{"id":6135,"date":"2025-08-19T08:00:46","date_gmt":"2025-08-19T01:00:46","guid":{"rendered":"https:\/\/biogroupvietnam.com\/?p=6135"},"modified":"2025-10-06T09:37:39","modified_gmt":"2025-10-06T02:37:39","slug":"moi-truong-nuoi-cay-te-bao-stemcell-cgmp","status":"publish","type":"post","link":"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/moi-truong-nuoi-cay-te-bao-stemcell-cgmp\/","title":{"rendered":"M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o STEMCELL \u0111\u00e1p \u1ee9ng cGMP"},"content":{"rendered":"\n<p>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o l\u00e0 n\u1ec1n t\u1ea3ng quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec v\u00e0 ph\u00e1t tri\u1ec3n t\u1ebf b\u00e0o. \u0110\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 hi\u1ec7u qu\u1ea3, c\u00e1c m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y ph\u1ea3i \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n nghi\u00eam ng\u1eb7t, trong \u0111\u00f3 c\u00f3 ti\u00eau chu\u1ea9n cGMP. M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o STEMCELL l\u00e0 s\u1ea3n ph\u1ea9m \u0111\u00e1p \u1ee9ng ho\u00e0n h\u1ea3o chu\u1ea9n cGMP, \u0111\u1ea3m b\u1ea3o s\u1ef1 ph\u00e1t tri\u1ec3n t\u1ed1i \u01b0u cho t\u1ebf b\u00e0o. D\u01b0\u1edbi \u0111\u00e2y l\u00e0 danh s\u00e1ch c\u00e1c m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o STEMCELL \u0111\u01b0\u1ee3c ch\u1ee9ng nh\u1eadn cGMP, ph\u00f9 h\u1ee3p cho \u1ee9ng d\u1ee5ng trong nghi\u00ean c\u1ee9u, s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o v\u00e0 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<figure class=\"wp-block-image alignnone wp-image-6628 size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1422\" height=\"800\" src=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Moi-truong-nuoi-cay-te-bao-STEMCELL-dap-ung-cGMP.png\" alt=\"\" class=\"wp-image-6628\" srcset=\"https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Moi-truong-nuoi-cay-te-bao-STEMCELL-dap-ung-cGMP.png 1422w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Moi-truong-nuoi-cay-te-bao-STEMCELL-dap-ung-cGMP-300x169.png 300w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Moi-truong-nuoi-cay-te-bao-STEMCELL-dap-ung-cGMP-1024x576.png 1024w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Moi-truong-nuoi-cay-te-bao-STEMCELL-dap-ung-cGMP-768x432.png 768w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Moi-truong-nuoi-cay-te-bao-STEMCELL-dap-ung-cGMP-600x338.png 600w, https:\/\/biogroupvietnam.com\/wp-content\/uploads\/2025\/09\/Moi-truong-nuoi-cay-te-bao-STEMCELL-dap-ung-cGMP-90x51.png 90w\" sizes=\"(max-width: 1422px) 100vw, 1422px\" \/><figcaption class=\"wp-element-caption\">M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o STEMCELL \u0111a d\u1ea1ng c\u00f3 th\u1ec3 \u1ee9ng d\u1ee5ng trong c\u00e1c li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o kh\u00e1c nhau<\/figcaption><\/figure>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">M\u1ee5c l\u1ee5c<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 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class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/moi-truong-nuoi-cay-te-bao-stemcell-cgmp\/#Moi_truong_nuoi_cay_te_bao_goc_tao_mau_HSC\" >M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (HSC)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/moi-truong-nuoi-cay-te-bao-stemcell-cgmp\/#Moi_truong_nuoi_cay_te_bao_mien_dich_T_cell_NK_cell\" >M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (T cell, NK cell)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/moi-truong-nuoi-cay-te-bao-stemcell-cgmp\/#Nguon_tham_khao\" >Ngu\u1ed3n tham kh\u1ea3o<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Moi_truong_nuoi_cay_te_bao_goc_da_nang_hPSC\"><\/span>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng (hPSC)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>S\u1ea3n ph\u1ea9m<\/strong>&nbsp;<\/td><td><strong>Ch\u1ee9c n\u0103ng ch\u00ednh \/ Lo\u1ea1i t\u1ebf b\u00e0o \u0111\u00edch<\/strong>&nbsp;<\/td><td><strong>Tu\u00e2n th\u1ee7 cGMP &amp; ch\u1ee9ng nh\u1eadn<\/strong>&nbsp;<\/td><td><strong>\u1ee8ng d\u1ee5ng s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p<\/strong>&nbsp;<\/td><td><strong>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng \u0111\u01b0\u01a1ng<\/strong>&nbsp;<\/td><\/tr><tr><td><a href=\"https:\/\/www.stemcell.com\/products\/tesr-e8.