{"id":4365,"date":"2024-02-25T08:22:10","date_gmt":"2024-02-25T08:22:10","guid":{"rendered":"http:\/\/biogroupvietnam-worldpress.local\/service\/terminology-used-in-research-and-application-of-cell-therapy\/"},"modified":"2025-09-29T13:01:50","modified_gmt":"2025-09-29T06:01:50","slug":"cac-thuat-ngu-dung-trong-nghien-cuu-va-ung-dung-tri-lieu-te-bao","status":"publish","type":"service","link":"https:\/\/biogroupvietnam.com\/vi\/dich-vu\/cac-thuat-ngu-dung-trong-nghien-cuu-va-ung-dung-tri-lieu-te-bao\/","title":{"rendered":"C\u00e1c Thu\u1eadt Ng\u1eef D\u00f9ng Trong Nghi\u00ean C\u1ee9u v\u00e0 \u1ee8ng D\u1ee5ng Tr\u1ecb Li\u1ec7u T\u1ebf B\u00e0o"},"content":{"rendered":"

C\u00e1c thu\u1eadt ng\u1eef d\u00f9ng trong h\u01b0\u1edbng d\u1eabn nghi\u00ean c\u1ee9u \u1ee9ng d\u1ee5ng t\u1ebf b\u00e0o v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o t\u1ea1i Vi\u1ec7t Nam theo Quy\u1ebft \u0111\u1ecbnh s\u1ed1 4259\/Q\u0110-BYT ng\u00e0y 12\/10\/2020 c\u1ee7a B\u1ed9 tr\u01b0\u1edfng B\u1ed9 Y t\u1ebf.<\/h2>\n

T\u1ebf b\u00e0o (cell):<\/strong> l\u00e0 m\u1ed9t \u0111\u01a1n v\u1ecb c\u1ea5u tr\u00fac c\u01a1 b\u1ea3n c\u00f3 ch\u1ee9c n\u0103ng sinh h\u1ecdc c\u1ee7a c\u01a1 th\u1ec3 ng\u01b0\u1eddi. T\u1ebf b\u00e0o bao g\u1ed3m m\u00e0ng t\u1ebf b\u00e0o bao quanh nguy\u00ean sinh ch\u1ea5t, trong \u0111\u00f3 c\u00f3 nhi\u1ec1u ph\u00e2n t\u1eed sinh h\u1ecdc nh\u01b0 c\u00e1c protein v\u00e0 acid nucleic.<\/p>\n

T\u1ebf b\u00e0o sinh d\u1ee5c (reproductive cell hay germ cell):<\/strong> l\u00e0 t\u1ebf b\u00e0o c\u00f3 kh\u1ea3 n\u0103ng sinh ra giao t\u1eed (tinh tr\u00f9ng ho\u1eb7c tr\u1ee9ng\/no\u00e3n).<\/p>\n

