{"id":4227,"date":"2024-02-25T10:19:22","date_gmt":"2024-02-25T10:19:22","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/uses-of-ethylene-vinyl-acetate-polymers-in-cell-therapy\/"},"modified":"2026-02-24T10:21:40","modified_gmt":"2026-02-24T03:21:40","slug":"cong-dung-cua-vat-lieu-eva-trong-tri-lieu-te-bao","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/dao-tao-webinar\/cong-dung-cua-vat-lieu-eva-trong-tri-lieu-te-bao\/","title":{"rendered":"C\u00f4ng D\u1ee5ng C\u1ee7a V\u1eadt Li\u1ec7u EVA Trong Tr\u1ecb Li\u1ec7u T\u1ebf B\u00e0o"},"content":{"rendered":"

Ethylene vinyl acetate copolymer \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng hai monomer: ethylene v\u00e0 vinyl acetate (VA). EVA \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i h\u01a1n 35 n\u0103m trong c\u00e1c \u1ee9ng d\u1ee5ng thi\u1ebft b\u1ecb y t\u1ebf.<\/p>\n

\"\"<\/h2>\n

H\u00ecnh 1. D\u00f2ng th\u1eddi gian c\u1ee7a v\u1eadt li\u1ec7u EVA trong l\u0129nh v\u1ef1c ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe t\u1eeb n\u0103m 1960.<\/p>\n