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>TeSR\u2122-E8\u2122<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng feeder-free, th\u00e0nh ph\u1ea7n x\u00e1c \u0111\u1ecbnh (\u0111\u1ecbnh d\u1ea1ng E8) \u0111\u1ec3 duy tr\u00ec v\u00e0 m\u1edf r\u1ed9ng t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i ng\u01b0\u1eddi v\u00e0 t\u1ebf b\u00e0o iPSC (kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt).&nbsp;<\/td><td>S\u1ea3n ph\u1ea9m RUO (nghi\u00ean c\u1ee9u) s\u1ea3n xu\u1ea5t theo quy tr\u00ecnh ISO 9001\/13485; c\u00f4ng th\u1ee9c kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt gi\u00fap gi\u1ea3m r\u1ee7i ro ngo\u1ea1i lai, h\u1ed7 tr\u1ee3 chuy\u1ec3n giao sang quy tr\u00ecnh l\u00e2m s\u00e0ng.<\/td><td>\u0110\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong nu\u00f4i c\u1ea5y hPSC cho nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p t\u00e1i t\u1ea1o; cung c\u1ea5p m\u00f4i tr\u01b0\u1eddng n\u1ec1n \u1ed5n \u0111\u1ecbnh cho vi\u1ec7c t\u1ea1o d\u00f2ng iPSC d\u00f9ng trong li\u1ec7u ph\u00e1p t\u01b0\u01a1ng lai. L\u00fd t\u01b0\u1edfng \u0111\u1ec3 chuy\u1ec3n \u0111\u1ed5i sang m\u00f4i tr\u01b0\u1eddng GMP khi ti\u1ebfn t\u1edbi th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.&nbsp;<\/td><td>Gibco CTS Essential 8 Medium \u2013 m\u00f4i tr\u01b0\u1eddng hPSC kh\u00f4ng ngu\u1ed3n g\u1ed1c \u0111\u1ed9ng v\u1eadt, s\u1ea3n xu\u1ea5t theo chu\u1ea9n GMP \u0111\u1ec3 \u0111\u00e1p \u1ee9ng y\u00eau c\u1ea7u qu\u1ea3n l\u00fd.<\/td><\/tr><tr><td><a href=\"https:\/\/biogroupvietnam.com\/san-pham\/mtesr1\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>mTeSR\u21221&nbsp;<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng nu\u00f4i d\u01b0\u1ee1ng kh\u00f4ng feeder, kh\u00f4ng serum d\u00e0nh cho duy tr\u00ec t\u1ebf b\u00e0o ES v\u00e0 iPS ng\u01b0\u1eddi (ho\u00e0n ch\u1ec9nh, c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng c\u1ea7n thi\u1ebft). R\u1ea5t ph\u1ed5 bi\u1ebfn trong nu\u00f4i c\u1ea5y hPSC.&nbsp;<\/td><td>S\u1ea3n xu\u1ea5t theo cGMP trong h\u1ec7 th\u1ed1ng qu\u1ea3n l\u00fd ch\u1ea5t l\u01b0\u1ee3ng ISO 13485; nguy\u00ean li\u1ec7u \u0111\u1ea7u v\u00e0o \u0111\u01b0\u1ee3c s\u00e0ng l\u1ecdc tr\u01b0\u1edbc \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o l\u00f4 s\u1ea3n xu\u1ea5t \u1ed5n \u0111\u1ecbnh. C\u00f3 h\u1ed3 s\u01a1 Master File FDA h\u1ed7 tr\u1ee3 h\u1ed3 s\u01a1 IND (cung c\u1ea5p th\u01b0 u\u1ef7 quy\u1ec1n LOA theo y\u00eau c\u1ea7u).<\/td><td>\u0110\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t \u0111\u1ec3 nu\u00f4i c\u1ea5y hPSC, k\u1ec3 c\u1ea3 trong nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n l\u1eabn s\u1ea3n xu\u1ea5t ti\u1ec1n l\u00e2m s\u00e0ng. \u0110\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng trong quy tr\u00ecnh ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o\/iPSC (v\u00ed d\u1ee5 duy tr\u00ec d\u00f2ng iPSC ch\u1ea5t l\u01b0\u1ee3ng l\u00e2m s\u00e0ng tr\u01b0\u1edbc khi bi\u1ec7t h\u00f3a).<\/td><td>NutriStem\u00ae hPSC XF Medium \u2013 m\u00f4i tr\u01b0\u1eddng \u0111\u1ecbnh ngh\u0129a, xeno-free cho hPSC (\u0111\u01b0\u1ee3c FDA ch\u1ea5p nh\u1eadn h\u1ed3 s\u01a1 DMF, s\u1ea3n xu\u1ea5t theo ti\u00eau chu\u1ea9n GMP).<\/td><\/tr><tr><td><a href=\"https:\/\/www.stemcell.com\/products\/mtesr-plus.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>mTeSR\u2122\u202fPlus&nbsp;<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng c\u1ea3i ti\u1ebfn t\u1eeb mTeSR1 d\u00e0nh cho hPSC \u2013 th\u00e0nh ph\u1ea7n kh\u00f4ng serum, c\u00f3 b\u1ed5 sung \u1ed5n \u0111\u1ecbnh FGF2 v\u00e0 buffer gi\u00fap gi\u1ea3m chu k\u1ef3 cho \u0103n v\u00e0 t\u0103ng t\u00ednh \u1ed5n \u0111\u1ecbnh khi nu\u00f4i c\u1ea5y d\u00e0i ng\u00e0y. Duy tr\u00ec hi\u1ec7u qu\u1ea3 t\u1ebf b\u00e0o ES\/iPS.&nbsp;<\/td><td>S\u1ea3n xu\u1ea5t cGMP t\u01b0\u01a1ng t\u1ef1 mTeSR1, \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng cao v\u00e0 t\u00ednh nh\u1ea5t qu\u00e1n cho nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng li\u1ec7u ph\u00e1p. C\u0169ng c\u00f3 h\u1ed3 s\u01a1 FDA Master File (c\u00f3 th\u1ec3 xin LOA) \u0111\u1ec3 h\u1ed7 tr\u1ee3 \u0111\u0103ng k\u00fd li\u1ec7u ph\u00e1p m\u1edbi.