c\u01a1 quan \u0111i\u1ec3n h\u00ecnh \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y tr\u00ean c\u01a1 th\u1ec3 s\u1ed1ng. K\u1ef9 thu\u1eadt m\u00f4 c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t c\u00e1c v\u1eadt li\u1ec7u v\u00e0 s\u1ef1 ph\u00e2n b\u1ed5 ch\u00ednh x\u00e1c c\u1ee7a c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau th\u00f4ng qua c\u00e1c lo\u1ea1i k\u1ef9 thu\u1eadt ch\u1ebf t\u1ea1o sinh h\u1ecdc, \u0111\u00e2y c\u0169ng l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn \u0111\u1ea7y h\u1ee9a h\u1eb9n \u0111\u1ec3 s\u1eed d\u1ee5ng n\u1ec1n t\u1ea3ng vi l\u1ecfng trong c\u00e1c organoid t\u1ed5ng h\u1ee3p. C\u00e1c h\u1ec7 th\u1ed1ng nu\u00f4i c\u1ea5y c\u00f3 th\u1ec3 mang l\u1ea1i nh\u1eefng l\u1ee3i th\u1ebf c\u1ee7a c\u00e1c h\u1ec7 th\u1ed1ng m\u00f4 h\u00ecnh organoid 3D \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c t\u01b0\u01a1ng t\u00e1c ch\u1ee9c n\u0103ng v\u00e0 \/ ho\u1eb7c th\u1eddi gian v\u00e0 kh\u00f4ng gian gi\u1eefa c\u00e1c qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o kh\u00e1c nhau. Theo c\u00e1c nguy\u00ean t\u1eafc ph\u00e1t sinh c\u01a1 quan trong giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n ph\u00f4i, quy \u0111\u1ecbnh v\u1ec1 s\u1ef1 bi\u1ec7t h\u00f3a t\u1ebf b\u00e0o theo kh\u00f4ng gian v\u00e0 th\u1eddi gian c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t tr\u1ef1c ti\u1ebfp trong \u1ed1ng nghi\u1ec7m th\u00f4ng qua vi\u1ec7c th\u1ef1c hi\u1ec7n c\u00e1c gradient n\u1ed3ng \u0111\u1ed9 v\u00e0 c\u00e1c trung t\u00e2m t\u00edn hi\u1ec7u c\u1ee7a c\u00e1c h\u00ecnh th\u00e1i \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn b\u1eb1ng h\u00ecnh d\u1ea1ng.<\/i><\/p>\n<p>\u0110\u1ea7u ti\u00ean, nu\u00f4i c\u1ea5y organoid c\u1ee7a con ng\u01b0\u1eddi ph\u1ee5 thu\u1ed9c v\u00e0o c\u00e1c ch\u1ea5t thay th\u1ebf ECM c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb chu\u1ed9t, ch\u1eb3ng h\u1ea1n nh\u01b0 chi\u1ebft xu\u1ea5t Matrigel v\u00e0 m\u00e0ng \u0111\u00e1y. Nh\u1eefng chi\u1ebft xu\u1ea5t n\u00e0y cho th\u1ea5y s\u1ef1 thay \u0111\u1ed5i th\u00e0nh ph\u1ea7n do s\u1ea3n xu\u1ea5t h\u00e0ng lo\u1ea1t, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng nh\u00e2n r\u1ed9ng c\u1ee7a k\u1ebft qu\u1ea3 th\u00ed nghi\u1ec7m trong nghi\u00ean c\u1ee9u sinh h\u1ecdc. Ngo\u00e0i ra, ch\u00fang c\u00f3 th\u1ec3 c\u1ea3n tr\u1edf qu\u00e1 tr\u00ecnh c\u1ea5y gh\u00e9p l\u00e2m s\u00e0ng tr\u1ef1c ti\u1ebfp do m\u1ea7m b\u1ec7nh ch\u01b0a bi\u1ebft v\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch ti\u1ec1m t\u00e0ng m\u00e0 ch\u00fang g\u00e2y ra. Thi\u1ebfu s\u00f3t n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3i quy\u1ebft th\u00f4ng qua nu\u00f4i c\u1ea5y v\u1edbi collagen c\u1ea5p \u0111\u1ed9 l\u00e2m s\u00e0ng. C\u00e1c chi\u1ebfn l\u01b0\u1ee3c c\u00f4ng ngh\u1ec7 sinh h\u1ecdc c\u0169ng s\u1ebd cung c\u1ea5p c\u00e1c h\u01b0\u1edbng m\u1edbi \u0111\u1ec3 c\u1ea3i thi\u1ec7n ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn.<\/p>\n<p>M\u1ed9t y\u1ebfu t\u1ed1 kh\u00e1c h\u1ea1n ch\u1ebf vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p nu\u00f4i c\u1ea5y organoid hi\u1ec7n t\u1ea1i trong c\u00e1c \u1ee9ng d\u1ee5ng y h\u1ecdc t\u00e1i t\u1ea1o trong t\u01b0\u01a1ng lai l\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p n\u00e0y kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng m\u00f4 h\u00ecnh h\u00f3a c\u00e1c b\u1ec7nh l\u00fd \u0111a c\u01a1 quan. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p nu\u00f4i c\u1ea5y c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft m\u1ed9t ph\u1ea7n v\u1ea5n \u0111\u1ec1 n\u00e0y. M\u1ed9t n\u1ed7 l\u1ef1c li\u00ean quan g\u1ea7n \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o li\u00ean quan \u0111\u1ebfn s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a c\u00e1c organoid \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb hPSC v\u00e0 c\u00e1c t\u1ebf b\u00e0o m\u00e0o th\u1ea7n kinh. H\u01a1n n\u1eefa, c\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ngh\u0129 ra c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111\u1ec3 t\u1ea1o ra c\u00e1c <strong>c\u00f4ng ngh\u1ec7 organ-on-a-chip<\/strong> nh\u1eb1m t\u1ea1o ra c\u00e1c h\u1ec7 th\u1ed1ng 3D cho ph\u00e9p k\u1ebft n\u1ed1i v\u00e0 giao ti\u1ebfp gi\u1eefa nhi\u1ec1u &#8216;c\u01a1 quan&#8217; \u0111\u01b0\u1ee3c t\u1ea1o h\u00ecnh s\u1eb5n.<\/p>\n<p>S\u1ef1 tr\u01b0\u1edfng th\u00e0nh c\u1ee7a m\u00f4 l\u00e0 y\u1ebfu t\u1ed1 quan tr\u1ecdng th\u1ee9 ba h\u1ea1n ch\u1ebf c\u00f4ng ngh\u1ec7 organoid ph\u00e1t huy h\u1ebft ti\u1ec1m n\u0103ng c\u1ee7a n\u00f3 \u0111\u1ed1i v\u1edbi c\u00e1c \u1ee9ng d\u1ee5ng ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 th\u1eadm ch\u00ed c\u1ea3 l\u00e2m s\u00e0ng. V\u00ed d\u1ee5, c\u00e1c h\u1ec7 th\u1ed1ng nu\u00f4i c\u1ea5y organoid t\u00e1i t\u1ea1o giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n n\u00e3o b\u1ed9 c\u1ee7a thai nhi \u1edf m\u1ee9c \u0111\u1ed9 l\u1edbn, \u0111i\u1ec1u n\u00e0y g\u00e2y kh\u00f3 kh\u0103n cho vi\u1ec7c m\u00f4 h\u00ecnh h\u00f3a c\u00e1c r\u1ed1i lo\u1ea1n th\u1ea7n kinh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u00e3o ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, ch\u1eb3ng h\u1ea1n nh\u01b0 b\u1ec7nh Alzheimer. \u0110\u1ec3 v\u01b0\u1ee3t qua nh\u1eefng r\u00e0o c\u1ea3n n\u00e0y, nhi\u1ec1u giao th\u1ee9c \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u h\u00f3a \u0111\u1ec3 bao g\u1ed3m ti\u1ec1n x\u1eed l\u00fd c\u00e1c organoid b\u1eb1ng <strong>c\u00e1c h\u1ee3p ch\u1ea5t ph\u00e2n t\u1eed nh\u1ecf<\/strong> nh\u01b0 BDNF261 \u0111\u1ec3 t\u0103ng t\u1ed1c \u0111\u1ed9 tr\u01b0\u1edfng th\u00e0nh. Oxy h\u00f3a v\u00e0 khu\u1ebfch t\u00e1n ch\u1ea5t dinh d\u01b0\u1ee1ng l\u00e0 hai y\u1ebfu t\u1ed1 quan tr\u1ecdng kh\u00e1c trong qu\u00e1 tr\u00ecnh tr\u01b0\u1edfng th\u00e0nh. Vi\u1ec7c nu\u00f4i c\u1ea5y organoid trong th\u1eddi gian d\u00e0i kh\u00f4ng m\u1edf r\u1ed9ng theo th\u1eddi gian, m\u00e0 d\u1eabn \u0111\u1ebfn qu\u00e1 tr\u00ecnh ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh\/ho\u1ea1i t\u1eed ngay l\u1eadp t\u1ee9c \u0111\u1ec3 t\u1ea1o th\u00e0nh m\u1ed9t khoang trong l\u00f5i c\u1ee7aorganoid, do thi\u1ebfu oxy. \u0110i\u1ec1u n\u00e0y \u0111\u01b0\u1ee3c quan s\u00e1t t\u01b0\u01a1ng \u0111\u1ed1i th\u01b0\u1eddng xuy\u00ean trong c\u00e1c h\u1ec7 th\u1ed1ng nu\u00f4i c\u1ea5y c\u01a1 quan n\u00e3o. C\u00f3 \u00fd ki\u1ebfn cho r\u1eb1ng khi \u0111\u01b0\u1eddng k\u00ednh c\u1ee7a c\u00e1c c\u01a1 quan n\u00e3o l\u00ean t\u1edbi x\u1ea5p x\u1ec9 500\u2009\u00b5m, ch\u00fang c\u00f3 th\u1ec3 b\u1eaft \u0111\u1ea7u bi\u1ec3u hi\u1ec7n s\u1ef1 c\u0103ng th\u1eb3ng c\u1ee7a t\u1ebf b\u00e0o chuy\u1ec3n h\u00f3a, do \u0111\u00f3 d\u1eabn \u0111\u1ebfn gi\u1ea3m s\u1ef1 phong ph\u00fa c\u1ee7a c\u00e1c ph\u00e2n nh\u00f3m t\u1ebf b\u00e0o so v\u1edbi m\u00f4 n\u00e3o c\u1ee7a thai nhi b\u1ecb h\u1ee7y b\u1ecf. \u0110\u1ec3 gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 n\u00e0y, c\u00e1c organoid ban \u0111\u1ea7u \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong bioreactor quay tr\u00f2n ho\u1eb7c s\u1eed d\u1ee5ng m\u00e1y l\u1eafc. Nh\u1eefng n\u1ed7 l\u1ef1c kh\u00e1c \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 \u0111\u01b0a ra nhi\u1ec1u chi\u1ebfn l\u01b0\u1ee3c k\u1ef9 thu\u1eadt cho m\u1ea1ch m\u00e1u. V\u00ed d\u1ee5, c\u00e1c organoid to\u00e0n b\u1ed9 n\u00e3o \u0111\u00e3 \u0111\u01b0\u1ee3c nh\u00fang l\u1ea1i v\u00e0o Matrigel c\u00f3 ch\u1ee9a c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 c\u00f3 ngu\u1ed3n g\u1ed1c iPSC \u0111\u1ec3 t\u1ea1o th\u00e0nh c\u00e1c organoid m\u1ea1ch m\u00e1u, gi\u00fap th\u00fac \u0111\u1ea9y h\u01a1n n\u1eefa s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a organoid v\u00e0 cung c\u1ea5p ch\u1ea5t dinh d\u01b0\u1ee1ng. M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng vi\u1ec7c c\u1ea5y gh\u00e9p c\u00e1c organoid v\u00e0o \u0111\u1ed9ng v\u1eadt d\u1eabn \u0111\u1ebfn s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u t\u1eeb n\u00e3o v\u1eadt ch\u1ee7; c\u00e1c m\u1ea1ch k\u1ebft qu\u1ea3 c\u00f3 th\u1ec3 v\u1eadn chuy\u1ec3n oxy v\u00e0 ch\u1ea5t dinh d\u01b0\u1ee1ng \u0111\u1ec3 h\u1ed7 tr\u1ee3 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh trong