{"id":4215,"date":"2024-02-25T10:11:46","date_gmt":"2024-02-25T10:11:46","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/immune-cell-therapy-new-direction-in-cancer-treatment\/"},"modified":"2025-09-29T14:00:05","modified_gmt":"2025-09-29T07:00:05","slug":"lieu-phap-te-bao-mien-dich-huong-moi-trong-dieu-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/lieu-phap-te-bao-mien-dich-huong-moi-trong-dieu-tri-ung-thu\/","title":{"rendered":"Li\u1ec7u Ph\u00e1p T\u1ebf B\u00e0o Mi\u1ec5n D\u1ecbch: H\u01b0\u1edbng M\u1edbi Trong \u0110i\u1ec1u Tr\u1ecb Ung Th\u01b0"},"content":{"rendered":"

Hi\u1ec7n nay, li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (Adoptive cell therapy) \u0111ang tr\u1edf th\u00e0nh xu h\u01b0\u1edbng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0, khi kh\u1eafc ph\u1ee5c \u0111\u01b0\u1ee3c nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng nh\u01b0 ph\u1eabu thu\u1eadt, h\u00f3a tr\u1ecb v\u00e0 b\u1ee9c x\u1ea1. T\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch l\u00e0 h\u1ec7 th\u1ed1ng b\u1ea3o v\u1ec7 t\u1ef1 nhi\u00ean c\u1ee7a c\u01a1 th\u1ec3 ch\u1ed1ng l\u1ea1i c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 virus. Khi ph\u00e2n t\u1eed mi\u1ec5n d\u1ecbch nh\u1eadn ra t\u1ebf b\u00e0o ung th\u01b0, ch\u00fang s\u1ebd ti\u1ebfn h\u00e0nh t\u1ea5n c\u00f4ng v\u00e0 gi\u1ebft ch\u1ebft ch\u00fang. Do \u0111\u00f3, li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch gi\u00fap c\u00e1c b\u1ec7nh nh\u00e2n ung th\u01b0 t\u0103ng c\u01b0\u1eddng s\u1ee9c \u0111\u1ec1 kh\u00e1ng c\u1ee7a c\u01a1 th\u1ec3 v\u00e0 gi\u1ea3i quy\u1ebft nh\u1eefng kh\u00f3 kh\u0103n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/h2>\n

\"\"<\/p>\n

Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m ng\u1eebng ho\u1eb7c l\u00e0m ch\u1eadm s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0.<\/i><\/p>\n

Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch l\u00e0 li\u1ec7u ph\u00e1p s\u1eed d\u1ee5ng ch\u00ednh c\u00e1c t\u1ebf b\u00e0o c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch \u0111\u1ec3 t\u1ea5n c\u00f4ng kh\u1ed1i u. Trong qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u, s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa ch\u00fang v\u00e0 h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch th\u01b0\u1eddng tr\u1ea3i qua 3 tr\u1ea1ng th\u00e1i, bao g\u1ed3m: lo\u1ea1i b\u1ecf, c\u00e2n b\u1eb1ng v\u00e0 tr\u1ed1n tho\u00e1t.<\/p>\n

