{"id":4303,"date":"2025-07-27T23:53:00","date_gmt":"2025-07-27T23:53:00","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/cfu-assay-evaluation-hematopoietic-stem-cells\/"},"modified":"2025-09-29T14:00:20","modified_gmt":"2025-09-29T07:00:20","slug":"cfu-assay-danh-gia-te-bao-goc-tao-mau","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/","title":{"rendered":"V\u00ec sao CFU Assay quan tr\u1ecdng trong ki\u1ec3m tra HSPCs tr\u01b0\u1edbc c\u1ea5y gh\u00e9p?"},"content":{"rendered":"<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Ki\u1ec3m nghi\u1ec7m CFU (Colony-Forming Units) \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u tr\u01b0\u1edbc c\u1ea5y gh\u00e9p. CFU Assay \u0111\u01b0\u1ee3c FDA, FACT &amp; AABB l\u1ea5y l\u00e0m ti\u00eau chu\u1ea9n \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c t\u1ebf b\u00e0o g\u1ed1c v\u00e0 t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HSPCs).<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure class=\"image\"><img fetchpriority=\"high\" decoding=\"async\" style=\"aspect-ratio:2240\/1260\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/07\/CFU-Assay-dong-vai-tro-quan-trong-trong-kiem-nghiem-HSCs.jpg\" alt=\"CFU Assay \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ki\u1ec3m nghi\u1ec7m HSCs\" width=\"2240\" height=\"1260\"><figcaption><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><i>CFU Assay \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ki\u1ec3m nghi\u1ec7m HSCs<\/i><\/span><\/figcaption><\/figure>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">M\u1ee5c l\u1ee5c<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Tong_quan_ve_te_bao_goc_tao_mau_HSCs_va_CFU_Assay\" >T\u1ed5ng quan v\u1ec1 t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (HSCs) v\u00e0 CFU Assay<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Te_bao_goc_va_te_bao_tien_than_tao_mau_HSPCs_la_gi\" >T\u1ebf b\u00e0o g\u1ed1c v\u00e0 t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HSPCs) l\u00e0 g\u00ec?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Cac_xet_nghiem_dac_tinh_cho_te_bao_goc_va_tien_than_tao_mau_HSPCs\" >C\u00e1c x\u00e9t nghi\u1ec7m \u0111\u1eb7c t\u00ednh cho t\u1ebf b\u00e0o g\u1ed1c v\u00e0 ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HSPCs)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Xet_nghiem_kieu_hinh\" >X\u00e9t nghi\u1ec7m ki\u1ec3u h\u00ecnh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Xet_nghiem_chuc_nang\" >X\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Tai_sao_CFU_assay_duoc_chuyen_gia_lua_chon\" >T\u1ea1i sao CFU assay \u0111\u01b0\u1ee3c chuy\u00ean gia l\u1ef1a ch\u1ecdn?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Quy_dinh_ve_CFU_assay_nhu_the_nao\" >Quy \u0111\u1ecbnh v\u1ec1 CFU assay nh\u01b0 th\u1ebf n\u00e0o?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Huong_dan_tuan_thu_cua_FDA\" >H\u01b0\u1edbng d\u1eabn tu\u00e2n th\u1ee7 c\u1ee7a FDA<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Tieu_chuan_FACT_%E2%80%93_JACIE_8th_edition\" >Ti\u00eau chu\u1ea9n FACT \u2013 JACIE (8th edition)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Tieu_chuan_AABB_11th_edition\" >Ti\u00eau chu\u1ea9n AABB (11th edition)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#NetCord-FACT_Banking_Standards_8th_Edition_%E2%80%93_DRAFT\" >NetCord-FACT Banking Standards (8th Edition &#8211; DRAFT)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Chuan_hoa_quy_trinh_CFU_Assay_voi_STEMCELL_Technologies\" >Chu\u1ea9n h\u00f3a quy tr\u00ecnh CFU Assay v\u1edbi STEMCELL Technologies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/#Tai_lieu_tham_khao\" >T\u00e0i li\u1ec7u tham kh\u1ea3o<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Tong_quan_ve_te_bao_goc_tao_mau_HSCs_va_CFU_Assay\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">T\u1ed5ng quan v\u1ec1 t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (HSCs) v\u00e0 CFU Assay<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">T\u1ebf b\u00e0o g\u1ed1c l\u00e0 c\u00e1c t\u1ebf b\u00e0o \u0111\u1eb7c bi\u1ec7t c\u00f3 