<\/td><td>Ph\u00f9 h\u1ee3p cho m\u1edf r\u1ed9ng quy m\u00f4 nu\u00f4i c\u1ea5y hPSC trong s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p do gi\u1ea3m t\u1ea7n su\u1ea5t cho m\u00f4i tr\u01b0\u1eddng v\u00e0 \u1ed5n \u0111\u1ecbnh t\u00ednh ch\u1ea5t m\u00f4i tr\u01b0\u1eddng. \u0110\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 nu\u00f4i c\u00e1c d\u00f2ng iPSC \u0111\u1ecbnh h\u01b0\u1edbng s\u1ea3n xu\u1ea5t (v\u00ed d\u1ee5 trong ng\u00e2n h\u00e0ng iPSC ho\u1eb7c giai \u0111o\u1ea1n ti\u1ec1n l\u00e2m s\u00e0ng tr\u01b0\u1edbc khi bi\u1ec7t h\u00f3a).&nbsp;<\/td><td>Gibco Essential 8 Flex \/ NutriStem XF \u2013 c\u00e1c m\u00f4i tr\u01b0\u1eddng hPSC \u1ed5n \u0111\u1ecbnh, xeno-free t\u01b0\u01a1ng t\u1ef1, cho ph\u00e9p nu\u00f4i c\u1ea5y d\u00e0i ng\u00e0y v\u1edbi \u00edt l\u1ea7n cho \u0103n, c\u00f3 phi\u00ean b\u1ea3n s\u1ea3n xu\u1ea5t GMP h\u1ed7 tr\u1ee3 quy tr\u00ecnh li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o.<\/td><\/tr><tr><td><a href=\"https:\/\/www.stemcell.com\/products\/tesr-aof.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>TeSR\u2122-AOF<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng duy tr\u00ec hPSC animal origin-free (AOF) ho\u00e0n to\u00e0n (kh\u00f4ng d\u00f9ng nguy\u00ean li\u1ec7u t\u1eeb \u0111\u1ed9ng v\u1eadt hay ng\u01b0\u1eddi \u0111\u1ebfn c\u1ea5p th\u1ee9 c\u1ea5p). H\u1ed7 tr\u1ee3 nu\u00f4i feeder-free c\u00e1c t\u1ebf b\u00e0o ES\/iPS v\u1edbi ch\u1ea5t l\u01b0\u1ee3ng cao, h\u00ecnh th\u00e1i colony t\u1ed1t, t\u1ed1c \u0111\u1ed9 nh\u00e2n b\u1ea3n cao.&nbsp;<\/td><td>S\u1ea3n xu\u1ea5t d\u01b0\u1edbi \u0111i\u1ec1u ki\u1ec7n cGMP; kh\u00f4ng ch\u1ee9a b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n ngu\u1ed3n g\u1ed1c \u0111\u1ed9ng v\u1eadt\/human (AOF) n\u00ean d\u1ec5 truy v\u1ebft nguy\u00ean li\u1ec7u v\u00e0 an to\u00e0n virus v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi m\u00f4i tr\u01b0\u1eddng ch\u1ec9 kh\u00f4ng th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt s\u01a1 c\u1ea5p. \u0110\u00e3 \u0111\u0103ng k\u00fd FDA Master File cho TeSR-AOF (c\u00f3 th\u1ec3 cung c\u1ea5p LOA).<\/td><td>\u0110\u01b0\u1ee3c thi\u1ebft k\u1ebf cho ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p t\u1eeb hPSC: gi\u1ea3m r\u1ee7i ro ngo\u1ea1i lai t\u1ed1i \u0111a, ph\u00f9 h\u1ee3p nu\u00f4i c\u00e1c d\u00f2ng iPSC \u0111\u1ecbnh h\u01b0\u1edbng \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng ho\u1eb7c c\u00e1c quy tr\u00ecnh t\u1ea1o s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o t\u1eeb iPSC (v\u00ed d\u1ee5 bi\u1ec7t h\u00f3a t\u1ebf b\u00e0o tr\u1ecb li\u1ec7u) trong m\u00f4i tr\u01b0\u1eddng tu\u00e2n th\u1ee7 GMP.<\/td><td>Thermo CTS Essential 8 ho\u1eb7c NutriStem\u00ae hPSC XF \u2013 c\u00e1c m\u00f4i tr\u01b0\u1eddng hPSC AOF\/xeno-free t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t GMP v\u00e0 h\u1ed7 tr\u1ee3 h\u1ed3 s\u01a1 qu\u1ea3n l\u00fd (v\u00ed d\u1ee5 Essential 8 tu\u00e2n th\u1ee7 ti\u00eau chu\u1ea9n to\u00e0n c\u1ea7u, NutriStem c\u00f3 DMF FDA).<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Moi_truong_nuoi_cay_te_bao_goc_trung_mo_MSC\"><\/span>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSC)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>S\u1ea3n ph\u1ea9m&nbsp;<\/strong><\/td><td><strong>Ch\u1ee9c n\u0103ng ch\u00ednh \/ Lo\u1ea1i t\u1ebf b\u00e0o \u0111\u00edch&nbsp;<\/strong><\/td><td><strong>Tu\u00e2n th\u1ee7 cGMP &amp; ch\u1ee9ng nh\u1eadn&nbsp;<\/strong><\/td><\/tr><tr><td><a href=\"https:\/\/biogroupvietnam.com\/san-pham\/mesencult-acf-plus\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>MesenCult\u2122-ACF Plus&nbsp;<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt d\u00e0nh cho t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSC) ng\u01b0\u1eddi; \u0111i k\u00e8m b\u1ed9 kit c\u00f3 m\u00f4i tr\u01b0\u1eddng + ch\u1ea5t n\u1ec1n k\u1ebft d\u00ednh t\u1ed1i \u01b0u cho MSC b\u00e1m d\u00ednh. Cho ph\u00e9p nu\u00f4i m\u1edf r\u1ed9ng MSC in vitro m\u00e0 kh\u00f4ng c\u1ea7n huy\u1ebft thanh (FBS).