\u1ede tr\u1ea1ng th\u00e1i lo\u1ea1i b\u1ecf, c\u00e1c kh\u1ed1i u \u0111ang ph\u00e1t tri\u1ec3n s\u1ebd b\u1ecb h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch nh\u1eadn di\u1ec7n t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u c\u0169ng nh\u01b0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o kh\u1ed1i u. Qu\u00e1 tr\u00ecnh n\u00e0y th\u01b0\u1eddng \u0111\u00f2i h\u1ecfi s\u1ef1 tham gia c\u1ee7a nhi\u1ec1u th\u00e0nh ph\u1ea7n trong h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch nh\u01b0 c\u00e1c t\u1ebf b\u00e0o tua, \u0111\u1ea1i th\u1ef1c b\u00e0o tham gia thu th\u1eadp, x\u1eed l\u00fd v\u00e0 tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean, c\u00e1c t\u1ebf b\u00e0o lympho, t\u1ebf b\u00e0o t\u1ef1 nhi\u00ean tham gia ti\u00eau di\u1ec7t t\u1ebf b\u00e0o \u00e1c t\u00ednh v\u00e0 \u0111i\u1ec1u h\u00f2a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch. Tuy nhi\u00ean, m\u1ed9t s\u1ed1 t\u1ebf b\u00e0o kh\u1ed1i u c\u00f3 th\u1ec3 v\u01b0\u1ee3t qua \u0111\u01b0\u1ee3c giai \u0111o\u1ea1n lo\u1ea1i b\u1ecf v\u00e0 ti\u1ebfn t\u1edbi giai \u0111o\u1ea1n c\u00e2n b\u1eb1ng, \u1edf tr\u1ea1ng th\u00e1i n\u00e0y, kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u m\u1ea1nh m\u1ebd h\u01a1n. \u0110\u00e1ng ch\u00fa \u00fd, t\u00f9y theo t\u1eebng \u0111i\u1ec1u ki\u1ec7n kh\u00e1c nhau, kh\u1ed1i u \u1edf tr\u1ea1ng th\u00e1i c\u00e2n b\u1eb1ng c\u00f3 th\u1ec3 tr\u1edf l\u1ea1i tr\u1ea1ng th\u00e1i lo\u1ea1i b\u1ecf ho\u1eb7c chuy\u1ec3n sang giai \u0111o\u1ea1n tr\u1ed1n tho\u00e1t. Trong tr\u1ea1ng th\u00e1i tr\u1ed1n tho\u00e1t, l\u00fac n\u00e0y, c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 \u0111\u00e3 tho\u00e1t kh\u1ecfi s\u1ef1 ki\u1ec3m so\u00e1t c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch v\u00e0 \u0111\u01b0\u1ee3c nh\u00e2n l\u00ean, d\u1eabn \u0111\u1ebfn c\u00e1c kh\u1ed1i u c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n nhanh ch\u00f3ng. Trong qu\u00e1 tr\u00ecnh n\u00e0y, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch kh\u00f3 nh\u1eadn di\u1ec7n \u0111\u01b0\u1ee3c c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u; c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u c\u00f3 th\u1ec3 kh\u00e1ng l\u1ea1i c\u00e1c cu\u1ed9c t\u1ea5n c\u00f4ng c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, m\u00f4i tr\u01b0\u1eddng kh\u1ed1i u g\u00e2y ra t\u00ecnh tr\u1ea1ng \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch… Tuy nhi\u00ean, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch v\u1ea5n k\u00ecm h\u00e3m l\u1ea1i m\u1ed9t ph\u1ea7n s\u1ef1 ph\u00e1t tri\u1ec3u c\u1ee7a kh\u1ed1i u. Nh\u1eefng tr\u1ea1ng th\u00e1i v\u1ec1 m\u1ed1i t\u01b0\u01a1ng t\u00e1c gi\u1eefa kh\u1ed1i u v\u00e0 h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch l\u00e0 n\u1ec1n t\u1ea3ng khoa h\u1ecdc quan tr\u1ecdng \u0111\u1ec3 c\u00e1c b\u00e1c s\u1ef9 s\u1eed d\u1ee5ng nh\u1eefng li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch ph\u00f9 h\u1ee3p trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh l\u00fd ung th\u01b0 cho b\u1ec7nh nh\u00e2n. <\/p>\n

Nguy\u00ean l\u00fd chung c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch l\u00e0 s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o b\u00ean ngo\u00e0i c\u01a1 th\u1ec3 nh\u1eb1m gia t\u0103ng s\u1ed1 l\u01b0\u1ee3ng v\u00e0 kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch, sau \u0111\u00f3 nh\u1eefng lo\u1ea1i t\u1ebf b\u00e0o n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c truy\u1ec1n l\u1ea1i v\u00e0o c\u01a1 th\u1ec3 \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i c\u00e1c kh\u1ed1i u nh\u1edd h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch.<\/p>\n

Quy tr\u00ecnh n\u00e0y th\u00f4ng th\u01b0\u1eddng g\u1ed3m c\u00e1c b\u01b0\u1edbc ch\u00ednh sau:<\/p>\n