kh\u1ea3 n\u0103ng t\u1ef1 l\u00e0m m\u1edbi m\u1ed9t c\u00e1ch \u0111\u1eb7c tr\u01b0ng, t\u1ea1o ra m\u1ed9t ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c ch\u01b0a bi\u1ec7t h\u00f3a m\u1edbi. Ch\u00fang c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o \u0111\u1eb7c hi\u1ec7u theo d\u00f2ng (lineage-specific) v\u1edbi c\u00e1c ch\u1ee9c n\u0103ng chuy\u00ean bi\u1ec7t v\u00e0 \u0111\u00e3 tr\u01b0\u1edfng th\u00e0nh. V\u00ec v\u1eady, t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c coi l\u00e0 nh\u1eefng \u201cvi\u00ean g\u1ea1ch n\u1ec1n t\u1ea3ng\u201d c\u1ee7a c\u00e1c m\u00f4 v\u00e0 c\u01a1 quan n\u01a1i ch\u00fang t\u1ed3n t\u1ea1i.&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">Trong s\u1ed1 nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c, t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (Hematopoietic Stem Cells &#8211; HSCs) l\u00e0 lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u nh\u1ea5t v\u00e0 \u0111\u01b0\u1ee3c coi l\u00e0 ngu\u1ed3n t\u1ebf b\u00e0o \u0111\u1ea7y h\u1ee9a h\u1eb9n cho c\u00e1c \u1ee9ng d\u1ee5ng trong khoa h\u1ecdc c\u01a1 b\u1ea3n v\u00e0 y h\u1ecdc l\u00e2m s\u00e0ng. V\u1ec1 m\u1eb7t l\u1ecbch s\u1eed, nghi\u00ean c\u1ee9u v\u1ec1 HSCs b\u1eaft \u0111\u1ea7u t\u1eeb nh\u1eefng n\u0103m 1940, khi m\u1ed9t th\u00ed nghi\u1ec7m mang t\u00ednh \u0111\u1ed9t ph\u00e1 cho th\u1ea5y c\u00e1c t\u1ebf b\u00e0o t\u1ee7y x\u01b0\u01a1ng (Bone Marrow &#8211; BM) \u0111\u01b0\u1ee3c ti\u00eam t\u0129nh m\u1ea1ch c\u00f3 th\u1ec3 ng\u0103n ng\u1eeba c\u00e1i ch\u1ebft \u1edf chu\u1ed9t b\u1ecb chi\u1ebfu x\u1ea1 b\u1eb1ng c\u00e1ch ph\u1ee5c h\u1ed3i qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o m\u00e1u. T\u1eeb \u0111\u00f3 \u0111\u1ebfn nay, HSCs \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng trong c\u00e1c li\u1ec7u ph\u00e1p y t\u1ebf v\u00e0 nghi\u00ean c\u1ee9u khoa h\u1ecdc trong su\u1ed1t nhi\u1ec1u th\u1eadp k\u1ef7.&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">Theo th\u1eddi gian, nhi\u1ec1u c\u00f4ng c\u1ee5 tinh vi h\u01a1n \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 h\u00e0nh vi c\u1ee7a c\u00e1c nh\u00f3m t\u1ebf b\u00e0o t\u1ea1o m\u00e1u tinh khi\u1ebft c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o m\u00e1u. M\u1ed9t trong nh\u1eefng c\u00f4ng c\u1ee5 \u0111\u00e1ng tin c\u1eady nh\u1ea5t l\u00e0 ph\u01b0\u01a1ng ph\u00e1p th\u1eed nghi\u1ec7m \u0111\u01a1n v\u1ecb t\u1ea1o c\u1ee5m (Colony-Forming Units &#8211; CFUs Assay). Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y gi\u00fap nh\u1eadn di\u1ec7n, \u0111\u1ebfm s\u1ed1 l\u01b0\u1ee3ng v\u00e0 ph\u00e2n t\u00edch c\u00e1c c\u1ee5m t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh t\u1eeb c\u00e1c t\u1ebf b\u00e0o g\u1ed1c v\u00e0 ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (Hematopoietic Stem and Progenitor Cells &#8211; HSPCs) \u0111\u00e3 bi\u1ec7t h\u00f3a thu\u1ed9c c\u00e1c d\u00f2ng myeloid, erythroid v\u00e0 lymphoid.&nbsp;<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Te_bao_goc_va_te_bao_tien_than_tao_mau_HSPCs_la_gi\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">T\u1ebf b\u00e0o g\u1ed1c v\u00e0 t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HSPCs) l\u00e0 g\u00ec?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">T\u1ebf b\u00e0o g\u1ed1c v\u00e0 ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HSPCs) l\u00e0 qu\u1ea7n th\u1ec3 h\u1ed7n h\u1ee3p bao g\u1ed3m c\u00e1c t\u1ebf b\u00e0o g\u1ed1c v\u00e0 t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u01a1 th\u1ec3. Trong \u0111\u00f3, t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HPCs) l\u00e0 c\u00e1c t\u1ebf b\u00e0o \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ecbnh h\u01b0\u1edbng bi\u1ec7t h\u00f3a, c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a \u0111a n\u0103ng (multi-potent), nh\u1ecb n\u0103ng (bi-potent), ho\u1eb7c \u0111\u01a1n n\u0103ng (uni-potent) \u0111\u1ec3 t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o m\u00e1u tr\u01b0\u1edfng th\u00e0nh h\u01a1n. M\u1ed7i n\u0103m, c\u01a1 th\u1ec3 con