&nbsp;<\/td><td>S\u1ea3n xu\u1ea5t theo quy tr\u00ecnh ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng ISO 13485; c\u00f4ng th\u1ee9c ACF (animal component-free) \u2013 kh\u00f4ng d\u00f9ng nguy\u00ean li\u1ec7u tr\u1ef1c ti\u1ebfp t\u1eeb \u0111\u1ed9ng v\u1eadt, gi\u00fap tr\u00e1nh bi\u1ebfn thi\u00ean v\u00e0 nguy c\u01a1 nhi\u1ec5m ngo\u1ea1i lai trong nu\u00f4i c\u1ea5y MSC. (L\u01b0u \u00fd: Hi\u1ec7n s\u1ea3n ph\u1ea9m \u1edf m\u1ee9c nghi\u00ean c\u1ee9u, c\u1ea7n th\u1ea9m \u0111\u1ecbnh th\u00eam khi \u0111\u01b0a v\u00e0o quy tr\u00ecnh GMP th\u1ef1c t\u1ebf).&nbsp;<\/td><\/tr><tr><td><a href=\"https:\/\/www.stemcell.com\/products\/mesencult-hpl-medium.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>MesenCult\u2122-hPL Medium<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng nu\u00f4i MSC s\u1eed d\u1ee5ng huy\u1ebft t\u01b0\u01a1ng gi\u00e0u ti\u1ec3u c\u1ea7u ng\u01b0\u1eddi (human platelet lysate, hPL) thay cho FBS. Cung c\u1ea5p c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng t\u1eeb ti\u1ec3u c\u1ea7u \u0111\u1ec3 th\u00fac \u0111\u1ea9y t\u0103ng sinh MSC m\u00e0 kh\u00f4ng c\u1ea7n huy\u1ebft thanh \u0111\u1ed9ng v\u1eadt. Ph\u00f9 h\u1ee3p m\u1edf r\u1ed9ng MSC b\u00e1m d\u00ednh t\u1eeb t\u1ee7y x\u01b0\u01a1ng, m\u00f4 m\u1ee1, d\u00e2y r\u1ed1n&#8230;&nbsp;<\/td><td>Th\u00e0nh ph\u1ea7n hPL \u0111\u00e3 x\u1eed l\u00fd lo\u1ea1i b\u1ecf m\u1ea7m b\u1ec7nh, \u0111\u1ea1t chu\u1ea9n GMP (c\u00f3 ch\u1ee9ng nh\u1eadn xu\u1ea5t x\u1ee9 v\u00e0 ph\u00e2n t\u00edch ch\u1ea5t l\u01b0\u1ee3ng). To\u00e0n b\u1ed9 m\u00f4i tr\u01b0\u1eddng kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt ngo\u1ea1i lai, gi\u1ea3m thi\u1ec3u r\u1ee7i ro nhi\u1ec5m prion\/virus b\u00f2. Do hPL c\u00f3 ngu\u1ed3n g\u1ed1c ng\u01b0\u1eddi n\u00ean l\u00f4 s\u1ea3n xu\u1ea5t c\u00f3 th\u1ec3 kh\u00e1c nhau, nh\u01b0ng \u0111\u00e3 \u0111\u01b0\u1ee3c chu\u1ea9n h\u00f3a t\u1ed1i \u0111a cho t\u00ednh nh\u1ea5t qu\u00e1n.&nbsp;<\/td><\/tr><tr><td><a href=\"https:\/\/biogroupvietnam.com\/san-pham\/mesencult-acf-plus\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>MesenCult\u2122-ACF Plus<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt d\u00e0nh cho t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSC) ng\u01b0\u1eddi; \u0111i k\u00e8m b\u1ed9 kit c\u00f3 m\u00f4i tr\u01b0\u1eddng + ch\u1ea5t n\u1ec1n k\u1ebft d\u00ednh t\u1ed1i \u01b0u cho MSC b\u00e1m d\u00ednh. Cho ph\u00e9p nu\u00f4i m\u1edf r\u1ed9ng MSC in vitro m\u00e0 kh\u00f4ng c\u1ea7n huy\u1ebft thanh (FBS).&nbsp;<\/td><td>S\u1ea3n xu\u1ea5t theo quy tr\u00ecnh ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng ISO 13485; c\u00f4ng th\u1ee9c ACF (animal component-free) \u2013 kh\u00f4ng d\u00f9ng nguy\u00ean li\u1ec7u tr\u1ef1c ti\u1ebfp t\u1eeb \u0111\u1ed9ng v\u1eadt, gi\u00fap tr\u00e1nh bi\u1ebfn thi\u00ean v\u00e0 nguy c\u01a1 nhi\u1ec5m ngo\u1ea1i lai trong nu\u00f4i c\u1ea5y MSC. (L\u01b0u \u00fd: Hi\u1ec7n s\u1ea3n ph\u1ea9m \u1edf m\u1ee9c nghi\u00ean c\u1ee9u, c\u1ea7n th\u1ea9m \u0111\u1ecbnh th\u00eam khi \u0111\u01b0a v\u00e0o quy tr\u00ecnh GMP th\u1ef1c t\u1ebf).&nbsp;<\/td><\/tr><tr><td><a href=\"https:\/\/biogroupvietnam.com\/san-pham\/bo-moi-truong-nuoi-cay-te-bao-mesencult-hpl\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>MesenCult\u2122-hPL Medium<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng nu\u00f4i MSC s\u1eed d\u1ee5ng huy\u1ebft t\u01b0\u01a1ng gi\u00e0u ti\u1ec3u c\u1ea7u ng\u01b0\u1eddi (human platelet lysate, hPL) thay cho FBS. Cung c\u1ea5p c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng t\u1eeb ti\u1ec3u c\u1ea7u \u0111\u1ec3 th\u00fac \u0111\u1ea9y t\u0103ng sinh MSC m\u00e0 kh\u00f4ng c\u1ea7n huy\u1ebft thanh \u0111\u1ed9ng v\u1eadt. Ph\u00f9 h\u1ee3p m\u1edf r\u1ed9ng MSC b\u00e1m d\u00ednh t\u1eeb t\u1ee7y x\u01b0\u01a1ng, m\u00f4 m\u1ee1, d\u00e2y r\u1ed1n&#8230;&nbsp;<\/td><td>Th\u00e0nh ph\u1ea7n hPL \u0111\u00e3 x\u1eed l\u00fd lo\u1ea1i b\u1ecf m\u1ea7m b\u1ec7nh, \u0111\u1ea1t chu\u1ea9n GMP (c\u00f3 ch\u1ee9ng nh\u1eadn xu\u1ea5t x\u1ee9 v\u00e0 ph\u00e2n t\u00edch ch\u1ea5t l\u01b0\u1ee3ng). To\u00e0n b\u1ed9 m\u00f4i tr\u01b0\u1eddng kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt ngo\u1ea1i lai, gi\u1ea3m thi\u1ec3u r\u1ee7i ro nhi\u1ec5m prion\/virus b\u00f2. Do hPL c\u00f3 ngu\u1ed3n g\u1ed1c ng\u01b0\u1eddi n\u00ean l\u00f4 s\u1ea3n xu\u1ea5t c\u00f3 th\u1ec3 kh\u00e1c nhau, nh\u01b0ng \u0111\u00e3 \u0111\u01b0\u1ee3c chu\u1ea9n h\u00f3a t\u1ed1i \u0111a cho t\u00ednh nh\u1ea5t qu\u00e1n.