EXODUS T-2800 & H-600 – Automated exosome extraction systems

Exodus Bio. a U.S.-based company specializing in exosome technology development, has successfully developed the EXODUS T-2800 & H-600 automated exosome isolation systems. This new technology has received high expert praise, perfectly replacing the previous wasteful isolation methods.

 

Introduction to the Exodus exosome extraction system

Exosomes are emerging as a key component in regenerative medicine and diagnostics. In particular, exosome-based cell therapy is expected to bring breakthroughs in treatment due to its ability to transmit information between cells and stimulate tissue regeneration. However, the isolation and extraction of exosomes from biological samples is a significant challenge. Traditional methods such as ultracentrifugation have many limitations regarding time, yield, and purity, hindering research progress and clinical applications. To address this issue, EXODUS T-2800 and EXODUS H-600 have been developed as two advanced automatic exosome separation machines, providing a comprehensive solution for isolating exosomes quickly, efficiently, and with high purity.

The EXODUS T-2800 & H-600 systems are designed to meet different needs: the H-600 serves research in laboratories and small-scale production, while the EXODUS T-2800 is suitable for industrial-scale production following GMP standards. Both systems use advanced ultrasonic nano-filtration technology and an automated closed process, making it easy for stem cell therapy centers, research institutes, and biotechnology companies in Vietnam to obtain high-quality exosomes for research and treatment purposes. Notably, the EXODUS exosome isolation method was published in Nature Methods in 2021, confirming this technology’s groundbreaking and reliable nature.

EXODUS T-2800 – Large-scale automated exosome separation solution, GMP compliant

 

While the EXODUS H-600 is designed for laboratory-scale operations, the EXODUS T-2800 is developed for large-scale industrial exosome production. The EXODUS T-2800 is a fully automated exosome isolation system integrating sample pretreatment, separation, and exosome recovery into a single device. Using advanced ultrasonic nano-filtration technology, this system offers a robust solution for exosome production for drug formulation, therapeutic applications, and regenerative medicine on an industrial scale. The EXODUS T-2800 ensures high purity and yield consistency between batches (batch-to-batch) while strictly adhering to GMP (Good Manufacturing Practices) for biological product production.

Regarding processing capacity, the EXODUS T-2800 handles input sample volumes from 0.5 to 10 liters, making it suitable for isolating exosomes from large-scale cell culture batches or high-volume sample sources. The separation speed of the machine is 1-2 liters per hour, significantly reducing processing time compared to traditional methods. After the separation process, exosomes can be concentrated at least 100 times higher than the initial sample, and users can adjust the concentration ratio as needed. This means that from several liters of the initial culture medium, the EXODUS T-2800 can isolate exosomes into a small volume, making it easy to store and use for subsequent applications.

 

Key Specifications of EXODUS T-2800: 

• Convenient “3-in-1” integration: The EXODUS T-2800 integrates three main functions into a single system: sample pretreatment, exosome isolation, and automatic recovery. Users do not need to operate multiple separate devices; the closed process reduces manual handling and contamination risk, simplifying large-scale exosome production.
• Exceptional separation efficiency: The system ensures high purity and exosome recovery efficiency. Specifically, the protein removal efficiency is >99%, the particle-to-protein ratio can reach 5×10⁸ particles/mg protein, and exosome concentrations after separation can reach 10¹¹–10¹² particles/mL, depending on the sample type. As a result, the exosome product is rich in vesicles and nearly free of excess protein, meeting stringent quality criteria for therapeutic applications.
• Reliable end product quality: The entire exosome separation process in the EXODUS T-2800 occurs in a sterile, closed system. The device uses sterile, single-use consumables that are endotoxin-free to ensure the exosomes are free of microbial contamination and endotoxins, making them safe for subsequent applications. Removing over 99% of background proteins from the culture medium minimizes the risk of adverse reactions when exosomes are used in the body, enhancing the biosafety of the product.
• Stable operation & smart control: The EXODUS T-2800 operates with a fully automated process, ensuring consistency between production batches. The system allows real-time monitoring of the separation process and has a clever error-handling mechanism, making it easy for operators to manage exosome quality in each batch. The integrated touchscreen provides a user-friendly interface for monitoring progress and adjusting parameters if necessary, similar to the EXODUS H-600.
• Safety & compliance: The EXODUS T-2800 is designed to meet strict standards in biopharmaceutical production. All consumables are sterilized and meet pharmacopeial cleanliness standards, ensuring the final exosome product meets human-use requirements. The hardware and data management software comply with GMP guidelines and 21 CFR Part 11 (FDA regulations on electronic records), making it easy for facilities to validate the system in exosome production processes and meet regulatory requirements before clinical application.

With these advantages, the EXODUS T-2800 is an ideal solution for industrial-scale exosome production. This system has been deployed at numerous research institutions and biotechnology companies worldwide, supporting projects in drug delivery, cancer therapy, vaccines, regenerative medicine, and other advanced fields. EXODUS T-2800 & H-600 have been used in studies published in prestigious journals like Nature Methods, ACS Nano, and Science Advances, further affirming the effectiveness and reliability of this technology.

EXODUS H-600 – Automated exosome isolation system for R&D

 

The EXODUS H-600 is an automated exosome isolation system that is label-free (no use of labels) and high-performance, designed for research laboratories and small-scale production. This device allows for rapidly isolating intact, high-quality exosomes from a wide range of biological samples with flexible sample volumes. The H-600 is compact (dimensions ~53.5 × 51.0 × 47.5 cm, weight ~40 kg), making it convenient for laboratory spaces. The EXODUS H-600 model has been used for research and preclinical purposes, helping scientists obtain purified exosomes for studies on stem cells, cancer, immunology, and various other fields.

