{"id":4306,"date":"2025-08-05T22:29:00","date_gmt":"2025-08-05T22:29:00","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/2025\/08\/18\/animal-testing-alternatives-nordic\/"},"modified":"2025-09-29T14:00:20","modified_gmt":"2025-09-29T07:00:20","slug":"thay-the-thu-nghiem-dong-vat-bac-au","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thay-the-thu-nghiem-dong-vat-bac-au\/","title":{"rendered":"B\u1eafc \u00c2u c\u1ee9ng r\u1eafn thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt v\u1edbi c\u00f4ng ngh\u1ec7 m\u1edbi"},"content":{"rendered":"<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">T\u1ea1i B\u1eafc \u00c2u, c\u00e1c ph\u01b0\u01a1ng \u00e1n thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt c\u00f3 \u0111i\u1ec1u ki\u1ec7n ph\u00e1t tri\u1ec3n m\u1ea1nh m\u1ebd. Nguy\u00ean t\u1eafc 3R (Replace &#8211; Reduce &#8211; Refine) \u0111\u00e3 tr\u1edf th\u00e0nh lu\u1eadt \u0111\u1ecbnh v\u00e0 th\u1ef1c h\u00e0nh r\u1ed9ng r\u00e3i. T\u1eeb d\u1ef1 \u00e1n VAC2VAC \u0111\u1ebfn m\u1ea1ng l\u01b0\u1edbi trung t\u00e2m 3R qu\u1ed1c gia, c\u00e1c n\u01b0\u1edbc nh\u01b0 Th\u1ee5y \u0110i\u1ec3n, \u0110an M\u1ea1ch v\u00e0 Na Uy \u0111ang \u0111\u1ecbnh h\u00ecnh h\u1ec7 sinh th\u00e1i nghi\u00ean c\u1ee9u d\u1ef1a tr\u00ean ng\u01b0\u1eddi v\u00e0 kh\u00f4ng d\u00f9ng \u0111\u1ed9ng v\u1eadt. B\u00e0i vi\u1ebft \u0111\u01b0a ra c\u00e1i nh\u00ecn chi ti\u1ebft v\u1ec1 m\u00f4 h\u00ecnh m\u00e0 th\u1ebf gi\u1edbi c\u00f3 th\u1ec3 h\u1ecdc h\u1ecfi.<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure class=\"image\"><img fetchpriority=\"high\" decoding=\"async\" style=\"aspect-ratio:2240\/1260\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Bac-Au-thay-the-thu-nghiem-dong-vat-voi-cong-nghe-moi.png\" alt=\"B\u1eafc \u00c2u thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt v\u1edbi c\u00f4ng ngh\u1ec7 m\u1edbi, n\u1ed5i b\u1eadt l\u00e0 organ-on-a-chip\" width=\"2240\" height=\"1260\"><figcaption><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><i>B\u1eafc \u00c2u thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt v\u1edbi c\u00f4ng ngh\u1ec7 m\u1edbi, n\u1ed5i b\u1eadt l\u00e0 organ-on-a-chip<\/i><\/span><\/figcaption><\/figure>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">M\u1ee5c l\u1ee5c<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" 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href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thay-the-thu-nghiem-dong-vat-bac-au\/#Xu_huong_va_tien_bo_cong_nghe_thay_the_thu_nghiem_dong_vat_tai_Bac_Au\" >Xu h\u01b0\u1edbng v\u00e0 ti\u1ebfn b\u1ed9 c\u00f4ng ngh\u1ec7 thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt t\u1ea1i B\u1eafc \u00c2u<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thay-the-thu-nghiem-dong-vat-bac-au\/#Trung_tam_3R_va_mang_luoi_nghien_cuu\" >Trung t\u00e2m 3R v\u00e0 m\u1ea1ng l\u01b0\u1edbi nghi\u00ean c\u1ee9u<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thay-the-thu-nghiem-dong-vat-bac-au\/#Du_an_VAC2VAC_%E2%80%93_Kiem_dinh_vac-xin_khong_dong_vat\" >D\u1ef1 \u00e1n VAC2VAC \u2013 Ki\u1ec3m \u0111\u1ecbnh v\u1eafc-xin kh\u00f4ng \u0111\u1ed9ng v\u1eadt<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thay-the-thu-nghiem-dong-vat-bac-au\/#Cong_nghe_%E2%80%9Cco_quan_tren_chip%E2%80%9D_va_vi_mo_trong_nghien_cuu_y_sinh\" >C\u00f4ng ngh\u1ec7 \u201cc\u01a1 quan tr\u00ean chip\u201d v\u00e0 vi m\u00f4 trong nghi\u00ean c\u1ee9u y sinh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thay-the-thu-nghiem-dong-vat-bac-au\/#Hop_tac_cong_%E2%80%93_tu_trong_nghien_cuu_NAMs\" >H\u1ee3p t\u00e1c c\u00f4ng \u2013 t\u01b0 trong nghi\u00ean c\u1ee9u NAMs<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/thay-the-thu-nghiem-dong-vat-bac-au\/#Tai_lieu_tham_khao\" >T\u00e0i li\u1ec7u tham kh\u1ea3o<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Chinh_sach_quoc_gia_va_dinh_huong_3R_tai_Bac_Au_Thuy_Dien_Na_Uy_Dan_Mach_Phan_Lan\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">Ch\u00ednh s\u00e1ch qu\u1ed1c gia v\u00e0 \u0111\u1ecbnh h\u01b0\u1edbng 3R t\u1ea1i B\u1eafc \u00c2u (Th\u1ee5y \u0110i\u1ec3n, Na Uy, \u0110an M\u1ea1ch, Ph\u1ea7n Lan)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Nh\u00f3m c\u00e1c n\u01b0\u1edbc B\u1eafc \u00c2u nh\u00ecn chung \u0111i \u0111\u1ea7u ch\u00e2u \u00c2u trong l\u0129nh v\u1ef1c ph\u00fac l\u1ee3i \u0111\u1ed9ng v\u1eadt v\u00e0 \u00e1p d\u1ee5ng 3R. Th\u1ee5y \u0110i\u1ec3n, \u0110an M\u1ea1ch, Ph\u1ea7n Lan l\u00e0 th\u00e0nh vi\u00ean EU n\u00ean tu\u00e2n th\u1ee7 ch\u1eb7t ch\u1ebd Ch\u1ec9 th\u1ecb 2010\/63\/EU c\u1ee7a EU v\u1ec1 b\u1ea3o v\u1ec7 \u0111\u1ed9ng v\u1eadt s\u1eed d\u1ee5ng cho m\u1ee5c \u0111\u00edch khoa h\u1ecdc. Ch\u1ec9 th\u1ecb n\u00e0y y\u00eau c\u1ea7u c\u00e1c qu\u1ed1c gia th\u00e0nh vi\u00ean thay th\u1ebf \u0111\u1ed9ng v\u1eadt ngay khi c\u00f3 ph\u01b0\u01a1ng ph\u00e1p khoa h\u1ecdc kh\u1ea3 thi, \u0111\u1ed3ng th\u1eddi b\u1eaft bu\u1ed9c m\u1ecdi d\u1ef1 \u00e1n s\u1eed d\u1ee5ng \u0111\u1ed9ng v\u1eadt ph\u1ea3i \u0111\u01b0\u1ee3c \u1ee7y ban \u0111\u1ea1o \u0111\u1ee9c c\u1ea5p ph\u00e9p v\u00e0 x\u00e9t \u0111\u1ebfn ph\u01b0\u01a1ng \u00e1n 3R. Th\u1ef1c t\u1ebf, B\u1eafc \u00c2u \u0111\u00e3 \u00e1p d\u1ee5ng 3R t\u1eeb r\u1ea5t s\u1edbm v\u1edbi Th\u1ee5y \u0110i\u1ec3n l\u00e0 n\u01b0\u1edbc ti\u00ean phong. N\u0103m 1979 Qu\u1ed1c h\u1ed9i Th\u1ee5y \u0110i\u1ec3n \u0111\u00e3 ra ngh\u1ecb quy\u1ebft c\u00f4ng nh\u1eadn th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u1ea1o \u0111\u1ee9c v\u00e0 ph\u1ea3i \u0111\u01b0\u1ee3c thay th\u1ebf s\u1edbm nh\u1ea5t c\u00f3 th\u1ec3, \u0111\u1ed3ng th\u1eddi c\u1ea5p ng\u00e2n s\u00e1ch cho nghi\u00ean c\u1ee9u thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt. \u0110\u00e2y \u0111\u01b0\u1ee3c coi l\u00e0 \u0111\u1ed9ng th\u00e1i \u0111i tr\u01b0\u1edbc c\u1ea3 EU (m\u00e3i 2010 EU m\u1edbi ra ch\u1ec9 th\u1ecb n\u00eau r\u00f5 m\u1ee5c ti\u00eau thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt). C\u00f9ng giai \u0111o\u1ea1n \u0111\u00f3, \u0110an M\u1ea1ch v\u00e0 Ph\u1ea7n Lan c\u0169ng thi\u1ebft l\u1eadp c\u00e1c \u1ee7y ban \u0111\u1ea1o \u0111\u1ee9c v\u00e0 qu\u1ef9 nghi\u00ean c\u1ee9u 3R.&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">\u1ede \u0110an M\u1ea1ch, ch\u00ednh ph\u1ee7 th\u00e0nh l\u1eadp Trung t\u00e2m 3R \u0110an M\u1ea1ch (Danish 3R-Center) t\u1eeb 2013, ho\u1ea1t \u0111\u1ed9ng nh\u01b0 quan h\u1ec7 \u0111\u1ed1i t\u00e1c nh\u00e0 n\u01b0\u1edbc, \u0111\u1ea1i h\u1ecdc nh\u1eb1m th\u00fac \u0111\u1ea9y ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf v\u00e0 \u0111\u00e0o t\u1ea1o v\u1ec1 3R. Ph\u1ea7n Lan tuy kh\u00f4ng c\u00f3 trung t\u00e2m 3R \u0111\u1ed9c l\u1eadp quy m\u00f4 qu\u1ed1c gia, nh\u01b0ng c\u00e1c tr\u01b0\u1eddng \u0111\u1ea1i h\u1ecdc v\u00e0 c\u01a1 quan th\u00fa y t\u1ea1i \u0111\u00e2y ph\u1ed1i h\u1ee3p v\u1edbi m\u1ea1ng l\u01b0\u1edbi 3R c\u1ee7a EU \u0111\u1ec3 th\u1ef1c hi\u1ec7n ch\u1ec9 th\u1ecb 2010\/63. Na Uy (kh\u00f4ng thu\u1ed9c EU nh\u01b0ng tu\u00e2n th\u1ee7 c\u00e1c ti\u00eau chu\u1ea9n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng qua kh\u1ed1i EEA) c\u0169ng r\u1ea5t t\u00edch c\u1ef1c: Na Uy c\u1ea5m ho\u00e0n to\u00e0n th\u1eed nghi\u1ec7m m\u1ef9 ph\u1ea9m tr\u00ean \u0111\u1ed9ng v\u1eadt t\u1eeb 2013, \u0111\u1ed3ng b\u1ed9 v\u1edbi l\u1ec7nh c\u1ea5m c\u1ee7a EU. Na Uy c\u00f3 t\u1ed5 ch\u1ee9c Norecopa \u2013 \u1ee6y ban \u0111\u1ed3ng thu\u1eadn qu\u1ed1c gia v\u1ec1 3R th\u00e0nh l\u1eadp t\u1eeb 2007, \u0111\u1ec3 t\u01b0 v\u1ea5n cho ch\u00ednh ph\u1ee7 v\u00e0 k\u1ebft n\u1ed1i c\u00e1c nh\u00e0 khoa h\u1ecdc v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf. Norecopa h\u1ed7 tr\u1ee3 x\u00e2y d\u1ef1ng c\u01a1 s\u1edf d\u1eef li\u1ec7u, gi\u1ea3i th\u01b0\u1edfng cho nghi\u00ean c\u1ee9u 3R v\u00e0 h\u1ee3p t\u00e1c v\u1edbi c\u00e1c trung t\u00e2m 3R B\u1eafc \u00c2u kh\u00e1c.