&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Moi_truong_nuoi_cay_te_bao_goc_tao_mau_HSC\"><\/span>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (HSC)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>S\u1ea3n ph\u1ea9m&nbsp;<\/strong><\/td><td><strong>Ch\u1ee9c n\u0103ng ch\u00ednh \/ Lo\u1ea1i t\u1ebf b\u00e0o \u0111\u00edch&nbsp;<\/strong><\/td><td><strong>Tu\u00e2n th\u1ee7 cGMP &amp; ch\u1ee9ng nh\u1eadn&nbsp;<\/strong><\/td><td><strong>\u1ee8ng d\u1ee5ng s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p&nbsp;<\/strong><\/td><td><strong>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng \u0111\u01b0\u01a1ng&nbsp;<\/strong><\/td><\/tr><tr><td><a href=\"https:\/\/biogroupvietnam.com\/san-pham\/stemspan-aof\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>StemSpan\u2122-AOF<\/strong><\/a>&nbsp;<\/td><td>M\u00f4i tr\u01b0\u1eddng kh\u00f4ng ngu\u1ed3n g\u1ed1c \u0111\u1ed9ng v\u1eadt (AOF) chuy\u00ean bi\u1ec7t cho nu\u00f4i c\u1ea5y v\u00e0 m\u1edf r\u1ed9ng t\u1ebf b\u00e0o g\u1ed1c\/t\u1ed5 ti\u00ean t\u1ea1o m\u00e1u CD34+ (t\u1eeb m\u00e1u cu\u1ed1ng r\u1ed1n, t\u1ee7y x\u01b0\u01a1ng, m\u00e1u ngo\u1ea1i vi) in vitro. Th\u00e0nh ph\u1ea7n ho\u00e0n to\u00e0n t\u1ed5ng h\u1ee3p ho\u1eb7c t\u00e1i t\u1ed5 h\u1ee3p (albumin, insulin, transferrin ng\u01b0\u1eddi t\u00e1i t\u1ed5 h\u1ee3p\u2026) v\u00e0 kh\u00f4ng c\u00f3 huy\u1ebft thanh. C\u1ea7n b\u1ed5 sung th\u00eam cytokine\/growth factor t\u00f9y m\u1ee5c \u0111\u00edch (v\u00ed d\u1ee5 SCF, TPO, IL-6\u2026) khi nu\u00f4i HSC.&nbsp;<\/td><td>S\u1ea3n xu\u1ea5t tu\u00e2n th\u1ee7 cGMP, \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh cao. \u0110\u00e3 \u0111\u0103ng k\u00fd Drug Master File (DMF) v\u1edbi FDA (M\u1ef9) v\u00e0 PMDA (Nh\u1eadt), c\u00f3 th\u1ec3 cung c\u1ea5p th\u01b0 LOA h\u1ed7 tr\u1ee3 h\u1ed3 s\u01a1 ph\u00e1p l\u00fd cho quy tr\u00ecnh li\u1ec7u ph\u00e1p gen\/t\u1ebf b\u00e0o. \u0110\u01b0\u1ee3c ch\u1ee9ng nh\u1eadn Animal Origin-Free t\u1edbi c\u1ea5p th\u1ee9 c\u1ea5p, thay th\u1ebf phi\u00ean b\u1ea3n StemSpan ACF tr\u01b0\u1edbc \u0111\u00e2y.&nbsp;<\/td><td>\u0110\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb s\u1eed d\u1ee5ng cho nu\u00f4i v\u00e0 m\u1edf r\u1ed9ng t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u CD34\u207a ex vivo tr\u01b0\u1edbc khi c\u1ea5y gh\u00e9p ho\u1eb7c ch\u1ec9nh s\u1eeda gen. \u0110\u00e3 ch\u1ee9ng minh kh\u1ea3 n\u0103ng t\u0103ng sinh m\u1ea1nh qu\u1ea7n th\u1ec3 HSC (CD34+CD90+&#8230;) m\u00e0 v\u1eabn gi\u1eef kh\u1ea3 n\u0103ng t\u1ea1o m\u00e1u l\u00e2u d\u00e0i in vivo. Th\u00edch h\u1ee3p trong s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p gen (vd. s\u1eeda ch\u1eefa HSC mang \u0111\u1ed9t bi\u1ebfn g\u00e2y b\u1ec7nh tr\u01b0\u1edbc khi truy\u1ec1n l\u1ea1i cho b\u1ec7nh nh\u00e2n) v\u00e0 c\u00e1c nghi\u00ean c\u1ee9u\/\u1ee9ng d\u1ee5ng v\u1ec1 t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (nh\u01b0 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u00e1u) nh\u1edd m\u00f4i tr\u01b0\u1eddng kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n ngo\u1ea1i lai v\u00e0 c\u00f3 h\u1ed7 tr\u1ee3 h\u1ed3 s\u01a1 qu\u1ea3n l\u00fd.&nbsp;<\/td><td>CellGenix GMP SCGM \u2013 m\u00f4i tr\u01b0\u1eddng m\u1edf r\u1ed9ng t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u kh\u00f4ng serum, xeno-free, s\u1ea3n xu\u1ea5t GMP (\u0111\u01b0\u1ee3c d\u00f9ng cho c\u1ea3 HSC v\u00e0 t\u1ebf b\u00e0o NK); Lonza TheraPEAK X-VIVO 10\/15 \u2013 m\u00f4i tr\u01b0\u1eddng kh\u00f4ng serum \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong nu\u00f4i c\u1ea5y HSC v\u00e0 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (c\u00f3 phi\u00ean b\u1ea3n s\u1ea3n xu\u1ea5t GMP, h\u1ed7 tr\u1ee3 nu\u00f4i CD34+ v\u00e0 t\u1ebf b\u00e0o lympho trong nhi\u1ec1u quy tr\u00ecnh li\u1ec7u ph\u00e1p).