ng\u01b0\u1eddi s\u1ea3n xu\u1ea5t kho\u1ea3ng 1.4 x 10\u00b9\u2074 t\u1ebf b\u00e0o m\u00e1u m\u1edbi, bao g\u1ed3m kho\u1ea3ng 1.75 x 10\u00b9\u00b9 h\u1ed3ng c\u1ea7u, 7 x 10\u00b9\u2070 b\u1ea1ch c\u1ea7u h\u1ea1t, v\u00e0 1.75 x 10\u00b9\u00b9 ti\u1ec3u c\u1ea7u. C\u00e2n b\u1eb1ng qu\u00e1 tr\u00ecnh t\u1ea1o m\u00e1u (homeostasis of hematopoiesis) \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00e1c t\u1ef7 l\u1ec7 ph\u00f9 h\u1ee3p c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n kh\u00e1c nhau \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t \u0111\u1ec3 \u0111\u00e1p \u1ee9ng nhu c\u1ea7u c\u1ee7a c\u01a1 th\u1ec3 khi b\u1ecb nhi\u1ec5m tr\u00f9ng ho\u1eb7c ch\u1ea5n th\u01b0\u01a1ng.&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">T\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (hematopoietic stem cells) c\u00f3 kh\u1ea3 n\u0103ng t\u1ef1 l\u00e0m m\u1edbi v\u00e0 bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c d\u00f2ng t\u1ebf b\u00e0o m\u00e1u kh\u00e1c nhau. T\u1eeb t\u1ebf b\u00e0o g\u1ed1c n\u00e0y, qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a s\u1ebd ph\u00e2n t\u00e1ch th\u00e0nh hai d\u00f2ng ch\u00ednh: d\u00f2ng t\u1ee7y (myeloid progenitor cells) v\u00e0 d\u00f2ng lympho (lymphoid progenitor cells). D\u00f2ng t\u1ee7y t\u1ea1o ra c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o nh\u01b0 b\u1ea1ch c\u1ea7u \u01b0a axit (eosinophil), b\u1ea1ch c\u1ea7u \u01b0a ki\u1ec1m (basophil), b\u1ea1ch c\u1ea7u trung t\u00ednh (neutrophil), \u0111\u1ea1i th\u1ef1c b\u00e0o (monocyte), ti\u1ec3u c\u1ea7u (platelets), v\u00e0 h\u1ed3ng c\u1ea7u (erythrocytes). Trong khi \u0111\u00f3, d\u00f2ng lympho bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch quan tr\u1ecdng nh\u01b0 t\u1ebf b\u00e0o T (T-cell) v\u00e0 t\u1ebf b\u00e0o B (B-cell). \u0110i\u1ec1u n\u00e0y cho th\u1ea5y vai tr\u00f2 quan tr\u1ecdng c\u1ee7a HSPCs trong vi\u1ec7c duy tr\u00ec s\u1ef1 c\u00e2n b\u1eb1ng v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ec7 th\u1ed1ng t\u1ea1o m\u00e1u trong c\u01a1 th\u1ec3.<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure class=\"image image_resized\" style=\"width:100%\"><img decoding=\"async\" style=\"aspect-ratio:511\/303\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/unnamed.png\" alt=\"Qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u\" width=\"511\" height=\"303\"><figcaption><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><i>Qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (Ngu\u1ed3n: Medical News Today)<\/i><\/span><\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"Cac_xet_nghiem_dac_tinh_cho_te_bao_goc_va_tien_than_tao_mau_HSPCs\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">C\u00e1c x\u00e9t nghi\u1ec7m \u0111\u1eb7c t\u00ednh cho t\u1ebf b\u00e0o g\u1ed1c v\u00e0 ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HSPCs)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:11pt\">C\u00f3 nhi\u1ec1u lo\u1ea1i x\u00e9t nghi\u1ec7m \u0111\u1eb7c t\u00ednh cho HSPC v\u00e0 x\u00e9t nghi\u1ec7m ph\u00f9 h\u1ee3p ph\u1ee5 thu\u1ed9c v\u00e0o \u0111\u1ed9 tr\u01b0\u1edfng th\u00e0nh c\u1ee7a t\u1ebf b\u00e0o m\u00e0 b\u1ea1n quan t\u00e2m. N\u00f3i chung, x\u00e9t nghi\u1ec7m c\u00f3 th\u1ec3 l\u00e0 x\u00e9t nghi\u1ec7m ki\u1ec3u h\u00ecnh (phenotypic assay) ho\u1eb7c x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng (functional assay).<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Xet_nghiem_kieu_hinh\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">X\u00e9t nghi\u1ec7m ki\u1ec3u h\u00ecnh<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">C\u00e1c ph\u01b0\u01a1ng ph\u00e1p x\u00e9t nghi\u1ec7m ki\u1ec3u h\u00ecnh (phenotypic assays), nh\u01b0 k\u1ef9 thu\u1eadt d\u00f2ng ch\u1ea3y t\u1ebf b\u00e0o (flow cytometry), \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 kh\u1ea3o s\u00e1t c\u00e1c d\u1ea5u \u1ea5n b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o, ch\u1eb3ng h\u1ea1n nh\u01b0 CD34 \u2013 m\u1ed9t lo\u1ea1i phospho-glyco-protein xuy\u00ean m\u00e0ng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n \u0111\u1ea7u ti\u00ean tr\u00ean HSPCs, m\u1eb7c d\u00f9 c\u0169ng c\u00f3 m\u1eb7t tr\u00ean c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nh\u01b0 m\u00f4 m\u1ea1ch m\u00e1u (vascular tissue).