&nbsp;<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">C\u00e1c n\u01b0\u1edbc B\u1eafc \u00c2u c\u0169ng tham gia m\u1ea1nh m\u1ebd v\u00e0o n\u1ed7 l\u1ef1c chung c\u1ee7a Li\u00ean minh ch\u00e2u \u00c2u h\u01b0\u1edbng t\u1edbi khoa h\u1ecdc kh\u00f4ng \u0111\u1ed9ng v\u1eadt. N\u0103m 2021, Ngh\u1ecb vi\u1ec7n Ch\u00e2u \u00c2u th\u00f4ng qua ngh\u1ecb quy\u1ebft k\u00eau g\u1ecdi x\u00e2y d\u1ef1ng k\u1ebf ho\u1ea1ch h\u00e0nh \u0111\u1ed9ng nh\u1eb1m ch\u1ea5m d\u1ee9t s\u1eed d\u1ee5ng \u0111\u1ed9ng v\u1eadt trong nghi\u00ean c\u1ee9u v\u00e0 th\u1eed nghi\u1ec7m. H\u01b0\u1edfng \u1ee9ng, \u1ee6y ban Ch\u00e2u \u00c2u n\u0103m 2023 \u0111\u00e3 b\u1eaft \u0111\u1ea7u x\u00e2y d\u1ef1ng Roadmap (l\u1ed9 tr\u00ecnh) ph\u1ed1i h\u1ee3p c\u00f9ng c\u00e1c n\u01b0\u1edbc th\u00e0nh vi\u00ean \u0111\u1ec3 th\u00fac \u0111\u1ea9y ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf, tr\u01b0\u1edbc m\u1eaft trong l\u0129nh v\u1ef1c \u0111\u00e1nh gi\u00e1 an to\u00e0n h\u00f3a ch\u1ea5t v\u00e0 xa h\u01a1n l\u00e0 gi\u1ea3m th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt trong nghi\u00ean c\u1ee9u, gi\u00e1o d\u1ee5c. Th\u1ee5y \u0110i\u1ec3n, \u0110an M\u1ea1ch, Ph\u1ea7n Lan \u0111\u1ec1u tuy\u00ean b\u1ed1 \u1ee7ng h\u1ed9 m\u1ea1nh m\u1ebd s\u00e1ng ki\u1ebfn n\u00e0y. \u0110\u1ea1i di\u1ec7n Trung t\u00e2m 3R Th\u1ee5y \u0110i\u1ec3n tham gia h\u1ed9i th\u1ea3o c\u1ee7a \u1ee6y ban Ch\u00e2u \u00c2u cu\u1ed1i 2023 \u0111\u1ec3 \u0111\u00f3ng g\u00f3p x\u00e2y d\u1ef1ng l\u1ed9 tr\u00ecnh lo\u1ea1i b\u1ecf \u0111\u1ed9ng v\u1eadt, kh\u1eb3ng \u0111\u1ecbnh m\u1ee5c ti\u00eau chung c\u1ee7a EU l\u00e0 l\u00e0m vi\u1ec7c t\u00edch c\u1ef1c \u0111\u1ec3 thay th\u1ebf \u0111\u1ed9ng v\u1eadt b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p nh\u00e2n \u0111\u1ea1o h\u01a1n. M\u1eb7c d\u00f9 v\u1eady, c\u0169ng ph\u1ea3i th\u1eb3ng th\u1eafn nh\u00ecn nh\u1eadn m\u1ed9t s\u1ed1 th\u00e1ch th\u1ee9c n\u1ed9i t\u1ea1i v\u1edbi ng\u00e2n s\u00e1ch d\u00e0nh cho 3R t\u1ea1i B\u1eafc \u00c2u ch\u01b0a t\u0103ng t\u01b0\u01a1ng x\u1ee9ng v\u1edbi k\u1ef3 v\u1ecdng. V\u00ed d\u1ee5, Th\u1ee5y \u0110i\u1ec3n th\u1eddi gian g\u1ea7n \u0111\u00e2y l\u1ea1i c\u1eaft gi\u1ea3m t\u00e0i tr\u1ee3 cho Trung t\u00e2m 3R (th\u00e0nh l\u1eadp 2017) do kh\u00f3 kh\u0103n ng\u00e2n s\u00e1ch, khi\u1ebfn gi\u1edbi khoa h\u1ecdc lo ng\u1ea1i Th\u1ee5y \u0110i\u1ec3n c\u00f3 th\u1ec3 t\u1ee5t l\u1ea1i ph\u00eda sau trong cu\u1ed9c c\u00e1ch m\u1ea1ng kh\u00f4ng \u0111\u1ed9ng v\u1eadt. C\u00e1c nh\u00e0 ho\u1ea1t \u0111\u1ed9ng 3R Th\u1ee5y \u0110i\u1ec3n \u0111\u00e3 l\u00ean ti\u1ebfng r\u1eb1ng \u0111\u00e2y l\u00e0 th\u1eddi \u0111i\u1ec3m c\u1ea7n t\u0103ng c\u01b0\u1eddng cam k\u1ebft, b\u1edfi EU \u0111ang \u0111\u1ea9y m\u1ea1nh s\u00e1ng ki\u1ebfn m\u1edbi 2025 &#8211; 2027 v\u1ec1 thay th\u1ebf \u0111\u1ed9ng v\u1eadt, n\u1ebfu Th\u1ee5y \u0110i\u1ec3n kh\u00f4ng gi\u1eef vai tr\u00f2 ch\u1ee7 \u0111\u1ed9ng s\u1ebd \u0111\u00e1nh m\u1ea5t v\u1ecb th\u1ebf ti\u00ean phong tr\u01b0\u1edbc \u0111\u00e2y.<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">T\u1ed5ng quan v\u1ec1 ch\u00ednh s\u00e1ch, c\u00e1c qu\u1ed1c gia B\u1eafc \u00c2u tu\u00e2n th\u1ee7 nghi\u00eam ng\u1eb7t lu\u1eadt EU v\u1ed1n r\u1ea5t ti\u1ebfn b\u1ed9 nh\u01b0 c\u1ea5m th\u1eed nghi\u1ec7m m\u1ef9 ph\u1ea9m tr\u00ean \u0111\u1ed9ng v\u1eadt (t\u1eeb 2013), y\u00eau c\u1ea7u \u0111\u00e1nh gi\u00e1 \u0111\u1ea1o \u0111\u1ee9c cho m\u1ecdi nghi\u00ean c\u1ee9u \u0111\u1ed9ng v\u1eadt, v\u00e0 b\u1eaft bu\u1ed9c xem x\u00e9t ph\u01b0\u01a1ng \u00e1n thay th\u1ebf trong c\u1ea5p ph\u00e9p d\u1ef1 \u00e1n. Song song, h\u1ecd x\u00e2y d\u1ef1ng th\u1ec3 ch\u1ebf ri\u00eang th\u00fac \u0111\u1ea9y 3R nh\u01b0 Gi\u1ea3i th\u01b0\u1edfng Nghi\u00ean c\u1ee9u 3R (do B\u1ed9 N\u00f4ng nghi\u1ec7p \u0110\u1ee9c v\u00e0 c\u00e1c \u0111\u1ed1i t\u00e1c B\u1eafc \u00c2u t\u00e0i tr\u1ee3 h\u00e0ng n\u0103m \u0111\u1ec3 vinh danh c\u00f4ng tr\u00ecnh 3R xu\u1ea5t s\u1eafc), hay c\u00e1c \u1ee7y ban qu\u1ed1c gia v\u1ec1 3R t\u1ea1i t\u1eebng n\u01b0\u1edbc \u0111\u1ec3 t\u01b0 v\u1ea5n ch\u00ednh s\u00e1ch (Th\u1ee5y \u0110i\u1ec3n c\u00f3 \u1ee6y ban Qu\u1ed1c gia B\u1ea3o v\u1ec7 \u0110\u1ed9ng v\u1eadt Th\u00ed nghi\u1ec7m, \u0110an M\u1ea1ch c\u00f3 \u1ee6y ban Qu\u1ed1c gia 3R tr\u1ef1c thu\u1ed9c B\u1ed9 Th\u00fa y&#8230;). Nh\u1eefng n\u1ed7 l\u1ef1c n\u00e0y ph\u1ea3n \u00e1nh cam k\u1ebft l\u00e2u d\u00e0i c\u1ee7a B\u1eafc \u00c2u, h\u01b0\u1edbng t\u1edbi tr\u1edf th\u00e0nh \u201ch\u00ecnh m\u1eabu to\u00e0n c\u1ea7u\u201d v\u1ec1 \u0111\u1ed5i m\u1edbi khoa h\u1ecdc kh\u00f4ng c\u1ea7n \u0111\u1ed9ng v\u1eadt.