T\u1ebf b\u00e0o sinh d\u01b0\u1ee1ng (somatic cell):<\/strong> l\u00e0 c\u00e1c t\u1ebf b\u00e0o kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o th\u00e0nh giao t\u1eed, ch\u1ec9 tham gia v\u00e0o c\u00e1c ch\u1ee9c n\u0103ng sinh d\u01b0\u1ee1ng c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c (stem cell): <\/strong>l\u00e0 nh\u1eefng t\u1ebf b\u00e0o xu\u1ea5t hi\u1ec7n t\u1ef1 nhi\u00ean trong c\u01a1 th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng ph\u00e2n chia v\u00e0 bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c ph\u00f4i (embryonic stem cells – ESC):<\/strong> l\u00e0 c\u00e1c TBG \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb kh\u1ed1i t\u1ebf b\u00e0o b\u00ean trong (inner cell mass) c\u1ee7a ph\u00f4i. TBG ph\u00f4i l\u00e0 c\u00e1c TBG v\u1ea1n ti\u1ec1m n\u0103ng v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh h\u1ea7u nh\u01b0 m\u1ecdi lo\u1ea1i t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u01a1 th\u1ec3 con ng\u01b0\u1eddi.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c sinh d\u01b0\u1ee1ng:<\/strong> T\u1ebf b\u00e0o g\u1ed1c sinh d\u01b0\u1ee1ng (somatic stem cell) hay t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh (adult stem cell) l\u00e0 c\u00e1c TBG c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o sinh d\u01b0\u1ee1ng, kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o sinh d\u1ee5c.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u:<\/strong> T\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u (hematopoietic stem cell – HSC) l\u00e0 m\u1ed9t l\u1edbp c\u1ee5 th\u1ec3 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o g\u1ed1c \u0111\u1eb7c hi\u1ec7u m\u00f4, c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o bi\u1ec7t h\u00f3a c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c d\u00f2ng t\u1ea1o m\u00e1u.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4:<\/strong> T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (mesenchylmal stem cell – MSC) c\u00f3 ngu\u1ed3n g\u1ed1c ch\u1ee7 y\u1ebfu t\u1eeb ch\u1ea5t n\u1ec1n t\u1ee7y x\u01b0\u01a1ng ho\u1eb7c m\u00f4 m\u1ee1. Ngo\u00e0i ra, MSC \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb nhi\u1ec1u m\u00f4 kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 v\u00f5ng m\u1ea1c, gan, bi\u1ec3u m\u00f4 d\u1ea1 d\u00e0y, g\u00e2n, bao ho\u1ea1t d\u1ecbch m\u00e0ng, nhau thai, d\u00e2y r\u1ed1n v\u00e0 m\u00e1u. MSC \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh d\u1ef1a tr\u00ean kh\u1ea3 n\u0103ng b\u00e1m d\u00ednh tr\u00ean n\u1ec1n nu\u00f4i c\u1ea5y, bi\u1ec3u hi\u1ec7n kh\u00e1ng nguy\u00ean b\u1ec1 m\u1eb7t c\u1ee5 th\u1ec3 v\u00e0 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a \u0111a ti\u1ec1m n\u0103ng. Ch\u00fang l\u00e0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c gi\u1edbi h\u1ea1n theo d\u00f2ng v\u00ec ch\u00fang c\u00f3 th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c d\u00f2ng t\u1ebf b\u00e0o c\u00f3 ngu\u1ed3n g\u1ed1c trung m\u00f4, nh\u01b0 l\u00e0 t\u1ebf b\u00e0o g\u1ed1c d\u00f2ng m\u00f4 m\u1ee1, m\u00f4 x\u01b0\u01a1ng v\u00e0 m\u00f4 s\u1ee5n. Trong \u0111i\u1ec1u ki\u1ec7n nu\u00f4i c\u1ea5y in vitro th\u00edch h\u1ee3p, MSC c\u00f3 th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh nguy\u00ean b\u00e0o s\u1ee3i, t\u1ebf b\u00e0o c\u01a1 x\u01b0\u01a1ng, t\u1ebf b\u00e0o h\u00ecnh sao v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh…<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c \u0111\u1eb7c hi\u1ec7u m\u00f4\/ t\u1ebf b\u00e0o \u0111\u1ea7u d\u00f2ng \u0111\u1eb7c hi\u1ec7u m\u00f4:<\/strong> l\u00e0 TBG c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a h\u1ea1n ch\u1ebf v\u00e0 th\u01b0\u1eddng t\u1ea1o ra m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o ho\u1eb7c m\u1ed9t v\u00e0i lo\u1ea1i t\u1ebf b\u00e0o d\u00e0nh ri\u00eang cho lo\u1ea1i m\u00f4 (v\u00ed d\u1ee5: nguy\u00ean b\u00e0o s\u1ee3i, nguy\u00ean b\u00e0o x\u01b0\u01a1ng, t\u1ebf b\u00e0o h\u00ecnh sao).<\/p>\n

C\u00e1c t\u1ebf b\u00e0o g\u1ed1c v\u1ea1n ti\u1ec1m n\u0103ng c\u1ea3m \u1ee9ng (iPSC)<\/strong>: l\u00e0 c\u00e1c TBG \u0111\u01b0\u1ee3c t\u1ea1o ra theo h\u00ecnh th\u1ee9c nh\u00e2n t\u1ea1o. Ch\u00fang \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh l\u1ea1i t\u1eeb c\u00e1c t\u1ebf b\u00e0o soma tr\u01b0\u1edfng th\u00e0nh nh\u01b0 nguy\u00ean b\u00e0o s\u1ee3i da, mang c\u00e1c \u0111\u1eb7c t\u00ednh g\u1ed1c t\u01b0\u01a1ng t\u1ef1 nh\u01b0 t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i nh\u01b0 kh\u1ea3 n\u0103ng t\u1ef1 \u0111\u1ed5i m\u1edbi v\u00e0 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a \u0111a d\u00f2ng, v\u00e0 c\u1ea3 kh\u1ea3 n\u0103ng t\u1ea1o u qu\u00e1i (teratomas). Ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u iPSC \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1eeb c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o tr\u01b0\u1edfng th\u00e0nh kh\u00e1c nhau. Kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u00e0y d\u01b0\u1eddng nh\u01b0 l\u00e0 ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i v\u00e0 tu\u1ed5i c\u1ee7a c\u00e1c t\u1ebf b\u00e0o m\u00e0 iPSC \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh l\u1ea1i.<\/p>\n