<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure class=\"image\"><img decoding=\"async\" style=\"aspect-ratio:575\/164\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/unnamed.png\" alt=\"Bi\u1ec3u \u0111\u1ed3 dot plot t\u1eeb ph\u00e2n t\u00edch FACS th\u1ec3 hi\u1ec7n t\u1ef7 l\u1ec7 t\u1ebf b\u00e0o CD34\u207a\/CD45\u207a\" width=\"575\" height=\"164\"><figcaption><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><i>Bi\u1ec3u \u0111\u1ed3 dot plot t\u1eeb ph\u00e2n t\u00edch FACS th\u1ec3 hi\u1ec7n t\u1ef7 l\u1ec7 t\u1ebf b\u00e0o CD34\u207a\/CD45\u207a (Ngu\u1ed3n: STEMCELL Technologies)<\/i><\/span><\/figcaption><\/figure>\n<h3><span class=\"ez-toc-section\" id=\"Xet_nghiem_chuc_nang\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">X\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">Ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng (functional assays) \u0111o l\u01b0\u1eddng c\u00e1c \u0111\u1eb7c t\u00ednh sinh h\u1ecdc c\u1ee5 th\u1ec3 cho th\u1ea5y ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o. C\u00e1c ph\u00e9p th\u1eed n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n th\u00f4ng qua ph\u01b0\u01a1ng ph\u00e1p in vivo ho\u1eb7c in vitro, m\u1ed7i ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ec1u c\u00f3 nh\u1eefng \u01b0u \u0111i\u1ec3m v\u00e0 nh\u01b0\u1ee3c \u0111i\u1ec3m ri\u00eang.<\/span><\/p>\n<p style=\"text-align:justify\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Ph\u01b0\u01a1ng ph\u00e1p t\u1ed1t nh\u1ea5t \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (HSCs) l\u00e0 ph\u01b0\u01a1ng ph\u00e1p gh\u00e9p t\u1ebf b\u00e0o tr\u00ean chu\u1ed9t&nbsp;<strong>in vivo<\/strong> (mouse engraftment assay), t\u01b0\u01a1ng t\u1ef1 nh\u01b0 th\u00ed nghi\u1ec7m c\u1ee7a Till &amp; McCulloch v\u00e0o nh\u1eefng n\u0103m 60. Tuy nhi\u00ean, lo\u1ea1i ph\u00e9p th\u1eed n\u00e0y th\u01b0\u1eddng t\u1ed1n nhi\u1ec1u th\u1eddi gian, chi ph\u00ed cao v\u00e0 kh\u00f3 \u0111\u00e1nh gi\u00e1. Do \u0111\u00f3,&nbsp;<strong>ph\u00e9p th\u1eed CFU in vitro<\/strong> \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a HSPCs tr\u01b0\u1edbc khi c\u1ea5y gh\u00e9p, v\u00ec n\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 t\u01b0\u01a1ng quan t\u1ed1t v\u1edbi c\u00e1c m\u00f4 h\u00ecnh gh\u00e9p t\u1ebf b\u00e0o&nbsp;<strong>in vivo<\/strong>.<\/span><\/p>\n<ul>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><strong>In vivo assays:<\/strong> D\u1ef1a tr\u00ean m\u00f4 h\u00ecnh c\u1ea5y gh\u00e9p tr\u00ean \u0111\u1ed9ng v\u1eadt, ph\u01b0\u01a1ng ph\u00e1p n\u00e0y \u0111\u00e1nh gi\u00e1 s\u1ef1 h\u00ecnh th\u00e0nh t\u1ebf b\u00e0o \u0111a d\u00f2ng sau h\u01a1n 5 tu\u1ea7n.<\/span><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><strong>In vitro assays:<\/strong> Ph\u01b0\u01a1ng ph\u00e1p CFU (Colony Forming Unit) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n (progenitor) v\u00e0 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a c\u1ee7a ch\u00fang.<\/span><br \/>&nbsp;<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Tai_sao_CFU_assay_duoc_chuyen_gia_lua_chon\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">T\u1ea1i sao CFU assay \u0111\u01b0\u1ee3c chuy\u00ean gia l\u1ef1a ch\u1ecdn?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<figure class=\"image\"><img loading=\"lazy\" decoding=\"async\" style=\"aspect-ratio:602\/265\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/unnamed.png\" alt=\"M\u00f4 h\u00ecnh th\u00e1p m\u00f4 t\u1ea3 qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a c\u1ee7a t\u1ebf b\u00e0o t\u1ea1o m\u00e1u (hematopoietic cells)\" width=\"602\" height=\"265\"><figcaption><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><i>M\u00f4 h\u00ecnh th\u00e1p m\u00f4 t\u1ea3 qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a c\u1ee7a t\u1ebf b\u00e0o t\u1ea1o m\u00e1u (hematopoietic