L\u0129nh v\u1ef1c tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o g\u1ed1c l\u00e0 m\u1ed9t l\u0129nh v\u1ef1c r\u1ea5t r\u1ed9ng l\u1edbn v\u00e0 \u0111\u1ea7y h\u1ee9a h\u1eb9n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nh\u01b0: Parkinson, ti\u1ec3u \u0111\u01b0\u1eddng, ALS v\u00e0 b\u1ec7nh tim. Nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00e0nh c\u00f4ng c\u00e1c b\u1ec7nh n\u00e0y cho ph\u00e9p \u0111i\u1ec1u tr\u1ecb t\u1eeb 100 tri\u1ec7u \u0111\u1ebfn 150 tri\u1ec7u ng\u01b0\u1eddi M\u1ef9 [1]. H\u00e3y nh\u00ecn v\u00e0o ti\u1ec1m n\u0103ng c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i. \u0110\u00e2y l\u00e0 m\u1ed9t t\u1ebf b\u00e0o c\u00f3 th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh b\u1ea5t k\u1ef3 lo\u1ea1i m\u00f4 c\u01a1 th\u1ec3 n\u00e0o. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u00e0 chuy\u00ean gia y t\u1ebf l\u01b0u tr\u1eef t\u1ebf b\u00e0o g\u1ed1c \u1edf \u0111i\u1ec1u ki\u1ec7n \u0111\u00f4ng l\u1ea1nh \u0111\u1ec3 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng khi c\u1ea7n thi\u1ebft. M\u1ed9t tr\u1ebb 2 tu\u1ed5i \u1edf Anh \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ee9u s\u1ed1ng b\u1eb1ng t\u1ebf b\u00e0o g\u1ed1c \u0111\u00f4ng l\u1ea1nh. B\u00e9 \u1ea5y m\u1eafc m\u1ed9t d\u1ea1ng b\u1ec7nh b\u1ea1ch c\u1ea7u d\u00f2ng t\u1ee7y c\u1ea5p t\u00ednh hi\u1ebfm g\u1eb7p \u0111e d\u1ecda t\u00ednh m\u1ea1ng v\u1edbi kh\u1ea3 n\u0103ng s\u1ed1ng l\u00e0 30%. B\u00e9 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c \u0111\u00f4ng l\u1ea1nh t\u1ea1i Tokyo v\u00e0 \u0111\u00e3 h\u1ed3i ph\u1ee5c ho\u00e0n to\u00e0n. V\u1eady lo\u1ea1i v\u1eadt li\u1ec7u y t\u1ebf n\u00e0o \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u01b0u tr\u1eef nh\u1eefng t\u1ebf b\u00e0o qu\u00fd gi\u00e1 n\u00e0y? Ch\u00ednh v\u1eadt li\u1ec7u EVA \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m polymer cho c\u00e1c v\u1eadt ch\u1ee9a n\u00e0y.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 t\u1eeb -156\u00b0<\/strong>C \u0111\u1ebfn -196\u00b0<\/strong>C [2]. C\u00e1c v\u1eadt li\u1ec7u kh\u00e1c nhau \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho t\u00fai l\u01b0u tr\u1eef, bao g\u1ed3m EVA v\u00e0 ethylene propylene fluoride (FEP) ho\u1eb7c polytetrafluoroethylene (PTFE). \u1ede M\u1ef9, EVA l\u00e0 v\u1eadt li\u1ec7u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn nh\u1ea5t cho v\u1eadt ch\u1ee9a \u0111\u00f4ng l\u1ea1nh [3]. Gi\u1ea5y ch\u1ee9ng nh\u1eadn FDA 510K minh h\u1ecda vi\u1ec7c s\u1eed d\u1ee5ng EVA. V\u1eadt li\u1ec7u EVA c\u00f3 c\u1ea5u tr\u00fac \u0111\u01a1n gi\u1ea3n v\u00e0 ng\u01b0\u1eddi ta th\u1ea5y r\u1eb1ng EVA c\u00f3 t\u00ednh linh ho\u1ea1t b\u1edfi hai monomer l\u00e0 ethylene v\u00e0 vinyl axetat. M\u1ed7i monomer c\u00f3 kh\u1ea3 n\u0103ng ph\u1ea3n \u1ee9ng sao cho th\u00e0nh ph\u1ea7n t\u1ed5ng th\u1ec3 c\u1ee7a ethylene v\u00e0 VA trong copolymer cu\u1ed1i c\u00f9ng x\u1ea5p x\u1ec9 t\u1ef7 l\u1ec7 c\u1ea5p li\u1ec7u t\u01b0\u01a1ng \u1ee9ng. Do \u0111\u00f3, ng\u01b0\u1eddi ta c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u0111\u1ed9 d\u1ebbo v\u00e0 nhi\u1ec7t \u0111\u1ed9 chuy\u1ec3n h\u00f3a th\u1ee7y tinh (Tg) b\u1eb1ng c\u00e1ch thay \u0111\u1ed5i h\u00e0m l\u01b0\u1ee3ng vinyl axetat. \u0110\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i c\u00f3 h\u00e0m l\u01b0\u1ee3ng VA cao, v\u00ed d\u1ee5: 28%, nhi\u1ec7t \u0111\u1ed9 chuy\u1ec3n h\u00f3a th\u1ee7y tinh c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c l\u00e0 -30\u00b0<\/strong>C. \u0110i\u1ec1u n\u00e0y mang l\u1ea1i hi\u1ec7u su\u1ea5t c\u1ee7a v\u1eadt ch\u1ee9a t\u1ed1t \u1edf nhi\u1ec7t \u0111\u1ed9 th\u1ea5p v\u1edbi \u0111\u1ed9 trong su\u1ed1t cao. H\u01a1n n\u1eefa, do t\u00ednh ch\u1ea5t c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u0111\u1eb7c t\u00ednh ch\u1ec9 b\u1eb1ng c\u00e1ch thay \u0111\u1ed5i h\u00e0m l\u01b0\u1ee3ng VA, ng\u01b0\u1eddi ta kh\u00f4ng c\u1ea7n th\u00eam c\u00e1c ch\u1ea5t ph\u1ee5 gia nh\u01b0 ch\u1ea5t l\u00e0m d\u1ebbo c\u00f3 nguy c\u01a1 th\u1ea5m v\u00e0o th\u00e0nh ph\u1ea7n m\u1eabu b\u1ea3o qu\u1ea3n. EVA d\u1ec5 d\u00e0ng \u0111\u01b0\u1ee3c kh\u1eed tr\u00f9ng b\u1eb1ng b\u1ee9c x\u1ea1 gamma. Kh\u1eed tr\u00f9ng b\u1eb1ng gamma kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb cho FEP do m\u1ee9c ch\u1ecbu \u0111\u1ef1ng th\u1ea5p l\u00e0 50 kYG. Polytetrafluoroethylene (PTFE) c\u00f3 m\u1ee9c ch\u1ecbu \u0111\u1ef1ng l\u00e0 5 kGY v\u00e0 c\u00f3 th\u1ec3 ph\u00e2n h\u1ee7y th\u00e0nh b\u1ed9t d\u01b0\u1edbi b\u1ee9c x\u1ea1 gamma. Ngo\u00e0i ra, PTFE c\u00f3 th\u1ec3 gi\u1ea3i ph\u00f3ng kh\u00ed flo trong qu\u00e1 tr\u00ecnh kh\u1eed tr\u00f9ng b\u1eb1ng gamma.<\/p>\n