    \n
  1. Thu th\u1eadp t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u1eeb kh\u1ed1i u ho\u1eb7c t\u1ed5 ch\u1ee9c ngo\u1ea1i vi<\/li>\n
  2. Nu\u00f4i c\u1ea5y<\/li>\n
  3. T\u0103ng sinh<\/li>\n
  4. Ho\u1ea1t h\u00f3a ho\u1eb7c bi\u1ebfn \u0111\u1ed5i c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch<\/li>\n
  5. Truy\u1ec1n l\u1ea1i cho b\u1ec7nh nh\u00e2n. <\/li>\n<\/ol>\n

    Cho t\u1edbi ng\u00e0y h\u00f4m nay, \u0111\u00e3 c\u00f3 nhi\u1ec1u li\u1ec7u ph\u00e1p s\u1eed d\u1ee5ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n nh\u01b0 t\u1ebf b\u00e0o lympho T g\u00e2y \u0111\u1ed9c (cytotoxic t lymphocyte therapy – CTL therapy), t\u1ebf b\u00e0o di\u1ec7t t\u1ef1 nhi\u00ean (natural killer therapy – NK therapy), t\u1ebf b\u00e0o gamma-delta T (\u03b3\u03b4 T cells therapy); t\u1ebf b\u00e0o lympho T bi\u1ebfn \u0111\u1ed5i gen bi\u1ec3u hi\u1ec7n th\u1ee5 th\u1ec3 TCR-T m\u1edbi (T-cell receptor); t\u1ebf b\u00e0o tua (dendritic cell therapy).<\/p>\n

    Ngu\u1ed3n b\u00e0i vi\u1ebft<\/a> | Nguy\u1ec5n Th\u1ecb Ng\u1ecdc Lan (B\u1ec7nh vi\u1ec7n \u0110\u1ea1i h\u1ecdc Y H\u00e0 N\u1ed9i)<\/p>\n

    1 Ludwik Gross (1964), \u201cAttempt at classification of mouse leukemia viruses: mouse leukemia virus type a and the friend virus\u201d, Acta Haematol<\/i>, 32(2)<\/strong>, pp.81-88.<\/p>\n

    2 M\u1ed9t nh\u00f3m c\u00e1c ph\u00e2n t\u1eed protein hay glycoprotein, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch v\u00e0 c\u00e1c t\u1ebf b\u00e0o kh\u00e1c trong c\u01a1 th\u1ec3 c\u1ee7a con ng\u01b0\u1eddi.<\/p>\n

    3 Ph\u00e2n t\u1eed MHC L\u1edbp I hi\u1ec7n di\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o c\u00f3 nh\u00e2n v\u00e0 l\u00e0 m\u1ed9t trong hai l\u1edbp ch\u00ednh c\u1ee7a ph\u00e2n t\u1eed MHC.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Hi\u1ec7n nay, li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (Adoptive cell therapy) \u0111ang tr\u1edf th\u00e0nh xu h\u01b0\u1edbng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0, khi kh\u1eafc ph\u1ee5c \u0111\u01b0\u1ee3c nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng nh\u01b0 ph\u1eabu thu\u1eadt, h\u00f3a tr\u1ecb v\u00e0 b\u1ee9c x\u1ea1. T\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch l\u00e0 h\u1ec7 th\u1ed1ng b\u1ea3o v\u1ec7 t\u1ef1 nhi\u00ean<\/p>\n

    Read More <\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":5681,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-4215","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe-san-pham-moi"],"acf":[],"yoast_head":"\nLi\u1ec7u Ph\u00e1p T\u1ebf B\u00e0o Mi\u1ec5n D\u1ecbch: H\u01b0\u1edbng M\u1edbi Trong \u0110i\u1ec1u Tr\u1ecb Ung Th\u01b0<\/title>\n<meta name=\"description\" content=\"Hi\u1ec7n nay, li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (Adoptive cell therapy) \u0111ang tr\u1edf th\u00e0nh xu h\u01b0\u1edbng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0, khi kh\u1eafc ph\u1ee5c \u0111\u01b0\u1ee3c nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng nh\u01b0 ph\u1eabu thu\u1eadt, h\u00f3a 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