T\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch:<\/strong> T\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (immune cell) l\u00e0 c\u00e1c t\u1ebf b\u00e0o c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, c\u00f3 ch\u1ee9c n\u0103ng tham gia v\u00e0o c\u00e1c \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch c\u1ee7a c\u01a1 th\u1ec3, bao g\u1ed3m c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u (lympho B, lympho T, t\u1ebf b\u00e0o NK; c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u nh\u00e2n \u0111a h\u00ecnh trung t\u00ednh, \u00e1i ki\u1ec1m, \u00e1i toan) h\u1ec7 c\u00e1c t\u1ebf b\u00e0o \u0111\u01a1n nh\u00e2n – \u0111\u1ea1i th\u1ef1c b\u00e0o, t\u1ebf b\u00e0o tua.<\/p>\n

Tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o (cell therapy hay cellular therapy):<\/strong> l\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c t\u1ebf b\u00e0o s\u1ed1ng d\u01b0\u1edbi h\u00ecnh th\u1ee9c ti\u00eam, truy\u1ec1n ho\u1eb7c c\u1ea5y gh\u00e9p v\u00e0o b\u1ec7nh nh\u00e2n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh.<\/p>\n

Tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o g\u1ed1c (stem cell therapy):<\/strong> l\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c t\u1ebf b\u00e0o g\u1ed1c d\u01b0\u1edbi h\u00ecnh th\u1ee9c ti\u00eam, truy\u1ec1n ho\u1eb7c c\u1ea5y gh\u00e9p v\u00e0o b\u1ec7nh nh\u00e2n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh.<\/p>\n

Tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (immune\/immuno cell therapy):<\/strong> l\u00e0 li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb d\u01b0\u1edbi h\u00ecnh th\u1ee9c ti\u00eam, truy\u1ec1n c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch nh\u1eb1m m\u1ee5c \u0111\u00edch thay \u0111\u1ed5i kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n

S\u1ea3n ph\u1ea9m tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o:<\/strong> S\u1ea3n ph\u1ea9m tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o (cell ho\u1eb7c cellular therapy product) l\u00e0 ch\u1ebf ph\u1ea9m t\u1ebf b\u00e0o sinh d\u01b0\u1ee1ng \u0111\u01b0\u1ee3c thu nh\u1eadn t\u1eeb m\u1ed9t ng\u01b0\u1eddi cho \u0111\u1ec3 s\u1eed d\u1ee5ng cho m\u1ee5c \u0111\u00edch c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o \u0111i\u1ec1u tr\u1ecb b\u1ec7nh.<\/p>\n

S\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o:<\/strong> S\u1ea3n ph\u1ea9m tr\u1ecb li\u1ec7u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o (cellderived therapeutical products) (g\u1ecdi t\u1eaft l\u00e0 s\u1ea3n ph\u1ea9n t\u1eeb t\u1ebf b\u00e0o) l\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m tr\u1ecb li\u1ec7u kh\u00f4ng ch\u1ee9a t\u1ebf b\u00e0o nh\u01b0ng ch\u1ee9a c\u00e1c h\u1ee3p ch\u1ea5t do t\u1ebf b\u00e0o ch\u1ebf ti\u1ebft ra m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o ho\u1eb7c c\u00e1c th\u00e0nh ph\u1ea7n d\u01b0\u1edbi t\u1ebf b\u00e0o thu \u0111\u01b0\u1ee3c sau khi ph\u00e1 v\u1ee1 c\u1ea5u tr\u00fac c\u1ee7a c\u00e1c t\u1ebf b\u00e0o.<\/p>\n

T\u1ef1 th\u00e2n:<\/strong> T\u1ef1 th\u00e2n (autologous) l\u00e0 h\u00ecnh th\u1ee9c s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o ho\u1eb7c s\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3 n\u00e0o ti\u00eam, truy\u1ec1n, c\u1ea5y gh\u00e9p cho c\u01a1 th\u1ec3 \u1ea5y; tr\u00ean th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng l\u00e0 c\u1ee7a ai \u0111\u01b0\u1ee3c ti\u00eam, truy\u1ec1n ho\u1eb7c c\u1ea5y gh\u00e9p cho ch\u00ednh ng\u01b0\u1eddi \u0111\u00f3.<\/p>\n