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Xu_huong_va_tien_bo_cong_nghe_thay_the_thu_nghiem_dong_vat_tai_Bac_Au\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">Xu h\u01b0\u1edbng v\u00e0 ti\u1ebfn b\u1ed9 c\u00f4ng ngh\u1ec7 thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt t\u1ea1i B\u1eafc \u00c2u<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">C\u00e1c n\u01b0\u1edbc B\u1eafc \u00c2u, v\u1edbi th\u1ebf m\u1ea1nh v\u1ec1 nghi\u00ean c\u1ee9u v\u00e0 ph\u00fac l\u1ee3i \u0111\u1ed9ng v\u1eadt, \u0111\u00e3 \u0111\u1ea1t nhi\u1ec1u ti\u1ebfn b\u1ed9 \u0111\u00e1ng k\u1ec3 trong vi\u1ec7c ph\u00e1t tri\u1ec3n v\u00e0 \u1ee9ng d\u1ee5ng c\u00f4ng ngh\u1ec7 thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Trung_tam_3R_va_mang_luoi_nghien_cuu\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">Trung t\u00e2m 3R v\u00e0 m\u1ea1ng l\u01b0\u1edbi nghi\u00ean c\u1ee9u<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Th\u1ee5y \u0110i\u1ec3n, \u0110an M\u1ea1ch, Na Uy \u0111\u1ec1u c\u00f3 trung t\u00e2m 3R ho\u1ea1t \u0111\u1ed9ng t\u00edch c\u1ef1c, t\u00e0i tr\u1ee3 cho c\u00e1c d\u1ef1 \u00e1n nghi\u00ean c\u1ee9u thay th\u1ebf. Trung t\u00e2m 3R Th\u1ee5y \u0110i\u1ec3n (thu\u1ed9c C\u1ee5c N\u00f4ng nghi\u1ec7p) trong 6 n\u0103m qua \u0111\u00e3 tr\u1edf th\u00e0nh \u0111\u1ea7u m\u1ed1i qu\u1ed1c gia, k\u1ebft n\u1ed1i c\u00e1c tr\u01b0\u1eddng \u0111\u1ea1i h\u1ecdc v\u00e0 c\u01a1 quan qu\u1ea3n l\u00fd \u0111\u1ec3 tri\u1ec3n khai 3R. Trung t\u00e2m n\u00e0y \u0111\u00e3 xu\u1ea5t b\u1ea3n c\u00e1c khuy\u1ebfn ngh\u1ecb v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf, t\u1ed5 ch\u1ee9c h\u1ed9i th\u1ea3o \u0111\u00e0o t\u1ea1o cho nh\u00e0 khoa h\u1ecdc, v\u00e0 quan tr\u1ecdng l\u00e0 ph\u1ed1i h\u1ee3p c\u00f9ng qu\u1ef9 t\u00e0i tr\u1ee3 nghi\u00ean c\u1ee9u Th\u1ee5y \u0110i\u1ec3n \u0111\u1ec3 \u0111\u01b0a ch\u1ee7 \u0111\u1ec1 3R v\u00e0o \u01b0u ti\u00ean c\u1ea5p v\u1ed1n. Trung t\u00e2m 3R \u0110an M\u1ea1ch th\u00ec ch\u00fa tr\u1ecdng h\u1ed7 tr\u1ee3 k\u1ef9 thu\u1eadt cho c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u. H\u1ecd duy tr\u00ec m\u1ed9t ng\u00e2n h\u00e0ng tri th\u1ee9c 3R chia s\u1ebb c\u00e1c ph\u01b0\u01a1ng ph\u00e1p in vitro\/ in silico s\u1eb5n c\u00f3 v\u00e0 t\u1ed5 ch\u1ee9c kh\u1ea3o s\u00e1t \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 hi\u1ec3u bi\u1ebft 3R trong gi\u1edbi khoa h\u1ecdc, qua \u0111\u00f3 \u0111\u1ecbnh h\u01b0\u1edbng ho\u1ea1t \u0111\u1ed9ng gi\u00e1o d\u1ee5c ph\u00f9 h\u1ee3p. M\u1ea1ng l\u01b0\u1edbi 3R B\u1eafc \u00c2u c\u0169ng th\u01b0\u1eddng xuy\u00ean h\u1ee3p t\u00e1c, v\u00ed d\u1ee5 nh\u01b0 c\u00e1c trung t\u00e2m 3R B\u1eafc \u00c2u \u0111\u1ed3ng t\u1ed5 ch\u1ee9c h\u1ed9i ngh\u1ecb 3R khu v\u1ef1c, th\u00fac \u0111\u1ea9y chia s\u1ebb c\u01a1 s\u1edf v\u1eadt ch\u1ea5t (ph\u00f2ng th\u00ed nghi\u1ec7m cell culture, c\u01a1 s\u1edf d\u1eef li\u1ec7u \u0111\u1ed9c t\u00ednh,\u2026) gi\u1eefa c\u00e1c n\u01b0\u1edbc.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Du_an_VAC2VAC_%E2%80%93_Kiem_dinh_vac-xin_khong_dong_vat\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">D\u1ef1 \u00e1n VAC2VAC \u2013 Ki\u1ec3m \u0111\u1ecbnh v\u1eafc-xin kh\u00f4ng \u0111\u1ed9ng v\u1eadt<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">C\u00e1c nh\u00e0 khoa h\u1ecdc v\u00e0 c\u00f4ng ty t\u1ea1i B\u1eafc \u00c2u \u0111\u00f3ng vai tr\u00f2 then ch\u1ed1t trong d\u1ef1 \u00e1n VAC2VAC (Vaccine batch to vaccine batch comparison) do Li\u00ean minh Ch\u00e2u \u00c2u t\u00e0i tr\u1ee3. M\u1ee5c ti\u00eau VAC2VAC l\u00e0 ph\u00e1t tri\u1ec3n ph\u01b0\u01a1ng ph\u00e1p ki\u1ec3m \u0111\u1ecbnh l\u00f4 v\u1eafc-xin d\u1ef1a tr\u00ean t\u00ednh nh\u1ea5t qu\u00e1n, thay cho c\u00e1ch ki\u1ec3m m\u1ed7i l\u00f4 tr\u00ean \u0111\u1ed9ng v\u1eadt nh\u01b0 hi\u1ec7n nay. D\u1ef1 \u00e1n (2016 &#8211; 2022) t\u1eadp h\u1ee3p nhi\u1ec1u h\u00e3ng d\u01b0\u1ee3c (GSK, Sanofi, Pfizer\u2026) v\u00e0 vi\u1ec7n nghi\u00ean c\u1ee9u ch\u00e2u \u00c2u. Trong \u0111\u00f3 c\u00f3 s\u1ef1 tham gia c\u1ee7a Vi\u1ec7n Paul-Ehrlich (\u0110\u1ee9c), C\u01a1 quan D\u01b0\u1ee3c ph\u1ea9m H\u00e0 Lan, v\u00e0 c\u00e1c \u0111\u1ed1i t\u00e1c B\u1eafc \u00c2u gi\u00e1n ti\u1ebfp qua m\u1ea1ng l\u01b0\u1edbi nghi\u00ean c\u1ee9u. Th\u00e0nh t\u1ef1u n\u1ed5i b\u1eadt l\u00e0 VAC2VAC \u0111\u00e3 ph\u00e1t tri\u1ec3n th\u00e0nh c\u00f4ng b\u1ed9 x\u00e9t nghi\u1ec7m thay th\u1ebf cho m\u1ed9t s\u1ed1 ph\u00e9p