m\u1ea3nh gh\u00e9p v\u00e0 s\u1ef1 tr\u01b0\u1edfng th\u00e0nh d\u1ea7n d\u1ea7n c\u1ee7a c\u00e1c c\u01a1 quan n\u00e3o. H\u01a1n n\u1eefa, s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a v\u1eadt li\u1ec7u sinh h\u1ecdc, c\u00f4ng ngh\u1ec7 nano, k\u1ef9 thu\u1eadt sinh h\u1ecdc v\u00e0 c\u00e1c giao th\u1ee9c ti\u00ean ti\u1ebfn kh\u00e1c c\u00f3 th\u1ec3 cho ph\u00e9p m\u1edf r\u1ed9ng v\u00e0 nu\u00f4i c\u1ea5y l\u00e2u d\u00e0i c\u00e1c organoid ng\u01b0\u1eddi trong t\u01b0\u01a1ng lai.<\/p>\n<p>Kh\u1ea3 n\u0103ng t\u00e1i s\u1ea3n xu\u1ea5t h\u1ea1n ch\u1ebf x\u1eed l\u00fd m\u1ed9t tr\u1edf ng\u1ea1i l\u1edbn trong vi\u1ec7c t\u1ea1o ra c\u00e1c organoid c\u1ea5p cao h\u01a1n v\u00e0 gi\u00e0nh quy\u1ec1n ki\u1ec3m so\u00e1t c\u00e1c ch\u1ee9c n\u0103ng c\u1ee7a ch\u00fang l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 kh\u00f3 hi\u1ec3u kh\u00e1c. C\u00e1c y\u1ebfu t\u1ed1 thi\u1ebft y\u1ebfu \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng t\u00e1i t\u1ea1o c\u1ee7a c\u00e1c organoid v\u1ec1 c\u01a1 b\u1ea3n l\u00e0 ch\u1ee9a s\u1ef1 bi\u1ebfn \u0111\u1ed5i theo l\u00f4, kh\u1ea3 n\u0103ng m\u1edf r\u1ed9ng s\u1ea3n xu\u1ea5t organoid, th\u00e0nh ph\u1ea7n t\u1ebf b\u00e0o v\u00e0 c\u1ea5u tr\u00fac c\u1ee7a c\u00e1c organoid. Krefft v\u00e0 nh\u00f3m c\u1ee7a \u00f4ng \u0111\u00e3 thi\u1ebft l\u1eadp m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn t\u1ed5 ch\u1ee9c ti\u1ec1n \u0111\u00ecnh gi\u00fap gi\u1ea3m t\u00ednh kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t b\u1eb1ng c\u00e1ch th\u00eam c\u00e1c y\u1ebfu t\u1ed1 t\u1ea1o m\u1eabu d\u1ef1a tr\u00ean kh\u1ea3 n\u0103ng t\u1ef1 t\u1ed5 ch\u1ee9c c\u1ee7a iPSC. Gi\u1ea3i quy\u1ebft nh\u1eefng th\u00e1ch th\u1ee9c n\u00e0y, c\u00f3 th\u1ec3 th\u1ea5y tr\u01b0\u1edbc r\u1eb1ng m\u1ed9t m\u00f4 h\u00ecnh 3D t\u01b0\u01a1ng \u0111\u1ed1i ch\u00ednh x\u00e1c, c\u00f3 th\u1ec3 t\u00e1i t\u1ea1o c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n, hi\u1ec7n th\u1ef1c h\u00f3a qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i c\u00f4ng ngh\u1ec7 organoid t\u1eeb nghi\u00ean c\u1ee9u khoa h\u1ecdc sang th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng v\u00e0 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t organoid quy m\u00f4 l\u1edbn h\u01a1n \u0111\u1ec3 s\u00e0ng l\u1ecdc thu\u1ed1c.<\/p>\n<p>\u0110\u00e1ng ch\u00fa \u00fd, kh\u00f4ng gi\u1ed1ng nh\u01b0 c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb PSC, c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb AdSC ch\u1ec9 \u0111\u1ea1i di\u1ec7n cho c\u00e1c b\u1ed9 ph\u1eadn bi\u1ec3u m\u00f4 c\u1ee7a c\u00e1c c\u01a1 quan, do \u0111\u00f3 t\u00f3m t\u1eaft c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng \u0111i\u1ec3n h\u00ecnh c\u1ee7a bi\u1ec3u