 

Key Specifications of EXODUS H-600:

• Rapid isolation: Maximum sample processing speed of up to 200 mL/hour, significantly reducing exosome isolation time compared to traditional methods. Users can obtain exosomes quickly, improving research and production efficiency.
• High recovery efficiency, optimal purity: Achieves a purity of ~99% and a recovery efficiency of ~90% of exosomes from the initial sample. The system removes >99% of protein contaminants, ensuring the exosome preparation is almost impurity-free. This ensures that the exosomes obtained are high quality and suitable for high-purity applications.
• Versatile sample applications: The EXODUS H-600 can process most common biological samples, including plasma, urine, saliva, cerebrospinal fluid, tears, cell culture media, bacterial culture media, tissue fluids, and plant samples. Input sample volumes range from 10 μL to 250 mL, suitable for rare and large-volume samples. This versatility makes the EXODUS H-600 ideal for various research purposes, from small-scale experiments to pilot production.
• Fully automated & convenient process: The EXODUS H-600 is pre-programmed with optimal protocols for each sample type. Operators load the sample and start the system, which automatically carries out the steps from sample processing and exosome filtration to final product recovery. The entire process is performed in a closed loop, minimizing errors due to manual handling and ensuring reproducibility between runs. The system features a 10.4-inch touchscreen that displays real-time operating parameters (sample type, time, separation progress, etc.) and can store data for up to 20,000 runs for traceability and quality management.
• Good control conditions & biosafety: The sample temperature is controlled at 2-8°C to preserve the stability of the exosomes during the isolation process. The device has an integrated UV sterilization light that automatically turns off every 30 minutes, preventing contamination and ensuring a sterile separation environment. The EXODUS H-600 uses PBS buffer for isolation, requiring no antibodies or labeled chemicals, making it entirely label-free and avoiding introducing foreign contaminants. It also features connectivity ports (USB, network, serial) for data export or integration with laboratory management systems.

With these advantages, the EXODUS H-600 is a valuable assistant for exosome research laboratories. It speeds up the automatic exosome collection process and ensures the obtained product is of high quality and consistency. Research centers in Vietnam can use the EXODUS H-600 to easily screen and analyze exosomes in oncology, molecular biology, cell therapy, and other fields, thus driving new scientific discoveries and the practical application of exosomes.

Applications and benefits of exosome therapy

The launch of the EXODUS T-2800 & H-600 systems opens up significant opportunities for Vietnam’s scientific and medical communities to harness the potential of exosomes. Stem cell therapy centers, research institutes, and biotechnology companies can proactively produce high-quality exosome products quickly, conveniently, and standardly. This is particularly important as exosome therapy develops, requiring pure and safe exosome sources for human trials and applications.

For larger-scale operations, the EXODUS T-2800 helps exosome production units meet commercial and clinical demands. By complying with GMP standards and ensuring consistent high-quality production, this device enables large batches of exosomes to meet the rigorous standards required for late-stage clinical trials and commercialization. For example, in mesenchymal stem cell-based exosome therapies, having the EXODUS T-2800 system ensures that each batch of exosomes meets safety and efficacy standards before being used for patient treatment. Furthermore, the large output of high-purity exosomes from the EXODUS T-2800 can boost new applications like exosome-based vaccine development, liquid biopsy, and targeted cancer therapies.

With the EXODUS T-2800 & H-600, R&D laboratories can accelerate research: from isolating exosomes for biomarker analysis, studying disease mechanisms, to preclinical testing of new therapies. The automated system saves time and workforce, allowing scientists to focus on analysis and product development rather than manual isolation procedures. The EXODUS H-600 is also helpful in preparing exosome samples for early-stage clinical trials or producing small batches for personalized therapies.

 

In summary, the EXODUS T-2800 & H-600 lead automated exosome extraction solutions, fully addressing research and industrial production needs. Investing in these systems will help institutions in Vietnam enhance their exosome research and production capabilities, keeping up with global scientific trends in exosome-based cell therapies. With outstanding performance, reliable product quality, and high automation, the EXODUS T-2800 & H-600 promise to be a strong technological foundation, supporting scientists and clinicians in developing new therapies for public health care. Automated exosome extraction systems are not just extraction devices but the key to unlocking a new era for applying exosomes in regenerative medicine and disease treatment worldwide.

 

 Contact us now for a free consultation on EXODUS T-2800 & H-600

• Website: https://biogroupvietnam.com/public/lien-he
• Hotline: +84 963 621 421
• Email: info@biogroupvietnam.vn 

 

References

1. EXODUS Bio Inc. (n.d.). Company Profile. Retrieved from https://www.exodusbio.com 
2. NEXUS Analytics Indonesia. (n.d.). Company Overview [LinkedIn page]. Retrieved from https://www.linkedin.com/company/nexus-analytics-indonesia/
3. Chen, Y., Zhu, Q., Cheng, L., Wang, Y., Li, M., Yang, Q., Hu, L., Lou, D., Li, J., Dong, X., Lee, L. P., & Liu, F. (2021). Exosome detection via the ultrafast‑isolation system: EXODUS. Nature Methods, 18(2), 212–218. https://doi.org/10.1038/s41592-020-01034-x