th\u1eed. N\u0103m 2024, d\u1ef1 \u00e1n c\u00f4ng b\u1ed1 ph\u01b0\u01a1ng ph\u00e1p Monocyte Activation Test (MAT) (d\u1ef1 \u00e1n d\u00f9ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u01a1n nh\u00e2n ng\u01b0\u1eddi \u0111\u1ec3 ph\u00e1t hi\u1ec7n ch\u1ea5t g\u00e2y s\u1ed1t) \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn thay th\u1ebf test g\u00e2y s\u1ed1t tr\u00ean th\u1ecf trong ki\u1ec3m \u0111\u1ecbnh v\u1eafc-xin vi\u00eam n\u00e3o m\u00f9a h\u00e8 (TBE) do h\u00e3ng GSK s\u1ea3n xu\u1ea5t. \u0110\u00e2y l\u00e0 tr\u01b0\u1eddng h\u1ee3p \u0111\u1ea7u ti\u00ean m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p VAC2VAC \u0111\u01b0\u1ee3c c\u01a1 quan qu\u1ea3n l\u00fd ch\u1ea5p nh\u1eadn v\u00e0 \u00e1p d\u1ee5ng th\u1ef1c t\u1ebf, \u0111\u01b0\u1ee3c ca ng\u1ee3i l\u00e0 quy\u1ebft \u0111\u1ecbnh \u201cmang t\u00ednh l\u1ecbch s\u1eed\u201d h\u01b0\u1edbng t\u1edbi ch\u1ea5m d\u1ee9t test g\u00e2y s\u1ed1t tr\u00ean \u0111\u1ed9ng v\u1eadt. Ngo\u00e0i ra, VAC2VAC c\u00f2n ph\u00e1t tri\u1ec3n c\u00e1c x\u00e9t nghi\u1ec7m ph\u00e2n t\u00edch \u0111\u1ecbnh l\u01b0\u1ee3ng kh\u00e1ng nguy\u00ean \u0111\u1ec3 thay th\u1ebf test hi\u1ec7u l\u1ef1c tr\u00ean chu\u1ed9t cho v\u1eafc-xin \u0111\u1ed9c t\u1ed1 b\u1ea1ch h\u1ea7u, u\u1ed1n v\u00e1n, v.v., hi\u1ec7n \u0111ang trong giai \u0111o\u1ea1n th\u1ea9m \u0111\u1ecbnh cu\u1ed1i. Nh\u1eefng ti\u1ebfn b\u1ed9 n\u00e0y cho th\u1ea5y ch\u00e2u \u00c2u n\u00f3i chung v\u00e0 B\u1eafc \u00c2u n\u00f3i ri\u00eang \u0111ang d\u1eabn \u0111\u1ea7u trong c\u1ea3i ti\u1ebfn quy tr\u00ecnh ki\u1ec3m \u0111\u1ecbnh v\u1eafc-xin th\u00e2n thi\u1ec7n h\u01a1n, kh\u00f4ng c\u1ea7n s\u1eed d\u1ee5ng \u0111\u1ed9ng v\u1eadt m\u1ed9t c\u00e1ch th\u01b0\u1eddng quy.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Cong_nghe_%E2%80%9Cco_quan_tren_chip%E2%80%9D_va_vi_mo_trong_nghien_cuu_y_sinh\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">C\u00f4ng ngh\u1ec7 \u201cc\u01a1 quan tr\u00ean chip\u201d v\u00e0 vi m\u00f4 trong nghi\u00ean c\u1ee9u y sinh<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">B\u1eafc \u00c2u c\u00f3 nhi\u1ec1u nh\u00f3m nghi\u00ean c\u1ee9u m\u1ea1nh v\u1ec1 vi k\u1ef9 thu\u1eadt v\u00e0 sinh h\u1ecdc t\u1ebf b\u00e0o, \u0111\u00e3 t\u1ea1o ra c\u00e1c n\u1ec1n t\u1ea3ng organ-on-chip ti\u00ean ti\u1ebfn. T\u1ea1i Na Uy, Vi\u1ec7n SINTEF h\u1ee3p t\u00e1c \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc v\u00e0 K\u1ef9 thu\u1eadt Na Uy \u0111ang ph\u00e1t tri\u1ec3n chip vi l\u01b0u (microfluidic chip) nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o ng\u01b0\u1eddi \u0111\u1ec3 m\u00f4 ph\u1ecfng m\u00f4 ph\u1ed5i v\u00e0 kh\u1ed1i u ph\u1ed5i trong m\u00f4i tr\u01b0\u1eddng c\u00f3 ki\u1ec3m so\u00e1t oxy t\u1ed1t h\u01a1n. Th\u00e1ch th\u1ee9c l\u1edbn c\u1ee7a organ-on-chip l\u00e0 duy tr\u00ec \u0111i\u1ec1u ki\u1ec7n sinh l\u00fd (nh\u01b0 n\u1ed3ng \u0111\u1ed9 oxy) \u1ed5n \u0111\u1ecbnh cho t\u1ebf b\u00e0o. Nh\u00f3m SINTEF \u0111\u00e3 t\u00ecm ra v\u1eadt li\u1ec7u polymer m\u1edbi (polymethylpentene) gi\u00fap chip th\u1ea9m th\u1ea5u oxy v\u00e0 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o b\u1ec1n t\u1edbi h\u01a1n 4 ng\u00e0y, m\u1edf ra kh\u1ea3 n\u0103ng th\u00ed nghi\u1ec7m d\u00e0i ng\u00e0y tr\u00ean chip m\u00e0 tr\u01b0\u1edbc \u0111\u00e2y kh\u00f3 th\u1ef1c hi\u1ec7n. C\u00f4ng ngh\u1ec7 n\u00e0y \u0111\u1eb7c bi\u1ec7t h\u1eefu \u00edch \u0111\u1ec3 nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c mi\u1ec5n d\u1ecbch v\u00e0 ung th\u01b0. D\u1ef1 \u00e1n ImmuneDroplets c\u1ee7a nh\u00f3m cho ph\u00e9p quan s\u00e1t t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u201cs\u00e1t th\u1ee7 t\u1ef1 nhi\u00ean\u201d t\u1ea5n c\u00f4ng t\u1ebf b\u00e0o ung th\u01b0 ph\u1ed5i tr\u00ean chip, thay v\u00ec ph\u1ea3i g\u00e2y kh\u1ed1i u tr\u00ean chu\u1ed9t nh\u01b0 truy\u1ec1n th\u1ed1ng. T\u1ea1i Th\u1ee5y \u0110i\u1ec3n, \u0110\u1ea1i h\u1ecdc Chalmers n\u1ed5i ti\u1ebfng v\u1edbi vi\u1ec7c \u00e1p d\u1ee5ng AI v\u00e0 organ-on-chip. Trong n\u0103m 2021 c\u00e1c nh\u00e0 khoa h\u1ecdc Chalmers ph\u00e1t tri\u1ec3n ph\u01b0\u01a1ng ph\u00e1p AI k\u1ebft h\u1ee3p d\u1eef li\u1ec7u \u0111\u1ed9c t\u00ednh in vitro \u0111\u1ec3 c\u1ea3i thi\u1ec7n