&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Moi_truong_nuoi_cay_te_bao_mien_dich_T_cell_NK_cell\"><\/span>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (T cell, NK cell)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>S\u1ea3n ph\u1ea9m&nbsp;<\/strong><\/td><td><strong>Ch\u1ee9c n\u0103ng ch\u00ednh \/ Lo\u1ea1i t\u1ebf b\u00e0o \u0111\u00edch&nbsp;<\/strong><\/td><td><strong>Tu\u00e2n th\u1ee7 cGMP &amp; ch\u1ee9ng nh\u1eadn&nbsp;<\/strong><\/td><td><strong>\u1ee8ng d\u1ee5ng s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p&nbsp;<\/strong><\/td><td><strong>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng \u0111\u01b0\u01a1ng&nbsp;<\/strong><\/td><\/tr><tr><td><a href=\"https:\/\/biogroupvietnam.com\/san-pham\/immunoculttm-xf\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>ImmunoCult\u2122-XF&nbsp;<\/strong><\/a><\/td><td>M\u00f4i tr\u01b0\u1eddng kh\u00f4ng serum, kh\u00f4ng th\u00e0nh ph\u1ea7n ngo\u1ea1i lai (xeno-free) d\u00e0nh cho m\u1edf r\u1ed9ng t\u1ebf b\u00e0o T (lympho T ng\u01b0\u1eddi) ex vivo. \u0110\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 nu\u00f4i t\u0103ng sinh m\u1ea1nh qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o T (CD3+) t\u1eeb m\u00e1u ngo\u1ea1i vi ho\u1eb7c t\u1eeb s\u1ea3n ph\u1ea9m t\u00e1ch ch\u1ecdn, \u0111\u1ed3ng th\u1eddi duy tr\u00ec t\u1ef7 l\u1ec7 s\u1ed1ng cao v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o T. Th\u01b0\u1eddng s\u1eed d\u1ee5ng k\u00e8m ch\u1ea5t ho\u1ea1t h\u00f3a ImmunoCult\u2122 CD3\/CD28 (ho\u1eb7c CD3\/CD28\/CD2) \u0111\u1ec3 k\u00edch th\u00edch T cell ph\u00e2n chia m\u00e0 kh\u00f4ng c\u1ea7n d\u00f9ng h\u1ea1t t\u1eeb t\u00ednh hay t\u1ebf b\u00e0o h\u1ed7 tr\u1ee3.&nbsp;<\/td><td>S\u1ea3n xu\u1ea5t theo c\u00e1c quy \u0111\u1ecbnh cGMP; ph\u00f9 h\u1ee3p h\u01b0\u1edbng d\u1eabn USP &lt;1043&gt; v\u00e0 ISO 20399 v\u1ec1 nguy\u00ean v\u1eadt li\u1ec7u h\u1ed7 tr\u1ee3 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o gen. C\u00f3 \u0111\u1ea7y \u0111\u1ee7 t\u00e0i li\u1ec7u truy xu\u1ea5t ngu\u1ed3n g\u1ed1c v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng (CoA, CoO) \u0111\u1ec3 h\u1ed7 tr\u1ee3 th\u1ea9m \u0111\u1ecbnh v\u00e0 h\u1ed3 s\u01a1 ph\u00e1p l\u00fd cho c\u00e1c nh\u00e0 ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p. (H\u1ed3 s\u01a1 FDA Master File cho d\u00f2ng ImmunoCult\u2122 \u0111ang \u0111\u01b0\u1ee3c ho\u00e0n thi\u1ec7n, d\u1ef1 ki\u1ebfn n\u1ed9p n\u0103m 2024).&nbsp;<\/td><td>\u0110\u01b0\u1ee3c t\u1ed1i \u01b0u cho quy tr\u00ecnh s\u1ea3n xu\u1ea5t li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T (nh\u01b0 CAR-T, TCR-T) \u1edf c\u00e1c giai \u0111o\u1ea1n l\u00e2m s\u00e0ng v\u00e0 th\u01b0\u01a1ng m\u1ea1i. M\u00f4i tr\u01b0\u1eddng n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 m\u1edf r\u1ed9ng t\u1ebf b\u00e0o T trong ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p ung th\u01b0, cho th\u1ea5y kh\u1ea3 n\u0103ng t\u0103ng sinh m\u1ea1nh v\u00e0 t\u1ea1o t\u1ebf b\u00e0o T ch\u1ee9c n\u0103ng (s\u1ea3n xu\u1ea5t cytokine t\u1ed1t) m\u00e0 kh\u00f4ng c\u1ea7n huy\u1ebft thanh. Quy tr\u00ecnh ImmunoCult-XF k\u1ebft h\u1ee3p ch\u1ea5t ho\u1ea1t h\u00f3a c\u00f2n gi\u00fap chu\u1ea9n h\u00f3a v\u00e0 m\u1edf r\u1ed9ng quy m\u00f4 s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o T t\u1eeb giai \u0111o\u1ea1n nghi\u00ean c\u1ee9u sang l\u00e2m s\u00e0ng m\u1ed9t c\u00e1ch li\u1ec1n m\u1ea1ch.&nbsp;<\/td><td>Lonza X-VIVO\u2122 15 (TheraPEAK) \u2013 m\u00f4i tr\u01b0\u1eddng kh\u00f4ng serum ph\u1ed5 bi\u1ebfn d\u00f9ng trong s\u1ea3n xu\u1ea5t CAR-T\/TIL (c\u00f3 phi\u00ean b\u1ea3n GMP, h\u1ed7 tr\u1ee3 t\u0103ng sinh m\u1ea1nh t\u1ebf b\u00e0o T); Miltenyi TexMACS\u2122 GMP Medium \u2013 m\u00f4i tr\u01b0\u1eddng chuy\u00ean bi\u1ec7t cho t\u1ebf b\u00e0o T\/Treg, kh\u00f4ng th\u00e0nh ph\u1ea7n \u0111\u1ed9ng v\u1eadt, \u0111\u1ea1t GMP; Gibco CTS NK-Xpander Medium \u2013 m\u00f4i tr\u01b0\u1eddng m\u1edf r\u1ed9ng t\u1ebf b\u00e0o NK chuy\u00ean d\u1ee5ng cho li\u1ec7u ph\u00e1p, c\u00f4ng th\u1ee9c t\u1ed1i \u01b0u cho t\u0103ng sinh NK \u1edf quy m\u00f4 l\u00e2m s\u00e0ng.