\u0110\u1ed3ng lo\u00e0i:<\/strong> \u0110\u1ed3ng lo\u00e0i hay kh\u00e1c gen \u0111\u1ed3ng lo\u00e0i (allogenic) l\u00e0 h\u00ecnh th\u1ee9c s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o ho\u1eb7c s\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3 n\u00e0y ti\u00eam, truy\u1ec1n, c\u1ea5y gh\u00e9p cho c\u01a1 th\u1ec3 kh\u00e1c trong c\u00f9ng m\u1ed9t lo\u00e0i; tr\u00ean th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng l\u00e0 c\u1ee7a ng\u01b0\u1eddi n\u00e0y ti\u00eam, truy\u1ec1n ho\u1eb7c c\u1ea5y gh\u00e9p cho ng\u01b0\u1eddi kh\u00e1c kh\u00f4ng ph\u1ea3i anh\/ch\u1ecb em sinh \u0111\u00f4i \u0111\u1ed3ng h\u1ee3p t\u1eed, th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u1ecdi t\u1eaft l\u00e0 \u201cd\u1ecb gh\u00e9p\u201d.<\/p>\n

\u0110\u1ed3ng gen:<\/strong> \u0110\u1ed3ng gen (iosogenic) l\u00e0 h\u00ecnh th\u1ee9c s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o ho\u1eb7c s\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3 n\u00e0y ti\u00eam, truy\u1ec1n, c\u1ea5y gh\u00e9p cho c\u01a1 th\u1ec3 kh\u00e1c c\u00f3 b\u1ed9 gen gi\u1ed1ng b\u1ed9 gen c\u1ee7a c\u01a1 th\u1ec3 cho; tr\u00ean th\u1ef1c nghi\u1ec7m l\u00e0 c\u00e1c \u0111\u1ed9ng v\u1eadt trong c\u00f9ng m\u1ed9t d\u00f2ng thu\u1ea7n ch\u1ee7ng, tr\u00ean th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng l\u00e0 c\u00e1c anh\/ch\u1ecb em sinh \u0111\u00f4i \u0111\u1ed3ng h\u1ee3p t\u1eed.<\/p>\n

D\u1ecb lo\u00e0i:<\/strong> \u0110\u1ed3ng gen (iosogenic) l\u00e0 h\u00ecnh th\u1ee9c s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o ho\u1eb7c s\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3 n\u00e0y ti\u00eam, truy\u1ec1n, c\u1ea5y gh\u00e9p cho c\u01a1 th\u1ec3 thu\u1ed9c lo\u00e0i kh\u00e1c; tr\u00ean th\u1ef1c nghi\u1ec7m l\u00e0 t\u1eeb ng\u01b0\u1eddi ho\u1eb7c \u0111\u1ed9ng v\u1eadt kh\u00e1c lo\u00e0i gh\u00e9p cho m\u1ed9t \u0111\u1ed9ng v\u1eadt th\u1ef1c nghi\u1ec7m; tr\u00ean th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng l\u00e0 t\u1eeb \u0111\u1ed9ng v\u1eadt gh\u00e9p cho ng\u01b0\u1eddi.<\/p>\n

Nguy c\u01a1 r\u1ee7i ro<\/strong> l\u00e0 m\u1ed9t t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i ti\u1ec1m t\u00e0ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c quy cho vi\u1ec7c s\u1eed d\u1ee5ng s\u1ea3n ph\u1ea9m tr\u1ecb li\u1ec7u tr\u00ean l\u00e2m s\u00e0ng v\u00e0 g\u00e2y lo ng\u1ea1i cho b\u1ec7nh nh\u00e2n v\u00e0 \/ ho\u1eb7c cho c\u00e1c nh\u00f3m d\u00e2n c\u01b0 kh\u00e1c<\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n

    \n
  1. H\u01b0\u1edbng d\u1eabn nghi\u00ean c\u1ee9u \u1ee9ng d\u1ee5ng t\u1ebf b\u00e0o v\u00e0 s\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o t\u1ea1i Vi\u1ec7t Nam. Quy\u1ebft \u0111\u1ecbnh s\u1ed1 4259\/Q\u0110-BYT ng\u00e0y 12\/10\/2020 c\u1ee7a B\u1ed9 tr\u01b0\u1edfng B\u1ed9 Y t\u1ebf<\/i><\/li>\n<\/ol>\n

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