d\u1ef1 \u0111o\u00e1n \u0111\u1ed9c ch\u1ea5t (\u0111\u1eb7c bi\u1ec7t trong l\u0129nh v\u1ef1c h\u00f3a ch\u1ea5t c\u00f4ng nghi\u1ec7p). \u0110\u00f3ng g\u00f3p n\u00e0y \u0111\u01b0\u1ee3c EU \u0111\u00e1nh gi\u00e1 cao trong l\u1ed9 tr\u00ecnh lo\u1ea1i b\u1ecf \u0111\u1ed9ng v\u1eadt. \u0110an M\u1ea1ch c\u0169ng c\u00f3 m\u1ed9t d\u1ef1 \u00e1n th\u00fa v\u1ecb n\u0103m 2022, c\u00e1c k\u1ef9 s\u01b0 t\u1ea1i \u0110\u1ea1i h\u1ecdc K\u1ef9 thu\u1eadt \u0110an M\u1ea1ch (DTU) ch\u1ebf t\u1ea1o m\u00f4 h\u00ecnh \u201cda nh\u00e2n t\u1ea1o\u201d t\u1eeb t\u1ebf b\u00e0o da ng\u01b0\u1eddi \u0111\u1ec3 th\u1eed nghi\u1ec7m ch\u1ea5t m\u1ef9 ph\u1ea9m, h\u01b0\u1edbng t\u1edbi ch\u1ee9ng nh\u1eadn thay th\u1ebf test tr\u00ean th\u1ecf. Ch\u00ednh ph\u1ee7 \u0110an M\u1ea1ch t\u00e0i tr\u1ee3 d\u1ef1 \u00e1n n\u00e0y trong khu\u00f4n kh\u1ed5 ch\u01b0\u01a1ng tr\u00ecnh \u201c\u0110\u1ed5i m\u1edbi 3R qu\u1ed1c gia\u201d, k\u1ef3 v\u1ecdng gi\u00fap ng\u00e0nh c\u00f4ng nghi\u1ec7p m\u1ef9 ph\u1ea9m tu\u00e2n th\u1ee7 quy \u0111\u1ecbnh kh\u00f4ng th\u1eed \u0111\u1ed9ng v\u1eadt m\u00e0 v\u1eabn \u0111\u1ea3m b\u1ea3o an to\u00e0n s\u1ea3n ph\u1ea9m.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Hop_tac_cong_%E2%80%93_tu_trong_nghien_cuu_NAMs\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:16pt\">H\u1ee3p t\u00e1c c\u00f4ng \u2013 t\u01b0 trong nghi\u00ean c\u1ee9u NAMs<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">M\u1ed9t \u0111i\u1ec3m m\u1ea1nh \u1edf B\u1eafc \u00c2u l\u00e0 s\u1ef1 chung tay gi\u1eefa ch\u00ednh quy\u1ec1n, tr\u01b0\u1eddng \u0111\u1ea1i h\u1ecdc v\u00e0 doanh nghi\u1ec7p trong ph\u00e1t tri\u1ec3n ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt. Ch\u1eb3ng h\u1ea1n, h\u00e3ng d\u01b0\u1ee3c AstraZeneca (c\u00f3 trung t\u00e2m R&amp;D l\u1edbn \u1edf Th\u1ee5y \u0110i\u1ec3n) tuy\u00ean b\u1ed1 \u0111ang \u0111\u1ea7u t\u01b0 v\u00e0o c\u00e1c m\u00f4 h\u00ecnh \u201corgan-on-chip\u201d v\u00e0 organoid \u0111\u1ec3 gi\u1ea3m th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt trong nghi\u00ean c\u1ee9u thu\u1ed1c ti\u1ec1n l\u00e2m s\u00e0ng. AstraZeneca h\u1ee3p t\u00e1c v\u1edbi \u0110\u1ea1i h\u1ecdc Cambridge v\u00e0 Gothenburg \u0111\u1ec3 th\u1eed nghi\u1ec7m chip gan d\u1ef1 \u0111o\u00e1n \u0111\u1ed9c t\u00ednh gan s\u1edbm. T\u01b0\u01a1ng t\u1ef1, c\u00f4ng ty Novo Nordisk (\u0110an M\u1ea1ch) h\u1ed7 tr\u1ee3 m\u1ed9t m\u1ea1ng l\u01b0\u1edbi h\u1ecdc thu\u1eadt nh\u1eb1m ph\u00e1t tri\u1ec3n m\u00f4 h\u00ecnh \u1ea3o (virtual modeling) cho b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, thay cho vi\u1ec7c s\u1eed d\u1ee5ng chu\u1ed9t GMO m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng nh\u01b0 tr\u01b0\u1edbc. Nh\u1eefng li\u00ean minh c\u00f4ng-t\u01b0 n\u00e0y th\u01b0\u1eddng n\u1eb1m d\u01b0\u1edbi s\u00e1ng ki\u1ebfn l\u1edbn nh\u01b0 European Partnership for Alternative Approaches (EPAA). Trong \u0111\u00f3, c\u00e1c ch\u00ednh ph\u1ee7 B\u1eafc \u00c2u v\u00e0 doanh nghi\u1ec7p c\u00f9ng t\u00e0i tr\u1ee3 nghi\u00ean c\u1ee9u 3R, chia s\u1ebb d\u1eef li\u1ec7u v\u00e0 th\u00fac \u0111\u1ea9y ch\u1ea5p nh\u1eadn quy \u0111\u1ecbnh cho ph\u01b0\u01a1ng ph\u00e1p m\u1edbi. K\u1ebft qu\u1ea3 l\u00e0 \u0111\u00e3 c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf \u0111\u01b0\u1ee3c OECD th\u00f4ng qua xu\u1ea5t ph\u00e1t t\u1eeb nghi\u00ean c\u1ee9u ch\u00e2u \u00c2u. V\u00ed d\u1ee5 nh\u01b0 ph\u01b0\u01a1ng ph\u00e1p k\u00edch \u1ee9ng da tr\u00ean m\u00f4 da nh\u00e2n t\u1ea1o EpiSkin do Ph\u00e1p ph\u00e1t tri\u1ec3n, test \u0111\u1ed9c t\u00ednh c\u00e1 tr\u00ean tr\u1ee9ng c\u00e1 Zebrafish t\u1eeb nh\u00f3m \u0110\u1ee9c-Na Uy, v.v.) v\u00e0 \u0111\u01b0\u1ee3c c\u00e1c n\u01b0\u1edbc B\u1eafc \u00c2u \u00e1p d\u1ee5ng ngay khi ban h\u00e0nh ti\u00eau chu\u1ea9n.