cells) (Ngu\u1ed3n: STEMCELL Technologies)<\/i><\/span><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Tr\u01b0\u1edbc h\u1ebft, m\u1eb7c d\u00f9 c\u00e1c ph\u00e9p th\u1eed ch\u1ee9c n\u0103ng kh\u00e1c nh\u01b0 nghi\u00ean c\u1ee9u c\u1ea5y gh\u00e9p tr\u00ean chu\u1ed9t in vivo ho\u1eb7c x\u00e9t nghi\u1ec7m t\u1ebf b\u00e0o kh\u1edfi \u0111\u1ea7u nu\u00f4i c\u1ea5y d\u00e0i h\u1ea1n (Long-Term Culture-Initiating Cell, LTC-IC) th\u01b0\u1eddng ph\u00f9 h\u1ee3p h\u01a1n trong vi\u1ec7c \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c HSPCs nguy\u00ean th\u1ee7y, nh\u01b0ng ch\u00fang l\u1ea1i r\u1ea5t ph\u1ee9c t\u1ea1p v\u00e0 t\u1ed1n nhi\u1ec1u th\u1eddi gian \u2013 c\u00f3 th\u1ec3 k\u00e9o d\u00e0i t\u1eeb 5 tu\u1ea7n \u0111\u1ebfn 6 th\u00e1ng \u0111\u1ec3 ho\u00e0n th\u00e0nh. Ng\u01b0\u1ee3c l\u1ea1i, CFU assay ch\u1ec9 m\u1ea5t kho\u1ea3ng 2 tu\u1ea7n, gi\u00fap \u0111\u00e1nh gi\u00e1 nhanh h\u01a1n \u0111\u00e1ng k\u1ec3.&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">H\u01a1n n\u1eefa, CFU assay t\u1eeb l\u00e2u \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 m\u1ed1i t\u01b0\u01a1ng quan ch\u1eb7t ch\u1ebd v\u1edbi s\u1ef1 gh\u00e9p th\u00e0nh c\u00f4ng \u1edf b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c c\u1ea5y gh\u00e9p. Nghi\u00ean c\u1ee9u c\u1ee7a KM Page (2011) cho th\u1ea5y &#8220;li\u1ec1u l\u01b0\u1ee3ng CFU&#8221; c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd nh\u1ea5t \u0111\u1ebfn s\u1ef1 gh\u00e9p c\u1ee7a b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 ti\u1ec3u c\u1ea7u. \u0110i\u1ec1u n\u00e0y ch\u1ee9ng t\u1ecf CFU assay kh\u00f4ng ch\u1ec9 \u0111\u00e1nh gi\u00e1 ti\u1ec1m n\u0103ng sinh c\u1ee5m m\u00e0 c\u00f2n d\u1ef1 \u0111o\u00e1n ch\u00ednh x\u00e1c hi\u1ec7u qu\u1ea3 c\u1ea5y gh\u00e9p trong l\u00e2m s\u00e0ng.&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">V\u1edbi th\u1eddi gian th\u1ef1c hi\u1ec7n ng\u1eafn v\u00e0 kh\u1ea3 n\u0103ng d\u1ef1 \u0111o\u00e1n ch\u00ednh x\u00e1c hi\u1ec7u qu\u1ea3 gh\u00e9p t\u1ebf b\u00e0o, CFU assay l\u00e0 l\u1ef1a ch\u1ecdn l\u00fd t\u01b0\u1edfng cho vi\u1ec7c \u0111\u00e1nh gi\u00e1 ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a HSPCs tr\u01b0\u1edbc khi c\u1ea5y gh\u00e9p. CFU assay \u0111\u01b0\u1ee3c xem l\u00e0 ti\u00eau chu\u1ea9n v\u00e0ng trong \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c c\u1ee7a c\u00e1c s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c v\u00ec n\u00f3 c\u00f3 m\u1ed1i t\u01b0\u01a1ng quan v\u1edbi t\u1ef7 l\u1ec7 gh\u00e9p th\u00e0nh c\u00f4ng v\u00e0 t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t t\u1ed5ng th\u1ec3 \u1edf nh\u1eefng ng\u01b0\u1eddi nh\u1eadn gh\u00e9p HSCs (Velier v\u00e0 c\u1ed9ng s\u1ef1, 2019).<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Quy_dinh_ve_CFU_assay_nhu_the_nao\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">Quy \u0111\u1ecbnh v\u1ec1 CFU assay nh\u01b0 th\u1ebf n\u00e0o?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">\u0110\u1ed1i v\u1edbi c\u00e1c ng\u00e2n h\u00e0ng m\u00e1u cu\u1ed1ng r\u1ed1n (Cord blood banks) \u1edf M\u1ef9, t\u1ea5t c\u1ea3 \u0111\u1ec1u ph\u1ea3i \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd v\u1edbi FDA. H\u1ea7u h\u1ebft c\u00e1c ng\u00e2n h\u00e0ng n\u00e0y \u0111\u1ec1u \u0111\u01b0\u1ee3c ch\u1ee9ng nh\u1eadn b\u1edfi AABB ho\u1eb7c FACT, v\u00e0 c\u1ea3 hai t\u1ed5 ch\u1ee9c n\u00e0y \u0111\u1ec1u y\u00eau c\u1ea7u d\u1eef li\u1ec7u CFU tr\u01b0\u1edbc khi \u0111\u00f4ng l\u1ea1nh (pre-freeze CFU data).