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o kh\u00f4ng \u1ed5n \u0111\u1ecbnh c\u00f3 th\u1ec3 g\u00e2y r\u1ee7i ro nghi\u00eam tr\u1ecdng trong nghi\u00ean c\u1ee9u. \u0110\u00e1p \u1ee9ng t\u1ed1t ti\u00eau chu\u1ea9n cGMP kh\u1eaft khe, STEMCELL \u0111\u1ea3m b\u1ea3o m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o c\u1ee7a b\u1ea1n lu\u00f4n \u1ed5n \u0111\u1ecbnh v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cao, gi\u00fap gi\u1ea3m thi\u1ec3u sai s\u00f3t v\u00e0 r\u1ee7i ro trong nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng. \u0110\u1ec3 l\u1ef1a ch\u1ecdn m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o ph\u00f9 h\u1ee3p nh\u1ea5t, h\u00e3y li\u00ean h\u1ec7 ngay v\u1edbi Biogroup Vietnam \u0111\u1ec3 nh\u1eadn t\u01b0 v\u1ea5n chuy\u00ean s\u00e2u v\u00e0 gi\u1ea3i ph\u00e1p t\u1ed1i \u01b0u.<\/p>\n\n\n\n<p>\ud83d\udce9&nbsp;<strong>Th\u00f4ng tin li\u00ean h\u1ec7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Website:<\/strong><a href=\"https:\/\/biogroupvietnam.com\/public\/lien-he\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/biogroupvietnam.com\/public\/lien-he<\/a><\/li>\n\n\n\n<li><strong>Hotline:\u00a0<\/strong>+84 963 621 421<\/li>\n\n\n\n<li><strong>Email:<\/strong>\u00a0info@biogroupvietnam.vn\u00a0<\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/biogroupvietnam.com\/danh-muc-san-pham?organization=stemcell-technologies\" target=\"_blank\" rel=\"noreferrer noopener\"><em>T\u00ecm hi\u1ec3u th\u00eam s\u1ea3n ph\u1ea9m c\u1ee7a STEMCELL Technologies<\/em><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nguon_tham_khao\"><\/span>Ngu\u1ed3n tham kh\u1ea3o<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>TeSR\u2122-E8 medium for pluripotent stem cells<\/em>.<a href=\"https:\/\/www.stemcell.com\/products\/tesr-e8.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/products\/tesr-e8.html<\/a><\/li>\n\n\n\n<li>Thermo Fisher Scientific. (n.d.).\u00a0<em>CTS Essential 8\u2122 Medium<\/em>.<a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/stem-cell-research\/induced-pluripotent-stem-cells\/essential-6-8-medium\/cts-essential-8-medium.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/stem-cell-research\/induced-pluripotent-stem-cells\/essential-6-8-medium\/cts-essential-8-medium.html<\/a><\/li>\n\n\n\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>mTeSR\u21221 medium<\/em>.<a href=\"https:\/\/www.stemcell.com\/products\/mtesr1.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/products\/mtesr1.html<\/a><\/li>\n\n\n\n<li>BioInformant. (n.d.).\u00a0<em>Biological Industries NutriStem hPSC XF medium<\/em>.<a href=\"https:\/\/bioinformant.com\/biological-industries-nutristem-hpsc-xf\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/bioinformant.com\/biological-industries-nutristem-hpsc-xf<\/a><\/li>\n\n\n\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>mTeSR\u2122 Plus medium<\/em>.<a href=\"https:\/\/www.stemcell.com\/products\/mtesr-plus.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/products\/mtesr-plus.html<\/a><\/li>\n\n\n\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>TeSR\u2122-AOF medium<\/em>.<a href=\"https:\/\/www.stemcell.com\/products\/tesr-aof.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/products\/tesr-aof.html<\/a><\/li>\n\n\n\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>Mesenchymal stem cell culture portfolio<\/em>.<a href=\"https:\/\/www.stemcell.com\/product-portfolios\/mesenchymal\/view-all.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/product-portfolios\/mesenchymal\/view-all.html<\/a><\/li>\n\n\n\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>StemSpan\u2122-AOF medium<\/em>.<a href=\"https:\/\/www.stemcell.com\/products\/stemspan-aof.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/products\/stemspan-aof.html<\/a><\/li>\n\n\n\n<li>CellGenix. (n.d.).\u00a0<em>CellGenix\u00ae GMP SCGM<\/em>.<a href=\"https:\/\/cellgenix.com\/products\/gmp-scgm\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/cellgenix.com\/products\/gmp-scgm<\/a><\/li>\n\n\n\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>ImmunoCult\u2122-XF<\/em>.<a href=\"https:\/\/www.stemcell.com\/immunocult-xf.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/immunocult-xf.html<\/a><\/li>\n\n\n\n<li>STEMCELL Technologies. (n.d.).\u00a0<em>ImmunoCult\u2122 for T cell therapy manufacturing<\/em>.