<\/span><\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">B\u1eafc \u00c2u duy tr\u00ec v\u1ecb th\u1ebf l\u00e0 m\u1ed9t trong nh\u1eefng c\u1ee5m qu\u1ed1c gia ti\u00ean phong v\u1ec1 thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt. H\u1ecd c\u00f3 n\u1ec1n t\u1ea3ng ch\u00ednh s\u00e1ch v\u1eefng ch\u1eafc c\u00f9ng v\u1edbi n\u0103ng l\u1ef1c khoa h\u1ecdc \u0111\u1ec3 hi\u1ec7n th\u1ef1c h\u00f3a m\u1ee5c ti\u00eau 3R trong th\u1ef1c t\u1ebf. D\u00f9 v\u1eabn c\u1ea7n n\u1ed7 l\u1ef1c th\u00eam (nh\u01b0 t\u0103ng \u0111\u1ea7u t\u01b0 t\u00e0i ch\u00ednh cho nghi\u00ean c\u1ee9u 3R), nh\u1eefng th\u00e0nh c\u00f4ng nh\u01b0 d\u1ef1 \u00e1n VAC2VAC hay c\u00e1c ph\u00e1t minh organ-on-chip m\u1edbi m\u1ebb cho th\u1ea5y B\u1eafc \u00c2u \u0111ang g\u00f3p ph\u1ea7n quan tr\u1ecdng th\u00fac \u0111\u1ea9y xu h\u01b0\u1edbng to\u00e0n c\u1ea7u thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt b\u1eb1ng c\u00e1c m\u00f4 h\u00ecnh tr\u00ean ng\u01b0\u1eddi hi\u1ec7u qu\u1ea3 h\u01a1n.&nbsp;<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:13.999999999999998pt\">\ud83d\udce9&nbsp;<strong>Th\u00f4ng tin li\u00ean h\u1ec7:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><strong>Website:<\/strong><\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/biogroupvietnam.com\/public\/lien-he\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/biogroupvietnam.com\/public\/lien-he<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><strong>Hotline:<\/strong> +84 963 621 421<\/span><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\"><strong>Email:<\/strong>&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">info@biogroupvietnam.vn<\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.stemcell.com\/products\/brands\/stemdiff-hpsc-esc-ipsc-differentiation.html\"><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\"><i>Tham kh\u1ea3o c\u00f4ng ngh\u1ec7 c\u1ee7a STEMCELL Technologies trong thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt<\/i><\/span><\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Tai_lieu_tham_khao\"><\/span><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:20pt\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ol>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Swedish Board of Agriculture. (2023, December 20).&nbsp;<i>50 years of replacing animal experiments<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/jordbruksverket.se\/languages\/english\/swedish-board-of-agriculture\/animals\/the-swedish-3rs-center\/news\/arkiv\/2023-12-20-50-years-of-replacing-animal-experiments\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/jordbruksverket.se\/languages\/english\/swedish-board-of-agriculture\/animals\/the-swedish-3rs-center\/news\/arkiv\/2023-12-20-50-years-of-replacing-animal-experiments<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Norecopa. (n.d.).&nbsp;<i>Danish 3R Center<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/norecopa.no\/3r-guide\/danish-3r-center\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/norecopa.no\/3r-guide\/danish-3r-center<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Center for Alternatives to Animal Testing. (n.d.).&nbsp;<i>Resources<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/caat.jhsph.edu\/resources\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/caat.jhsph.edu\/resources<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Humane Society International. (n.d.).&nbsp;<i>Timeline: Cosmetics testing on animals<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.humaneworld.org\/en\/issue\/timeline-cosmetics-testing-animals\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.humaneworld.org\/en\/issue\/timeline-cosmetics-testing-animals<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Norecopa. (n.d.).&nbsp;<i>Alternatives to animal research<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/norecopa.no\/alternatives\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/norecopa.no\/alternatives<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Obelis Group. (n.d.).&nbsp;<i>European Parliament calls for action plan to phase out animal testing<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.obelis.net\/news\/european-parliament-calls-for-action-plan-to-phase-out-animal-testing\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.obelis.net\/news\/european-parliament-calls-for-action-plan-to-phase-out-animal-testing<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Federal Ministry of Food and Agriculture (BMEL). (n.d.).