<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Huong_dan_tuan_thu_cua_FDA\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">H\u01b0\u1edbng d\u1eabn tu\u00e2n th\u1ee7 c\u1ee7a FDA<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">FDA y\u00eau c\u1ea7u th\u1eed nghi\u1ec7m \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 \u0111\u1ec1 xu\u1ea5t CFU assay c\u1ee5 th\u1ec3: &#8220;Ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m tra \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh n\u00ean bao g\u1ed3m, nh\u01b0ng kh\u00f4ng gi\u1edbi h\u1ea1n \u1edf, hi\u1ec7u l\u1ef1c (potency), t\u00ednh to\u00e0n v\u1eb9n (integrity) v\u00e0 v\u00f4 tr\u00f9ng (sterility) c\u1ee7a s\u1ea3n ph\u1ea9m. D\u1eef li\u1ec7u ph\u00f2ng th\u00ed nghi\u1ec7m phi l\u00e2m s\u00e0ng, ch\u1eb3ng h\u1ea1n nh\u01b0 CFU assay in vitro, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t ph\u1ea7n c\u1ee7a ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m tra \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh, k\u00e8m theo d\u1eef li\u1ec7u c\u1ea5y gh\u00e9p l\u00e2m s\u00e0ng n\u1ebfu c\u00f3.&#8221; (FDA-2006-D-0157)<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Tieu_chuan_FACT_%E2%80%93_JACIE_8th_edition\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">Ti\u00eau chu\u1ea9n FACT \u2013 JACIE (8th edition)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">FACT y\u00eau c\u1ea7u c\u1ea7n c\u00f3 ch\u01b0\u01a1ng tr\u00ecnh \u0111\u00e1nh gi\u00e1 \u1ed5n \u0111\u1ecbnh h\u1eb1ng n\u0103m v\u1ec1 t\u1ec9 l\u1ec7 s\u1ed1ng v\u00e0 hi\u1ec7u l\u1ef1c (viability and potency) c\u1ee7a c\u00e1c s\u1ea3n ph\u1ea9m tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh. (D9.2.3)&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">\u0110\u00e1nh gi\u00e1 ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean m\u1eabu: \u0111\u1ea1i di\u1ec7n cho t\u1ea5t c\u1ea3 ph\u01b0\u01a1ng ph\u00e1p x\u1eed l\u00fd (all processing methods) v\u00e0 \u0111\u1ea1i di\u1ec7n cho th\u1eddi gian l\u01b0u m\u1eabu t\u1ed1i \u0111a (maximum storage duration). (D9.2.3.1).<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Tieu_chuan_AABB_11th_edition\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">Ti\u00eau chu\u1ea9n AABB (11th edition)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">Ch\u01b0\u01a1ng tr\u00ecnh \u0111\u00e1nh gi\u00e1 \u1ed5n \u0111\u1ecbnh ph\u1ea3i bao g\u1ed3m: T\u00ednh to\u00e0n v\u1eb9n c\u1ee7a bao b\u00ec ch\u1ee9a s\u1ea3n ph\u1ea9m (product container integrity); kh\u1ea3 n\u0103ng thu h\u1ed3i t\u1ebf b\u00e0o s\u1ed1ng (viable cell recovery); v\u00e0 \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c (measure of potency) c\u1ee7a c\u00e1c t\u1ebf b\u00e0o li\u00ean quan. (5.20.2.1). Ph\u01b0\u01a1ng ph\u00e1p \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c li\u00ean quan (Relevant potency assay) ph\u1ea3i \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1edfi c\u01a1 s\u1edf th\u1ef1c hi\u1ec7n (defined by the facility). (5.17C, 5a).<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"NetCord-FACT_Banking_Standards_8th_Edition_%E2%80%93_DRAFT\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">NetCord-FACT Banking Standards (8th Edition &#8211; DRAFT)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">Ph\u1ea3i c\u00f3 b\u1eb1ng ch\u1ee9ng v\u1ec1 hi\u1ec7u l\u1ef1c (evidence of potency) th\u00f4ng qua CFU assay ho\u1eb7c c\u00e1c ph\u00e9p th\u1eed hi\u1ec7u l\u1ef1c \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c th\u1ef1c (other validated potency assay) tr\u00ean m\u1eabu t\u01b0\u01a1i sau khi x\u1eed l\u00fd (fresh post-processing sample). \u0110\u1ed3ng th\u1eddi, tr\u00ean m\u1eabu \u0111\u1ea1i di\u1ec7n tr\u01b0\u1edbc khi ph\u00e1t h\u00e0nh cho ch\u01b0\u01a1ng tr\u00ecnh l\u00e2m s\u00e0ng (representative sample prior to release to the clinical program). (D9, appendix V). [1]<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">\u0110i\u1ec1u n\u00e0y nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a CFU assay trong vi\u1ec7c \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 hi\u1ec7u l\u1ef1c c\u1ee7a c\u00e1c s\u1ea3n ph\u1ea9m m\u00e1u cu\u1ed1ng r\u1ed1n tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng cho m\u1ee5c \u0111\u00edch c\u1ea5y gh\u00e9p l\u00e2m s\u00e0ng.