B\u1ea3n ch\u1ea5t \u0111\u1ed5i m\u1edbi c\u1ee7a EVA v\u00e0 s\u1ef1 \u0111\u01a1n gi\u1ea3n c\u1ee7a c\u1ea5u tr\u00fac ph\u00e2n t\u1eed \u0111\u00e3 gi\u00fap n\u00f3 tr\u1edf th\u00e0nh v\u1eadt li\u1ec7u h\u00e0ng \u0111\u1ea7u trong l\u0129nh v\u1ef1c l\u01b0u tr\u1eef t\u1ebf b\u00e0o g\u1ed1c \u0111\u00f4ng l\u1ea1nh.<\/p>\n

Vi\u1ec7c l\u1ef1a ch\u1ecdn lo\u1ea1i v\u1eadt ch\u1ee9a ph\u00f9 h\u1ee3p l\u00e0 m\u1ed9t trong nh\u1eefng y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a ngu\u1ed3n m\u1eabu.<\/strong> T\u00fai b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh CryoStore<\/a> c\u1ee7a h\u00e3ng OriGen Biomedical (M\u1ef9) \u0111\u1ec1u \u0111\u01b0\u1ee3c l\u00e0m t\u1eeb EVA, c\u00f3 \u0111\u1ed9 an to\u00e0n v\u00e0 \u0111\u1ed9 b\u1ec1n \u0111\u01b0\u1ee3c ch\u1ee9ng minh th\u00f4ng qua x\u00e1c nh\u1eadn v\u00e0 th\u00e0nh c\u00f4ng c\u1ee7a kh\u00e1ch h\u00e0ng. Ngo\u00e0i ra, t\u00fai CryoStore c\u00f2n \u0111\u1ea1t c\u00e1c ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng ISO 13485:2016; CE; FDA 510(k); MDSAP v\u00e0 cGMP.<\/p>\n

B\u00e0i vi\u1ebft g\u1ed1c<\/a><\/p>\n

Ngu\u1ed3n t\u00e0i li\u1ec7u tham kh\u1ea3o<\/p>\n

1. J. Shaw, Stem Cell Science, Harvard Magazine, July-August 2004.<\/p>\n

2. www.ncbi.nlm.nih.gov\/pmc\/articles\/PM C 2075525<\/a>.<\/p>\n

3. Ibid.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ethylene vinyl acetate copolymer \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng hai monomer: ethylene v\u00e0 vinyl acetate (VA). EVA \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i h\u01a1n 35 n\u0103m trong c\u00e1c \u1ee9ng d\u1ee5ng thi\u1ebft b\u1ecb y t\u1ebf. H\u00ecnh 1. D\u00f2ng th\u1eddi gian c\u1ee7a v\u1eadt li\u1ec7u EVA trong l\u0129nh v\u1ef1c ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe t\u1eeb n\u0103m 1960.<\/p>\n

Read More <\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":5694,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[18],"tags":[],"class_list":["post-4227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dao-tao-webinar"],"acf":[],"yoast_head":"\nC\u00f4ng D\u1ee5ng C\u1ee7a V\u1eadt Li\u1ec7u EVA Trong Tr\u1ecb Li\u1ec7u T\u1ebf B\u00e0o<\/title>\n<meta name=\"description\" content=\"Ethylene vinyl acetate copolymer \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng hai monomer: ethylene v\u00e0 vinyl acetate (VA). 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