m\u00f4 nguy\u00ean th\u1ee7y; ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c ng\u0103n c\u1ee7a m\u00f4 \u0111\u1ec7m, d\u00e2y th\u1ea7n kinh, t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch v\u00e0 m\u1ea1ch m\u00e1u kh\u00f4ng c\u00f3. Do \u0111\u00f3, c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ASC th\u1ec3 hi\u1ec7n \u0111\u1ed9 ph\u1ee9c t\u1ea1p v\u1ec1 c\u1ea5u tr\u00fac th\u1ea5p h\u01a1n so v\u1edbi c\u00e1c organoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb PSC, nh\u01b0ng g\u1ea7n v\u1edbi m\u00f4 tr\u01b0\u1edfng th\u00e0nh h\u01a1n.<\/p>\n<p>Nh\u00ecn chung, c\u00e1c c\u00f4ng ngh\u1ec7 organoid m\u1edbi n\u1ed5i \u0111\u00e3 r\u1ea5t h\u1eefu \u00edch cho nghi\u00ean c\u1ee9u y sinh, s\u00e0ng l\u1ecdc thu\u1ed1c trong y h\u1ecdc c\u00e1 nh\u00e2n v\u00e0 k\u1ebft h\u1ee3p v\u1edbi c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda b\u1ed9 gen, cho li\u1ec7u ph\u00e1p gen. C\u00e1c \u1ee9ng d\u1ee5ng r\u1ed9ng r\u00e3i h\u01a1n c\u1ee7a organoids \u0111ang trong giai \u0111o\u1ea1n b\u1eaft \u0111\u1ea7u kh\u00e1m ph\u00e1. Nghi\u00ean c\u1ee9u m\u1edf r\u1ed9ng s\u1ebd cho ph\u00e9p c\u00e1c h\u1ec7 th\u1ed1ng 3D organoid b\u1ed5 sung cho c\u00e1c h\u1ec7 th\u1ed1ng m\u00f4 h\u00ecnh hi\u1ec7n c\u00f3, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 c\u1ee7ng c\u1ed1 c\u00e1c nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 l\u00e2m s\u00e0ng trong t\u01b0\u01a1ng lai.<\/p>\n<p>(Ngu\u1ed3n: Theo t\u1ea1p ch\u00ed Signal Transduction and Targeted Therapy volume 7, Article number: 168 (2022) \u0111\u0103ng ng\u00e0y 24\/5\/2022. <a href=\"https:\/\/www.nature.com\/articles\/s41392-022-01024-9\">https:\/\/www.nature.com\/articles\/s41392-022-01024-9<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Organoids l\u00e0 c\u00e1c c\u1ea5u tr\u00fac thu nh\u1ecf ba chi\u1ec1u (3D) \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong \u1ed1ng nghi\u1ec7m \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng c\u1ee7a con ng\u01b0\u1eddi (hPSC) ho\u1eb7c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh (AdSC) c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb c\u00e1c c\u00e1 nh\u00e2n ho\u1eb7c b\u1ec7nh nh\u00e2n kh\u1ecfe m\u1ea1nh t\u00e1i h\u1ea5p thu t\u00ednh kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/ung-dung-organoids-nguoi-trong-nghien-cuu-co-ban-lam-sang\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":5672,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-4209","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe-san-pham-moi"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u1ee8ng D\u1ee5ng Organoids Ng\u01b0\u1eddi Trong Nghi\u00ean C\u1ee9u C\u01a1 B\u1ea3n &amp; 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