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Chuan_hoa_quy_trinh_CFU_Assay_voi_STEMCELL_Technologies\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">Chu\u1ea9n h\u00f3a quy tr\u00ecnh CFU Assay v\u1edbi STEMCELL Technologies<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<figure class=\"image\"><img loading=\"lazy\" decoding=\"async\" style=\"aspect-ratio:602\/327\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/unnamed.png\" alt=\"C\u00f4ng c\u1ee5 c\u1ee7a STEMCELL Technologies cung c\u1ea5p \u0111\u1ec3 chu\u1ea9n h\u00f3a x\u00e9t nghi\u1ec7m CFU\" width=\"602\" height=\"327\"><figcaption><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><i>C\u00f4ng c\u1ee5 c\u1ee7a STEMCELL Technologies cung c\u1ea5p \u0111\u1ec3 chu\u1ea9n h\u00f3a x\u00e9t nghi\u1ec7m CFU (Ngu\u1ed3n: STEMCELL Technologies)<\/i><\/span><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">\u0110\u1ec3 ki\u1ec3m so\u00e1t s\u1ef1 bi\u1ebfn thi\u00ean c\u1ee7a CFU Assay, c\u1ea7n s\u1eed d\u1ee5ng c\u00e1c h\u00f3a ch\u1ea5t \u0111\u1ea1t chu\u1ea9n v\u00e0 c\u00f3 t\u00ednh \u1ed5n \u0111\u1ecbnh l\u00e2u d\u00e0i. \u0110i\u1ec1u n\u00e0y \u0111\u1ea3m b\u1ea3o t\u00ednh nh\u1ea5t qu\u00e1n v\u00e0 \u0111\u1ed9 tin c\u1eady c\u1ee7a ph\u00e9p th\u1eed. M\u1ed9t v\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh l\u00e0&nbsp;<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/biogroupvietnam.com\/danh-muc-san-pham\/xet-nghiem-nuoi-cay-cum-te-bao-cfu-assay\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">MethoCult medium<\/span><\/a><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\"> \u2013 s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u01b0\u1ee3c&nbsp;<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.stemcell.com\/\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">STEMCELL Technologies<\/span><\/a><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\"> cung c\u1ea5p h\u01a1n 30 n\u0103m, \u0111\u1ea3m b\u1ea3o t\u00ednh \u1ed5n \u0111\u1ecbnh v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cho CFU Assay. Ngo\u00e0i ra, ti\u00eau chu\u1ea9n h\u00f3a quy tr\u00ecnh thao t\u00e1c c\u0169ng r\u1ea5t quan tr\u1ecdng b\u1eb1ng c\u00e1ch th\u1ef1c hi\u1ec7n c\u00e1c quy tr\u00ecnh thao t\u00e1c chu\u1ea9n (SOPs) v\u00e0 \u0111\u1ea3m b\u1ea3o \u0111\u00e0o t\u1ea1o nh\u00e2n vi\u00ean \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ec3 duy tr\u00ec t\u00ednh nh\u1ea5t qu\u00e1n trong k\u1ef9 thu\u1eadt v\u00e0 ph\u00e2n t\u00edch. \u0110\u1ec3 h\u1ed7 tr\u1ee3 \u0111i\u1ec1u n\u00e0y, STEMCELL Technologies cung c\u1ea5p t\u00e0i li\u1ec7u gi\u00e1o d\u1ee5c v\u00e0 ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m tra tr\u00ecnh \u0111\u1ed9 nh\u1eb1m n\u00e2ng cao n\u0103ng l\u1ef1c chuy\u00ean m\u00f4n. B\u00ean c\u1ea1nh \u0111\u00f3, vi\u1ec7c nh\u1eadn di\u1ec7n v\u00e0 \u0111\u1ebfm c\u1ee5m khu\u1ea9n l\u1ea1c h\u00ecnh th\u00e0nh \u2013 kh\u00e2u c\u00f3 t\u00ednh ch\u1ee7 quan cao nh\u1ea5t trong CFU Assay \u2013 c\u1ea7n \u0111\u01b0\u1ee3c ti\u00eau chu\u1ea9n h\u00f3a th\u00f4ng qua \u0111\u00e0o t\u1ea1o nghi\u00eam ng\u1eb7t cho ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n th\u1ee7 c\u00f4ng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o s\u1ef1 ch\u00ednh x\u00e1c v\u00e0 nh\u1ea5t qu\u00e1n. Tuy nhi\u00ean, t\u1ef1 \u0111\u1ed9ng h\u00f3a \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m thi\u1ec3u s\u1ef1 sai l\u1ec7ch gi\u1eefa c\u00e1c ng\u01b0\u1eddi thao t\u00e1c, c\u1ea3i thi\u1ec7n t\u00ednh nh\u1ea5t qu\u00e1n v\u00e0 t\u0103ng t\u1ed1c \u0111\u1ed9 ph\u00e2n t\u00edch d\u1eef li\u1ec7u. Nh\u1eefng bi\u1ec7n ph\u00e1p n\u00e0y gi\u00fap gi\u1ea3m thi\u1ec3u s\u1ef1 bi\u1ebfn thi\u00ean trong CFU Assay, t\u1eeb \u0111\u00f3 t\u0103ng t\u00ednh ch\u00ednh x\u00e1c v\u00e0 \u0111\u1ed9 tin c\u1eady c\u1ee7a k\u1ebft qu\u1ea3 ph\u00e2n t\u00edch.<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#0e101a;font-family:Arial,sans-serif;font-size:12pt\">Biogroup Vietnam v\u1edbi \u0111\u1ed9i ng\u0169 chuy\u00ean gia gi\u00e0u kinh nghi\u1ec7m v\u00e0 s\u1ef1 h\u1ed7 tr\u1ee3 t\u1eeb h\u00e3ng STEMCELL Technologies, ch\u00fang t\u00f4i s\u1eb5n s\u00e0ng \u0111\u1ed3ng h\u00e0nh c\u00f9ng Qu\u00fd v\u1ecb trong vi\u1ec7c chu\u1ea9n h\u00f3a quy tr\u00ecnh CFU Assay \u0111\u1ea1t chu\u1ea9n qu\u1ed1c t\u1ebf.