&nbsp;<i>Animal welfare research prize 2025<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.bmel.de\/EN\/topics\/animals\/animal-health\/animal-protection-research-prize-25.html\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.bmel.de\/EN\/topics\/animals\/animal-health\/animal-protection-research-prize-25.html<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Doctors Against Animal Experiments. (n.d.).&nbsp;<i>Global approaches to achieve the transition to non-animal research<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.aerzte-gegen-tierversuche.de\/en\/specific-infos\/international\/global-approaches-to-achieve-the-transition-to-non-animal-research\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.aerzte-gegen-tierversuche.de\/en\/specific-infos\/international\/global-approaches-to-achieve-the-transition-to-non-animal-research<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">CABI Digital Library. (n.d.).&nbsp;<i>The Danish 3R survey: Knowledge, attitudes and implementation for people working with laboratory animals<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.cabidigitallibrary.org\/doi\/abs\/10.5555\/20163208858\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.cabidigitallibrary.org\/doi\/abs\/10.5555\/20163208858<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">Norwegian SciTech News. (2023, October).&nbsp;<i>We develop new technologies that may reduce the need for animal testing in medical research<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/norwegianscitechnews.com\/2023\/10\/we-develop-new-technologies-that-may-reduce-the-need-for-animal-testing-in-medical-research\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/norwegianscitechnews.com\/2023\/10\/we-develop-new-technologies-that-may-reduce-the-need-for-animal-testing-in-medical-research<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">European Animal Research Association. (n.d.).&nbsp;<i>Replacing animals in biomedical research<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.eara.eu\/replacing-animals-in-biomedical-research\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.eara.eu\/replacing-animals-in-biomedical-research<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">AstraZeneca. (n.d.).&nbsp;<i>Animals in research<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.astrazeneca.com\/sustainability\/ethics-compliance\/animals-in-research.html\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/www.astrazeneca.com\/sustainability\/ethics-compliance\/animals-in-research.html<\/span><\/a><\/li>\n<li><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">National Toxicology Program. (n.d.).&nbsp;<i>International Cooperation on Alternative Test Methods (ICATM)<\/i>.<\/span><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/ntp.niehs.nih.gov\/whatwestudy\/niceatm\/iccvam\/international-partnerships\/icatm\"><span style=\"background-color:transparent;color:#000000;font-family:Arial,sans-serif;font-size:12pt\">&nbsp;<\/span><span style=\"background-color:transparent;color:#1155cc;font-family:Arial,sans-serif;font-size:12pt\">https:\/\/ntp.niehs.nih.gov\/whatwestudy\/niceatm\/iccvam\/international-partnerships\/icatm<\/span><\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>In Northern Europe, alternatives to animal testing have developed strongly under certain conditions. The 3R principles (Replace &#8211; Reduce &#8211; Refine) have become widely practiced and legally enforced. From the VAC2VAC project to the national 3R centers network, countries like Sweden, Denmark, and Norway are shaping a human-based, animal-free research ecosystem. This article provides a detailed insight into the model that the world can learn from.<\/p>\n","protected":false},"author":1,"featured_media":6079,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-4306","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe-san-pham-moi"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>B\u1eafc \u00c2u c\u1ee9ng r\u1eafn thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt v\u1edbi c\u00f4ng ngh\u1ec7 m\u1edbi<\/title>\n<meta name=\"description\" content=\"B\u1eafc \u00c2u ti\u00ean phong thay th\u1ebf th\u1eed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt b\u1eb1ng m\u00f4 h\u00ecnh phi \u0111\u1ed9ng v\u1eadt v\u00e0 ch\u00ednh s\u00e1ch 3R nghi\u00eam ng\u1eb7t. 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