<a href=\"https:\/\/www.stemcell.com\/immunocult-for-t-cell-therapy-manufacturing\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.stemcell.com\/immunocult-for-t-cell-therapy-manufacturing<\/a><\/li>\n\n\n\n<li>Miltenyi Biotec. (n.d.).\u00a0<em>TexMACS\u2122 GMP Medium<\/em>.<a href=\"https:\/\/www.miltenyibiotec.com\/US-en\/products\/texmacs-gmp-medium.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.miltenyibiotec.com\/US-en\/products\/texmacs-gmp-medium.html<\/a><\/li>\n\n\n\n<li>Fisher Scientific. (n.d.).\u00a0<em>Natural killer cell culture media<\/em>.<a href=\"https:\/\/www.fishersci.com\/us\/en\/browse\/90300242\/natural-killer-cell-culture-media?page=1\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.fishersci.com\/us\/en\/browse\/90300242\/natural-killer-cell-culture-media?page=1<\/a><\/li>\n\n\n\n<li>Hernandez, R., M\u00fcller, T., P\u00f6rtner, R., &amp; Czermak, P. (2023). Developing GMP-compliant serum-free media for stem cell culture.\u00a0<em>Biotechnology Journal, 18<\/em>(6), e2300381.\u00a0<a href=\"https:\/\/doi.org\/10.1002\/biot.202300381\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1002\/biot.202300381<\/a>\u00a0<\/li>\n\n\n\n<li>Moll, G., Gei\u00dfler, S., Catar, R., Ignatowicz, L., Hoogduijn, M., Strunk, D., &#8230; &amp; Ringd\u00e9n, O. (2016). Evaluation of GMP-compliant culture media for mesenchymal stromal cell expansion for clinical applications.\u00a0<em>Journal of Environmental Management, 171<\/em>, 13\u201320.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.jenvman.2016.01.018\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.jenvman.2016.01.018<\/a>\u00a0<\/li>\n\n\n\n<li>Zhao, Y., Aldoss, I., Qu, C., Song, M., Li, C., &amp; Chen, G. (2020). Enhancing chimeric antigen receptor T cell therapeutic efficacy with media optimization.\u00a0<em>Molecular Therapy \u2013 Methods &amp; Clinical Development, 18<\/em>, 761\u2013771.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.omtm.2020.08.017\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.omtm.2020.08.017<\/a>\u00a0<\/li>\n\n\n\n<li>\u00a0Veritas. (n.d.).\u00a0<em>Products for your mesenchymal stromal cell research<\/em> [PDF].<a href=\"https:\/\/www.veritastk.co.jp\/products\/images\/BR27152-Products_for_Your_Mesenchymal_Stromal_Cell_Research.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0https:\/\/www.veritastk.co.jp\/products\/images\/BR27152-Products_for_Your_Mesenchymal_Stromal_Cell_Research.pdf<\/a><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o l\u00e0 n\u1ec1n t\u1ea3ng quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec v\u00e0 ph\u00e1t tri\u1ec3n t\u1ebf b\u00e0o. \u0110\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 hi\u1ec7u qu\u1ea3, c\u00e1c m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y ph\u1ea3i \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n nghi\u00eam ng\u1eb7t, trong \u0111\u00f3 c\u00f3 ti\u00eau chu\u1ea9n cGMP. M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o STEMCELL l\u00e0 s\u1ea3n<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/moi-truong-nuoi-cay-te-bao-stemcell-cgmp\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>\n","protected":false},"author":1,"featured_media":6630,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-6135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe-san-pham-moi"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o STEMCELL \u0111\u00e1p \u1ee9ng cGMP | Biogroup Vietnam<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biogroupvietnam.com\/vi\/cong-nghe-san-pham-moi\/moi-truong-nuoi-cay-te-bao-stemcell-cgmp\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o STEMCELL \u0111\u00e1p \u1ee9ng cGMP | Biogroup Vietnam\" \/>\n<meta property=\"og:description\" content=\"M\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o l\u00e0 n\u1ec1n t\u1ea3ng quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec v\u00e0 ph\u00e1t tri\u1ec3n t\u1ebf b\u00e0o. \u0110\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 hi\u1ec7u qu\u1ea3, c\u00e1c m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y ph\u1ea3i \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n nghi\u00eam ng\u1eb7t, trong \u0111\u00f3 c\u00f3 ti\u00eau chu\u1ea9n cGMP. 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