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:13.999999999999998pt\">\ud83d\udce9&nbsp;<strong>Li\u00ean h\u1ec7 chuy\u00ean gia t\u01b0 v\u1ea5n t\u1ea1i Biogroup Vietnam:&nbsp;<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Website:<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/biogroupvietnam.com\/public\/lien-he\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><\/a><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/biogroupvietnam.com\/public\/<\/span><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Hotline: +84 963 621 421<\/span><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Email:&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">info@biogroupvietnam.vn<\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/biogroupvietnam.com\/danh-muc-san-pham\/xet-nghiem-nuoi-cay-cum-te-bao-cfu-assay\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\"><i>&gt;&gt; T\u00ecm hi\u1ec3u c\u00e1c s\u1ea3n ph\u1ea9m X\u00e9t nghi\u1ec7m nu\u00f4i c\u1ea5y c\u1ee5m t\u1ebf b\u00e0o (CFU Assay)<\/i><\/span><\/a><\/p>\n<p><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/biogroupvietnam.com\/danh-muc-san-pham?organization=stemcell-technologies\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\"><i>&gt;&gt; T\u00ecm hi\u1ec3u th\u00eam c\u00e1c s\u1ea3n ph\u1ea9m c\u1ee7a STEMCELL Technologies<\/i><\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Tai_lieu_tham_khao\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">1. STEMCELL Technologies. (n.d.). <i>Homepage.<\/i>&nbsp;<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.stemcell.com\/\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.stemcell.com\/<\/span><\/a><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">2. Wong, C. (2023, August 31). <i>What to know about hematopoietic stem cells.<\/i> Medical News Today.&nbsp;<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.medicalnewstoday.com\/articles\/285666\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.medicalnewstoday.com\/articles\/285666<\/span><\/a><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">3. STEMCELL Technologies. (n.d.). <i>Hematopoietic stem and progenitor cells<\/i> [Brochure].&nbsp;<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/cdn.stemcell.com\/media\/files\/brochure\/BR29054-Hematopoeitic_Stem_and_Progenitor_Cells.pdf\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/cdn.stemcell.com\/media\/files\/brochure\/BR29054-Hematopoeitic_Stem_and_Progenitor_Cells.pdf<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ki\u1ec3m nghi\u1ec7m CFU (Colony-Forming Units) \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u tr\u01b0\u1edbc c\u1ea5y gh\u00e9p. CFU Assay \u0111\u01b0\u1ee3c FDA, FACT &amp; AABB l\u1ea5y l\u00e0m ti\u00eau chu\u1ea9n \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c t\u1ebf b\u00e0o g\u1ed1c v\u00e0 t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n t\u1ea1o m\u00e1u (HSPCs). &nbsp; CFU Assay \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ki\u1ec3m nghi\u1ec7m HSCs<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":6434,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4303","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>V\u00ec sao CFU Assay quan tr\u1ecdng trong ki\u1ec3m tra HSPCs tr\u01b0\u1edbc c\u1ea5y gh\u00e9p?<\/title>\n<meta name=\"description\" content=\"Ki\u1ec3m nghi\u1ec7m CFU (Colony-Forming Units) \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u tr\u01b0\u1edbc c\u1ea5y gh\u00e9p. CFU Assay \u0111\u01b0\u1ee3c FDA, FACT &amp; AABB l\u1ea5y l\u00e0m ti\u00eau chu\u1ea9n \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c HSCs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biogroupvietnam.com\/vi\/blog\/cfu-assay-danh-gia-te-bao-goc-tao-mau\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"V\u00ec sao CFU Assay quan tr\u1ecdng trong ki\u1ec3m tra HSPCs tr\u01b0\u1edbc c\u1ea5y gh\u00e9p?\" \/>\n<meta property=\"og:description\" content=\"Ki\u1ec3m nghi\u1ec7m CFU (Colony-Forming Units) \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u tr\u01b0\u1edbc c\u1ea5y gh\u00e9p. 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